{"id":"https://openalex.org/W2117934603","doi":null,"title":"The role of gonadal hormones in mesencephalic dopaminergic systems","display_name":"The role of gonadal hormones in mesencephalic dopaminergic systems","publication_year":2008,"publication_date":"2008-08-11","ids":{"openalex":"https://openalex.org/W2117934603","mag":"2117934603"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/686","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/686","pdf_url":"http://hdl.handle.net/10161/686","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/686","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109195701","display_name":"Misha L. Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Misha L. Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109195701"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadal-hormones","display_name":"gonadal hormones","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6740000247955322},{"id":"https://openalex.org/keywords/midbrain-dopaminergic-neurons","display_name":"midbrain dopaminergic neurons","score":0.8539999723434448},{"id":"https://openalex.org/keywords/substantia-nigra-pars-compacta","display_name":"substantia nigra pars compacta","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.8309999704360962},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.8140000104904175},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.781000018119812},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":1.0},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7126930356025696},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6237191557884216},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5848742723464966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38408294320106506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3709884285926819},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35211998224258423},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2838643789291382}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/686","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/686","pdf_url":"http://hdl.handle.net/10161/686","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2117934603","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/686/1/D_Johnson_Misha_a_200808.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/686","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/686","pdf_url":"http://hdl.handle.net/10161/686","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117934603.pdf","grobid_xml":"https://content.openalex.org/works/W2117934603.grobid-xml"},"referenced_works_count":157,"referenced_works":["https://openalex.org/W99762335","https://openalex.org/W112387632","https://openalex.org/W1497427077","https://openalex.org/W1526271356","https://openalex.org/W1532111285","https://openalex.org/W1564115604","https://openalex.org/W1570699532","https://openalex.org/W1771495220","https://openalex.org/W1848517268","https://openalex.org/W1927703270","https://openalex.org/W1937161249","https://openalex.org/W1948173875","https://openalex.org/W1952968669","https://openalex.org/W1964302273","https://openalex.org/W1968507832","https://openalex.org/W1972253922","https://openalex.org/W1973772110","https://openalex.org/W1973775511","https://openalex.org/W1974516972","https://openalex.org/W1976492591","https://openalex.org/W1977827405","https://openalex.org/W1980571433","https://openalex.org/W1980813865","https://openalex.org/W1981353792","https://openalex.org/W1982541490","https://openalex.org/W1983488393","https://openalex.org/W1985323921","https://openalex.org/W1985378500","https://openalex.org/W1986319043","https://openalex.org/W1986662149","https://openalex.org/W1987183940","https://openalex.org/W1987607933","https://openalex.org/W1989623523","https://openalex.org/W1992853156","https://openalex.org/W1993087404","https://openalex.org/W1994044142","https://openalex.org/W1995749463","https://openalex.org/W1998843722","https://