{"id":"https://openalex.org/W2118201387","doi":"https://doi.org/10.1073/pnas.40.7.627","title":"NOTE ON A \u201cPERMANENT\u201d EXPERIMENTAL ALTERATION OF GENETIC CONSTITUTION IN A NATURAL POPULATION","display_name":"NOTE ON A \u201cPERMANENT\u201d EXPERIMENTAL ALTERATION OF GENETIC CONSTITUTION IN A NATURAL POPULATION","publication_year":1954,"publication_date":"1954-07-01","ids":{"openalex":"https://openalex.org/W2118201387","doi":"https://doi.org/10.1073/pnas.40.7.627","mag":"2118201387","pmid":"https://pubmed.ncbi.nlm.nih.gov/16589535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/528007"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.40.7.627","doi":"https://doi.org/10.1073/pnas.40.7.627","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.40.7.627","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC528007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108291013","display_name":"Caryl Parker Haskins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177328695","display_name":"Union College","ror":"https://ror.org/058w5nk68","country_code":"US","type":"education","lineage":["https://openalex.org/I177328695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caryl P. Haskins","raw_affiliation_strings":["Union College, Schenectady, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union College, Schenectady, N. Y","institution_ids":["https://openalex.org/I177328695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075319512","display_name":"Edna F. Haskins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177328695","display_name":"Union College","ror":"https://ror.org/058w5nk68","country_code":"US","type":"education","lineage":["https://openalex.org/I177328695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edna F. Haskins","raw_affiliation_strings":["UNION COLLEGE, SCHENECTADY, N.Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNION COLLEGE, SCHENECTADY, N.Y","institution_ids":["https://openalex.org/I177328695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177328695"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.17725014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"7","first_page":"627","last_page":"635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.36820000410079956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.36820000410079956,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.1177000030875206,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wild-populations","display_name":"natural populations","score":0.6779999732971191},{"id":"https://openalex.org/keywords/genetic-constitution","display_name":"genetic constitution","score":0.7480000257492065},{"id":"https://openalex.org/keywords/nucleic-acid-conformation","display_name":"nucleic acid conformation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/small-molecule-binding","display_name":"small molecule binding","score":0.9559999704360962},{"id":"https://openalex.org/keywords/time-resolved-detection","display_name":"time-resolved detection","score":0.5759999752044678},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.9034357070922852},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.674322783946991},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.5878132581710815},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.46585020422935486},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4566026031970978},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4512835144996643},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4478500783443451},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4330568313598633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4313998520374298},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4254578948020935},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.33442598581314087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32355019450187683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08194363117218018},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.40.7.627","doi":"https://doi.org/10.1073/pnas.40.7.627","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.40.7.627","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:243859","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC528007","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:528007","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/528007","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:16589535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16589535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:243859","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC528007","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1865144196","https://openalex.org/W1968304827","https://openalex.org/W2134967967","https://openalex.org/W2138628383","https://openalex.org/W2156957878","https://openalex.org/W2288397913"],"related_works":["https://openalex.org/W2051086082","https://openalex.org/W1971171299","https://openalex.org/W2032957122","https://openalex.org/W2069955512","https://openalex.org/W2057811376","https://openalex.org/W1963916229","https://openalex.org/W2087850593","https://openalex.org/W2072917939","https://openalex.org/W4213174560","https://openalex.org/W2021446420"],"abstract_inverted_index":{"Fast,":[0],"low-cost,":[1],"accurate":[2],"detection":[3],"of":[4,21,27,56,61],"time-resolved":[5],"dynamic":[6],"nucleic":[7,22],"acid":[8,23],"conformational":[9,37,44],"variation":[10],"in":[11],"response":[12],"to":[13,49],"small":[14,30,41],"molecule":[15],"binding:":[16],"1)":[17],"enriches":[18],"our":[19],"understanding":[20],"structure,":[24],"and":[25,64],"regulation":[26],"structure":[28],"by":[29],"molecules":[31],"as":[32],"...Nucleic":[33],"acids":[34],"can":[35,46,65],"undergo":[36],"changes":[38,45],"upon":[39],"binding":[40],"molecules.":[42],"These":[43],"be":[47,67],"exploited":[48],"develop":[50],"new":[51],"therapeutic":[52],"strategies":[53],"through":[54],"control":[55],"gene":[57],"expression":[58],"or":[59],"triggering":[60],"cellular":[62],"responses":[63],"also":[66],"used":[68],"...":[69]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
