{"id":"https://openalex.org/W2118445296","doi":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","title":"A Toxoplasma gondii-derived factor(s) stimulates immune downregulation: an in vitro model","display_name":"A Toxoplasma gondii-derived factor(s) stimulates immune downregulation: an in vitro model","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2118445296","doi":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","mag":"2118445296","pmid":"https://pubmed.ncbi.nlm.nih.gov/7642275","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/173474"},"language":"en","primary_location":{"id":"doi:10.1128/iai.63.9.3442-3447.1995","doi":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","pdf_url":"https://iai.asm.org/content/iai/63/9/3442.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/63/9/3442.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113683639","display_name":"Sakhina Haque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Haque","raw_affiliation_strings":["Department of Medicine and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058574345","display_name":"Azizul Haque","orcid":"https://orcid.org/0000-0002-3772-9773","observed_orcids":["https://orcid.org/0000-0002-3772-9773"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Haque","raw_affiliation_strings":["Department of Medicine and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109686023","display_name":"L H Kasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L H Kasper","raw_affiliation_strings":["Department of Medicine and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I107672454"],"apc_list":null,"apc_paid":null,"fwci":2.499,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.88470588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"63","issue":"9","first_page":"3442","last_page":"3447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":1.0},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.984000027179718},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.859000027179718},{"id":"https://openalex.org/keywords/soluble-inhibitory-factor","display_name":"soluble inhibitory factor","score":0.6790000200271606},{"id":"https://openalex.org/keywords/parasite-antigens","display_name":"parasite antigens","score":0.6650000214576721},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tachyzoites","display_name":"tachyzoites","score":0.8100000023841858},{"id":"https://openalex.org/keywords/in-vitro-infection-model","display_name":"in vitro infection model","score":0.5149999856948853},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7828927636146545},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.7071280479431152},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6180816888809204},{"id":"https://openalex.org/C2776969849","wikidata":"https://www.wikidata.org/wiki/Q16889497","display_name":"Lymphoproliferative response","level":4,"score":0.5810421705245972},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5739004611968994},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.5087535977363586},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4930414855480194},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4875302016735077},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4811078906059265},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.47862640023231506},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4321633279323578},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4255402088165283},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39794230461120605},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3944956958293915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06343439221382141},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013491","descriptor_name":"Suppressor Factors, Immunologic","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.63.9.3442-3447.1995","doi":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","pdf_url":"https://iai.asm.org/content/iai/63/9/3442.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:173474","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/173474","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:7642275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7642275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/iai.63.9.3442-3447.1995","doi":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.63.9.3442-3447.1995","pdf_url":"https://iai.asm.org/content/iai/63/9/3442.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G140029258","display_name":"T. Gondii: Antigenic Characterization and Immunity","funder_award_id":"R01AI019613","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2176843339","display_name":"TOXOPLASMA GONDII--ROLE OF IMMUNE CYTOKINES","funder_award_id":"R01AI035956","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118445296.pdf"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1506157243","https://openalex.org/W1515615230","https://openalex.org/W1517658874","https://openalex.org/W1518149648","https://openalex.org/W1545910465","https://openalex.org/W1561202481","https://openalex.org/W1573470869","https://openalex.org/W1605538680","https://openalex.org/W1639400191","https://openalex.org/W1762742043","https://openalex.org/W1828307599","https://openalex.org/W1944330918","https://openalex.org/W1946914556","https://openalex.org/W1957298029","https://openalex.org/W1964599133","https://openalex.org/W1966413388","https://openalex.org/W1967475931","https://openalex.org/W1967705305","https://openalex.org/W1985691997","https://openalex.org/W2029836713","https://openalex.org/W2032252611","https://openalex.org/W2068590793","https://openalex.org/W2082268424","https://openalex.org/W2084162837","https://openalex.org/W2214453724","https://openalex.org/W2332136869"],"related_works":["https://openalex.org/W2082268424","https://openalex.org/W2214453724","https://openalex.org/W2007980119","https://openalex.org/W2077145134","https://openalex.org/W1985691997","https://openalex.org/W1965945300","https://openalex.org/W1987448669","https://openalex.org/W2048504165","https://openalex.org/W2428576004","https://openalex.org/W1933382243"],"abstract_inverted_index":{"Suppression":[0],"of":[1,8,38,81,113,136,175,185],"the":[2,36,73,79,96,106,123,128,137,144,173],"T-cell":[3],"lymphoproliferative":[4,74],"response":[5,75,94],"and":[6,57,148,151],"downregulation":[7],"interleukin":[9],"2":[10],"(IL-2)":[11],"production":[12,102],"by":[13,66,95],"Toxoplasma":[14,60],"gondii":[15],"has":[16],"been":[17],"observed":[18,77],"following":[19],"in":[20,28,72,83,100,108,143,154,162,165],"vivo":[21],"infection.":[22],"In":[23],"this":[24,92],"study,":[25],"an":[26,53,114,152],"experimental":[27],"vitro":[29,163],"murine":[30,167],"system":[31],"was":[32,76,103],"developed":[33],"to":[34,116,122],"evaluate":[35],"kinetics":[37],"these":[39,157],"responses.":[40],"Normal":[41],"splenocytes":[42,139],"from":[43],"uninfected":[44],"mice":[45],"were":[46],"stimulated":[47,91],"with":[48,59,105],"either":[49,62],"concanavalin":[50],"A":[51,69,98],"or":[52,64,118],"anti-CD3":[54],"monoclonal":[55],"antibody":[56,115],"cocultured":[58],"tachyzoites":[61],"directly":[63],"separated":[65],"a":[67,141,166,176],"transwell.":[68],"progressive":[70],"decline":[71,99],"as":[78,180],"concentration":[80],"parasites":[82,90],"culture":[84,124,164],"increased.":[85],"Neither":[86],"heat-killed":[87],"nor":[88],"formaldehyde-fixed":[89],"downregulatory":[93],"splenocytes.":[97],"IL-2":[101,147,149],"associated":[104],"decrease":[107,142],"lymphocyte":[109,132],"proliferation.":[110,133],"The":[111],"addition":[112],"IL-10":[117],"heat-inactivated":[119],"anti-Toxoplasma":[120],"sera":[121],"supernatant":[125],"partially":[126],"neutralized":[127],"inhibitory":[129],"effect":[130],"on":[131],"Cytokine":[134],"analysis":[135],"responder":[138],"demonstrated":[140],"message":[145],"for":[146],"receptor":[150],"increase":[153],"IL-10.":[155],"Together,":[156],"observations":[158],"suggest":[159],"that":[160,171,182],"during":[161],"system,":[168],"parasite":[169],"antigens":[170],"stimulate":[172],"release":[174],"soluble":[177],"factor(s),":[178],"such":[179],"IL-10,":[181],"inhibits":[183],"proliferation":[184],"mitogen-stimulated":[186],"T":[187],"cells":[188],"are":[189],"expressed.":[190]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
