{"id":"https://openalex.org/W2117693172","doi":null,"title":"Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study.","display_name":"Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2117693172","mag":"2117693172","pmid":"https://pubmed.ncbi.nlm.nih.gov/25120770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129005"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4129005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101674600","display_name":"Ying\u2010Ying Xu","orcid":"https://orcid.org/0000-0001-9711-057X","observed_orcids":["https://orcid.org/0000-0001-9711-057X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Ying Xu","raw_affiliation_strings":["Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051915881","display_name":"Tingting Wu","orcid":"https://orcid.org/0000-0002-3773-5938","observed_orcids":["https://orcid.org/0000-0002-3773-5938"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting-Ting Wu","raw_affiliation_strings":["Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006364436","display_name":"Shui\u2010Hong Zhou","orcid":"https://orcid.org/0000-0002-7163-2289","observed_orcids":["https://orcid.org/0000-0002-7163-2289","https://orcid.org/0000-0002-9545-0068"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shui-Hong Zhou","raw_affiliation_strings":["Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032959437","display_name":"Yang\u2010Yang Bao","orcid":"https://orcid.org/0000-0001-7857-9954","observed_orcids":["https://orcid.org/0000-0001-7857-9954"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang-Yang Bao","raw_affiliation_strings":["Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887498","display_name":"Qinying Wang","orcid":"https://orcid.org/0000-0002-4149-5607","observed_orcids":["https://orcid.org/0000-0002-4149-5607"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin-Ying Wang","raw_affiliation_strings":["Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101416429","display_name":"Jun Fan","orcid":"https://orcid.org/0000-0003-4419-0312","observed_orcids":["https://orcid.org/0000-0003-4419-0312"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Fan","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102022337","display_name":"Yaping Huang","orcid":"https://orcid.org/0000-0001-8124-555X","observed_orcids":["https://orcid.org/0000-0001-8124-555X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Ping Huang","raw_affiliation_strings":["State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4276,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.86684959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"7","first_page":"3938","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":1.0},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8679999709129333},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hep-2-cells","display_name":"HEp-2 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8640000224113464},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.5809999704360962},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8867751359939575},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7029350996017456},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6084893345832825},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6043425798416138},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.5235074162483215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4150981903076172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35257720947265625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33283644914627075},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33072909712791443},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.20895832777023315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09424212574958801},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047310","descriptor_name":"Apigenin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4129005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:25120770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25120770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:2117693172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25120770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4129005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4129005","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W188363728","https://openalex.org/W1516354149","https://openalex.org/W1546627335","https://openalex.org/W1968753011","https://openalex.org/W1970516269","https://openalex.org/W1999163659","https://openalex.org/W2002625825","https://openalex.org/W2005661588","https://openalex.org/W2011502135","https://openalex.org/W2012699604","https://openalex.org/W2020444094","https://openalex.org/W2033653404","https://openalex.org/W2056073295","https://openalex.org/W2062826804","https://openalex.org/W2068501775","https://openalex.org/W2078549862","https://openalex.org/W2083252271","https://openalex.org/W2107947815","https://openalex.org/W2107975811","https://openalex.org/W2112025827","https://openalex.org/W2114903592","https://openalex.org/W2115823834","https://openalex.org/W2116176394","https://openalex.org/W2121167229","https://openalex.org/W2132057867","https://openalex.org/W2141575790","https://openalex.org/W2147784100","https://openalex.org/W2153445591","https://openalex.org/W2155081607","https://openalex.org/W2161100502","https://openalex.org/W2161817637","https://openalex.org/W2162868196","https://openalex.org/W2163335322","https://openalex.org/W2166268973","https://openalex.org/W2168816764","https://openalex.org/W4249795909"],"related_works":["https://openalex.org/W2900159878","https://openalex.org/W2112025827","https://openalex.org/W1988681153","https://openalex.org/W2083252271","https://openalex.org/W2023348465","https://openalex.org/W2153445591","https://openalex.org/W4214888319","https://openalex.org/W2288735625","https://openalex.org/W2419534933","https://openalex.org/W2184045819"],"abstract_inverted_index":{"Glucose":[0],"transporter-1":[1],"(GLUT-1)":[2],"and":[3,20,38,48,68,82,91,93,130,142,144,154,191],"PI3K/Akt":[4,21,40],"are":[5],"known":[6],"to":[7,13,55,78,108,169,181],"be":[8,111,164],"closely":[9],"involved":[10],"in":[11,71,96,147,151],"resistance":[12,54,102,168],"chemotherapy.":[14],"Co-targeted":[15],"therapy":[16],"reducing":[17],"GLUT-1":[18,37,47,67,89,92,140,143,161,190],"expression":[19,35],"pathway":[22],"activity":[23],"may":[24,32,134,163,177],"overcome":[25],"the":[26,34,39,53,86,119,137,167,179],"chemoresistance":[27],"of":[28,36,46,57,73,88,105,122,139,160,171,183,189],"human":[29],"cancers.":[30],"Apigenin":[31,116,176],"inhibit":[33],"pathway.":[41],"We":[42,62,99],"hypothesized":[43],"that":[44,101],"over-expression":[45],"p-Akt":[49,94,145,192],"was":[50,128],"associated":[51,112,165],"with":[52,113,166],"cisplatin":[56,109,170,182],"laryngeal":[58,74,172,184],"carcinoma":[59,75,173,185],"Hep-2":[60,76,97,106,123,149,174],"cells.":[61,98,175],"explored":[63],"whether":[64],"apigenin":[65,133],"inhibited":[66],"p-Akt,":[69],"resulting":[70],"sensitization":[72],"cells":[77,107,186],"cisplatin.":[79],"Real-time":[80],"RT-PCR":[81],"Western":[83],"blotting":[84],"confirmed":[85],"presence":[87],"mRNA,":[90,141],"proteins":[95],"found":[100],"or":[103],"insensitivity":[104],"might":[110],"such":[114],"expression.":[115,193],"markedly":[117],"enhanced":[118],"cisplatin-induced":[120],"suppression":[121],"cell":[124],"growth.":[125],"This":[126],"effect":[127],"concentration-":[129,153],"time-dependent.":[131],"Thus":[132],"significantly":[135],"reduce":[136],"levels":[138],"proteins,":[146],"cisplatin-treated":[148],"cells,":[150],"a":[152],"time-dependent":[155],"manner.":[156],"To":[157],"conclude,":[158],"overexpression":[159],"mRNA":[162],"enhance":[178],"sensitivity":[180],"via":[187],"inhibition":[188]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}