{"id":"https://openalex.org/W2117592829","doi":"https://doi.org/10.1517/17425250903397381","title":"Issues in drug metabolism of major antihypertensive drugs: \u03b2-blockers, calcium channel antagonists and angiotensin receptor blockers","display_name":"Issues in drug metabolism of major antihypertensive drugs: \u03b2-blockers, calcium channel antagonists and angiotensin receptor blockers","publication_year":2010,"publication_date":"2010-01-22","ids":{"openalex":"https://openalex.org/W2117592829","doi":"https://doi.org/10.1517/17425250903397381","mag":"2117592829","pmid":"https://pubmed.ncbi.nlm.nih.gov/20095790"},"language":"en","primary_location":{"id":"doi:10.1517/17425250903397381","doi":"https://doi.org/10.1517/17425250903397381","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17425250903397381","pdf_url":null,"source":{"id":"https://openalex.org/S102336391","display_name":"Expert Opinion on Drug Metabolism & Toxicology","issn_l":"1742-5255","issn":["1742-5255","1744-7607"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Metabolism & Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11336/113682","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045403820","display_name":"Christi\u00e1n H\u00f6cht","orcid":"https://orcid.org/0000-0001-8992-9841","observed_orcids":["https://orcid.org/0000-0001-8992-9841"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Christian H\u00f6cht","raw_affiliation_strings":["Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina. chocht@ffyb.uba.ar","+54 11 4508 3645","Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina. chocht@ffyb.uba.ar","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"+54 11 4508 3645","institution_ids":[]},{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109450053","display_name":"Facundo Mart\u00edn Bertera","orcid":"https://orcid.org/0000-0002-1646-4542","observed_orcids":["https://orcid.org/0000-0002-1646-4542"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Facundo Mart\u00edn Bertera","raw_affiliation_strings":["Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; chocht@ffyb.uba.ar","+54 11 4508 3645","Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; chocht@ffyb.uba.ar","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"+54 11 4508 3645","institution_ids":[]},{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089455586","display_name":"Marcos Alejandro Mayer","orcid":"https://orcid.org/0000-0001-6702-2835","observed_orcids":["https://orcid.org/0000-0001-6702-2835"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcos Alejandro Mayer","raw_affiliation_strings":["Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; chocht@ffyb.uba.ar; Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","+54 11 4508 3645","Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; chocht@ffyb.uba.ar; Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"+54 11 4508 3645","institution_ids":[]},{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111812918","display_name":"Carlos Alberto Taira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Carlos Alberto Taira","raw_affiliation_strings":["Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; chocht@ffyb.uba.ar; Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","+54 11 4508 3645","Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265; +54 11 4508 3645; chocht@ffyb.uba.ar; Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"+54 11 4508 3645","institution_ids":[]},{"raw_affiliation_string":"Universidad de Buenos Aires, Facultad de Farmacia y Bioqu\u00edmica, C\u00e1tedra de Farmacolog\u00eda, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina +54 11 4964 8265","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Universidad de Buenos Aires, Instituto de Fisiopatolog\u00eda y Bioqu\u00edmica Cl\u00ednica, Jun\u00edn 956, (C1113AAD) Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I24354313"],"apc_list":null,"apc_paid":null,"fwci":0.6271,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.40514469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"2","first_page":"199","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cytochrome-p450-isoforms","display_name":"cytochrome P450 isoforms","score":0.8510000109672546},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8849999904632568},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hepatic-clearance","display_name":"hepatic clearance","score":0.7820000052452087},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6980000138282776},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.8920000195503235},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8799999952316284},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7113588452339172},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6996814012527466},{"id":"https://openalex.org/C2780192228","wikidata":"https://www.wikidata.org/wiki/Q575890","display_name":"Antihypertensive drug","level":3,"score":0.6882544159889221},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6254392266273499},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5691792964935303},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.5622929334640503},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5038432478904724},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.49626976251602173},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.46272483468055725},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45807382464408875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3151775002479553},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1657848060131073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11568978428840637},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047228","descriptor_name":"Angiotensin II Type 1 Receptor Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1517/17425250903397381","doi":"https://doi.org/10.1517/17425250903397381","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17425250903397381","pdf_url":null,"source":{"id":"https://openalex.org/S102336391","display_name":"Expert