{"id":"https://openalex.org/W2118310862","doi":"https://doi.org/10.1016/s1074-7613(00)80011-4","title":"Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells","display_name":"Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2118310862","doi":"https://doi.org/10.1016/s1074-7613(00)80011-4","mag":"2118310862","pmid":"https://pubmed.ncbi.nlm.nih.gov/10023775"},"language":"en","primary_location":{"id":"doi:10.1016/s1074-7613(00)80011-4","doi":"https://doi.org/10.1016/s1074-7613(00)80011-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80011-4","pdf_url":"http://www.cell.com/article/S1074761300800114/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1074761300800114/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065474989","display_name":"Robyn Catlett-Falcone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robyn Catlett-Falcone","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612, USA","Department of Pathology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Pathology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112739082","display_name":"Terry H. Landowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry H Landowski","raw_affiliation_strings":["Clinical Investigations Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Investigations Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966507","display_name":"Marc M. Oshiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc M Oshiro","raw_affiliation_strings":["Clinical Investigations Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Investigations Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087339928","display_name":"James Turkson","orcid":"https://orcid.org/0000-0002-6964-1602","observed_orcids":["https://orcid.org/0000-0002-6964-1602"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Turkson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086404962","display_name":"Alexander Levitzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexander Levitzki","raw_affiliation_strings":["Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013135039","display_name":"Rocco Savino","orcid":"https://orcid.org/0000-0002-4046-1472","observed_orcids":["https://orcid.org/0000-0002-4046-1472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rocco Savino","raw_affiliation_strings":["Istituto di Recerche di Biologia Molecolare P. Angeletti, Pomezia 00040, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Recerche di Biologia Molecolare P. Angeletti, Pomezia 00040, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052593572","display_name":"Gennaro Ciliberto","orcid":"https://orcid.org/0000-0003-2851-8605","observed_orcids":["https://orcid.org/0000-0003-2851-8605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gennaro Ciliberto","raw_affiliation_strings":["Istituto di Recerche di Biologia Molecolare P. Angeletti, Pomezia 00040, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Recerche di Biologia Molecolare P. Angeletti, Pomezia 00040, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111687725","display_name":"Lynn C. Moscinski","orcid":"https://orcid.org/0000-0002-2609-4063","observed_orcids":["https://orcid.org/0000-0002-2609-4063"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Moscinski","raw_affiliation_strings":["Department of Pathology, University of South Florida College of Medicine, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050077300","display_name":"Jos\u00e9 L. Fern\u00e1ndez-Luna","orcid":"https://orcid.org/0000-0002-1273-3338","observed_orcids":["https://orcid.org/0000-0002-1273-3338"]},"institutions":[{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Luis Fern\u00e1ndez-Luna","raw_affiliation_strings":["Hospital Universitario Marques de Valdecilla, Santander 39008, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Marques de Valdecilla, Santander 39008, Spain","institution_ids":["https://openalex.org/I4210099858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040117830","display_name":"Gabriel N\u00fa\u00f1ez","orcid":"https://orcid.org/0000-0002-6529-2695","observed_orcids":["https://orcid.org/0000-0002-6529-2695"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Nu\u00f1ez","raw_affiliation_strings":["Department of Pathology and Comprehensive, Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Comprehensive, Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103061547","display_name":"William S. Dalton","orcid":"https://orcid.org/0000-0001-9417-2599","observed_orcids":["https://orcid.org/0000-0001-9417-2599"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S Dalton","raw_affiliation_strings":["Clinical Investigations Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Investigations Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022795218","display_name":"Richard Jove","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard Jove","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","Department of Pathology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Department of Pathology, University of South Florida College of Medicine, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022795218"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":29.5626,"has_fulltext":false,"cited_by_count":1625,"citation_normalized_percentile":{"value":0.99833854,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"105","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/u266-cells","display_name":"U266 cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.7689999938011169},{"id":"https://openalex.org/keywords/fas-mediated-apoptosis","display_name":"Fas-mediated apoptosis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9539999961853027},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9100000262260437},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.8230000138282776},{"id":"https://openalex.org/keywords/janus-kinase","display_name":"Janus kinase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/constitutive-activation","display_name":"constitutive activation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/myeloma-cell-survival","display_name":"myeloma cell survival","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6763201355934143},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6733779311180115},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6293495893478394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5999647378921509},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5992385149002075},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5797852277755737},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4279627799987793},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.42202839255332947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4152941107749939},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3763312101364136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26598772406578064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1074-7613(00)80011-4","doi":"https://doi.org/10.1016/s1074-7613(00)80011-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80011-4","pdf_url":"http://www.cell.com/article/S1074761300800114/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmid:10023775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10023775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1074-7613(00)80011-4","doi":"https://doi.org/10.1016/s1074-7613(00)80011-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1074-7613(00)80011-4","pdf_url":"http://www.cell.com/article/S1074761300800114/pdf","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1714834778","display_name":"Drug Resistance in Multiple Myeloma","funder_award_id":"R01CA077859","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1727770634","display_name":"Molecular Signatures of STAT Regulated Genes in Cancer","funder_award_id":"R01CA055652","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2118310862.pdf"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W29766578","https://openalex.org/W72273961","https://openalex.org/W139500099","https://openalex.org/W157103782","https://openalex.org/W159302622","https://openalex.org/W168754456","https://openalex.org/W1483520515","https://openalex.org/W1495457417","https://openalex.org/W1546871754","https://openalex.org/W1550156431","https://openalex.org/W1556315117","https://openalex.org/W1568956696","https://openalex.org/W1621124914","https://openalex.org/W1652716702","https://openalex.org/W1748388485","https://openalex.org/W1777794242","https://openalex.org/W1803183847","https://openalex.org/W1833723119","https://openalex.org/W1871715553","https://openalex.org/W1933735120","https://openalex.org/W1959486232","https://openalex.org/W1975225141","https://openalex.org/W1981799488","https://openalex.org/W1988917700","https://openalex.org/W1991865867","https://openalex.org/W1999375479","https://openalex.org/W2007000374","https://openalex.org/W2007119824","https://openalex.org/W2029275361","https://openalex.org/W2029312116","https://openalex.org/W2032674547","https://openalex.org/W2035134361","https://openalex.org/W2041466047","https://openalex.org/W2045843248","https://openalex.org/W2062005942","https://openalex.org/W2063176993","https://openalex.org/W2081003617","https://openalex.org/W2083802827","https://openalex.org/W2097765112","https://openalex.org/W2106515248","https://openalex.org/W2107631090","https://openalex.org/W2109585569","https://openalex.org/W2115798976","https://openalex.org/W2127048642","https://openalex.org/W2131616553","https://openalex.org/W2132633540","https://openalex.org/W2132893561","https://openalex.org/W2135055828","https://openalex.org/W2145106676","https://openalex.org/W2158552404","https://openalex.org/W2163046152","https://openalex.org/W2165119257","https://openalex.org/W2175994433","https://openalex.org/W2258341156","https://openalex.org/W2412273027","https://openalex.org/W2474873081","https://openalex.org/W3195431600","https://openalex.org/W4285719527","https://openalex.org/W6629019079","https://openalex.org/W6632773610","https://openalex.org/W6637095441"],"related_works":["https://openalex.org/W13080709","https://openalex.org/W2165238462","https://openalex.org/W2144322759","https://openalex.org/W2045410276","https://openalex.org/W2389310533","https://openalex.org/W2024076223","https://openalex.org/W2080476012","https://openalex.org/W2085793397","https://openalex.org/W2072493113","https://openalex.org/W2061476381"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":41},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":52},{"year":2016,"cited_by_count":50},{"year":2015,"cited_by_count":60},{"year":2014,"cited_by_count":70},{"year":2013,"cited_by_count":83},{"year":2012,"cited_by_count":85}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}