{"id":"https://openalex.org/W2118077148","doi":"https://doi.org/10.1371/journal.pbio.1000015","title":"Cell Lineages and the Logic of Proliferative Control","display_name":"Cell Lineages and the Logic of Proliferative Control","publication_year":2009,"publication_date":"2009-01-16","ids":{"openalex":"https://openalex.org/W2118077148","doi":"https://doi.org/10.1371/journal.pbio.1000015","mag":"2118077148","pmid":"https://pubmed.ncbi.nlm.nih.gov/19166268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2628408"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.1000015","doi":"https://doi.org/10.1371/journal.pbio.1000015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.1000015","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000015&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000015&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030125759","display_name":"Arthur D. Lander","orcid":"https://orcid.org/0000-0002-4380-5525","observed_orcids":["https://orcid.org/0000-0002-4380-5525"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur D Lander","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA. adlander@uci.edu","Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA. adlander@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052141060","display_name":"Kimberly Kinga Gokoffski","orcid":"https://orcid.org/0000-0003-3589-0296","observed_orcids":["https://orcid.org/0000-0003-3589-0296"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly K Gokoffski","raw_affiliation_strings":["","Anatomy and Neurobiology, University of California, Irvine, Irvine, California, United States of America","Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","Mathematics, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Anatomy and Neurobiology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Mathematics, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081316629","display_name":"Frederic Y. M. Wan","orcid":"https://orcid.org/0000-0002-5184-1227","observed_orcids":["https://orcid.org/0000-0002-5184-1227"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederic Y. M Wan","raw_affiliation_strings":["","Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Mathematics, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Mathematics, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076311980","display_name":"Qing Hua Nie","orcid":"https://orcid.org/0000-0002-8804-3368","observed_orcids":["https://orcid.org/0000-0002-8804-3368"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Nie","raw_affiliation_strings":["","Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Mathematics, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Mathematics, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020125811","display_name":"Anne L. Calof","orcid":"https://orcid.org/0000-0003-3676-2499","observed_orcids":["https://orcid.org/0000-0003-3676-2499"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne L Calof","raw_affiliation_strings":["","Anatomy and Neurobiology, University of California, Irvine, Irvine, California, United States of America","Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Anatomy and Neurobiology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Center for Complex Biological Systems, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020125811","https://openalex.org/A5030125759"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":5.4938,"has_fulltext":true,"cited_by_count":294,"citation_normalized_percentile":{"value":0.97366842,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"e1000015","last_page":"e1000015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7231000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7231000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.11990000307559967,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.09279999881982803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-lineage","display_name":"cell lineage","score":0.7260000109672546},{"id":"https://openalex.org/keywords/chalone","display_name":"chalone","score":0.6650000214576721},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"negative feedback","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gdf11","display_name":"GDF11","score":0.8960000276565552},{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/olfactory-epithelium","display_name":"olfactory epithelium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7409999966621399},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.6320000290870667},{"id":"https://openalex.org/keywords/transit-amplifying-cells","display_name":"transit amplifying cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.7369999885559082},{"id":"https://openalex.org/keywords/feedback-sensitivity","display_name":"feedback sensitivity","score":0.765999972820282},{"id":"https://openalex.org/keywords/tissue-architecture","display_name":"tissue