{"id":"https://openalex.org/W2118098299","doi":"https://doi.org/10.1186/jbiol186","title":"What are pharmacological chaperones and why are they interesting?","display_name":"What are pharmacological chaperones and why are they interesting?","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2118098299","doi":"https://doi.org/10.1186/jbiol186","mag":"2118098299","pmid":"https://pubmed.ncbi.nlm.nih.gov/19833004","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776907"},"language":"en","primary_location":{"id":"doi:10.1186/jbiol186","doi":"https://doi.org/10.1186/jbiol186","is_oa":true,"landing_page_url":"https://doi.org/10.1186/jbiol186","pdf_url":"https://jbiol.biomedcentral.com/counter/pdf/10.1186/jbiol186","source":{"id":"https://openalex.org/S199926325","display_name":"Journal of Biology","issn_l":"1475-4924","issn":["1475-4924","1478-5854"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jbiol.biomedcentral.com/counter/pdf/10.1186/jbiol186","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dagmar Ringe","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA. ringe@brandeis.edu","Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA. ringe@brandeis.edu","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, Waltham, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory A Petsko","raw_affiliation_strings":["Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, 415 South Street, Waltham, MA, 02454, USA","Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, Waltham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, 415 South Street, Waltham, MA, 02454, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Departments of Biochemistry and Chemistry and the Rosenstiel Center, Brandeis University, Waltham, USA","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007934367","https://openalex.org/A5014900252"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":2190,"currency":"GBP","value_usd":2686},"apc_paid":{"value":2190,"currency":"GBP","value_usd":2686},"fwci":2.2499,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.88146814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"8","issue":"9","first_page":"80","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacological-chaperones","display_name":"pharmacological chaperones","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reversible-inhibitors","display_name":"reversible inhibitors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.652999997138977},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5210000276565552},{"id":"https://openalex.org/keywords/inhibitor-binding-affinity","display_name":"inhibitor binding affinity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/michaelis-constant","display_name":"Michaelis constant","score":0.7009999752044678},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46896377205848694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.364192396402359},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33698129653930664}],"mesh":[{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/jbiol186","doi":"https://doi.org/10.1186/jbiol186","is_oa":true,"landing_page_url":"https://doi.org/10.1186/jbiol186","pdf_url":"https://jbiol.biomedcentral.com/counter/pdf/10.1186/jbiol186","source":{"id":"https://openalex.org/S199926325","display_name":"Journal of Biology","issn_l":"1475-4924","issn":["1475-4924","1478-5854"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2776907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2776907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol","raw_type":"Text"},{"id":"pmid:19833004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19833004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/jbiol186","doi":"https://doi.org/10.1186/jbiol186","is_oa":true,"landing_page_url":"https://doi.org/10.1186/jbiol186","pdf_url":"https://jbiol.biomedcentral.com/counter/pdf/10.1186/jbiol186","source":{"id":"https://openalex.org/S199926325","display_name":"Journal of Biology","issn_l":"1475-4924","issn":["1475-4924","1478-5854"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118098299.pdf","grobid_xml":"https://content.openalex.org/works/W2118098299.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1505577908","https://openalex.org/W1530374442","https://openalex.org/W1585607520","https://openalex.org/W1940027108","https://openalex.org/W1965705234","https://openalex.org/W1972309823","https://openalex.org/W1975596553","https://openalex.org/W1991103963","https://openalex.org/W2000953906","https://openalex.org/W2008421309","https://openalex.org/W2010687395","https://openalex.org/W2032922131","https://openalex.org/W2048456744","https://openalex.org/W2057511642","https://openalex.org/W2068891048","https://openalex.org/W2072118579","https://openalex.org/W2078010704","https://openalex.org/W2106019968","https://openalex.org/W2111256689","https://openalex.org/W2113354295","https://openalex.org/W2115253113","https://openalex.org/W2122215922","https://openalex.org/W2147700328","https://openalex.org/W2157837974","https://openalex.org/W2162710350","https://openalex.org/W2168865322","https://openalex.org/W4252486092"],"related_works":["https://openalex.org/W3000046224","https://openalex.org/W919001635","https://openalex.org/W2181442596","https://openalex.org/W3041498459","https://openalex.org/W1898452719","https://openalex.org/W2109972885","https://openalex.org/W2600557325","https://openalex.org/W4386772797","https://openalex.org/W2045470787","https://openalex.org/W2335358041"],"abstract_inverted_index":{"We":[0],"should":[1],"have":[2],"said,":[3],"reversible":[4,37],"inhibitor.":[5],"That":[6],"is":[7,52,69],"the":[8,11,41,62,67,98,114,119],"key":[9],"to":[10,24,91,100,113,126],"use":[12],"of":[13,32,43,47,66,97,118],"active-site-directed":[14],"ligands":[15],"as":[16],"pharmacological":[17],"chaperones.":[18],"An":[19],"inhibitor":[20,38,68],"that":[21,29],"binds":[22,74,85],"irreversibly":[23],"a":[25,36,93,107,122],"target":[26],"protein":[27,30],"takes":[28],"out":[31],"circulation,":[33],"activity-wise.":[34],"But":[35,82],"always":[39],"allows":[40],"presence":[42],"some":[44],"equilibrium":[45],"amount":[46],"free":[48],"enzyme":[49],"[12],":[50],"which":[51],"then":[53],"available":[54],"for":[55],"substrate":[56,120],"binding":[57],"(which":[58],"will":[59],"also":[60,70],"stabilize":[61],"protein).":[63],"The":[64],"affinity":[65],"important.":[71],"If":[72],"it":[73,77,84,88],"too":[75,86],"tightly,":[76],"may":[78,89],"be":[79,101,127],"effectively":[80],"irreversible.":[81],"if":[83],"weakly,":[87],"impossible":[90],"supply":[92],"high":[94],"enough":[95],"concentration":[96],"chaperone":[99],"effective.":[102],"In":[103],"practice,":[104],"inhibitors":[105],"with":[106],"Ki":[108],"(equilibrium":[109],"disassociation":[110],"constant)":[111,117],"close":[112],"Km":[115],"(Michaelis-Menten":[116],"or":[121],"bit":[123],"tighter":[124],"seem":[125],"useful.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
