{"id":"https://openalex.org/W2118731971","doi":"https://doi.org/10.4049/jimmunol.0900055","title":"Eosinophil Ribonucleases and Their Cutaneous Lesion-Forming Activity","display_name":"Eosinophil Ribonucleases and Their Cutaneous Lesion-Forming Activity","publication_year":2009,"publication_date":"2009-08-28","ids":{"openalex":"https://openalex.org/W2118731971","doi":"https://doi.org/10.4049/jimmunol.0900055","mag":"2118731971","pmid":"https://pubmed.ncbi.nlm.nih.gov/19717523","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2852253"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.0900055","doi":"https://doi.org/10.4049/jimmunol.0900055","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.0900055","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/183/6/4013/1286749/zim01809004013.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/183/6/4013/1286749/zim01809004013.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078086876","display_name":"Douglas A. Plager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A Plager","raw_affiliation_strings":["Department of Dermatology","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103464712","display_name":"Mark D.P. Davis","orcid":"https://orcid.org/0000-0003-0936-580X","observed_orcids":["https://orcid.org/0000-0003-0936-580X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D P Davis","raw_affiliation_strings":["Department of Dermatology","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075821665","display_name":"Amy G. Andrews","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy G Andrews","raw_affiliation_strings":["Department of Comparative Medicine","Comparative Medicine (Veterinary Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Medicine","institution_ids":[]},{"raw_affiliation_string":"Comparative Medicine (Veterinary Medicine)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113964994","display_name":"Michael J. Coenen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Coenen","raw_affiliation_strings":["Department of Dermatology","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018741229","display_name":"Terry J. George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry J George","raw_affiliation_strings":["Department of Dermatology","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089757484","display_name":"Gerald J. Gleich","orcid":"https://orcid.org/0000-0002-6317-0811","observed_orcids":["https://orcid.org/0000-0002-6317-0811"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J Gleich","raw_affiliation_strings":["Department of Immunology","\u00a7Department of Medicine, Mayo Clinic, Rochester, MN 55905","\u2021Department of Immunology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology","institution_ids":[]},{"raw_affiliation_string":"\u00a7Department of Medicine, Mayo Clinic, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"\u2021Department of Immunology, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080324106","display_name":"Kristin M. Leiferman","orcid":"https://orcid.org/0000-0001-9421-0575","observed_orcids":["https://orcid.org/0000-0001-9421-0575"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin M Leiferman","raw_affiliation_strings":["Department of Dermatology","Mayo Clinic Rochester, MN","University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.6739,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.73033106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"183","issue":"6","first_page":"4013","last_page":"4020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophil-cationic-protein","display_name":"eosinophil cationic protein","score":0.953000009059906},{"id":"https://openalex.org/keywords/eosinophil-derived-neurotoxin","display_name":"eosinophil-derived neurotoxin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/eosinophil-peroxidase","display_name":"eosinophil peroxidase","score":0.859000027179718},{"id":"https://openalex.org/keywords/major-basic-protein","display_name":"major basic protein","score":0.8870000243186951},{"id":"https://openalex.org/keywords/eosinophil-granule-proteins","display_name":"eosinophil granule proteins","score":0.9549999833106995},{"id":"https://openalex.org/keywords/skin-lesions","display_name":"skin lesions","score":0.8299999833106995},{"id":"https://openalex.org/keywords/skin-ulcers","display_name":"skin ulcers","score":0.699999988079071},{"id":"https://openalex.org/keywords/intradermal-injection","display_name":"intradermal injection","score":0.8379999995231628},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/hypereosinophilic-syndrome","display_name":"hypereosinophilic syndrome","score":0.9319999814033508},{"id":"https://openalex.org/keywords/guinea-pig-skin","display_name":"guinea pig skin","score":0.550000011920929},{"id":"https://openalex.org/keywords/rabbit-skin","display_name":"rabbit