{"id":"https://openalex.org/W2118440944","doi":null,"title":"Evidence of cross-hybridization artifact in expressed sequence tags (ESTs) on cDNA microarrays","display_name":"Evidence of cross-hybridization artifact in expressed sequence tags (ESTs) on cDNA microarrays","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2118440944","mag":"2118440944"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.172.211","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.172.211","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.phil.cmu.edu/projects/genegroup/papers/handley2002a.pdf","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062413747","display_name":"Dan Handley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Handley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Melvin Field","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melvin Field","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008942398","display_name":"Nicoleta Serban","orcid":"https://orcid.org/0000-0002-5813-7435","observed_orcids":["https://orcid.org/0000-0002-5813-7435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicoleta Serban","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062033062","display_name":"Larry Wasserman","orcid":"https://orcid.org/0000-0001-5461-8760","observed_orcids":["https://orcid.org/0000-0001-5461-8760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry Wasserman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026405069","display_name":"David Gerard Peters","orcid":"https://orcid.org/0000-0003-4354-1125","observed_orcids":["https://orcid.org/0000-0003-4354-1125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047533473","display_name":"Peter Spirtes","orcid":"https://orcid.org/0000-0002-1385-190X","observed_orcids":["https://orcid.org/0000-0002-1385-190X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Spirtes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Robert O&amp;apos;Doherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert O&amp;apos;Doherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073733316","display_name":"Richard Scheines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Scheines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047903148","display_name":"Clark Glymour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clark Glymour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.14161817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cross-hybridization","display_name":"cross-hybridization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cdna-microarray","display_name":"cDNA microarray","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.9194730520248413},{"id":"https://openalex.org/C149034497","wikidata":"https://www.wikidata.org/wiki/Q1384835","display_name":"Expressed sequence tag","level":4,"score":0.7818769216537476},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6836709380149841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6673445701599121},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.5440733432769775},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.5071442127227783},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49694421887397766},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4958377778530121},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3991415500640869},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3203364908695221},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30879712104797363}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.172.211","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.172.211","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.phil.cmu.edu/projects/genegroup/papers/handley2002a.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1998415512","https://openalex.org/W2000730583","https://openalex.org/W2097879961","https://openalex.org/W2139683115","https://openalex.org/W3203165331","https://openalex.org/W4388386281"],"related_works":["https://openalex.org/W7099981577","https://openalex.org/W1999825945","https://openalex.org/W7100990724","https://openalex.org/W7100162478","https://openalex.org/W1549313475","https://openalex.org/W7095880062","https://openalex.org/W7096091671","https://openalex.org/W2094613397","https://openalex.org/W7097518459","https://openalex.org/W2135357252"],"abstract_inverted_index":{"We":[0],"present":[1],"evidence":[2],"of":[3,15,20,38,50,135],"cross-hybridization":[4,101],"artifact":[5],"intrinsic":[6],"to":[7,78,97,100,125,147],"spotted":[8],"single-dye":[9],"cDNA":[10,16,43,61,116,136,145],"microarrays":[11,62,117,137],"as":[12],"a":[13,45],"result":[14,28],"containing":[17,91,129],"5\u2019-end":[18,74],"sequences":[19,68,90,128],"consecutive":[21,73],"thymidine":[22],"(dT)":[23,34],"residues.":[24,132],"These":[25],"poly(dT)":[26,93,131,142],"tracts":[27,94],"from":[29,44,54,88,144],"the":[30,104,150],"synthesis,":[31],"via":[32],"oligo":[33],"primed":[35],"reverse":[36],"transcription,":[37],"expressed":[39],"sequence":[40],"tags":[41],"(EST)":[42],"polyadenylated":[46],"mRNA":[47,106],"template.":[48],"Analysis":[49],"gene":[51],"expression":[52,86,107],"data":[53,87,113],"two":[55],"separate":[56],"experiments":[57],"involving":[58],"commercially":[59],"available":[60],"showed":[63],"that":[64,85,111],"ESTs":[65],"whose":[66],"reported":[67],"contain":[69],"more":[70],"than":[71,103],"11":[72],"dT":[75],"residues":[76],"appeared":[77],"be":[79,98,119,123],"strongly":[80],"co-expressed.":[81],"Our":[82],"results":[83],"suggest":[84],"microarray":[89],"5\u2019":[92,141],"is":[95],"likely":[96],"due":[99],"rather":[102],"actual":[105],"signal.":[108],"This":[109],"indicates":[110],"existing":[112],"generated":[114],"by":[115],"may":[118],"unreliable":[120],"and":[121],"should":[122,138],"\u00a3ltered":[124],"remove":[126],"EST":[127],"signi\u00a3cant":[130],"Ideally,":[133],"manufacturers":[134],"excise":[139],"any":[140],"tract":[143],"prior":[146],"deposition":[148],"on":[149],"substrate.":[151]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}
