{"id":"https://openalex.org/W2118644684","doi":"https://doi.org/10.1172/jci33361","title":"Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits","display_name":"Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W2118644684","doi":"https://doi.org/10.1172/jci33361","mag":"2118644684","pmid":"https://pubmed.ncbi.nlm.nih.gov/18483622","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2381746"},"language":"en","primary_location":{"id":"doi:10.1172/jci33361","doi":"https://doi.org/10.1172/jci33361","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci33361","pdf_url":"http://www.jci.org/articles/view/33361/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/33361/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009807468","display_name":"Lea Scheppke","orcid":"https://orcid.org/0000-0003-2633-7886","observed_orcids":["https://orcid.org/0000-0003-2633-7886"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lea Scheppke","raw_affiliation_strings":["Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068500478","display_name":"Edith Aguilar","orcid":"https://orcid.org/0000-0003-2507-6637","observed_orcids":["https://orcid.org/0000-0003-2507-6637"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edith Aguilar","raw_affiliation_strings":["Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022084957","display_name":"Ray F. Gariano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray F. Gariano","raw_affiliation_strings":["Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024801565","display_name":"Ruth Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Jacobson","raw_affiliation_strings":["Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109426437","display_name":"John D. Hood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Hood","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076682507","display_name":"John Doukas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Doukas","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071679572","display_name":"Jon Cao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jon Cao","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002654513","display_name":"Glenn Noronha","orcid":"https://orcid.org/0000-0001-6241-9091","observed_orcids":["https://orcid.org/0000-0001-6241-9091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn Noronha","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037951466","display_name":"Shiyin Yee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiyin Yee","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030557212","display_name":"Sara M. Weis","orcid":"https://orcid.org/0009-0008-3137-4239","observed_orcids":["https://orcid.org/0009-0008-3137-4239"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Weis","raw_affiliation_strings":["Moores Cancer Center, UCSD, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, UCSD, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005873374","display_name":"Michael Martin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael B. Martin","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011805749","display_name":"Richard S\u00f6ll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Soll","raw_affiliation_strings":["TargeGen Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TargeGen Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089796560","display_name":"David A. Cheresh","orcid":"https://orcid.org/0000-0002-7193-8595","observed_orcids":["https://orcid.org/0000-0002-7193-8595"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Cheresh","raw_affiliation_strings":["Moores Cancer Center, UCSD, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moores Cancer Center, UCSD, La Jolla, California, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040174959","display_name":"Martin Friedlander","orcid":"https://orcid.org/0000-0003-4238-9651","observed_orcids":["https://orcid.org/0000-0003-4238-9651"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Friedlander","raw_affiliation_strings":["Department of Cell Biology , MB28 , The Scripps Research Institute , 10550 N. Torrey Pines Rd. , La Jolla , California 92037 , USA","Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology , MB28 , The Scripps Research Institute , 10550 N. Torrey Pines Rd. , La Jolla , California 92037 , USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Cell Biology, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040174959"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.1348,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.98766656,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"118","issue":"6","first_page":"2337","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.08980000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-vascular-permeability","display_name":"retinal vascular permeability","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.875},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.6869999766349792},{"id":"https://openalex.org/keywords/neovascular-eye-diseases","display_name":"neovascular eye diseases","score":0.6970000267028809},{"id":"https://openalex.org/keywords/retinal-edema","display_name":"retinal edema","score":0.9190000295639038},{"id":"https://openalex.org/keywords/yes-kinase","display_name":"Yes kinase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.7490000128746033},{"id":"https://openalex.org/keywords/choroidal-vascular-disease","display_name":"choroidal vascular disease","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.8457566499710083},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6837072372436523},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.591090202331543},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5570988059043884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5094702839851379},{"id":"https://openalex.org/C2779742858","wikidata":"https://www.wikidata.org/wiki/Q180609","display_name":"Intravitreal