{"id":"https://openalex.org/W2118352397","doi":null,"title":"Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis.","display_name":"Correlation of collagen organization with polarization sensitive imaging of in vitro cartilage: implications for osteoarthritis.","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W2118352397","mag":"2118352397","pmid":"https://pubmed.ncbi.nlm.nih.gov/11409125"},"language":"en","primary_location":{"id":"pmid:11409125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11409125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037124866","display_name":"Wolfgang Drexler","orcid":"https://orcid.org/0000-0002-3557-6398","observed_orcids":["https://orcid.org/0000-0002-3557-6398"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Drexler","raw_affiliation_strings":["Division of Orthopedic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthopedic Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113492258","display_name":"Debra L. Stamper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Stamper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035593642","display_name":"Christine A. Jesser","orcid":"https://orcid.org/0000-0002-7986-9184","observed_orcids":["https://orcid.org/0000-0002-7986-9184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Jesser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014330564","display_name":"Xingde D. Li","orcid":"https://orcid.org/0000-0002-4725-3297","observed_orcids":["https://orcid.org/0000-0002-4725-3297"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060880632","display_name":"Costas Pitris","orcid":"https://orcid.org/0000-0002-5559-1050","observed_orcids":["https://orcid.org/0000-0002-5559-1050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Pitris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059954909","display_name":"Kathleen Saunders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Saunders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078112684","display_name":"SCOTT DAVID MARTIN","orcid":"https://orcid.org/0000-0003-1263-5014","observed_orcids":["https://orcid.org/0000-0003-1263-5014","https://orcid.org/0009-0006-1909-706X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019591663","display_name":"M B Lodge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B Lodge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019768182","display_name":"James G. Fujimoto","orcid":"https://orcid.org/0000-0002-0828-4357","observed_orcids":["https://orcid.org/0000-0002-0828-4357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G Fujimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019132256","display_name":"Mark E. Brezinski","orcid":"https://orcid.org/0000-0002-8081-8763","observed_orcids":["https://orcid.org/0000-0002-8081-8763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Brezinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5211,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.96117791,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"6","first_page":"1311","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12050","display_name":"Optical Polarization and Ellipsometry","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9869999885559082},{"id":"https://openalex.org/keywords/collagen-organization","display_name":"collagen organization","score":0.9660000205039978},{"id":"https://openalex.org/keywords/polarization-sensitive-optical-coherence-tomography","display_name":"polarization-sensitive optical coherence tomography","score":0.972000002861023},{"id":"https://openalex.org/keywords/polarized-light-microscopy","display_name":"polarized light microscopy","score":0.628000020980835},{"id":"https://openalex.org/keywords/birefringence","display_name":"birefringence","score":0.8970000147819519},{"id":"https://openalex.org/keywords/early-osteoarthritis-detection","display_name":"early osteoarthritis detection","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cartilage-histology","display_name":"cartilage histology","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7856069803237915},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.7527948617935181},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7303471565246582},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7277105450630188},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4979076385498047},{"id":"https://openalex.org/C111643667","wikidata":"https://www.wikidata.org/wiki/Q12046176","display_name":"Polarized light microscopy","level":2,"score":0.47956007719039917},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.45589542388916016},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4399249851703644},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.4241979122161865},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3344830870628357},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2163979709148407},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1366603672504425},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11409125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11409125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Journal Article"},{"id":"mag:2118352397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11409125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1645435362","display_name":"Mechanism & Efficacy of Assessing Osteoarthritis by OCT","funder_award_id":"R01AR044812","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3799663561","display_name":"Novel Optical Diagnostics with Optical Coherence Tomography","funder_award_id":"R01EY011289","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7068158391","display_name":"INTRAVASCULAR IMAGING WITH OPTICAL COHERENCE TOMOGRAPHY","funder_award_id":"R29HL055686","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7605025223","display_name":"Optical Biopsy Using Optical Coherence Tomography","funder_award_id":"5r01ca075289-21","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047105202","https://openalex.org/W1504849413","https://openalex.org/W2154606486","https://openalex.org/W2080331180","https://openalex.org/W2129715077","https://openalex.org/W2415869338","https://openalex.org/W2772203473","https://openalex.org/W3017000532","https://openalex.org/W7101025690","https://openalex.org/W2915882478"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Optical":[1],"coherence":[2],"tomography":[3],"(OCT),":[4],"a":[5,176],"new":[6],"method":[7],"of":[8,37,46,70,98,161,166,183],"high":[9,167],"resolution":[10,45,168],"imaging,":[11],"has":[12],"shown":[13],"feasibility":[14],"for":[15,180],"assessing":[16],"articular":[17],"cartilage":[18,88,121,138,155],"to":[19,32,51,84,158],"identify":[20],"early":[21,181],"changes":[22,63,86,100,153],"in":[23,73,87,91,148,154],"osteoarthritis":[24],"(OA)":[25],"and":[26,67,127,143,171],"monitor":[27],"therapy.":[28],"OCT":[29,66,79,175],"is":[30,49],"analogous":[31],"ultrasound,":[33],"measuring":[34],"the":[35,60,68,159],"intensity":[36],"backreflected":[38],"infrared":[39],"light":[40],"rather":[41],"than":[42,55],"sound.":[43],"The":[44,94,164],"this":[47],"technology":[48,179],"up":[50],"25":[52],"times":[53],"higher":[54],"existing":[56],"methods.":[57],"We":[58],"investigated":[59],"correlation":[61],"between":[62],"observed":[64],"by":[65,111,124,134],"degree":[69],"collagen":[71,89,103,162],"organization":[72,90,104],"OA":[74],"cartilage.":[75],"METHODS:":[76],"Polarization":[77],"sensitive":[78],"(PSOCT)":[80],"imaging":[81,170],"was":[82,122,131],"used":[83],"assess":[85],"vitro.":[92],"RESULTS:":[93],"presence":[95],"(or":[96,105],"absence)":[97],"PSOCT":[99,126,152],"correlated":[101],"with":[102],"disorganization)":[106],"on":[107],"histology":[108],"as":[109],"assessed":[110],"picrosirius":[112],"polarization":[113,128],"microscopy":[114],"(no":[115],"significant":[116],"difference).":[117],"In":[118],"multiple":[119],"cases,":[120],"abnormal":[123],"both":[125],"microscopy,":[129],"but":[130],"grossly":[132],"normal":[133],"routine":[135],"staining,":[136],"showing":[137],"thickness":[139],">":[140],"2":[141],"mm":[142],"no":[144],"fibrillations.":[145],"CONCLUSION:":[146],"This":[147],"vitro":[149],"study":[150],"suggests":[151],"are":[156],"due":[157],"state":[160],"organization.":[163],"combination":[165],"structural":[169],"birefringence":[172],"detection":[173],"make":[174],"potentially":[177],"powerful":[178],"assessment":[182],"OA.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}