openalex.org/W1999105147","https://openalex.org/W1999253703","https://openalex.org/W1999474741","https://openalex.org/W1999565344","https://openalex.org/W1999649731","https://openalex.org/W2001865657","https://openalex.org/W2002737481","https://openalex.org/W2003422375","https://openalex.org/W2005547107","https://openalex.org/W2005673668","https://openalex.org/W2006878746","https://openalex.org/W2009139369","https://openalex.org/W2009694650","https://openalex.org/W2009868334","https://openalex.org/W2010178943","https://openalex.org/W2011735277","https://openalex.org/W2013816726","https://openalex.org/W2014086109","https://openalex.org/W2014754503","https://openalex.org/W2015334840","https://openalex.org/W2016373232","https://openalex.org/W2018038828","https://openalex.org/W2020013943","https://openalex.org/W2020725121","https://openalex.org/W2023060892","https://openalex.org/W2024017898","https://openalex.org/W2024539113","https://openalex.org/W2025595769","https://openalex.org/W2026463041","https://openalex.org/W2028365448","https://openalex.org/W2028619376","https://openalex.org/W2029193046","https://openalex.org/W2029460899","https://openalex.org/W2031865166","https://openalex.org/W2033449172","https://openalex.org/W2036768410","https://openalex.org/W2036842877","https://openalex.org/W2037367554","https://openalex.org/W2037457092","https://openalex.org/W2039287048","https://openalex.org/W2039369023","https://openalex.org/W2039924079","https://openalex.org/W2040036798","https://openalex.org/W2041367940","https://openalex.org/W2042639976","https://openalex.org/W2043652943","https://openalex.org/W2046220523","https://openalex.org/W2047093218","https://openalex.org/W2047172433","https://openalex.org/W2047315078","https://openalex.org/W2048135038","https://openalex.org/W2049111053","https://openalex.org/W2050008180","https://openalex.org/W2050581082","https://openalex.org/W2050847082","https://openalex.org/W2052435478","https://openalex.org/W2053036896","https://openalex.org/W2054267961","https://openalex.org/W2054882471","https://openalex.org/W2058272963","https://openalex.org/W2058677249","https://openalex.org/W2058756954","https://openalex.org/W2059278369","https://openalex.org/W2061755658","https://openalex.org/W2062911573","https://openalex.org/W2063746042","https://openalex.org/W2063793220","https://openalex.org/W2065411915","https://openalex.org/W2065909153","https://openalex.org/W2066710181","https://openalex.org/W2066961374","https://openalex.org/W2069557943","https://openalex.org/W2070907292","https://openalex.org/W2070991943","https://openalex.org/W2073672013","https://openalex.org/W2073883348","https://openalex.org/W2073985171","https://openalex.org/W2076106112","https://openalex.org/W2079743814","https://openalex.org/W2081358654","https://openalex.org/W2082995961","https://openalex.org/W2083600423","https://openalex.org/W2084114882","https://openalex.org/W2084188625","https://openalex.org/W2084248175","https://openalex.org/W2085250627","https://openalex.org/W2085930600","https://openalex.org/W2086483799","https://openalex.org/W2087632836","https://openalex.org/W2090245298","https://openalex.org/W2090801797","https://openalex.org/W2091189511","https://openalex.org/W2092411075","https://openalex.org/W2093350076","https://openalex.org/W2107256884","https://openalex.org/W2111405228","https://openalex.org/W2111516838","https://openalex.org/W2114875317","https://openalex.org/W2117110861","https://openalex.org/W2117532626","https://openalex.org/W2119791710","https://openalex.org/W2120387391","https://openalex.org/W2126019931","https://openalex.org/W2133659918","https://openalex.org/W2139945587","https://openalex.org/W2144029402","https://openalex.org/W2145865543","https://openalex.org/W2150405978","https://openalex.org/W2150771326","https://openalex.org/W2150936467","https://openalex.org/W2156965301","https://openalex.org/W2162114669","https://openalex.org/W2163389230","https://openalex.org/W2163837911","https