{"id":"https://openalex.org/W2118519085","doi":"https://doi.org/10.1530/rep.0.1220227","title":"Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice","display_name":"Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2118519085","doi":"https://doi.org/10.1530/rep.0.1220227","mag":"2118519085","pmid":"https://pubmed.ncbi.nlm.nih.gov/11467973"},"language":"en","primary_location":{"id":"doi:10.1530/rep.0.1220227","doi":"https://doi.org/10.1530/rep.0.1220227","is_oa":false,"landing_page_url":"https://doi.org/10.1530/rep.0.1220227","pdf_url":null,"source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2118519085"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/122/2/227.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067000104","display_name":"PJ Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P J Baker","raw_affiliation_strings":["Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039881832","display_name":"P.J. O'Shaughnessy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"P J O'Shaughnessy","raw_affiliation_strings":["Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Veterinary Physiology and Pharmacology, Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039881832"],"corresponding_institution_ids":["https://openalex.org/I7882870"],"apc_list":null,"apc_paid":null,"fwci":6.9964,"has_fulltext":false,"cited_by_count":181,"citation_normalized_percentile":{"value":0.97770701,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"122","issue":"2","first_page":"227","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.9649999737739563},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":1.0},{"id":"https://openalex.org/keywords/testicular-development","display_name":"testicular development","score":0.6259999871253967},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.6990000009536743},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gonocytes","display_name":"gonocytes","score":0.5879999995231628},{"id":"https://openalex.org/keywords/spermatogonia","display_name":"spermatogonia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.41200000047683716},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5559999942779541},{"id":"https://openalex.org/keywords/gonadotropin-deficiency","display_name":"gonadotropin deficiency","score":0.5839999914169312},{"id":"https://openalex.org/keywords/spermatogonial-differentiation","display_name":"spermatogonial differentiation","score":0.4869999885559082},{"id":"https://openalex.org/keywords/leydig-cell-differentiation","display_name":"Leydig cell differentiation","score":0.5299999713897705},{"id":"https://openalex.org/keywords/sertoli-cell-differentiation","display_name":"Sertoli cell differentiation","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.8525179624557495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7454257011413574},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7326393127441406},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.7018492221832275},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.6888191103935242},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6711117625236511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.552219033241272},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.49820923805236816},{"id":"https://openalex.org/C2779066085","wikidata":"https://www.wikidata.org/wiki/Q9384","display_name":"Testicle","level":2,"score":0.49370989203453064},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.40651243925094604},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3669583201408386},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3118738830089569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2263023555278778},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.1808350384235382},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006062","descriptor_name":"Gonadotropins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013093","descriptor_name":"Spermatogonia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1530/rep.0.1220227","doi":"https://doi.org/10.1530/rep.0.1220227","is_oa":false,"landing_page_url":"https://doi.org/10.1530/rep.0.1220227","pdf_url":null,"source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"doi:10.1530/reprod/122.2.227","doi":"https://doi.org/10.1530/reprod/122.2.227","is_oa":true,"landing_page_url":"https://doi.org/10.1530/reprod/122.2.227","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/122/2/227.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:11467973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11467973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:27356","doi":null,"is_oa":false,"landing_page_url":"https://eprints.gla.ac.uk/27356/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":{"id":"doi:10.1530/reprod/122.2.227","doi":"https://doi.org/10.1530/reprod/122.2.227","is_oa":true,"landing_page_url":"https://doi.org/10.1530/reprod/122.2.227","pdf_url":"https://rep.bioscientifica.com/downloadpdf/journals/rep/122/2/227.pdf","source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118519085.pdf","grobid_xml":"https://content.openalex.org/works/W2118519085.