{"id":"https://openalex.org/W2118236802","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0370","title":"Identification of the Molecular Mechanisms for Dedifferentiation at the Invasion Front of Colorectal Cancer by a Gene Expression Analysis","display_name":"Identification of the Molecular Mechanisms for Dedifferentiation at the Invasion Front of Colorectal Cancer by a Gene Expression Analysis","publication_year":2008,"publication_date":"2008-11-14","ids":{"openalex":"https://openalex.org/W2118236802","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0370","mag":"2118236802","pmid":"https://pubmed.ncbi.nlm.nih.gov/19010838"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-08-0370","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0370","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-0370","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/14/22/7215/1978812/7215.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/clincancerres/article-pdf/14/22/7215/1978812/7215.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011209329","display_name":"Yoshimasa Oku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Oku","raw_affiliation_strings":["1Genome Center, Japanese Foundation for Cancer Research;","4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genome Center, Japanese Foundation for Cancer Research;","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112331168","display_name":"Takashi Shimoji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Shimoji","raw_affiliation_strings":["1Genome Center, Japanese Foundation for Cancer Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genome Center, Japanese Foundation for Cancer Research;","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086210627","display_name":"Katsunari Takifuji","orcid":"https://orcid.org/0000-0002-1776-001X","observed_orcids":["https://orcid.org/0000-0002-1776-001X"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunari Takifuji","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113739016","display_name":"Tsukasa Hotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsukasa Hotta","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050600975","display_name":"Shozo Yokoyama","orcid":"https://orcid.org/0000-0003-1301-6434","observed_orcids":["https://orcid.org/0000-0003-1301-6434"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo Yokoyama","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791237","display_name":"Kenji Matsuda","orcid":"https://orcid.org/0000-0002-3093-0095","observed_orcids":["https://orcid.org/0000-0002-3093-0095"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Matsuda","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111814753","display_name":"Takashi Higashiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Higashiguchi","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050281631","display_name":"Toshiji Tominaga","orcid":"https://orcid.org/0000-0001-6463-4182","observed_orcids":["https://orcid.org/0000-0001-6463-4182"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiji Tominaga","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005616066","display_name":"Toru Nasu","orcid":"https://orcid.org/0000-0002-8870-076X","observed_orcids":["https://orcid.org/0000-0002-8870-076X"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Nasu","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004391555","display_name":"Koichi Tamura","orcid":"https://orcid.org/0000-0002-1016-9817","observed_orcids":["https://orcid.org/0000-0002-1016-9817","https://orcid.org/0000-0002-0660-5372"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Tamura","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103995048","display_name":"Masaaki Matsuura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Matsuura","raw_affiliation_strings":["1Genome Center, Japanese Foundation for Cancer Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genome Center, Japanese Foundation for Cancer Research;","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021218765","display_name":"Satoshi Miyata","orcid":"https://orcid.org/0000-0003-2400-7525","observed_orcids":["https://orcid.org/0000-0003-2400-7525"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Miyata","raw_affiliation_strings":["1Genome Center, Japanese Foundation for Cancer Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genome Center, Japanese Foundation for Cancer Research;","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105690995","display_name":"Yo Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yo Kato","raw_affiliation_strings":["2Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research;","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073275097","display_name":"Hiroki Yamaue","orcid":"https://orcid.org/0000-0002-6982-3457","observed_orcids":["https://orcid.org/0000-0002-6982-3457"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Yamaue","raw_affiliation_strings":["4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091623593","display_name":"Yoshio Miki","orcid":"https://orcid.org/0000-0003-0114-392X","observed_orcids":["https://orcid.org/0000-0003-0114-392X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshio Miki","raw_affiliation_strings":["1Genome Center, Japanese Foundation for Cancer Research;","3Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Genome Center, Japanese Foundation for Cancer Research;","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"3Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan and","institution_ids":["https://openalex.org/I125602781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9199,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.75692896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"22","first_page":"7215","last_page":"7222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.02290000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/dedifferentiation","display_name":"dedifferentiation","score":0.828000009059906},{"id":"https://openalex.org/keywords/invasive-front","display_name":"invasion front","score":0.6970000267028809},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":1.0},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.5289999842643738},{"id":"https://openalex.org/keywords/superficial-lesions","display_name":"superficial