{"id":"https://openalex.org/W2118376548","doi":"https://doi.org/10.3171/jns.1984.61.6.1107","title":"Thromboxane synthetase inhibition in acute focal cerebral ischemia in cats","display_name":"Thromboxane synthetase inhibition in acute focal cerebral ischemia in cats","publication_year":1984,"publication_date":"1984-12-01","ids":{"openalex":"https://openalex.org/W2118376548","doi":"https://doi.org/10.3171/jns.1984.61.6.1107","mag":"2118376548","pmid":"https://pubmed.ncbi.nlm.nih.gov/6542131"},"language":"en","primary_location":{"id":"doi:10.3171/jns.1984.61.6.1107","doi":"https://doi.org/10.3171/jns.1984.61.6.1107","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.1984.61.6.1107","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051705778","display_name":"Nazih A. Moufarrij","orcid":"https://orcid.org/0000-0002-2063-3732","observed_orcids":["https://orcid.org/0000-0002-2063-3732"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazih A. Moufarrij","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091328673","display_name":"John R. Little","orcid":"https://orcid.org/0000-0003-2034-2684","observed_orcids":["https://orcid.org/0000-0003-2034-2684"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Little","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049818967","display_name":"Victor Skrinska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Skrinska","raw_affiliation_strings":["Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108450374","display_name":"Fred V. Lucas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred V. Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080069743","display_name":"John P. Latchaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. Latchaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056598687","display_name":"Robert M. Slugg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Slugg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091678274","display_name":"Ronald Peter Lesser","orcid":"https://orcid.org/0000-0003-2232-7410","observed_orcids":["https://orcid.org/0000-0003-2232-7410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald P. Lesser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7027,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.89598811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"6","first_page":"1107","last_page":"1112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboxane-synthase-inhibitor","display_name":"thromboxane synthetase inhibitor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.734000027179718},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.9350000023841858},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8500000238418579},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.8610000014305115},{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.845973789691925},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.7367673516273499},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.73007732629776},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7164078950881958},{"id":"https://openalex.org/C2775841333","wikidata":"https://www.wikidata.org/wiki/Q498179","display_name":"Middle cerebral artery","level":3,"score":0.5972362756729126},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5120182633399963},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.5101328492164612},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4936124086380005},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.44640398025512695},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.4249765872955322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2470504641532898},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.16868501901626587},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16096451878547668}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013930","descriptor_name":"Thromboxane-A Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013931","descriptor_name":"Thromboxanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3171/jns.1984.61.6.1107","doi":"https://doi.org/10.3171/jns.1984.61.6.1107","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.1984.61.6.1107","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:6542131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6542131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1837807301","https://openalex.org/W1971209543","https