://openalex.org/W2168233886","https://openalex.org/W2172256092","https://openalex.org/W2173951281","https://openalex.org/W2216094174","https://openalex.org/W4214829914"],"related_works":["https://openalex.org/W2019694318","https://openalex.org/W2018601731","https://openalex.org/W2065909153","https://openalex.org/W2513719851","https://openalex.org/W2102863672","https://openalex.org/W7153630089","https://openalex.org/W2008689860","https://openalex.org/W2017673513","https://openalex.org/W1532111285","https://openalex.org/W2093270829"],"abstract_inverted_index":{"Dopamine":[0],"regulates":[1],"movement,":[2],"cognition":[3],"and":[4,45,83,95,109,113,116,129,141,170,174,209,225,241,255,257,270,280,286,295],"the":[5,61,102,107,145,152,158,207,232,238,261,321,338],"rewarding":[6],"effects":[7,90,153,234,244,262],"of":[8,19,104,111,147,186,235,245,263,323],"addictive":[9],"drugs.":[10],"Sex":[11],"differences":[12,54,66,123,194],"mediated":[13,181],"by":[14],"gonadal":[15,135,183],"hormones":[16,86,136],"affect":[17],"each":[18],"these":[20,65,176],"processes.":[21],"An":[22],"extensive":[23],"literature":[24],"suggests":[25],"that":[26,34,55,72,84,160,175,214,308,316,327],"estrogen":[27,236,251,317],"augments":[28],"dopaminergic":[29,138,324],"function.":[30],"Our":[31],"laboratory":[32],"found":[33,213],"female":[35,73,114,201,304],"rats":[36,74,115],"exhibit":[37],"increased":[38,226],"locomotor":[39],"stimulation":[40],"in":[41,57,80,106,124,151,195,206,216,223,229,237,268,283,302,333],"response":[42],"to":[43,51,100,118,167,178,276,331,337],"cocaine":[44,179],"greater":[46],"cocaine-induced":[47],"dopamine":[48,78,92,125,161,172,188,197,220,293],"overflow":[49],"compared":[50],"males,":[52,230,271],"sex":[53,122,193,340],"emerge":[56],"early":[58],"adulthood.":[59],"Currently,":[60],"underlying":[62],"mechanisms":[63],"for":[64,250,320],"are":[67,180],"poorly":[68],"understood.":[69],"I":[70,191],"hypothesized":[71],"would":[75,87],"have":[76,203],"more":[77,204],"neurons":[79,205],"midbrain":[81,187,196,219,240],"regions":[82],"ovarian":[85],"exert":[88],"trophic":[89,233],"on":[91,154,265],"neurons.":[93],"Immunohistochemical":[94],"stereological":[96],"techniques":[97],"were":[98,299],"used":[99],"quantitate":[101],"number":[103,127,140,156,163,222,228,267,282],"cells":[105],"SNpc":[108,208,296],"VTA":[110],"male":[112],"mice":[117],"assess:":[119],"(1)":[120],"if":[121],"neuron":[126,162,189,198,221,227],"exist":[128],"when":[130],"they":[131],"emerge,":[132],"(2)":[133],"how":[134],"influence":[137],"cell":[139,155,266,281,297,325],"dopamine-mediated":[142],"behaviors":[143],"(3)":[144],"role":[146],"specific":[148],"hormone":[149,184],"receptors":[150],"(4)":[157],"possibility":[159],"is":[164,309,318],"directly":[165],"linked":[166],"cocaine-stimulated":[168,278,291],"behavior":[169,279],"electrically-stimulated":[171],"release":[173,294],"responses":[177,330],"through":[182],"modulation":[185],"number.":[190],"discovered":[192,290],"number;":[199],"adult":[200],"rodents":[202],"VTA.":[210],"We":[211],"also":[212],"gonadectomy":[215,264],"adulthood":[217],"reduced":[218],"females":[224,269],"establishing":[231],"intact":[239,303],"possible":[242],"suppressive":[243],"androgens.":[246],"Treatment":[247],"with":[248,311],"agonists":[249],"receptor":[252,259],"subtypes":[253],"alpha":[254],"beta":[256],"androgen":[258],"reversed":[260],"respectively.":[272],"In":[273],"an":[274,306],"effort":[275],"bridge":[277],"sham":[284],"ovariectomized":[285,287],"females,":[288,334],"we":[289],"behavior,":[292],"density":[298],"positively":[300],"correlated":[301],"rats,":[305],"effect":[307],"lost":[310],"ovariectomy.":[312],"This":[313],"dissertation":[314],"demonstrates":[315],"critical":[319],"maintenance":[322],"populations":[326],"enhance":[328],"behavioral":[329],"psychostimulants":[332],"thereby":[335],"contributing":[336],"observed":[339],"differences.":[341]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}