{"id":"https://openalex.org/W2117869152","doi":"https://doi.org/10.1152/ajpgi.00199.2001","title":"The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin","display_name":"The ferrireductase paraferritin contains divalent metal transporter as well as mobilferrin","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2117869152","doi":"https://doi.org/10.1152/ajpgi.00199.2001","mag":"2117869152","pmid":"https://pubmed.ncbi.nlm.nih.gov/11842004"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00199.2001","doi":"https://doi.org/10.1152/ajpgi.00199.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00199.2001","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073142609","display_name":"Jay N. Umbreit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151789","display_name":"University of South Alabama Medical Center","ror":"https://ror.org/05388sw24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151789"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay N. Umbreit","raw_affiliation_strings":["University of South Alabama Cancer Center, Mobile, Alabama 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama Cancer Center, Mobile, Alabama 36688","institution_ids":["https://openalex.org/I4210151789","https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108800678","display_name":"Marcel E. Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151789","display_name":"University of South Alabama Medical Center","ror":"https://ror.org/05388sw24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151789"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel E. Conrad","raw_affiliation_strings":["University of South Alabama Cancer Center, Mobile, Alabama 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama Cancer Center, Mobile, Alabama 36688","institution_ids":["https://openalex.org/I4210151789","https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043648988","display_name":"Lucille N. Hainsworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151789","display_name":"University of South Alabama Medical Center","ror":"https://ror.org/05388sw24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151789"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucille N. Hainsworth","raw_affiliation_strings":["University of South Alabama Cancer Center, Mobile, Alabama 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama Cancer Center, Mobile, Alabama 36688","institution_ids":["https://openalex.org/I4210151789","https://openalex.org/I83809506"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064775686","display_name":"Marcia J. Simovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151789","display_name":"University of South Alabama Medical Center","ror":"https://ror.org/05388sw24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151789"]},{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcia Simovich","raw_affiliation_strings":["University of South Alabama Cancer Center, Mobile, Alabama 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Alabama Cancer Center, Mobile, Alabama 36688","institution_ids":["https://openalex.org/I4210151789","https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2974,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79839194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"282","issue":"3","first_page":"G534","last_page":"G539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/divalent-metal-transporter-1","display_name":"DMT1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ferrireductase","display_name":"ferrireductase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/iron-transport","display_name":"iron transport","score":0.5849999785423279},{"id":"https://openalex.org/keywords/ferrous-iron-uptake","display_name":"ferrous iron uptake","score":0.734000027179718},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.5989999771118164},{"id":"https://openalex.org/keywords/flavin-containing-monooxygenase","display_name":"flavin-containing monooxygenase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ferrochelatase","display_name":"ferrochelatase","score":0.9359999895095825},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nadph-dependent-reduction","display_name":"NADPH-dependent reduction","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2775832776","wikidata":"https://www.wikidata.org/wiki/Q65122087","display_name":"Ferrous","level":2,"score":0.8414620161056519},{"id":"https://openalex.org/C2776531687","wikidata":"https://www.wikidata.org/wiki/Q14914133","display_name":"DMT1","level":4,"score":0.8237261772155762},{"id":"https://openalex.org/C2780534640","wikidata":"https://www.wikidata.org/wiki/Q3233795","display_name":"Ferric","level":2,"score":0.7618889808654785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7477377653121948},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.6272914409637451},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.624677300453186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5952816605567932},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5319887399673462},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42104774713516235},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.4128206968307495},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.3252714276313782},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09301099181175232},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05510863661766052}],"mesh":[{"descriptor_ui":"D000099236","descriptor_name":"Solute