://openalex.org/W1997380862","https://openalex.org/W2006496556","https://openalex.org/W2009212843","https://openalex.org/W2031939730","https://openalex.org/W2041815933","https://openalex.org/W2047086590","https://openalex.org/W2048878502","https://openalex.org/W2059464453","https://openalex.org/W2064415194","https://openalex.org/W2088516593","https://openalex.org/W2097726615","https://openalex.org/W2124915306","https://openalex.org/W2317586421"],"related_works":["https://openalex.org/W134897890","https://openalex.org/W2035610823","https://openalex.org/W7100189298","https://openalex.org/W2322869816","https://openalex.org/W3146803045","https://openalex.org/W2006496556","https://openalex.org/W2172297004","https://openalex.org/W2083241313","https://openalex.org/W1992408553","https://openalex.org/W2029421116"],"abstract_inverted_index":{"The":[0,84,158,187,210],"purpose":[1],"of":[2,10,22,50,95,260,282,299,320],"this":[3],"investigation":[4],"was":[5,87,121,147,231,301,325],"to":[6,225,315,333],"study":[7],"the":[8,20,26,93,124,167,206,220,241,318],"effects":[9],"a":[11,47,232],"selective":[12],"thromboxane":[13,275,311],"A2":[14],"(TXA2)":[15],"synthetase":[16,312],"inhibitor":[17],"(TSI)":[18],"upon":[19],"evolution":[21,319],"cerebral":[23,38,117,321,330],"infarction":[24,331],"in":[25,240,305],"cat.":[27],"Adult":[28],"cats,":[29],"lightly":[30],"anesthetized":[31],"with":[32,163,244],"nitrous":[33],"oxide,":[34],"underwent":[35],"right":[36],"middle":[37],"artery":[39],"(MCA)":[40],"occlusion":[41,251],"for":[42,172,256],"4":[43],"hours":[44],"followed":[45],"by":[46,303],"2-hour":[48],"period":[49],"reperfusion":[51,253],"before":[52,103,129,138,144,327],"sacrifice.":[53],"Ten":[54,75,246],"cats":[55,65,76,242,248,288,306],"received":[56,66,262],"3":[57,67,263],"mg/kg":[58,68,264],"TSI":[59,69,265,324],"intravenously":[60,70,266],"immediately":[61,71,267],"before,":[62],"and":[63,91,104,108,111,130,137,152,166,170,178,184,197,215,252,271,274,292],"10":[64],"after":[72,105,131,134,268],"MCA":[73,106,109,132,135,250,269,328],"occlusion.":[74],"were":[77,101,155,160,201,237,254,284,289,296],"used":[78,255],"as":[79],"controls":[80],"receiving":[81,307],"no":[82],"treatment.":[83],"bleeding":[85,188],"time":[86],"determined":[88],"at":[89,92,112],"baseline":[90],"end":[94],"each":[96,140,145],"experiment.":[97,141],"Electroencephalographic":[98],"(EEG)":[99],"recordings":[100],"obtained":[102],"clipping":[107],"release,":[110],"hourly":[113],"intervals":[114],"thereafter.":[115],"Regional":[116],"blood":[118,191],"flow":[119],"(rCBF)":[120],"measured":[122],"using":[123],"xenon-133":[125],"(133Xe)":[126],"clearance":[127],"technique":[128],"occlusion,":[133,270,329],"reopening,":[136],"terminating":[139],"Thirty":[142],"minutes":[143],"cat":[146],"sacrificed,":[148],"Evans":[149,175],"blue":[150,176],"dye":[151,177,199],"sodium":[153,179],"fluorescein":[154,180],"given":[156,326],"intravenously.":[157],"animals":[159],"then":[161],"perfused":[162],"colloidal":[164],"carbon":[165,182,213],"brains":[168],"removed":[169],"evaluated":[171],"midline":[173],"shift.":[174],"extravasation,":[181],"staining,":[183,214],"infarct":[185,216],"size.":[186],"time,":[189],"arterial":[190],"pressure,":[192],"rCBF":[193],"changes,":[194,212],"brain":[195],"swelling,":[196],"vital":[198],"extravasation":[200],"not":[202,290],"statistically":[203],"different":[204],"between":[205,219],"three":[207,221],"treatment":[208],"groups.":[209],"EEG":[211],"size":[217],"differences":[218],"groups":[222],"also":[223],"failed":[224,314],"reach":[226],"statistical":[227],"significance,":[228],"but":[229],"there":[230],"suggestion":[233],"that":[234],"these":[235],"parameters":[236],"adversely":[238],"affected":[239],"pretreated":[243],"TSI.":[245,308],"additional":[247],"undergoing":[249],"pharmacological":[257],"studies.":[258],"Five":[259],"them":[261],"serial":[272,293],"drug":[273],"B2":[276],"(TXB2)":[277],"levels":[278,295],"(a":[279],"stable":[280],"metabolite":[281],"TXA2)":[283],"determined.":[285],"Another":[286],"five":[287],"treated":[291],"TXB2":[294],"obtained.":[297],"Production":[298],"TXA2":[300],"inhibited":[302],"95%":[304],"In":[309],"conclusion,":[310],"inhibition":[313],"modify":[316],"favorably":[317],"infarction.":[322],"When":[323],"tended":[332],"be":[334],"more":[335],"extensive.":[336]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
