{"id":"https://openalex.org/W2117959142","doi":"https://doi.org/10.1073/pnas.1109625108","title":"Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia","display_name":"Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia","publication_year":2011,"publication_date":"2011-10-03","ids":{"openalex":"https://openalex.org/W2117959142","doi":"https://doi.org/10.1073/pnas.1109625108","mag":"2117959142","pmid":"https://pubmed.ncbi.nlm.nih.gov/21969553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3203764"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1109625108","doi":"https://doi.org/10.1073/pnas.1109625108","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1109625108","pdf_url":"https://www.pnas.org/content/pnas/108/43/E962.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/108/43/E962.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109949551","display_name":"Gregory C. Carlson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory C. Carlson","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403, USA. gregc@mail.med.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403, USA. gregc@mail.med.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076399911","display_name":"Konrad Talbot","orcid":"https://orcid.org/0000-0003-4549-0835","observed_orcids":["https://orcid.org/0000-0003-4549-0835"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konrad Talbot","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044875398","display_name":"Tobias B. Halene","orcid":"https://orcid.org/0000-0003-1944-4683","observed_orcids":["https://orcid.org/0000-0003-1944-4683"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobias B. Halene","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008274391","display_name":"Michael J. Gandal","orcid":"https://orcid.org/0000-0001-5800-5128","observed_orcids":["https://orcid.org/0000-0001-5800-5128"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Gandal","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035286186","display_name":"Hala Kazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hala A. Kazi","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109347081","display_name":"Laura O. Schlosser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Schlosser","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041960747","display_name":"Quan H. Phung","orcid":"https://orcid.org/0000-0001-5681-8723","observed_orcids":["https://orcid.org/0000-0001-5681-8723"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quan H. Phung","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018607314","display_name":"Raquel E. Gur","orcid":"https://orcid.org/0000-0002-4082-8502","observed_orcids":["https://orcid.org/0000-0002-4082-8502"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel E. Gur","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088881304","display_name":"Steven Edward Arnold","orcid":"https://orcid.org/0000-0002-9487-415X","observed_orcids":["https://orcid.org/0000-0002-9487-415X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Arnold","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081502149","display_name":"Steven J. Siegel","orcid":"https://orcid.org/0000-0001-8058-9713","observed_orcids":["https://orcid.org/0000-0001-8058-9713"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Siegel","raw_affiliation_strings":["Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3403; and","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":7.8508,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.98248771,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"108","issue":"43","first_page":"E962","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dysbindin-1","display_name":"dysbindin-1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dtnbp1","display_name":"DTNBP1","score":0.984000027179718},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/parvalbumin-positive-interneurons","display_name":"parvalbumin interneurons","score":0.9459999799728394},{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.8450000286102295},{"id":"https://openalex.org/keywords/gamma-oscillations","display_name":"gamma oscillations","score":0.8370000123977661},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.8360000252723694},{"id":"https://openalex.org/keywords/candidate-susceptibility-genes","display_name":"candidate susceptibility genes","score":0.5680000185966492},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.8349999785423279},{"id":"https://openalex.org/keywords/voltage-sensitive-dye-imaging","display_name":"voltage-sensitive dye imaging","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.9096752405166626},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.762458086013794},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.646605372428894},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6244192123413086},{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.6219919323921204},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5359009504318237},{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.5008754730224609},{"id":"https://openalex.org/C2909172351","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle reaction","level":3,"score":0.4880892038345337},{"id":"https://openalex.org/C2777845764","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle response","level":2,"score":0.4756750166416168},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.453625351190567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42996805906295776},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.3871251940727234},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31223422288894653},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12941649556159973},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.08537992835044861},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074765","descriptor_name":"Dysbindin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005072","descriptor_name":"Evoked Potentials, Auditory","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005072","descriptor_name":"Evoked Potentials, Auditory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049029","descriptor_name":"Dystrophin-Associated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1109625108","doi":"https://doi.org/10.1073/pnas.1109625108","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1109625108","pdf_url":"https://www.pnas.org/content/pnas/108/43/E962.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2339320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3203764","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3203764","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3203764","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:21969553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21969553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1109625108","doi":"https://doi.org/10.1073/pnas.1109625108","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1109625108","pdf_url":"https://www.pnas.org/content/pnas/108/43/E962.