skin","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7602924108505249},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.7264868021011353},{"id":"https://openalex.org/C2778081958","wikidata":"https://www.wikidata.org/wiki/Q14906786","display_name":"Eosinophil peroxidase","level":4,"score":0.7073596715927124},{"id":"https://openalex.org/C60483475","wikidata":"https://www.wikidata.org/wiki/Q1886099","display_name":"Major basic protein","level":4,"score":0.5309492945671082},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5259054899215698},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5155167579650879},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5012967586517334},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49220576882362366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4802663326263428},{"id":"https://openalex.org/C2910475272","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil Granule Proteins","level":5,"score":0.45624226331710815},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.42414969205856323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38922321796417236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35424697399139404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31372401118278503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12426412105560303},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12244468927383423},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014456","descriptor_name":"Ulcer","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D047093","descriptor_name":"Eosinophil Major Basic Protein","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047093","descriptor_name":"Eosinophil Major Basic Protein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D047150","descriptor_name":"Eosinophil Cationic Protein","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047150","descriptor_name":"Eosinophil Cationic Protein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D047208","descriptor_name":"Eosinophil-Derived Neurotoxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047208","descriptor_name":"Eosinophil-Derived Neurotoxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D047209","descriptor_name":"Eosinophil Peroxidase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047209","descriptor_name":"Eosinophil Peroxidase","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.0900055","doi":"https://doi.org/10.4049/jimmunol.0900055","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.0900055","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/183/6/4013/1286749/zim01809004013.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:19717523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19717523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2852253","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2852253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.0900055","doi":"https://doi.org/10.4049/jimmunol.0900055","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.0900055","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/183/6/4013/1286749/zim01809004013.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1189270403","display_name":null,"funder_award_id":"AI 34577","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3048955356","display_name":"ASTHMA AND ALLERGIC DISEASE CENTER PROGRAM GRANT","funder_award_id":"5p50ai011483-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4981684286","display_name":null,"funder_award_id":"AI 09728","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G515077985","display_name":null,"funder_award_id":"AI-11483","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5265033475","display_name":"Training Grant in Allergic Diseases","funder_award_id":"T32AI007047","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G535375355","display_name":"Mechanisms of Eosinophilic Inflammation in Human Asthma","funder_award_id":"P01AI050494","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5691533785","display_name":"Eosinophil Granule Proteins and Their Functions","funder_award_id":"R01AI009728","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G63116619","display_name":"MECHANISMS OF EOSINOPHIL ASSOCIATED INFLAMATION","funder_award_id":"U19AI034577","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G659161913","display_name":null,"funder_award_id":"AI07047","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000048947","display_name":null,"funder_award_id":"AI 11483","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000248947","display_name":null,"funder_award_id":"AI 09728","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G984188801","display_name":null,"funder_award_id":"AI-50494","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320307133","display_name":"American Academy of Allergy Asthma and Immunology","ror":"https://ror.org/02n27h954"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118731971.pdf","grobid_xml":"https://content.openalex.org/works/W2118731971.