{"id":"https://openalex.org/W2118401037","doi":"https://doi.org/10.1093/hmg/ddp334","title":"Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice","display_name":"Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice","publication_year":2009,"publication_date":"2009-07-19","ids":{"openalex":"https://openalex.org/W2118401037","doi":"https://doi.org/10.1093/hmg/ddp334","mag":"2118401037","pmid":"https://pubmed.ncbi.nlm.nih.gov/19617637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748897"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddp334","doi":"https://doi.org/10.1093/hmg/ddp334","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddp334","pdf_url":"https://academic.oup.com/hmg/article-pdf/18/20/3914/1819269/ddp334.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/hmg/article-pdf/18/20/3914/1819269/ddp334.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032882360","display_name":"Go Suzuki","orcid":"https://orcid.org/0000-0003-3120-8683","observed_orcids":["https://orcid.org/0000-0003-3120-8683"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Suzuki","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA","Department of Psychiatry and Behavioral Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047283665","display_name":"Kathryn M. Harper","orcid":"https://orcid.org/0000-0002-6297-0032","observed_orcids":["https://orcid.org/0000-0002-6297-0032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. M. Harper","raw_affiliation_strings":["Dominick P. Purpura Department of Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dominick P. Purpura Department of Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Hiramoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Hiramoto","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082601374","display_name":"Birgit Funke","orcid":"https://orcid.org/0000-0001-6643-3640","observed_orcids":["https://orcid.org/0000-0001-6643-3640"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Funke","raw_affiliation_strings":["Brigham and Women's Hospital, Harvard Medical School, New Research Building, Room 250, 77 Avenue Louis Pasteur, Boston, MA 02115, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, New Research Building, Room 250, 77 Avenue Louis Pasteur, Boston, MA 02115, USA,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000116792","display_name":"M. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Lee","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Kang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Kang","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108389007","display_name":"Mah\u00e1lah R. Buell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Buell","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA and","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034576114","display_name":"Mark A. Geyer","orcid":"https://orcid.org/0000-0001-6137-9331","observed_orcids":["https://orcid.org/0000-0001-6137-9331"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Geyer","raw_affiliation_strings":["Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA and","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008864263","display_name":"Raju Kucherlapati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Kucherlapati","raw_affiliation_strings":["Brigham and Women's Hospital, Harvard Medical School, New Research Building, Room 250, 77 Avenue Louis Pasteur, Boston, MA 02115, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Harvard Medical School, New Research Building, Room 250, 77 Avenue Louis Pasteur, Boston, MA 02115, USA,","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029381108","display_name":"Bernice E. Morrow","orcid":"https://orcid.org/0000-0002-8076-4726","observed_orcids":["https://orcid.org/0000-0002-8076-4726"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Morrow","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA,","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015022975","display_name":"Pekka T. M\u00e4nnist\u00f6","orcid":"https://orcid.org/0000-0002-8708-1979","observed_orcids":["https://orcid.org/0000-0002-8708-1979"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. T. Mannisto","raw_affiliation_strings":["Division of Pharmacology and Toxicology, Faculty of Pharmacy, PO Box 56 (Viikinkaari 5E), University of Helsinki, Helsinki FIN-00014, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Toxicology, Faculty of Pharmacy, PO Box 56 (Viikinkaari 5E), University of Helsinki, Helsinki FIN-00014, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021786873","display_name":"Soh Agatsuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Agatsuma","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035129193","display_name":"Noboru Hiroi","orcid":"https://orcid.org/0000-0002-6846-5969","observed_orcids":["https://orcid.org/0000-0002-6846-5969"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"N. Hiroi","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences,","Dominick