{"id":"https://openalex.org/W2117859871","doi":"https://doi.org/10.1016/j.jchromb.2006.10.017","title":"Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography","display_name":"Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography","publication_year":2006,"publication_date":"2006-11-10","ids":{"openalex":"https://openalex.org/W2117859871","doi":"https://doi.org/10.1016/j.jchromb.2006.10.017","mag":"2117859871","pmid":"https://pubmed.ncbi.nlm.nih.gov/17097357","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2001235"},"language":"en","primary_location":{"id":"doi:10.1016/j.jchromb.2006.10.017","doi":"https://doi.org/10.1016/j.jchromb.2006.10.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2006.10.017","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2001235","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054415248","display_name":"David J. Boocock","orcid":"https://orcid.org/0000-0002-7333-3549","observed_orcids":["https://orcid.org/0000-0002-7333-3549"]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David J. Boocock","raw_affiliation_strings":["Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK. djb27@le.ac.uk","Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK. djb27@le.ac.uk","institution_ids":["https://openalex.org/I2800281165"]},{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073989904","display_name":"Ketan R. Patel","orcid":"https://orcid.org/0000-0001-8252-0234","observed_orcids":["https://orcid.org/0000-0001-8252-0234"]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ketan R. Patel","raw_affiliation_strings":["Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054713131","display_name":"Guy E.S. Faust","orcid":"https://orcid.org/0000-0003-0864-0961","observed_orcids":["https://orcid.org/0000-0003-0864-0961"]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy E.S. Faust","raw_affiliation_strings":["Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056886978","display_name":"Daniel Paul Normolle","orcid":"https://orcid.org/0000-0001-8675-5014","observed_orcids":["https://orcid.org/0000-0001-8675-5014"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel P. Normolle","raw_affiliation_strings":["Department of Radiation Oncology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108233326","display_name":"Timothy H. Marczylo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy H. Marczylo","raw_affiliation_strings":["Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113560256","display_name":"James A. Crowell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Crowell","raw_affiliation_strings":["Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905614","display_name":"Dean E. Brenner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210122509","display_name":"Ann Arbor VA Medical Center","ror":"https://ror.org/039n0s143","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210122509","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean E. Brenner","raw_affiliation_strings":["Departments of Internal Medicine, & Pharmacology, University of Michigan Medical School and VA Medical Center, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, & Pharmacology, University of Michigan Medical School and VA Medical Center, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I4210122509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056296777","display_name":"Tristan D. Booth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tristan D. Booth","raw_affiliation_strings":["Royalmount Pharma, 6111 Avenue, Royalmount, Bureau 104, Montr\u00e9al, Quebec, Canada H4P 2T4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royalmount Pharma, 6111 Avenue, Royalmount, Bureau 104, Montr\u00e9al, Quebec, Canada H4P 2T4","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090645051","display_name":"Andreas J. Gescher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreas Gescher","raw_affiliation_strings":["Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109832911","display_name":"William P. Steward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William P. Steward","raw_affiliation_strings":["Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Studies & Molecular Medicine, Cancer Biomarkers & Prevention Group, 5th Floor RKCSB, Leicester Royal Infirmary, Leicester LE2 7LX, UK","institution_ids":["https://openalex.org/I2800281165"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5054415248"],"corresponding_institution_ids":["https://openalex.org/I2800281165"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":5.3579,"has_fulltext":false,"cited_by_count":199,"citation_normalized_percentile":{"value":0.95390349,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"848","issue":"2","first_page":"182","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trans-resveratrol","display_name":"trans-resveratrol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/resveratrol-metabolites","display_name":"resveratrol metabolites","score":0.9819999933242798},{"id":"https://openalex.org/keywords/conjugated-metabolites","display_name":"conjugated metabolites","score":0.8529999852180481},{"id":"https://openalex.org/keywords/human-plasma","display_name":"human plasma","score":0.7160000205039978},{"id":"https://openalex.org/keywords/urine","display_name":"urine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/reversed-phase-hplc","display_name":"reversed-phase HPLC","score":0.7300000190734863},{"id":"https://openalex.org/keywords/gradient-elution","display_name":"gradient elution","score":0.6349999904632568},{"id":"https://openalex.org/keywords/uv-detection","display_name":"UV detection","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bioanalytical-method-validation","display_name":"bioanalytical method validation","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9339603185653687},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.9020699858665466},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.8635967969894409},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.705486536026001},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6402568221092224},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6267791986465454},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6027134656906128},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.5657148957252502},{"id":"https://openalex.org/C2780782300","wikidata":"https://www.wikidata.org/wiki/Q410156","display_name":"Ammonium acetate","level":3,"score":0.5591473579406738},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.4851732850074768},{"id":"https://openalex.org/C45188465","wikidata":"https://www.wikidata.org/wiki/Q645497","display_name":"Reversed-phase chromatography","level":3,"score":0.423012912273407},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.41927894949913025},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13463839888572693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07892251014709473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jchromb.2006.10.017","doi":"https://doi.org/10.1016/j.jchromb.2006.10.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2006.10.017","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},{"id":"pmid:17097357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17097357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2001235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2001235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Chromatogr B Analyt Technol Biomed Life Sci","raw_type":"Text"},{"id":"pmh:oai:lra.le.ac.uk:2381/16137","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/16137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2001235","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2001235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Chromatogr B Analyt Technol Biomed Life Sci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2962621426","display_name":null,"funder_award_id":"N01 CN025025","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G535061102","display_name":"PHASE I CLINICAL STUDIES. SINGLE AND MULTIPLE-DOSE SAFETY AND PHARMACO-261025025","funder_award_id":"n01cn025025-001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W78348731","https://openalex.org/W154564172","https://openalex.org/W168087750","https://openalex.org/W174908875","https://openalex.org/W1489369582","https://openalex.org/W1550871940","https://openalex.org/W1789813876","https://openalex.org/W1888086016","https://openalex.org/W1971135728","https://openalex.org/W1987013638","https://openalex.org/W1994190235","https://openalex.org/W1999373749","https://openalex.org/W1999481655","https://openalex.org/W2032407464","https://openalex.org/W2039067888","https://openalex.org/W2045175501","https://openalex.org/W2052196943","https://openalex.org/W2060760516","https://openalex.org/W2062269191","https://openalex.org/W2068940613","https://openalex.org/W2071221889","https://openalex.org/W2110385920","https://openalex.org/W2122886283","https://openalex.org/W2130774920","https://openalex.org/W2135400388","https://openalex.org/W2136830554","https://openalex.org/W2146350175","https://openalex.org/W2146698208","https://openalex.org/W2151089147","https://openalex.org/W2169999439","https://openalex.org/W2337341934","https://openalex.org/W4388257503"],"related_works":["https://openalex.org/W2044074716","https://openalex.org/W2068940613","https://openalex.org/W1976547440","https://openalex.org/W2079567901","https://openalex.org/W2052196943","https://openalex.org/W2989585206","https://openalex.org/W2900510078","https://openalex.org/W1924621929","https://openalex.org/W3132950310","https://openalex.org/W1993009149"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}