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W6156749","https://openalex.org/W122912720","https://openalex.org/W1522344193","https://openalex.org/W1540816832","https://openalex.org/W1547396258","https://openalex.org/W1558693276","https://openalex.org/W1562857066","https://openalex.org/W1565585976","https://openalex.org/W1849498460","https://openalex.org/W1943694240","https://openalex.org/W1964102602","https://openalex.org/W1973651546","https://openalex.org/W1978330466","https://openalex.org/W1986763896","https://openalex.org/W1991046721","https://openalex.org/W2007446673","https://openalex.org/W2008353413","https://openalex.org/W2014943803","https://openalex.org/W2020410433","https://openalex.org/W2021420392","https://openalex.org/W2024849650","https://openalex.org/W2045741895","https://openalex.org/W2045816749","https://openalex.org/W2063196721","https://openalex.org/W2087306389","https://openalex.org/W2089499714","https://openalex.org/W2090639986","https://openalex.org/W2092703416","https://openalex.org/W2130671398","https://openalex.org/W2136239275","https://openalex.org/W2138251267","https://openalex.org/W2138422023","https://openalex.org/W2142587628","https://openalex.org/W2150365288","https://openalex.org/W2154517243","https://openalex.org/W2155494562","https://openalex.org/W2156309972","https://openalex.org/W2165736819","https://openalex.org/W2166592629","https://openalex.org/W2168089480","https://openalex.org/W2168270635","https://openalex.org/W2168301435","https://openalex.org/W2171373028","https://openalex.org/W2320683364","https://openalex.org/W2398060890","https://openalex.org/W2411410378","https://openalex.org/W2432533224","https://openalex.org/W2475144314","https://openalex.org/W3134983447","https://openalex.org/W3134986606","https://openalex.org/W4211182004","https://openalex.org/W4240211429","https://openalex.org/W4250518377"],"related_works":["https://openalex.org/W1558693276","https://openalex.org/W7098981245","https://openalex.org/W6156749","https://openalex.org/W3016375533","https://openalex.org/W2889814866","https://openalex.org/W2063953755","https://openalex.org/W2024691309","https://openalex.org/W16268699","https://openalex.org/W2470180731","https://openalex.org/W1991046721"],"abstract_inverted_index":{"Eosinophil":[0],"granule":[1],"proteins":[2,15],"are":[3],"deposited":[4],"in":[5,8,171,188,196],"cutaneous":[6],"lesions":[7,58,79,156,191],"many":[9],"human":[10,197],"diseases,":[11],"but":[12],"how":[13],"these":[14],"contribute":[16],"to":[17,75,113,169],"pathophysiology":[18],"is":[19],"obscure.":[20],"We":[21],"injected":[22],"eosinophil":[23,36],"cationic":[24,143],"protein":[25],"(ECP":[26],"or":[27,33,83,145],"RNase":[28,34,129,146],"3),":[29],"eosinophil-derived":[30],"neurotoxin":[31],"(EDN":[32],"2),":[35],"peroxidase":[37],"(EPO),":[38],"and":[39,48,52,72,91,99,110,121,128,133,165,178,183],"major":[40],"basic":[41],"protein-1":[42],"(MBP1)":[43],"intradermally":[44],"into":[45],"guinea":[46,172],"pig":[47,173],"rabbit":[49],"skin.":[50,174],"ECP":[51,109,132,164,177],"EDN":[53,111,134,166,179],"each":[54,95],"induced":[55],"distinct":[56],"skin":[57,181,190],"at":[59,64,68],">or=2.5":[60],"microM":[61],"that":[62,170],"began":[63],"2":[65,107,117],"days,":[66,118],"peaking":[67],"approximately":[69],"7":[70],"days":[71],"persisting":[73],"up":[74],"6":[76],"wk.":[77,108],"These":[78],"were":[80,135],"ulcerated":[81],"(ECP)":[82],"crusted":[84],"(EDN)":[85],"with":[86,101,159],"marked":[87],"cellular":[88,103,126],"infiltration.":[89],"EPO":[90,120],"MBP1":[92,122],"(10":[93],"microM)":[94],"produced":[96],"perceptible":[97],"induration":[98],"erythema":[100],"moderate":[102],"infiltration":[104],"resolving":[105],"within":[106,116],"localized":[112],"dermal":[114],"cells":[115],"whereas":[119],"remained":[123],"extracellular.":[124],"Overall,":[125],"localization":[127],"activity":[130,147],"of":[131],"critical":[136],"for":[137,152],"lesion":[138,153],"formation;":[139],"differential":[140],"glycosylation,":[141],"net":[142],"charge,":[144],"alone":[148],"did":[149],"not":[150],"account":[151],"formation.":[154],"Ulcerated":[155],"from":[157],"patients":[158],"the":[160],"hypereosinophilic":[161],"syndrome":[162],"showed":[163],"deposition":[167],"comparable":[168],"In":[175],"conclusion,":[176],"disrupt":[180],"integrity":[182],"cause":[184],"inflammation.":[185],"Their":[186],"presence":[187],"ulcerative":[189],"may":[192],"explain":[193],"certain":[194],"findings":[195],"eosinophil-associated":[198],"diseases.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}