P. Purpura Department of Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences,","institution_ids":[]},{"raw_affiliation_string":"Dominick P. Purpura Department of Neuroscience and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035129193"],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.7127,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.9024642,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"20","first_page":"3914","last_page":"3925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/22q11-2-deletion-syndrome","display_name":"22q11.2 deletion syndrome","score":0.7850000262260437},{"id":"https://openalex.org/keywords/txnrd2","display_name":"TXNRD2","score":0.8009999990463257},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/arvcf","display_name":"ARVCF","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bac-transgenic-mice","display_name":"BAC transgenic mice","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/incentive-learning","display_name":"incentive learning","score":0.9829999804496765},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9639999866485596},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9419999718666077},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stress-behavior","display_name":"stress behavior","score":0.6330000162124634},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6949487924575806},{"id":"https://openalex.org/C2775847253","wikidata":"https://www.wikidata.org/wiki/Q7579050","display_name":"Spontaneous alternation","level":3,"score":0.5998747944831848},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5485103130340576},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5321297645568848},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5128822326660156},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.46897658705711365},{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.45829328894615173},{"id":"https://openalex.org/C182901222","wikidata":"https://www.wikidata.org/wiki/Q419061","display_name":"Bacterial artificial chromosome","level":4,"score":0.4323536157608032},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.426778107881546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3907961845397949},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29963189363479614},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2542329430580139},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24323564767837524},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.17432284355163574},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002892","descriptor_name":"Chromosomes, Human, Pair 22","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002892","descriptor_name":"Chromosomes, Human, Pair 22","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051186","descriptor_name":"Armadillo Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051186","descriptor_name":"Armadillo Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054482","descriptor_name":"Thioredoxin Reductase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054482","descriptor_name":"Thioredoxin Reductase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/hmg/ddp334","doi":"https://doi.org/10.1093/hmg/ddp334","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddp334","pdf_url":"https://academic.oup.com/hmg/article-pdf/18/20/3914/1819269/ddp334.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2748897","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2748897","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Mol Genet","raw_type":"Text"},{"id":"pmid:19617637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19617637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/hmg/ddp334","doi":"https://doi.org/10.1093/hmg/ddp334","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddp334","pdf_url":"https://academic.oup.com/hmg/article-pdf/18/20/3914/1819269/ddp334.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3026249562","display_name":null,"funder_award_id":"210758","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G5120007597","display_name":null,"funder_award_id":"HD05311","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7021792866","display_name":"22q11 Genes and Complex Behavior in Mice","funder_award_id":"R21HD053114","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118401037.pdf","grobid_xml":"https://content.openalex.org/works/W2118401037.