{"id":"https://openalex.org/W2118147138","doi":"https://doi.org/10.1158/1535-7163.mct-11-0096","title":"MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration","display_name":"MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration","publication_year":2011,"publication_date":"2011-06-11","ids":{"openalex":"https://openalex.org/W2118147138","doi":"https://doi.org/10.1158/1535-7163.mct-11-0096","mag":"2118147138","pmid":"https://pubmed.ncbi.nlm.nih.gov/21666078","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3711153"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-11-0096","doi":"https://doi.org/10.1158/1535-7163.mct-11-0096","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-11-0096","pdf_url":"https://aacrjournals.org/mct/article-pdf/10/8/1337/2320543/1337.pdf","source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/mct/article-pdf/10/8/1337/2320543/1337.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055817420","display_name":"Zhenfeng Duan","orcid":"https://orcid.org/0000-0003-1453-2430","observed_orcids":["https://orcid.org/0000-0003-1453-2430"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhenfeng Duan","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071532449","display_name":"Edwin Choy","orcid":"https://orcid.org/0000-0001-9896-8084","observed_orcids":["https://orcid.org/0000-0001-9896-8084"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin Choy","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017550859","display_name":"David C. Harmon","orcid":"https://orcid.org/0000-0002-4181-0179","observed_orcids":["https://orcid.org/0000-0002-4181-0179"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Harmon","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022588641","display_name":"Xianzhe Liu","orcid":"https://orcid.org/0000-0002-7635-5671","observed_orcids":["https://orcid.org/0000-0002-7635-5671"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianzhe Liu","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055164957","display_name":"Michiro Susa","orcid":"https://orcid.org/0000-0002-6687-0477","observed_orcids":["https://orcid.org/0000-0002-6687-0477"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michiro Susa","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","Department of Orthopaedics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Orthopaedics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108135955","display_name":"Henry J. Mankin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry Mankin","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082130171","display_name":"Francis John Hornicek","orcid":"https://orcid.org/0000-0002-6916-8042","observed_orcids":["https://orcid.org/0000-0002-6916-8042"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Hornicek","raw_affiliation_strings":["Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055817420"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":6.6997,"has_fulltext":true,"cited_by_count":241,"citation_normalized_percentile":{"value":0.97492497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"10","issue":"8","first_page":"1337","last_page":"1345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.996999979019165},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mir-127-3p","display_name":"miR-127-3p","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mir-151-3p","display_name":"miR-151-3p","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mir-191","display_name":"miR-191","score":0.996999979019165},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8199999928474426},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.9334001541137695},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7752664089202881},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6785765886306763},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5695928931236267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5675738453865051},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5646933317184448},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5380269289016724},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5273666977882385},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.45205825567245483},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4380396902561188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39059093594551086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1565399467945099},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11847826838493347}],"mesh":[{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1535-7163.mct-11-0096","doi":"https://doi.org/10.1158/1535-7163.mct-11-0096","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-11-0096","pdf_url":"https://aacrjournals.org/mct/article-pdf/10/8/1337/2320543/1337.pdf","source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:21666078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21666078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2706878","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3711153","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3711153","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3711153","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.mct-11-0096","doi":"https://doi.org/10.1158/1535-7163.mct-11-0096","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-11-0096","pdf_url":"https://aacrjournals.org/mct/article-pdf/10/8/1337/2320543/1337.pdf","source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3447108572","display_name":"Harvard Clinical and Translational Science Center (UL1)","funder_award_id":"UL1RR025758","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118147138.pdf","grobid_xml":"https://content.openalex.org/works/W2118147138.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1520622777","https://openalex.org/W1629179716","https://openalex.org/W1814922229","https://openalex.org/W1970583256","https://openalex.org/W1970760326","https://openalex.org/W1971460830","https://openalex.org/W1980860406","https://openalex.org/W1981951689","https://openalex.org/W1984687960","https://openalex.org/W1990521145","https://openalex.org/W1995055135","https://openalex.org/W1998461609","https://openalex.org/W1998767538","https://openalex.org/W1999163791","https://openalex.org/W2004339436","https://openalex.org/W2017903813","https://openalex.org/W2023947760","https://openalex.org/W2028945916","https://openalex.org/W2047611248","https://openalex.org/W2059531433","https://openalex.org/W2060863314","https://openalex.org/W2078021701","https://openalex.org/W2082241903","https://openalex.org/W2089858439","https://openalex.org/W2100084607","https://openalex.org/W2114918609","https://openalex.org/W2138344908","https://openalex.org/W2140927361","https://openalex.org/W2145720555","https://openalex.org/W2150597604","https://openalex.org/W2170685293","https://openalex.org/W4237473415"],"related_works":["https://openalex.org/W2047422323","https://openalex.org/W2328511328","https://openalex.org/W2580293203","https://openalex.org/W2985813858","https://openalex.org/W263960805","https://openalex.org/W2611170483","https://openalex.org/W1967915040","https://openalex.org/W2081879088","https://openalex.org/W2982121499","https://openalex.org/W895771146"],"abstract_inverted_index":{"microRNAs":[0],"(miRNA,":[1],"miR)":[2],"play":[3,147],"an":[4,107],"important":[5],"role":[6,150],"in":[7,19,44,66,76,80,109,129,140,151,164],"cancer":[8],"cell":[9,46,68,78,90,94,118,153],"growth":[10,95,154],"and":[11,30,48,61,72,96,112,126,142,155],"migration;":[12],"however,":[13],"the":[14,101,110,116],"potential":[15],"roles":[16],"of":[17,85,115],"miRNAs":[18,39,139],"osteosarcoma":[20,45,67,77,89,141,152],"remain":[21],"largely":[22],"uncharacterized.":[23],"By":[24],"applying":[25],"a":[26,113,148],"miRNA":[27],"microarray":[28],"platform":[29],"unsupervised":[31],"hierarchical":[32],"clustering":[33],"analysis,":[34],"we":[35,122],"found":[36],"that":[37,100,144],"several":[38],"have":[40],"altered":[41],"expression":[42,128],"levels":[43],"lines":[47,79,91],"tumor":[49],"tissues":[50],"when":[51],"compared":[52],"with":[53,82,106],"normal":[54],"human":[55],"osteoblasts.":[56,83],"Three":[57],"miRNAs,":[58],"miR-199a-3p,":[59],"miR-127-3p,":[60],"miR-376c,":[62],"were":[63,74],"significantly":[64,92],"decreased":[65,93,124],"lines,":[69],"whereas":[70],"miR-151-3p":[71],"miR-191":[73],"increased":[75],"comparison":[81],"Transfection":[84],"precursor":[86],"miR-199a-3p":[87,130,145],"into":[88],"migration,":[97],"thus":[98],"indicating":[99],"inhibition":[102],"effect":[103],"is":[104],"associated":[105],"increase":[108],"G(1)-phase":[111],"decrease":[114],"S-phase":[117],"population.":[119],"In":[120],"addition,":[121],"observed":[123],"mTOR":[125],"Stat3":[127],"transfected":[131],"cells.":[132],"This":[133],"study":[134],"provides":[135],"new":[136],"insights":[137],"for":[138],"suggests":[143],"may":[146,160],"functional":[149],"proliferation.":[156],"Restoring":[157],"miR-199a-3p's":[158],"function":[159],"provide":[161],"therapeutic":[162],"benefits":[163],"osteosarcoma.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":34},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}