{"id":"https://openalex.org/W2118702155","doi":null,"title":"Review Article and Clinical Experience: NEW INSIGHTS INTO ORAL AGENTS IN THE TREATMENT OF T2DM (THE ROLES OF FIXED-DOSE ORAL AGENTS COMBINATION) (The Roles of Fixed-Dose Oral Agents Combination)","display_name":"Review Article and Clinical Experience: NEW INSIGHTS INTO ORAL AGENTS IN THE TREATMENT OF T2DM (THE ROLES OF FIXED-DOSE ORAL AGENTS COMBINATION) (The Roles of Fixed-Dose Oral Agents Combination)","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2118702155","mag":"2118702155"},"language":"en","primary_location":{"id":"mag:2118702155","doi":null,"is_oa":true,"landing_page_url":"http://journal.unair.ac.id/filerPDF/abstrak_6123_tpjua.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210179714","display_name":"Folia Medica Indonesiana","issn_l":"2355-8393","issn":["2355-8393","2599-056X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315151","host_organization_name":"Airlangga University","host_organization_lineage":["https://openalex.org/P4310315151"],"host_organization_lineage_names":["Airlangga University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Folia Medica Indonesiana","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://journal.unair.ac.id/filerPDF/abstrak_6123_tpjua.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063812781","display_name":"Askandar Tjokroprawiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Askandar Tjokroprawiro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063812781"],"corresponding_institution_ids":[],"apc_list":{"value":1500000,"currency":"IDR","value_usd":98},"apc_paid":{"value":1500000,"currency":"IDR","value_usd":98},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":0.6600000262260437},{"id":"https://openalex.org/keywords/glinides","display_name":"glinides","score":0.7639999985694885},{"id":"https://openalex.org/keywords/gliclazide","display_name":"gliclazide","score":0.9380000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/atheroprotection","display_name":"atheroprotection","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cardiovascular-benefits","display_name":"cardiovascular benefits","score":0.7400000095367432},{"id":"https://openalex.org/keywords/ukpds","display_name":"UKPDS","score":0.6859999895095825},{"id":"https://openalex.org/keywords/postprandial-hyperglycemia","display_name":"postprandial hyperglycemia","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.9286308288574219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8322468996047974},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.7404495477676392},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6902778148651123},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6280097961425781},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.6274294853210449},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6078256964683533},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5971181392669678},{"id":"https://openalex.org/C2777448766","wikidata":"https://www.wikidata.org/wiki/Q290001","display_name":"Gliclazide","level":3,"score":0.5915840864181519},{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.569797694683075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5597387552261353},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5010650157928467},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4882981777191162},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34908533096313477}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2118702155","doi":null,"is_oa":true,"landing_page_url":"http://journal.unair.ac.id/filerPDF/abstrak_6123_tpjua.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210179714","display_name":"Folia Medica Indonesiana","issn_l":"2355-8393","issn":["2355-8393","2599-056X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315151","host_organization_name":"Airlangga University","host_organization_lineage":["https://openalex.org/P4310315151"],"host_organization_lineage_names":["Airlangga University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Folia Medica Indonesiana","raw_type":null},{"id":"mag:2184320797","doi":null,"is_oa":false,"landing_page_url":"http://journal.unair.ac.id/filerPDF/FMI-41-2-11.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"mag:2118702155","doi":null,"is_oa":true,"landing_page_url":"http://journal.unair.ac.id/filerPDF/abstrak_6123_tpjua.