structure","score":0.5450000166893005},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8528674244880676},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6349328756332397},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.579288125038147},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5372263193130493},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5361684560775757},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5288694500923157},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.5174156427383423},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4825715124607086},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.45882296562194824},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.44168195128440857},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44127631187438965},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.43871521949768066},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4146963059902191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1845996379852295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14761999249458313},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13806667923927307},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09686017036437988},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08430635929107666},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050150","descriptor_name":"Chalones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055412","descriptor_name":"Growth Differentiation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pbio.1000015","doi":"https://doi.org/10.1371/journal.pbio.1000015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.1000015","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000015&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2628408","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2628408","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biol","raw_type":"Text"},{"id":"pmid:19166268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19166268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.358.9706","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.9706","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f7/61/PLoS_Biol_2009_Jan_20_7(1)_e1000015.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.545.849","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.545.849","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.math.uci.edu/~fwan/pdf/148_Cell_LinII.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.590.7456","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.590.7456","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ics.uci.edu/~welling/teaching/273ASpring10/journal.pbio.1000015.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.709.1628","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.709.1628","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://math.univ-lyon1.fr/homes-www/bernard/teach/popdyn/lander2009PLoSBiol.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pbio00:1000015","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000015","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d00df3baf72e4d36af02a215ea20cd6a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d00df3baf72e4d36af02a215ea20cd6a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 7, Iss 1, p e15 (2009)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt1kc0b236","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/1kc0b236","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, vol 7, iss 1","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148733","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Cell_Lineages_and_the_Logic_of_Proliferative_Control/148733","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.1000015","doi":"https://doi.org/10.1371/journal.pbio.1000015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.1000015","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000015&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1439476342","display_name":"Principles of Robust Developmental Patterning","funder_award_id":"R01GM067247","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G479823528","display_name":"Systems Biology of Morphogeneisis and Spatial Information Flow","funder_award_id":"P50GM076516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G694063290","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM008620","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7264898069","display_name":"FEEDBACK REGULATION OF NEUROGENESIS IN MAMMALS","funder_award_id":"R01DC003583","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8779413901","display_name":"Specificity and Spatial Dynamics of Cell Signaling: The*","funder_award_id":"R01GM075309","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000877839","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA062203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118077148.pdf","grobid_xml":"https://content.openalex.org/works/W2118077148.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W103672796","https://openalex.org/W120093904","https://openalex.org/W144693476","https://openalex.org/W298269813","https://openalex.org/W658888909","https://openalex.org/W1482498530","https://openalex.org/W1491378240","https://openalex.org/W1506736186","https://openalex.org/W1507275008","https://openalex.org/W1513029763","https://openalex.org/W1537079504","https://openalex.org/W1570507925","https://openalex.org/W1580359002","https://openalex.org/W1598256437","https://openalex.org/W1599969036","https://openalex.org/W1765469392","https://openalex.org/W1811163336","https://openalex.org/W1965558704","https://openalex.org/W1965884916","https://openalex.org/W1969544207","https://openalex.org/W1977410508","https://openalex.org/W1977909615","https://openalex.org/W1978177808","https://openalex.org/W1978858698","https://openalex.org/W1979812265","https://openalex.org/W1982677883","https://openalex.org/W1983323548","https://openalex.org/W1983483869","https://openalex.org/W1988