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1136351547","display_name":null,"funder_award_id":"P50 MH-064045","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1357906432","display_name":"Transdisciplinary Tobacco Use Research Centers","funder_award_id":"P50CA084718","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1733485027","display_name":"Long-term neurobehavioral effects of ketamine exposure in adolescent mice","funder_award_id":"5r01da023210-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1837832890","display_name":null,"funder_award_id":"IRTG1328","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2703138655","display_name":null,"funder_award_id":"R01-DA023210","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4127344256","display_name":null,"funder_award_id":"5R01-DA02321002","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G686067781","display_name":"Neurobiology of Dysbindin in Schizophrenia and sdy Mouse","funder_award_id":"R01MH072880","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G751029544","display_name":null,"funder_award_id":"P50 MH 64045","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8012680803","display_name":"The Neurobiology of Stimulus Encoding in Schizophrenia","funder_award_id":"5p50mh064045-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000170264","display_name":null,"funder_award_id":"MH64045","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117959142.pdf","grobid_xml":"https://content.openalex.org/works/W2117959142.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1512252703","https://openalex.org/W1522048223","https://openalex.org/W1967324141","https://openalex.org/W1973541245","https://openalex.org/W1975242828","https://openalex.org/W1978759112","https://openalex.org/W1982135531","https://openalex.org/W1985900119","https://openalex.org/W1992902151","https://openalex.org/W1995079626","https://openalex.org/W1996489930","https://openalex.org/W1997345848","https://openalex.org/W1998776339","https://openalex.org/W1998943160","https://openalex.org/W2001896608","https://openalex.org/W2004385576","https://openalex.org/W2005887069","https://openalex.org/W2009522724","https://openalex.org/W2011565599","https://openalex.org/W2022044536","https://openalex.org/W2023407872","https://openalex.org/W2030179847","https://openalex.org/W2030538289","https://openalex.org/W2031240433","https://openalex.org/W2034165723","https://openalex.org/W2038837541","https://openalex.org/W2039128802","https://openalex.org/W2043321552","https://openalex.org/W2044866059","https://openalex.org/W2046365356","https://openalex.org/W2047232679","https://openalex.org/W2047347093","https://openalex.org/W2047403459","https://openalex.org/W2048104747","https://openalex.org/W2048271986","https://openalex.org/W2048920034","https://openalex.org/W2052124027","https://openalex.org/W2053732550","https://openalex.org/W2060589548","https://openalex.org/W2061126954","https://openalex.org/W2061902128","https://openalex.org/W2063918687","https://openalex.org/W2066786883","https://openalex.org/W2071090720","https://openalex.org/W2074795674","https://openalex.org/W2076020270","https://openalex.org/W2076347107","https://openalex.org/W2076361433","https://openalex.org/W2076664481","https://openalex.org/W2083140052","https://openalex.org/W2089762801","https://openalex.org/W2089912569","https://openalex.org/W2090982878","https://openalex.org/W2093411259","https://openalex.org/W2095060637","https://openalex.org/W2097364564","https://openalex.org/W2098205950","https://openalex.org/W2106319065","https://openalex.org/W2108776106","https://openalex.org/W2109124439","https://openalex.org/W2116254744","https://openalex.org/W2119383776","https://openalex.org/W2123029057","https://openalex.org/W2124289190","https://openalex.org/W2124307069","https://openalex.org/W2125737923","https://openalex.org/W2128495200","https://openalex.org/W2135278585","https://openalex.org/W2138222426","https://openalex.org/W2141220522","https://openalex.org/W2145936409","https://openalex.org/W2153227271","https://openalex.org/W2154340693","https://openalex.org/W2156420407","https://openalex.org/W2159361468","https://openalex.org/W2159399714","https://openalex.org/W2161162274","https://openalex.org/W2163383667","https://openalex.org/W2163563093","https://openalex.org/W2164859750","https://openalex.org/W2165294134","https://openalex.org/W2165329858","https://openalex.org/W2166873937","https://openalex.org/W2171668474","https://openalex.org/W2171865323","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2510965167","https://openalex.org/W3112659253","https://openalex.org/W1512252703","https://openalex.org/W2734893337","https://openalex.org/W1988334858","https://openalex.org/W7048136043","https://openalex.org/W1999095609","https://openalex.org/W2016271454","https://openalex.org/W2076079955","https://openalex.org/W2937600381"],"abstract_inverted_index":{"DTNBP1":[0],"(dystrobrevin":[1],"binding":[2],"protein":[3,27,29],"1)":[4],"is":[5,14,32],"a":[6,148,151,167],"leading":[7],"candidate":[8,153],"susceptibility":[9],"gene":[10,154],"in":[11,20,35,45,49,63,72,77,88,120],"schizophrenia":[12,78],"and":[13,57,86,105,117,138,155],"associated":[15],"with":[16],"working":[17],"memory":[18],"capacity":[19],"normal":[21],"subjects.":[22],"In":[23,65],"schizophrenia,":[24],"the":[25,68,96,106],"encoded":[26],"dystrobrevin-binding":[28],"1":[30],"(dysbindin-1)":[31],"often":[33,81],"reduced":[34,43,103,133,163],"excitatory":[36],"cortical":[37],"limbic":[38],"synapses.":[39],"We":[40],"found":[41],"that":[42],"dysbindin-1":[44,71,104,134],"mice":[46],"yielded":[47],"deficits":[48,100],"auditory-evoked":[50],"response":[51],"adaptation,":[52],"prepulse":[53],"inhibition":[54,85,165],"of":[55,70,109,132,171],"startle,":[56],"evoked":[58],"\u03b3-activity,":[59],"similar":[60],"to":[61,67,83,102],"patterns":[62],"schizophrenia.":[64],"contrast":[66],"role":[69,108],"glutamatergic":[73],"transmission,":[74],"\u03b3-band":[75],"abnormalities":[76],"are":[79],"most":[80],"attributed":[82],"disrupted":[84],"reductions":[87],"parvalbumin-positive":[89],"interneuron":[90],"(PV":[91],"cell)":[92],"activity.":[93],"To":[94],"determine":[95],"mechanism":[97,170],"underlying":[98,169],"electrophysiological":[99],"related":[101],"potential":[107],"PV":[110,114,139],"cells,":[111],"we":[112],"examined":[113],"cell":[115,140],"immunoreactivity":[116,141],"measured":[118],"changes":[119],"net":[121],"circuit":[122,130],"activity":[123],"using":[124],"voltage-sensitive":[125],"dye":[126],"imaging.":[127],"The":[128],"dominant":[129],"impact":[131],"was":[135,142],"impaired":[136],"inhibition,":[137],"reduced.":[143],"Thus,":[144],"this":[145],"model":[146],"provides":[147],"link":[149],"between":[150],"validated":[152],"an":[156],"auditory":[157],"endophenotypes.":[158],"Furthermore,":[159],"these":[160],"data":[161],"implicate":[162],"fast-phasic":[164],"as":[166],"common":[168],"schizophrenia-associated":[172],"intermediate":[173],"phenotypes.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}