{"id":"https://openalex.org/W2117918529","doi":null,"title":"Acute drug induced hepatitis due to erlotinib.","display_name":"Acute drug induced hepatitis due to erlotinib.","publication_year":2007,"publication_date":"2007-01-09","ids":{"openalex":"https://openalex.org/W2117918529","mag":"2117918529","pmid":"https://pubmed.ncbi.nlm.nih.gov/17228132"},"language":"en","primary_location":{"id":"pmid:17228132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17228132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026753115","display_name":"Jeyanthi Ramanarayanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeyanthi Ramanarayanan","raw_affiliation_strings":["Division of Hematology and Oncology, Stratton VA Medical Center, Albany, NY 12208, USA. jeyanthi.ramanarayanan2@med.va.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Stratton VA Medical Center, Albany, NY 12208, USA. jeyanthi.ramanarayanan2@med.va.gov","institution_ids":["https://openalex.org/I4210109456"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033161501","display_name":"Sarah L Scarpace","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah L Scarpace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4264,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86226303,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"39","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-induced-hepatitis","display_name":"drug-induced hepatitis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7319999933242798},{"id":"https://openalex.org/keywords/transaminase-elevation","display_name":"transaminase elevation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.9822601675987244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8865659832954407},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.7743841409683228},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5616459250450134},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5461131930351257},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.5382885932922363},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4744476079940796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4608331322669983},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4201755225658417},{"id":"https://openalex.org/C2909325608","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib Hydrochloride","level":5,"score":0.419309139251709},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3572313189506531},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3131910264492035}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:17228132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17228132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JOP : Journal of the pancreas","raw_type":"Case Reports"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.606.8507","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.606.8507","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.joplink.net/prev/200701/200701_06.pdf","raw_type":"text"},{"id":"mag:2117918529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17228132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W118213103","https://openalex.org/W1931508686","https://openalex.org/W1963592300","https://openalex.org/W1985211051","https://openalex.org/W2002714857","https://openalex.org/W2063123552","https://openalex.org/W2103134643","https://openalex.org/W2109678955","https://openalex.org/W2115497785","https://openalex.org/W2118520585","https://openalex.org/W2123035611","https://openalex.org/W2135836172","https://openalex.org/W2138297714","https://openalex.org/W2146404049","https://openalex.org/W2158134441","https://openalex.org/W2158664495","https://openalex.org/W2162724777","https://openalex.org/W2163958696","https://openalex.org/W2246417197"],"related_works":["https://openalex.org/W7100224364","https://openalex.org/W2329248921","https://openalex.org/W122825480","https://openalex.org/W2039408467","https://openalex.org/W80423414","https://openalex.org/W2254921300","https://openalex.org/W1998644344","https://openalex.org/W2132596236","https://openalex.org/W7029073417","https://openalex.org/W2784652931"],"abstract_inverted_index":{"CONTEXT:":[0],"Acute":[1,74],"drug":[2],"induced":[3],"hepatitis":[4,46,76],"has":[5],"not":[6],"been":[7],"commonly":[8],"associated":[9],"with":[10,19,32,54,82,94],"epidermal":[11],"growth":[12],"factor":[13],"receptor":[14],"(EGFR)":[15],"inhibitors.":[16],"Hepatotoxicity":[17,59],"seen":[18],"erlotinib,":[20],"a":[21,41,52],"small":[22],"molecule":[23],"tyrosine":[24],"kinase":[25],"inhibitor":[26],"to":[27,69],"EGFR,":[28],"is":[29,79],"usually":[30],"transient":[31],"mild":[33],"elevation":[34],"of":[35,43,104],"transaminases.":[36],"CASE":[37],"REPORT:":[38],"We":[39],"report":[40],"case":[42],"acute":[44],"severe":[45,75],"resulting":[47],"from":[48],"erlotinib":[49,62],"monotherapy":[50],"in":[51,96],"patient":[53],"locally":[55],"advanced":[56,97],"pancreatic":[57,98],"cancer.":[58],"resolved":[60],"once":[61],"was":[63],"discontinued":[64],"and":[65],"serum":[66],"transaminases":[67],"returned":[68],"baseline":[70],"normal":[71],"values.":[72],"CONCLUSIONS:":[73],"though":[77],"rare":[78],"occasionally":[80],"observed":[81],"EGFR":[83,89],"inhibitors":[84,90],"gefitinib":[85],"or":[86],"erlotinib.":[87],"As":[88],"are":[91],"now":[92],"incorporated":[93],"chemotherapy":[95],"cancers,":[99],"clinicians":[100],"should":[101],"be":[102],"aware":[103],"this":[105],"potential":[106],"complication.":[107]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}