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210179714","display_name":"Folia Medica Indonesiana","issn_l":"2355-8393","issn":["2355-8393","2599-056X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315151","host_organization_name":"Airlangga University","host_organization_lineage":["https://openalex.org/P4310315151"],"host_organization_lineage_names":["Airlangga University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Folia Medica Indonesiana","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1977893502","https://openalex.org/W2001655802","https://openalex.org/W2007365318","https://openalex.org/W2011175385","https://openalex.org/W2015871595","https://openalex.org/W2136798233","https://openalex.org/W2158822657","https://openalex.org/W2160234571","https://openalex.org/W2337454357","https://openalex.org/W2345903479"],"related_works":["https://openalex.org/W2184320797","https://openalex.org/W1523055845","https://openalex.org/W2123826132","https://openalex.org/W2049463175","https://openalex.org/W2163097094","https://openalex.org/W1799193569","https://openalex.org/W2543415957","https://openalex.org/W1704891933","https://openalex.org/W1986699928","https://openalex.org/W2096999369"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,53,86,99,146,164,223,252,280,291,306,315],"the":[3,8,50,140,172,200,233,327,358,363,384],"development":[4],"of":[5,10,19,76,81,95,133,174,203,216,254,263,324,331,345,350,353,386],"strategies":[6],"for":[7,22,210,371,383,392],"treatment":[9,270,385],"type":[11],"2":[12,103],"diabetes":[13,23,104],"mellitus":[14,105],"(T2DM)":[15,106],"including":[16],"a":[17,219,312,346,367],"map":[18],"oral":[20],"agents":[21],"(OADS)":[24],"should":[25,337],"be":[26,59,338,378],"recognized.":[27,340],"It":[28],"has":[29,56],"been":[30],"widely":[31],"reported":[32,48,163],"that":[33,267],"metformin,":[34],"glimepiride,":[35],"glinides,":[36],"and":[37,79,92,150,159,168,195,205,208,245,258,303,326,334,355],"gliclazide":[38],"were":[39],"4(four)":[40],"OADS":[41],"which":[42],"showed":[43,266],"atheroprotective":[44],"properties.":[45],"Importantly,":[46],"as":[47,72,380],"by":[49],"landmark":[51,364],"UKPDS":[52],"1998,":[54],"metformin":[55,96,149,167,204,221,354],"proven":[57],"to":[58,118,230,240],"more":[60],"than":[61],"an":[62],"OAD":[63],"beyond":[64],"its":[65],"antihyperglycemia":[66],"effects.":[67],"Its":[68],"pleiotropic":[69],"effects,":[70],"such":[71,154],"antiatherogenic":[73],"properties,":[74],"inhibitor":[75],"glyclation":[77],"processes,":[78],"reducer":[80],"microvascular":[82],"dysfunction":[83],"may":[84,107,228],"result":[85],"cardiovascular":[87,260,316,359],"benefits.":[88,261],"Moreover,":[89],"21":[90],"metabolic":[91,257],"endocrine":[93,142,156,329],"effects":[94],"are":[97,144,251],"summarized":[98],"this":[100,272],"paper.":[101],"Type":[102],"range":[108],"from":[109,218,362],"predominantly":[110,119],"insulin":[111,116,124,134,137],"resistance":[112],"(IR)":[113],"with":[114,136,226,232,242,271,277],"relative":[115],"deficiency":[117],"secretory":[120],"defect":[121],"(impaired":[122],"acute":[123],"response":[125],"=":[126,286],"impaired":[127,130,160,335],"AIR":[128],"or":[129],"first":[131,342],"phase":[132],"secretion)":[135],"resistance.":[138],"Thus,":[139],"dual":[141,155,328],"defects":[143,157,330],"involved":[145],"T2DM.":[147],"Rationally,":[148],"glibenclamide":[151,169,206,217,356],"address":[152],"directly":[153],"(IR":[158,333],"AIR).":[161],"As":[162],"UKPDS-1998,":[165],"both":[166,243],"decreased":[170],"significantly":[171],"risk":[173,317],"diabetic":[175],"vascular":[176],"complications":[177],"diabetes-related":[179,187],"death":[180],"42%,":[181],"all":[182,186],"cause":[183],"mortality":[184],"36%,":[185],"end":[188],"point":[189],"32":[190],"%,":[191],"myocardial":[192],"infarction":[193],"39%,":[194],"stroke":[196],"41%.":[197],"Glucovance":[198,236],"is":[199,237],"ideal":[201],"combination":[202,352,369],"formulated":[207],"engineered":[209,370],"optimal":[211,372],"drug":[212,274],"delivery.":[213],"Earlier":[214],"absorption":[215],"freely-soluble":[220],"matrix":[222],"glucovance":[224,255],"taken":[225],"meals":[227],"help":[229],"deal":[231],"postprandial":[234,246],"hyperglycemia.":[235,247],"therefore":[238],"optimized":[239],"cope":[241],"fasting":[244,283],"Many":[248],"reports":[249],"(2001-2003)":[250],"favour":[253],"showing":[256],"potential":[259],"One":[262],"them":[264],"(2003)":[265],"one":[268],"year":[269],"new":[273,381],"was":[275,301],"associated":[276],"durable":[278],"improvement":[279,290,314],"AIC":[281],"(-1.7%),":[282],"plasma":[284],"glucose":[285],"FPG":[287],"(-55":[288],"mg/dl),":[289],"lipid":[292],"profiles":[293],"(Total":[294],"Cholesterol,":[295],"LDL-Cholesterol,":[296],"Slightly":[297],"HDL-Cholesterol)":[298],"but":[299],"TG":[300],"unaffected,":[302],"no":[304,389],"increase":[305],"body":[307],"weight.":[308],"These":[309],"changes":[310],"imply":[311],"modest":[313],"profile.":[318],"Conclusions":[320],"The":[322,341],"pathophysiology":[323],"T2DM":[325,332,387],"AIR)":[336],"well":[339],"strong":[343],"indication":[344],"potentially":[347],"beneficial":[348],"effect":[349],"fixed":[351,368],"on":[357],"system":[360],"comes":[361],"UKPDS.":[365],"Such":[366],"release":[373],"called":[374],"glucovance,":[375],"therefore,":[376],"can":[377],"used":[379],"strategy":[382],"if":[388],"contraindications":[390],"(especially":[391],"metformin)":[393],"exist.":[394]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}