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1565433182","https://openalex.org/W1583309920","https://openalex.org/W1879001643","https://openalex.org/W1963687045","https://openalex.org/W1967985978","https://openalex.org/W1971321176","https://openalex.org/W1974345995","https://openalex.org/W1984198463","https://openalex.org/W1985996981","https://openalex.org/W1986059489","https://openalex.org/W1994593489","https://openalex.org/W1997031801","https://openalex.org/W1997343027","https://openalex.org/W2002960068","https://openalex.org/W2002969945","https://openalex.org/W2005775181","https://openalex.org/W2005800358","https://openalex.org/W2012796647","https://openalex.org/W2018384285","https://openalex.org/W2018486902","https://openalex.org/W2021700795","https://openalex.org/W2024910541","https://openalex.org/W2042004678","https://openalex.org/W2043050818","https://openalex.org/W2044141056","https://openalex.org/W2054856852","https://openalex.org/W2054861645","https://openalex.org/W2062616602","https://openalex.org/W2063627630","https://openalex.org/W2064990689","https://openalex.org/W2065341809","https://openalex.org/W2068024783","https://openalex.org/W2070007640","https://openalex.org/W2074356620","https://openalex.org/W2076199524","https://openalex.org/W2077686291","https://openalex.org/W2077718913","https://openalex.org/W2080292373","https://openalex.org/W2081281175","https://openalex.org/W2083610831","https://openalex.org/W2087276835","https://openalex.org/W2088097462","https://openalex.org/W2088848325","https://openalex.org/W2101446132","https://openalex.org/W2101895134","https://openalex.org/W2104341883","https://openalex.org/W2105837661","https://openalex.org/W2108994411","https://openalex.org/W2119907069","https://openalex.org/W2122664375","https://openalex.org/W2129684141","https://openalex.org/W2133579501","https://openalex.org/W2133810312","https://openalex.org/W2140869203","https://openalex.org/W2147623733","https://openalex.org/W2151566815","https://openalex.org/W2153572594","https://openalex.org/W2159703558","https://openalex.org/W2165554230","https://openalex.org/W2170290905","https://openalex.org/W2329674734","https://openalex.org/W2588914676","https://openalex.org/W2760456113","https://openalex.org/W4243699706"],"related_works":["https://openalex.org/W2002960068","https://openalex.org/W2748233396","https://openalex.org/W2150456584","https://openalex.org/W2502521380","https://openalex.org/W2123282017","https://openalex.org/W1966399964","https://openalex.org/W2158616499","https://openalex.org/W2794682640","https://openalex.org/W2946912682","https://openalex.org/W2170290905"],"abstract_inverted_index":{"Duplication":[0],"of":[1,10,31,48,50,56,102,110,117,180,195,207,230,241],"human":[2,57],"chromosome":[3,72],"22q11.2":[4,32,197,232],"is":[5,36],"associated":[6],"with":[7,168],"elevated":[8],"rates":[9],"mental":[11],"retardation,":[12],"autism":[13],"and":[14,65,80,91,94,99,143,161,164,188,202,221,245],"many":[15],"other":[16],"behavioral":[17],"phenotypes.":[18],"However,":[19],"because":[20],"duplications":[21],"cover":[22],"1.5-6":[23],"Mb,":[24],"the":[25,45,61,108,114,184,204],"precise":[26],"manner":[27],"in":[28,39,69,133,148,183,243],"which":[29,59],"segments":[30],"causally":[33],"affect":[34],"behavior":[35],"not":[37],"known":[38],"humans.":[40],"We":[41],"have":[42],"now":[43],"determined":[44,107],"developmental":[46],"impact":[47,109],"over-expression":[49,112,194],"an":[51,175],"approximately":[52,176],"190":[53],"kb":[54],"segment":[55,198,233],"22q11.2,":[58],"includes":[60],"genes":[62],"TXNRD2,":[63],"COMT":[64,181],"ARVCF,":[66],"on":[67,113,215],"behaviors":[68,93,163,223],"bacterial":[70],"artificial":[71],"(BAC)":[73],"transgenic":[74],"(TG)":[75],"mice.":[76],"BAC":[77,111,119,141,171],"TG":[78,120,142,172],"mice":[79,83,121,145,173],"wild-type":[81],"(WT)":[82],"were":[84,131,146],"tested":[85],"for":[86],"their":[87],"cognitive":[88],"capacities,":[89],"affect-":[90,220],"stress-related":[92,222],"motor":[95,165,225],"activity":[96,115,182],"at":[97],"1":[98],"2":[100],"months":[101],"age.":[103],"An":[104],"enzymatic":[105],"assay":[106],"level":[116,179],"COMT.":[118],"approached":[122],"a":[123,237],"rewarded":[124,135,149],"goal":[125],"faster":[126],"(i.e.":[127],"incentive":[128,200],"learning),":[129],"but":[130,210],"impaired":[132],"delayed":[134],"alternation":[136,150],"during":[137,247],"development.":[138,248],"In":[139],"contrast,":[140],"WT":[144,169],"indistinguishable":[147],"without":[151],"delays,":[152],"spontaneous":[153],"alternation,":[154],"prepulse":[155],"inhibition,":[156],"social":[157],"interaction,":[158],"anxiety-,":[159],"stress-":[160],"fear-related":[162],"activity.":[166],"Compared":[167],"mice,":[170],"had":[174],"2-fold":[177],"higher":[178],"prefrontal":[185],"cortex,":[186],"striatum":[187],"hippocampus.":[189],"These":[190],"data":[191],"suggest":[192],"that":[193],"this":[196,231],"enhances":[199],"learning":[201,244],"impairs":[203],"prolonged":[205],"maintenance":[206],"working":[208,216],"memory,":[209],"has":[211],"no":[212],"apparent":[213],"effect":[214],"memory":[217],"per":[218],"se,":[219],"or":[224],"capacity.":[226],"High":[227],"copy":[228],"numbers":[229],"might":[234],"contribute":[235],"to":[236],"highly":[238],"selective":[239],"set":[240],"phenotypes":[242],"cognition":[246]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
