{"id":"https://openalex.org/W2117873449","doi":"https://doi.org/10.1017/s1092852900016151","title":"Mild Cognitive Impairment: An Overview","display_name":"Mild Cognitive Impairment: An Overview","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2117873449","doi":"https://doi.org/10.1017/s1092852900016151","mag":"2117873449","pmid":"https://pubmed.ncbi.nlm.nih.gov/18204414"},"language":"en","primary_location":{"id":"doi:10.1017/s1092852900016151","doi":"https://doi.org/10.1017/s1092852900016151","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1092852900016151","pdf_url":null,"source":{"id":"https://openalex.org/S4210237982","display_name":"CNS Spectrums","issn_l":"1092-8529","issn":["1092-8529","2165-6509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Spectrums","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2117873449"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110342810","display_name":"Ronald Carl Petersen","orcid":"https://orcid.org/0000-0002-8178-6601","observed_orcids":["https://orcid.org/0000-0002-8178-6601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C. Petersen","raw_affiliation_strings":["Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. peter8@mayo.edu","Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. peter8@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017912969","display_name":"Selam Negash","orcid":"https://orcid.org/0000-0001-7150-7181","observed_orcids":["https://orcid.org/0000-0001-7150-7181"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selamawit Negash","raw_affiliation_strings":["Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":5.389,"has_fulltext":false,"cited_by_count":699,"citation_normalized_percentile":{"value":0.98698699,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"1","first_page":"45","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/dementia-progression","display_name":"dementia progression","score":0.843999981880188},{"id":"https://openalex.org/keywords/prodromal-dementia","display_name":"prodromal dementia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mci-subtypes","display_name":"MCI subtypes","score":0.8320000171661377},{"id":"https://openalex.org/keywords/progression-factors","display_name":"progression factors","score":0.6510000228881836},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuropsychological-intervention","display_name":"neuropsychological intervention","score":0.7570000290870667},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.9409999847412109},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.816421389579773},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.6652588844299316},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5973709225654602},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5714529752731323},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.52178955078125},{"id":"https://openalex.org/C2910528735","wikidata":"https://www.wikidata.org/wiki/Q1140331","display_name":"Prodromal Stage","level":4,"score":0.5040625333786011},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.501697301864624},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48820096254348755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48231077194213867},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47151315212249756},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.45225927233695984},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4228241443634033},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.40632447600364685},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.365274041891098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15111559629440308},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s1092852900016151","doi":"https://doi.org/10.1017/s1092852900016151","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1092852900016151","pdf_url":null,"source":{"id":"https://openalex.org/S4210237982","display_name":"CNS Spectrums","issn_l":"1092-8529","issn":["1092-8529","2165-6509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Spectrums","raw_type":"journal-article"},{"id":"pmid:18204414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18204414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS spectrums","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7867016969","display_name":"Alzheimer's Disease Cooperative Study","funder_award_id":"U19AG010483","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W2594165","https://openalex.org/W254573068","https://openalex.org/W566871166","https://openalex.org/W1644143258","https://openalex.org/W1968080096","https://openalex.org/W1970567308","https://openalex.org/W1976908613","https://openalex.org/W1981832748","https://openalex.org/W1984283611","https://openalex.org/W1991952617","https://openalex.org/W2005503435","https://openalex.org/W2006247983","https://openalex.org/W2008180577","https://openalex.org/W2010981056","https://openalex.org/W2018047120","https://openalex.org/W2018121148","https://openalex.org/W2023121717","https://openalex.org/W2027467488","https://openalex.org/W2028436804","https://openalex.org/W2035600871","https://openalex.org/W2036362108","https://openalex.org/W2037917702","https://openalex.org/W2051274997","https://openalex.org/W2051776695","https://openalex.org/W2055649795","https://openalex.org/W2069898420","https://openalex.org/W2072164919","https://openalex.org/W2072691846","https://openalex.org/W2076892667","https://openalex.org/W2083163028","https://openalex.org/W2086978209","https://openalex.org/W2095173617","https://openalex.org/W2099489910","https://openalex.org/W2099905211","https://openalex.org/W2101820237","https://openalex.org/W2107820540","https://openalex.org/W2111564049","https://openalex.org/W2122888777","https://openalex.org/W2123024907","https://openalex.org/W2124114508","https://openalex.org/W2129047299","https://openalex.org/W2132387058","https://openalex.org/W2137554996","https://openalex.org/W2145609805","https://openalex.org/W2149614271","https://openalex.org/W2153631628","https://openalex.org/W2154170073","https://openalex.org/W2155513557","https://openalex.org/W2156311276","https://openalex.org/W2159122349","https://openalex.org/W2159538597","https://openalex.org/W2161737267","https://openalex.org/W2167720733","https://openalex.org/W2198692946","https://openalex.org/W4210821588","https://openalex.org/W4388325297","https://openalex.org/W4388325694","https://openalex.org/W6674921842","https://openalex.org/W7028228764"],"related_works":["https://openalex.org/W2028436804","https://openalex.org/W2997724811","https://openalex.org/W1136349486","https://openalex.org/W7098734682","https://openalex.org/W2113708991","https://openalex.org/W2041987394","https://openalex.org/W2149614271","https://openalex.org/W2945911483","https://openalex.org/W1970329576","https://openalex.org/W2373477660"],"abstract_inverted_index":{"Mild":[0],"cognitive":[1,11],"impairment":[2],"(MCI)":[3],"refers":[4],"to":[5,46,63,80],"the":[6,10,65,82,91,140],"transitional":[7],"state":[8,112],"between":[9,113],"changes":[12],"of":[13,26,44,58,71,74,94,143],"normal":[14,114],"aging":[15,115],"and":[16,31,36,48,67,87,102,116,134,145],"very":[17],"early":[18,117],"dementia.":[19],"MCI":[20,59,122],"has":[21],"generated":[22],"a":[23,72],"great":[24],"deal":[25],"research":[27,32,149],"from":[28],"both":[29],"clinical":[30,103,128,141],"perspectives.":[33],"Several":[34],"population-":[35],"community-based":[37],"studies":[38,108],"have":[39,60],"documented":[40],"an":[41,110],"accelerated":[42],"rate":[43],"progression":[45],"dementia":[47,118],"Alzheimer's":[49],"disease":[50],"in":[51,84,119],"individuals":[52],"diagnosed":[53],"with":[54,121],"MCI.":[55,95],"Clinical":[56],"subtypes":[57],"been":[61],"proposed":[62],"broaden":[64],"concept":[66],"include":[68],"prodromal":[69],"forms":[70],"variety":[73],"dementias.":[75],"An":[76],"algorithm":[77],"is":[78],"presented":[79],"assist":[81],"clinician":[83],"identifying":[85],"subjects":[86,120],"subclassifying":[88],"them":[89],"into":[90],"various":[92],"types":[93],"Progression":[96],"factors,":[97],"including":[98],"genetic,":[99],"neuroimaging,":[100],"biomarker,":[101],"characteristics,":[104],"are":[105,123,137,150],"discussed.":[106,138],"Neuropathological":[107],"indicating":[109],"intermediate":[111],"presented.":[124],"The":[125],"recently":[126],"completed":[127],"trials":[129],"as":[130,132],"well":[131],"neuropsychological":[133],"nutritional":[135],"interventions":[136],"Finally,":[139],"utility":[142],"MCI,":[144],"directions":[146],"for":[147],"future":[148],"proposed.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":48},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":37},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":35},{"year":2014,"cited_by_count":42},{"year":2013,"cited_by_count":43},{"year":2012,"cited_by_count":44}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}