816781","https://openalex.org/W1989021197","https://openalex.org/W1998597603","https://openalex.org/W1999970417","https://openalex.org/W2004087690","https://openalex.org/W2004090362","https://openalex.org/W2013375714","https://openalex.org/W2017116537","https://openalex.org/W2018311787","https://openalex.org/W2027217408","https://openalex.org/W2029675195","https://openalex.org/W2030036012","https://openalex.org/W2035690311","https://openalex.org/W2035835088","https://openalex.org/W2037153840","https://openalex.org/W2037921918","https://openalex.org/W2039119477","https://openalex.org/W2039396493","https://openalex.org/W2040404307","https://openalex.org/W2040662877","https://openalex.org/W2041042514","https://openalex.org/W2041603328","https://openalex.org/W2042275920","https://openalex.org/W2046314965","https://openalex.org/W2047164219","https://openalex.org/W2048134135","https://openalex.org/W2048275890","https://openalex.org/W2053079324","https://openalex.org/W2059345773","https://openalex.org/W2060101684","https://openalex.org/W2061899690","https://openalex.org/W2066267678","https://openalex.org/W2068756636","https://openalex.org/W2070897110","https://openalex.org/W2070995184","https://openalex.org/W2071308813","https://openalex.org/W2072686591","https://openalex.org/W2076425777","https://openalex.org/W2076453831","https://openalex.org/W2079120043","https://openalex.org/W2079760054","https://openalex.org/W2081471404","https://openalex.org/W2081858421","https://openalex.org/W2086852682","https://openalex.org/W2087418408","https://openalex.org/W2090806860","https://openalex.org/W2091708438","https://openalex.org/W2093712120","https://openalex.org/W2097192405","https://openalex.org/W2098800695","https://openalex.org/W2100706309","https://openalex.org/W2102639593","https://openalex.org/W2105145237","https://openalex.org/W2105714668","https://openalex.org/W2106362845","https://openalex.org/W2107280554","https://openalex.org/W2115279938","https://openalex.org/W2117056464","https://openalex.org/W2119138198","https://openalex.org/W2120157258","https://openalex.org/W2124166865","https://openalex.org/W2128584428","https://openalex.org/W2133254839","https://openalex.org/W2138852914","https://openalex.org/W2139450672","https://openalex.org/W2142072523","https://openalex.org/W2144470070","https://openalex.org/W2144969130","https://openalex.org/W2153123460","https://openalex.org/W2165220352","https://openalex.org/W2165285607","https://openalex.org/W2165519158","https://openalex.org/W2165625463","https://openalex.org/W2290374156","https://openalex.org/W2430167550","https://openalex.org/W4211173486","https://openalex.org/W4235821864","https://openalex.org/W4241088457","https://openalex.org/W4246051402","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2520392158","https://openalex.org/W7053080933","https://openalex.org/W2018311787","https://openalex.org/W3083096356","https://openalex.org/W3198408907","https://openalex.org/W2141210417","https://openalex.org/W2114351911","https://openalex.org/W2016447525","https://openalex.org/W2090806860","https://openalex.org/W3202816438"],"abstract_inverted_index":{"It":[0],"is":[1,13,29,85,166,177],"widely":[2],"accepted":[3],"that":[4,113,151,154],"the":[5,35,53,62,73,117,123,130,136,141,184],"growth":[6,179],"and":[7,11,66,88,105,160,188],"regeneration":[8],"of":[9,55,64,100,116,120,132,186,192],"tissues":[10],"organs":[12],"tightly":[14],"controlled.":[15],"Although":[16],"experimental":[17],"studies":[18],"are":[19,155],"beginning":[20],"to":[21,51,89,94],"reveal":[22],"molecular":[23,198],"mechanisms":[24],"underlying":[25],"such":[26],"control,":[27,187],"there":[28],"still":[30],"very":[31],"little":[32],"known":[33],"about":[34],"control":[36,52],"strategies":[37],"themselves.":[38],"Here,":[39],"we":[40,111,148],"consider":[41],"how":[42,96],"secreted":[43],"negative":[44],"feedback":[45,101,103,121],"factors":[46],"(\"chalones\")":[47],"may":[48],"be":[49,183],"used":[50],"output":[54],"multistage":[56],"cell":[57,165,169],"lineages,":[58],"as":[59,162],"exemplified":[60],"by":[61,80,127],"actions":[63],"GDF11":[65],"activin":[67],"in":[68,195],"a":[69,164,167,175,178,190],"self-renewing":[70],"neural":[71],"tissue,":[72],"mammalian":[74],"olfactory":[75],"epithelium":[76],"(OE).":[77],"We":[78],"begin":[79],"specifying":[81],"performance":[82],"objectives-what,":[83],"precisely,":[84],"being":[86],"controlled,":[87],"what":[90],"degree-and":[91],"go":[92],"on":[93],"calculate":[95],"well":[97],"different":[98],"types":[99],"configurations,":[102],"sensitivities,":[104],"tissue":[106],"architectures":[107],"achieve":[108],"control.":[109,144],"Ultimately,":[110],"show":[112,150],"many":[114],"features":[115],"OE-the":[118],"number":[119],"loops,":[122],"cellular":[124,196],"processes":[125],"targeted":[126],"feedback,":[128],"even":[129],"location":[131],"progenitor":[133],"cells":[134,159],"within":[135],"tissue-fit":[137],"with":[138],"expectations":[139],"for":[140],"best":[142],"possible":[143],"In":[145],"so":[146],"doing,":[147],"also":[149],"certain":[152],"distinctions":[153],"commonly":[156],"drawn":[157],"among":[158],"molecules-such":[161],"whether":[163,174],"stem":[168],"or":[170,173,181,197],"transit-amplifying":[171],"cell,":[172],"molecule":[176],"inhibitor":[180],"stimulator-may":[182],"consequences":[185],"not":[189],"reflection":[191],"intrinsic":[193],"differences":[194],"character.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
