{"id":"https://openalex.org/W2117690122","doi":"https://doi.org/10.3389/fimmu.2015.00308","title":"Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies","display_name":"Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies","publication_year":2015,"publication_date":"2015-06-15","ids":{"openalex":"https://openalex.org/W2117690122","doi":"https://doi.org/10.3389/fimmu.2015.00308","mag":"2117690122","pmid":"https://pubmed.ncbi.nlm.nih.gov/26124760","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4467247"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2015.00308","doi":"https://doi.org/10.3389/fimmu.2015.00308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2015.00308","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2015.00308/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2015.00308/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050967876","display_name":"Martine C. Morrison","orcid":"https://orcid.org/0000-0003-4996-943X","observed_orcids":["https://orcid.org/0000-0003-4996-943X"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Martine C. Morrison","raw_affiliation_strings":["Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063674598","display_name":"Robert Kleemann","orcid":"https://orcid.org/0000-0002-1350-0149","observed_orcids":["https://orcid.org/0000-0002-1350-0149"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]},{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert Kleemann","raw_affiliation_strings":["Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO) , Leiden , Netherlands ; Department of Human and Animal Physiology, Wageningen University , Wageningen , Netherlands","Department of Human and Animal Physiology, Wageningen University, Wageningen, Netherlands","Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO) , Leiden , Netherlands ; Department of Human and Animal Physiology, Wageningen University , Wageningen , Netherlands","institution_ids":["https://openalex.org/I148297040","https://openalex.org/I913481162"]},{"raw_affiliation_string":"Department of Human and Animal Physiology, Wageningen University, Wageningen, Netherlands","institution_ids":["https://openalex.org/I913481162"]},{"raw_affiliation_string":"Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, Netherlands","institution_ids":["https://openalex.org/I148297040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050967876"],"corresponding_institution_ids":["https://openalex.org/I148297040"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.944,"has_fulltext":true,"cited_by_count":102,"citation_normalized_percentile":{"value":0.70721817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":null,"first_page":"308","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13846","display_name":"Mangiferin and Mango Extracts","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-inflammation","display_name":"metabolic inflammation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hepatic-lipid-accumulation","display_name":"hepatic lipid accumulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/weight-loss-interventions","display_name":"weight loss interventions","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8794180154800415},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7861300706863403},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7324483394622803},{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.6905819177627563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6600906252861023},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6420993804931641},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5921745300292969},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5254774689674377},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5243678092956543},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5122663378715515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5087557435035706},{"id":"https://openalex.org/C106646824","wikidata":"https://www.wikidata.org/wiki/Q5425475","display_name":"FGF21","level":4,"score":0.4405691623687744},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40572279691696167},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.23160099983215332},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.0}],"mesh":[],"locations_count":15,"locations":[{"id":"doi:10.3389/fimmu.2015.00308","doi":"https://doi.org/10.3389/fimmu.2015.00308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2015.00308","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2015.00308/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3443342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4467247","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4467247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4467247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:26124760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26124760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/495789","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/role-of-macrophage-migration-inhibitory-factor-in-obesity-insulin","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 1664-3224","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:oai-pmh.tno.nl:42140","doi":null,"is_oa":true,"landing_page_url":"https://resolver.tno.nl/uuid:6f454b2a-5c75-47e0-bca0-3fff0d0a2790","pdf_url":"https://publications.tno.nl/publication/34617071/bwKqAO/morrison-2015-role.pdf","source":{"id":"https://openalex.org/S7407055233","display_name":"TNO Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 6(308)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2994709","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/88029","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 6, 1 - 13","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940754457502711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/88029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol. 6, p. 1-13","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:a394cf543dae4c69baecad4d4e2d1d44","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a394cf543dae4c69baecad4d4e2d1d44","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 6 (2015)","raw_type":"article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/88029","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/88029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"6","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2994709","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/88029","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:tudelft.nl:uuid:6f454b2a-5c75-47e0-bca0-3fff0d0a2790","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:6f454b2a-5c75-47e0-bca0-3fff0d0a2790","pdf_url":null,"source":{"id":"https://openalex.org/S4306402238","display_name":"Repository hosted