Carrier Family 11, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004915","descriptor_name":"Leukemia, Erythroblastic, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005296","descriptor_name":"Ferrous Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009247","descriptor_name":"NADH, NADPH Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D033862","descriptor_name":"Iron-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038181","descriptor_name":"FMN Reductase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00199.2001","doi":"https://doi.org/10.1152/ajpgi.00199.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00199.2001","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:11842004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11842004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1003.550","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1003.550","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpgi.physiology.org/content/ajpgi/early/2001/11/21/ajpgi.00199.2001.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6737619326","display_name":"REGULATORS OF IRON ABSORPTION","funder_award_id":"R37DK036112","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W19259724","https://openalex.org/W63436701","https://openalex.org/W639526789","https://openalex.org/W1487373273","https://openalex.org/W1514927033","https://openalex.org/W1568628619","https://openalex.org/W1591755807","https://openalex.org/W1602078008","https://openalex.org/W1603453266","https://openalex.org/W1603628987","https://openalex.org/W1977342487","https://openalex.org/W1980812650","https://openalex.org/W1983595623","https://openalex.org/W1999992384","https://openalex.org/W2005990206","https://openalex.org/W2006012000","https://openalex.org/W2049127831","https://openalex.org/W2061251706","https://openalex.org/W2070236309","https://openalex.org/W2082806735","https://openalex.org/W2084416493","https://openalex.org/W2091806624","https://openalex.org/W2105749655","https://openalex.org/W2128464392","https://openalex.org/W2136459252","https://openalex.org/W2146903969","https://openalex.org/W2172213806","https://openalex.org/W2408195885"],"related_works":["https://openalex.org/W7100014613","https://openalex.org/W2005990206","https://openalex.org/W19259724","https://openalex.org/W2884202833","https://openalex.org/W2136459252","https://openalex.org/W2373866508","https://openalex.org/W2008883395","https://openalex.org/W2030040725","https://openalex.org/W4403824365","https://openalex.org/W2149160367"],"abstract_inverted_index":{"Inorganic":[0],"iron":[1,13,22,58,61,92,130,133,150,159],"can":[2,136],"be":[3],"transported":[4,128],"into":[5],"cells":[6,15],"in":[7,70,147,165],"the":[8,37,65,71,74,90,116,119,155,161,166],"absence":[9],"of":[10,77,86,105,115,149,163],"transferrin.":[11],"Ferric":[12],"enters":[14],"utilizing":[16,62,157],"an":[17,53],"integrin-mobilferrin-paraferritin":[18],"pathway,":[19],"whereas":[20],"ferrous":[21,60,132,138,158],"uptake":[23,76],"is":[24],"facilitated":[25],"by":[26],"divalent":[27],"metal":[28],"transporter-1":[29],"(DMT-1).":[30],"Immunoprecipitation":[31],"studies":[32],"using":[33],"antimobilferrin":[34],"antibody":[35],"precipitated":[36],"previously":[38,47],"described":[39],"large-molecular-weight":[40],"protein":[41,82,94],"complex":[42],"named":[43],"paraferritin.":[44],"It":[45,68],"was":[46],"shown":[48],"that":[49],"paraferritin":[50,106,120,123,152],"functions":[51,69,124],"as":[52,64,113],"intracellular":[54],"ferrireductase,":[55],"reducing":[56],"ferric":[57,78,91,129],"to":[59,125,131,153],"NADPH":[63],"energy":[66],"source.":[67],"pathway":[72],"for":[73,145,160],"cellular":[75],"iron.":[79],"This":[80,110],"multipeptide":[81],"contains":[83],"a":[84,97,143],"number":[85],"active":[87],"peptides,":[88],"including":[89],"binding":[93],"mobilferrin":[95],"and":[96,102,134],"flavin":[98],"monooxygenase.":[99],"The":[100],"immunoprecipitates":[101],"purified":[103],"preparations":[104],"also":[107],"contained":[108],"DMT-1.":[109],"identifies":[111],"DMT-1":[112,135,146],"one":[114],"peptides":[117],"constituting":[118],"complex.":[121],"Since":[122],"reduce":[126],"newly":[127],"transport":[137],"iron,":[139],"these":[140],"findings":[141],"suggest":[142],"role":[144],"conveyance":[148],"from":[151],"ferrochelatase,":[154],"enzyme":[156],"synthesis":[162],"heme":[164],"mitochondrion.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