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W347790389","https://openalex.org/W1915101347","https://openalex.org/W1996809299","https://openalex.org/W2020719725","https://openalex.org/W2029651564","https://openalex.org/W2074057319","https://openalex.org/W2084619421","https://openalex.org/W2097902697","https://openalex.org/W2109832629","https://openalex.org/W2116112998","https://openalex.org/W2118368182","https://openalex.org/W2119364472","https://openalex.org/W2119935765","https://openalex.org/W2122693798","https://openalex.org/W2124566195","https://openalex.org/W2131727903","https://openalex.org/W2143457750","https://openalex.org/W2143781769","https://openalex.org/W2144005229","https://openalex.org/W2144687593","https://openalex.org/W2146671884","https://openalex.org/W2408867634","https://openalex.org/W2418937096","https://openalex.org/W4294730393"],"related_works":["https://openalex.org/W1710144557","https://openalex.org/W2119935765","https://openalex.org/W2057185316","https://openalex.org/W2040070665","https://openalex.org/W2025705782","https://openalex.org/W2069510236","https://openalex.org/W2060946765","https://openalex.org/W2101319977","https://openalex.org/W1979580281","https://openalex.org/W1923943691"],"abstract_inverted_index":{"The":[0,31,49,126,214,240,310,334],"role":[1],"of":[2,8,40,45,51,61,98,117,119,128,156,161,208,216,224,242,263,291,297,308,312,320,336,382,390,398,415,422,445],"the":[3,38,96,154,279,289,304,399,413,420,443],"gonadotrophins":[4],"in":[5,68,78,95,101,131,173,188,196,211,231,245,278,301,340,346,361,442],"regulating":[6],"numbers":[7,50,77],"Leydig":[9,52,99,129,168,191,386,401],"and":[10,15,23,63,71,107,124,140,150,182,204,234,322,325,331,352,364,370,385,396,417,439],"Sertoli":[11,217,243,266,292,384,423],"cells":[12,41,53,100,120,130,157,218,244,267,293,387,424],"during":[13],"fetal":[14,251,380],"postnatal":[16],"development":[17,381],"was":[18,34,91,158,171,194,205,248,254,294,306],"examined":[19],"using":[20],"normal":[21,69,102,162,174,195,209,232,249,298,330,341,363,394],"mice":[22,70,80,103,233,303],"hypogonadal":[24],"(hpg)":[25],"mice,":[26],"which":[27],"lack":[28],"circulating":[29],"gonadotrophins.":[30,446],"disector":[32],"method":[33],"used":[35],"to":[36,85,179,226],"determine":[37],"number":[39,97,118,127,155,215,241,290,305,311,335,421],"from":[42,76,164,176,221],"day":[43,59,64,86,105,108,122,138,141,148,165,180,222,227,260,285,318,323,350,353,368,371,406],"16":[44,60,223,319],"gestation":[46,62,225,230,321],"until":[47,238],"adulthood.":[48,125,239],"did":[54,134,314,326],"not":[55,73,135,315,327],"change":[56,136,316],"significantly":[57,74],"between":[58,104,121,137,147,317,329,349,367],"5":[65,87,106,139,354,369],"after":[66,88,110,143,229,287,355,373,408,425],"parturition":[67,144,288],"were":[72],"different":[75],"hpg":[79,132,197,246,280,332,347,365],"at":[81,199,269,435],"any":[82],"age":[83],"up":[84,178],"parturition.":[89,356,374],"There":[90],"a":[92,114,185,270,275,436],"16-fold":[93],"increase":[94,187],"20":[109,123,142,149,166,181,228,286,372],"parturition,":[111],"followed":[112],"by":[113,256,429],"further":[115],"doubling":[116],"testes":[133,198,247,342,348,366],"but":[145,201,253,273,343],"doubled":[146],"adulthood":[151],"so":[152,282],"that":[153,283,379,393,419],"about":[159,206,257,295,405],"10%":[160],"values":[163],"onwards.":[167],"cell":[169,192,402],"volume":[170,193,210],"constant":[172],"animals":[175],"birth":[177,200,426],"then":[183,235],"showed":[184],"2.5-fold":[186],"adult":[189,212,302,400],"animals.":[190],"decreased":[202],"thereafter":[203],"20%":[207],"mice.":[213],"increased":[219,338],"continuously":[220],"remained":[236],"static":[237],"throughout":[250],"life":[252],"reduced":[255],"30%":[258],"on":[259,284,412],"1":[261,324,351],"(day":[262],"parturition).":[264],"Thereafter,":[265],"proliferated":[268],"slower":[271],"rate":[272,438],"over":[274],"longer":[276],"period":[277],"testis":[281],"50%":[296],"values,":[299],"whereas":[300],"65%":[307],"normal.":[309],"gonocytes":[313,337],"differ":[328],"testes.":[333],"nine-fold":[339],"only":[344],"three-fold":[345],"Gonocytes":[357],"differentiated":[358],"into":[359],"spermatogonia":[360],"both":[362,383],"These":[375],"results":[376],"show:":[377],"(i)":[378],"is":[388,410,427],"independent":[389],"gonadotrophins;":[391,416],"(ii)":[392],"differentiation":[395],"proliferation":[397,432],"population":[403],"(starting":[404],"10":[407],"parturition)":[409],"dependent":[411],"presence":[414],"(iii)":[418],"regulated":[428],"gonadotrophins,":[430],"although":[431],"will":[433],"continue,":[434],"lower":[437],"for":[440],"longer,":[441],"absence":[444]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}