by TU Delft Library (TU Delft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 308, 6","raw_type":"article"},{"id":"pmh:tno:oai:tudelft.nl:uuid:6f454b2a-5c75-47e0-bca0-3fff0d0a2790","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:6f454b2a-5c75-47e0-bca0-3fff0d0a2790","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/495789","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/role-of-macrophage-migration-inhibitory-factor-in-obesity-insulin","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, 6","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2889818268","doi":null,"is_oa":true,"landing_page_url":"https://edepot.wur.nl/372231","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology","raw_type":null}],"best_oa_location":{"id":"doi:10.3389/fimmu.2015.00308","doi":"https://doi.org/10.3389/fimmu.2015.00308","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2015.00308","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2015.00308/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117690122.pdf","grobid_xml":"https://content.openalex.org/works/W2117690122.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W148852109","https://openalex.org/W1524800873","https://openalex.org/W1762876317","https://openalex.org/W1936275650","https://openalex.org/W1964777818","https://openalex.org/W1965676362","https://openalex.org/W1965928911","https://openalex.org/W1968571710","https://openalex.org/W1972820017","https://openalex.org/W1980619336","https://openalex.org/W1981263336","https://openalex.org/W1981443571","https://openalex.org/W1985236996","https://openalex.org/W1987860439","https://openalex.org/W1990757970","https://openalex.org/W1991838762","https://openalex.org/W1992725312","https://openalex.org/W1997838054","https://openalex.org/W1999691363","https://openalex.org/W2000541661","https://openalex.org/W2000653200","https://openalex.org/W2001119887","https://openalex.org/W2001467009","https://openalex.org/W2005052233","https://openalex.org/W2007198197","https://openalex.org/W2012759923","https://openalex.org/W2013282142","https://openalex.org/W2013839742","https://openalex.org/W2019535641","https://openalex.org/W2022184946","https://openalex.org/W2029174607","https://openalex.org/W2033665384","https://openalex.org/W2035191034","https://openalex.org/W2039378959","https://openalex.org/W2042461795","https://openalex.org/W2045955534","https://openalex.org/W2050053600","https://openalex.org/W2054668472","https://openalex.org/W2056224810","https://openalex.org/W2059021156","https://openalex.org/W2059086755","https://openalex.org/W2060251234","https://openalex.org/W2060345230","https://openalex.org/W2064535683","https://openalex.org/W2066172067","https://openalex.org/W2069955333","https://openalex.org/W2070069766","https://openalex.org/W2076537942","https://openalex.org/W2085046655","https://openalex.org/W2086225923","https://openalex.org/W2088945149","https://openalex.org/W2089037198","https://openalex.org/W2091843594","https://openalex.org/W2093272556","https://openalex.org/W2095080422","https://openalex.org/W2107146684","https://openalex.org/W2108285949","https://openalex.org/W2118547508","https://openalex.org/W2130495917","https://openalex.org/W2132643437","https://openalex.org/W2135970281","https://openalex.org/W2140544322","https://openalex.org/W2143807844","https://openalex.org/W2156302492","https://openalex.org/W2157097329","https://openalex.org/W2165604976","https://openalex.org/W2166009190","https://openalex.org/W2166518338","https://openalex.org/W2169839828","https://openalex.org/W2171119405","https://openalex.org/W2187321354","https://openalex.org/W2318600050","https://openalex.org/W4245400081"],"related_works":["https://openalex.org/W2889818268","https://openalex.org/W2068595072","https://openalex.org/W7096103946","https://openalex.org/W2038679124","https://openalex.org/W2158217861","https://openalex.org/W7097832538","https://openalex.org/W2001467009","https://openalex.org/W7065730367","https://openalex.org/W2902035854","https://openalex.org/W2998658597"],"abstract_inverted_index":{"Obesity":[0],"is":[1,33,49,72,100,113,123],"associated":[2],"with":[3,199],"a":[4,141,239],"chronic":[5],"low-grade":[6],"inflammatory":[7,66,129],"state":[8],"that":[9,94,111,121,131,252],"drives":[10],"the":[11,38,76,101,133,149,164,176,215,236],"-development":[12],"of":[13,65,78,82,135,144,151,166,217,235,242],"obesity-related":[14,136],"co-morbidities":[15],"such":[16,84],"as":[17,85,190,192],"insulin":[18,45,167,200,222],"resistance/type":[19],"2":[20,87,170,204,225],"diabetes,":[21,171,226],"non-alcoholic":[22],"fatty":[23],"liver":[24],"disease":[25,83,212,245],"(NAFLD),":[26],"and":[27,44,60,89,120,128,160,172,186,202,221,227,231],"cardiovascular":[28],"disease.":[29],"This":[30,138],"metabolic":[31,98,127],"inflammation":[32,99],"thought":[34,73],"to":[35,53,57,74,97],"originate":[36],"in":[37,55,118,126,153,163,183,197,219,244],"adipose":[39,70,116,158],"tissue,":[40,159],"which":[41],"becomes":[42],"inflamed":[43],"resistant":[46],"when":[47],"it":[48,122],"no":[50],"longer":[51],"able":[52],"expand":[54],"response":[56],"excess":[58],"caloric":[59],"nutrient":[61],"intake.":[62],"The":[63],"production":[64,156],"mediators":[67],"by":[68,115,157],"dysfunctional":[69],"tissue":[71,117],"drive":[75],"development":[77,134,165],"more":[79],"complex":[80],"forms":[81],"type":[86,169,203,224],"diabetes":[88],"NAFLD.":[90,173],"An":[91],"important":[92],"factor":[93,106],"may":[95,254],"contribute":[96],"cytokine":[102],"macrophage":[103],"migration":[104],"inhibitory":[105],"(MIF).":[107],"Increasing":[108],"evidence":[109],"suggests":[110],"MIF":[112,152,218,243,253],"released":[114],"obesity":[119,220],"also":[124,249],"involved":[125],"processes":[130],"underlie":[132],"pathologies.":[137],"review":[139],"provides":[140],"comprehensive":[142],"summary":[143],"our":[145],"current":[146],"knowledge":[147],"on":[148],"role":[150,241],"obesity,":[154],"its":[155,161],"involvement":[162],"resistance,":[168,223],"We":[174],"discuss":[175],"main":[177],"findings":[178,209,237],"from":[179,194,210],"recent":[180,247],"clinical":[181,195],"studies":[182,189,196],"obese":[184],"subjects":[185],"weight-loss":[187],"intervention":[188],"well":[191],"results":[193],"patients":[198],"resistance":[201],"diabetes.":[205],"Furthermore,":[206],"we":[207],"summarize":[208],"experimental":[211],"models":[213],"studying":[214],"contribution":[216],"hepatic":[228],"lipid":[229],"accumulation":[230],"fibrosis.":[232],"Although":[233],"many":[234],"support":[238],"pro-inflammatory":[240],"development,":[246],"reports":[248],"provide":[250],"indications":[251],"exert":[255],"protective":[256],"effects":[257],"under":[258],"certain":[259],"conditions.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