lesions","score":0.6570000052452087},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7340472936630249},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6674148440361023},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.646786630153656},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6135699152946472},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5991532802581787},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.5597013831138611},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4909968674182892},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48626387119293213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4247540235519409},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.42468971014022827},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35506874322891235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23116326332092285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16277316212654114}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042282","descriptor_name":"Microdissection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.ccr-08-0370","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0370","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-0370","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/14/22/7215/1978812/7215.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:19010838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19010838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006725926","doi":null,"is_oa":false,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2010535","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.ccr-08-0370","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0370","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-0370","pdf_url":"https://aacrjournals.org/clincancerres/article-pdf/14/22/7215/1978812/7215.pdf","source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118236802.pdf","grobid_xml":"https://content.openalex.org/works/W2118236802.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1506680628","https://openalex.org/W1903224084","https://openalex.org/W1974012433","https://openalex.org/W1975218692","https://openalex.org/W1978912122","https://openalex.org/W1987572263","https://openalex.org/W2013011994","https://openalex.org/W2015577765","https://openalex.org/W2016249631","https://openalex.org/W2026372823","https://openalex.org/W2028550299","https://openalex.org/W2029138620","https://openalex.org/W2038361153","https://openalex.org/W2039205449","https://openalex.org/W2047619166","https://openalex.org/W2051993489","https://openalex.org/W2053717292","https://openalex.org/W2074381728","https://openalex.org/W2075983586","https://openalex.org/W2086152184","https://openalex.org/W2087863957","https://openalex.org/W2092868756","https://openalex.org/W2100668965","https://openalex.org/W2102794349","https://openalex.org/W2106877063","https://openalex.org/W2113047648","https://openalex.org/W2115792588","https://openalex.org/W2119069769","https://openalex.org/W2119297613","https://openalex.org/W2125578099","https://openalex.org/W2125772033","https://openalex.org/W2152106804","https://openalex.org/W2162499816","https://openalex.org/W2167638513","https://openalex.org/W2611104316","https://openalex.org/W2887635189","https://openalex.org/W2921883081"],"related_works":["https://openalex.org/W2895607883","https://openalex.org/W2189999970","https://openalex.org/W2068142269","https://openalex.org/W37775499","https://openalex.org/W2751236108","https://openalex.org/W2061463569","https://openalex.org/W6999901301","https://openalex.org/W2428341563","https://openalex.org/W2149517051","https://openalex.org/W3192995951"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,140,160,174,202,220],"aim":[2],"of":[3,27,110,125,153,166,177,206,230,248],"this":[4],"study":[5],"is":[6],"to":[7,80,191,240],"identify":[8],"gene":[9,203],"expression":[10,175,204],"signatures":[11],"that":[12],"accompany":[13],"dedifferentiation":[14,152,243],"at":[15,37,47,63,156,244],"the":[16,38,48,55,64,82,86,104,108,123,126,133,157,164,245],"cancer":[17,29,61,154],"invasion":[18,49,65,87,127,158,246],"front":[19,50,66,88,128,247],"in":[20,89,103,148],"colorectal":[21,28,90,249],"cancer.":[22,250],"EXPERIMENTAL":[23],"DESIGN:":[24],"Two":[25],"types":[26,33,99,198],"were":[30,34,95,113,129,180,189,238],"selected.":[31],"Both":[32],"well-differentiated":[35],"adenocarcinomas":[36],"superficial":[39,83,105,111],"lesion.":[40],"One":[41],"type":[42],"showed":[43,57],"a":[44,76],"dedifferentiated":[45,60],"phenotype":[46],"(type":[51,67],"A,":[52],"13":[53],"samples);":[54],"other":[56],"almost":[58],"no":[59],"cells":[62,155],"B,":[68],"12":[69,210],"samples).":[70],"Laser":[71],"microdissection":[72],"was":[73],"combined":[74],"with":[75,216,224,242],"cDNA":[77],"microarray":[78],"analysis":[79],"investigate":[81],"lesions":[84,112],"and":[85,101,107,171,186,235],"cancers.":[91],"RESULTS:":[92],"Eighty-three":[93],"genes":[94,146,179,188,208,226],"differentially":[96,194],"expressed":[97,195],"between":[98,196],"A":[100],"B":[102],"lesions,":[106],"samples":[109,124],"divided":[114,131,209],"correctly":[115],"into":[116,132,213],"two":[117,134,197,214],"clusters":[118,136,215],"by":[119,137,182],"these":[120,138],"genes.":[121,139],"Interestingly,":[122],"also":[130],"same":[135],"text":[141],"mining":[142],"method":[143],"selected":[144],"10":[145,178],"involved":[147],"potential":[149,161],"mechanisms":[150,162,222],"causing":[151],"front.":[159],"include":[163],"networks":[165,229],"transforming":[167,231],"growth":[168,232],"factor-beta,":[169,233],"Wnt,":[170,234],"Hedgehog":[172,236],"signals.":[173],"levels":[176],"calculated":[181],"quantitative":[183],"reverse":[184],"transcription-PCR":[185],"8":[187,207,225],"confirmed":[190],"be":[192],"significantly":[193],"(P":[199],"<":[200],"0.05).":[201],"profiles":[205],"test":[211],"cases":[212],"one":[217],"misclassification.":[218],"CONCLUSIONS:":[219],"molecular":[221],"constructed":[223],"from":[227],"three":[228],"signals":[237],"found":[239],"correlate":[241]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}