administration","level":3,"score":0.45656096935272217},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.4471844434738159},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.4457116723060608},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.43070682883262634},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4278002977371216},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41846203804016113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37318846583366394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26785025000572205},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2624779939651489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25697892904281616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24709516763687134},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.18936029076576233},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17942243814468384},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1354680061340332}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci33361","doi":"https://doi.org/10.1172/jci33361","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci33361","pdf_url":"http://www.jci.org/articles/view/33361/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2381746","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2381746","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:18483622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18483622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci33361","doi":"https://doi.org/10.1172/jci33361","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci33361","pdf_url":"http://www.jci.org/articles/view/33361/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4879226594","display_name":null,"funder_award_id":"EY11254","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8880823136","display_name":"Integrins and Ocular Angiogenesis","funder_award_id":"R01EY011254","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8976061772","display_name":"Fragments of TrpRS to Treat Neovascular Eye Diseases","funder_award_id":"R24EY014174","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G970211416","display_name":null,"funder_award_id":"EY 014174","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118644684.pdf","grobid_xml":"https://content.openalex.org/works/W2118644684.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W12276332","https://openalex.org/W1488792046","https://openalex.org/W1491931749","https://openalex.org/W1514513302","https://openalex.org/W1521950982","https://openalex.org/W1552787667","https://openalex.org/W1579034041","https://openalex.org/W1601092960","https://openalex.org/W1679250118","https://openalex.org/W1863396779","https://openalex.org/W1903720360","https://openalex.org/W1963804365","https://openalex.org/W1964677780","https://openalex.org/W1971222830","https://openalex.org/W1971945408","https://openalex.org/W1975216289","https://openalex.org/W1992191481","https://openalex.org/W1994014733","https://openalex.org/W1996537616","https://openalex.org/W1997358493","https://openalex.org/W2000292756","https://openalex.org/W2004376521","https://openalex.org/W2004643661","https://openalex.org/W2009212522","https://openalex.org/W2016795705","https://openalex.org/W2033245558","https://openalex.org/W2033710219","https://openalex.org/W2033728878","https://openalex.org/W2042794231","https://openalex.org/W2048538454","https://openalex.org/W2049746210","https://openalex.org/W2057711788","https://openalex.org/W2058843732","https://openalex.org/W2063709616","https://openalex.org/W2069561372","https://openalex.org/W2084128822","https://openalex.org/W2084971502","https://openalex.org/W2091586787","https://openalex.org/W2099078722","https://openalex.org/W2124415048","https://openalex.org/W2124545173","https://openalex.org/W2132755748","https://openalex.org/W2134807546","https://openalex.org/W2146330804","https://openalex.org/W2151081020","https://openalex.org/W2166394159","https://openalex.org/W2169265493","https://openalex.org/W2169882258","https://openalex.org/W2170923870","https://openalex.org/W2171998177","https://openalex.org/W2330112263","https://openalex.org/W2469872747","https://openalex.org/W3134431802","https://openalex.org/W4254778823"],"related_works":["https://openalex.org/W2060060779","https://openalex.org/W2993073368","https://openalex.org/W1124780299","https://openalex.org/W2105346243","https://openalex.org/W29642377","https://openalex.org/W2029864279","https://openalex.org/W2151732732","https://openalex.org/W1988143227","https://openalex.org/W3017094669","https://openalex.org/W2565476167"],"abstract_inverted_index":{"Retinal":[0],"and":[1,32,63,148,186,191,225],"choroidal":[2],"vascular":[3,10,38,81,120,134,140,168,184,209],"diseases,":[4,70],"with":[5,18,67],"their":[6],"associated":[7,66],"abnormalities":[8],"in":[9,21,26,40,54,88,110,119,128,142,170,181],"permeability,":[11],"account":[12],"for":[13,57,178,197,227],"the":[14,59],"majority":[15],"of":[16,43,86,97,113,163,223,229,243],"patients":[17],"vision":[19,199],"loss":[20,200],"industrialized":[22],"nations.VEGF":[23],"is":[24,33,101],"upregulated":[25],"ischemic":[27],"retinopathies":[28],"such":[29,72],"as":[30],"diabetes":[31],"known":[34],"to":[35,116,137,172,202,212,220],"dramatically":[36],"alter":[37],"permeability":[39,121,135,141,185],"a":[41,102,176,188],"number":[42],"nonocular":[44],"tissues":[45],"via":[46],"Src":[47,114,143,153,157,179,241],"kinase-regulated":[48],"signaling":[49],"pathways.VEGF":[50],"antagonists":[51],"are":[52,150],"currently":[53],"clinical":[55],"use":[56],"treating":[58,198],"new":[60],"blood":[61],"vessels":[62],"retinal":[64,139,183,204,208,215],"edema":[65],"neovascular":[68],"eye":[69],"but":[71],"therapies":[73],"require":[74],"repeated":[75],"intraocular":[76],"injections.We":[77],"have":[78],"found":[79],"that":[80],"leakage":[82],"following":[83],"intravitreal":[84,221],"administration":[85,222],"VEGF":[87,130,224],"mice":[89,217],"was":[90,108,122],"abolished":[91],"by":[92,125],"systemic":[93],"or":[94,132],"topical":[95],"delivery":[96],"what":[98],"we":[99],"believe":[100],"novel":[103],"VEGFR2/Src":[104],"kinase":[105,154,180],"inhibitor;":[106],"this":[107],"confirmed":[109],"rabbits.The":[111],"relevance":[112],"inhibition":[115],"VEGF-associated":[117],"alterations":[118],"further":[123],"substantiated":[124],"genetic":[126],"studies":[127],"which":[129],"injection":[131],"laser-induced":[133],"failed":[136],"augment":[138],"-/-and":[144,158],"Yes":[145,149,159],"-/-mice":[146,160],"(Src":[147],"ubiquitously":[151],"expressed":[152],"family":[155,242],"members;":[156],"lacking":[161],"expression":[162],"these":[164],"kinases":[165],"show":[166],"no":[167],"leak":[169],"response":[171],"VEGF).These":[173],"findings":[174],"establish":[175,187],"role":[177],"VEGF-mediated":[182],"potentially":[189],"safe":[190],"painless":[192],"topically":[193],"applied":[194],"therapeutic":[195],"option":[196],"due":[201],"neovascular-associated":[203],"edema.":[205],"Results":[206],"VEGF-induced":[207,214],"permeability.In":[210],"order":[211],"evaluate":[213],"leakage,":[216],"were":[218],"subjected":[219],"monitored":[226],"extravasation":[228],"FITC-Nonstandard":[230],"abbreviations":[231],"used:":[232],"EB,":[233],"Evans":[234],"blue;":[235],"FAK,":[236],"focal":[237],"adhesion":[238],"kinase;":[239],"SFK,":[240],"tyrosine":[244],"kinase.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}