Opinion on Drug Metabolism & Toxicology","issn_l":"1742-5255","issn":["1742-5255","1744-7607"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Metabolism & Toxicology","raw_type":"journal-article"},{"id":"pmid:20095790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20095790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug metabolism & toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/113682","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/113682","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ri.conicet.gov.ar:11336/113682","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/113682","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320971","display_name":"Monash University","ror":"https://ror.org/02bfwt286"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W12874785","https://openalex.org/W38374612","https://openalex.org/W74300047","https://openalex.org/W95527936","https://openalex.org/W1491002974","https://openalex.org/W1494377166","https://openalex.org/W1902589901","https://openalex.org/W1911592487","https://openalex.org/W1966060815","https://openalex.org/W1967788840","https://openalex.org/W1971107382","https://openalex.org/W1973492562","https://openalex.org/W1973660985","https://openalex.org/W1980292160","https://openalex.org/W1981327374","https://openalex.org/W1988853236","https://openalex.org/W1994322532","https://openalex.org/W1994438706","https://openalex.org/W1994904603","https://openalex.org/W1996479763","https://openalex.org/W1997656392","https://openalex.org/W2000754407","https://openalex.org/W2000894443","https://openalex.org/W2001110690","https://openalex.org/W2002972052","https://openalex.org/W2005100940","https://openalex.org/W2012146205","https://openalex.org/W2013038434","https://openalex.org/W2013648322","https://openalex.org/W2018080987","https://openalex.org/W2021467594","https://openalex.org/W2023648176","https://openalex.org/W2024513252","https://openalex.org/W2025927392","https://openalex.org/W2028221670","https://openalex.org/W2032034515","https://openalex.org/W2034037052","https://openalex.org/W2034389937","https://openalex.org/W2035654373","https://openalex.org/W2035705985","https://openalex.org/W2038197600","https://openalex.org/W2038868952","https://openalex.org/W2038871242","https://openalex.org/W2040679011","https://openalex.org/W2046989904","https://openalex.org/W2049635464","https://openalex.org/W2049952152","https://openalex.org/W2060360036","https://openalex.org/W2063217857","https://openalex.org/W2065556910","https://openalex.org/W2066024428","https://openalex.org/W2066178204","https://openalex.org/W2068780263","https://openalex.org/W2069057046","https://openalex.org/W2070647463","https://openalex.org/W2077461050","https://openalex.org/W2079057400","https://openalex.org/W2086968218","https://openalex.org/W2087558676","https://openalex.org/W2087759307","https://openalex.org/W2089256074","https://openalex.org/W2090719682","https://openalex.org/W2096561537","https://openalex.org/W2098591026","https://openalex.org/W2099644064","https://openalex.org/W2104491341","https://openalex.org/W2110926352","https://openalex.org/W2123139119","https://openalex.org/W2125573444","https://openalex.org/W2126083802","https://openalex.org/W2133948398","https://openalex.org/W2134422033","https://openalex.org/W2135906411","https://openalex.org/W2136465695","https://openalex.org/W2137876486","https://openalex.org/W2143954917","https://openalex.org/W2148547630","https://openalex.org/W2149319043","https://openalex.org/W2156121263","https://openalex.org/W2156159475","https://openalex.org/W2157352621","https://openalex.org/W2166015765","https://openalex.org/W2167557672","https://openalex.org/W2168950306","https://openalex.org/W2303651371","https://openalex.org/W2321430508","https://openalex.org/W2325127578","https://openalex.org/W2410485920","https://openalex.org/W2416223295","https://openalex.org/W2460103661","https://openalex.org/W2626091144","https://openalex.org/W4211124708"],"related_works":["https://openalex.org/W2905935141","https://openalex.org/W4412781665","https://openalex.org/W6968585981","https://openalex.org/W2132236118","https://openalex.org/W4309633646","https://openalex.org/W2990794606","https://openalex.org/W2155699385","https://openalex.org/W2761583101","https://openalex.org/W2073808088","https://openalex.org/W1976235415"],"abstract_inverted_index":{"Several":[0,49],"first-line":[1],"antihypertensive":[2,33,76,92,108],"drugs,":[3],"including":[4,51],"calcium":[5],"channel":[6],"blockers,":[7,13],"beta-adrenergic":[8],"blockers":[9],"and":[10,46,62,69,78,110,125],"angiotensin":[11],"receptor":[12],"undergo":[14],"metabolism":[15,150],"through":[16],"different":[17],"CYP":[18],"isoforms.":[19],"As":[20],"a":[21,96],"consequence":[22],"of":[23,29,32,85,99,102,105,113,122,139,148,154],"CYP-dependent":[24],"metabolism,":[25],"wide":[26],"interindividual":[27],"variability":[28,104],"plasma":[30,94],"concentrations":[31],"drugs":[34,109],"has":[35],"been":[36],"found":[37],"in":[38,67,117,151],"clinical":[39,47],"practice":[40],"compromising":[41],"blood":[42,60,86,130],"pressure":[43,87,131],"lowering":[44,132],"response":[45,133],"outcomes.":[48],"factors,":[50],"aging,":[52],"hepatic":[53,59],"impairment,":[54],"drug":[55,73,93,149],"interactions,":[56],"conditions":[57],"affecting":[58,72],"supply":[61],"polymorphisms,":[63],"contribute":[64],"to":[65,91,134,144],"changes":[66],"oral":[68],"systemic":[70],"clearance":[71],"exposure":[74],"during":[75],"therapy":[77],"cardiovascular":[79],"response.":[80],"Considering":[81],"that":[82],"the":[83,100,111,140,146,152],"degree":[84],"reduction":[88],"is":[89,143],"related":[90],"concentrations,":[95],"greater":[97],"knowledge":[98],"sources":[101],"pharmacokinetic":[103],"hepatically":[106],"eliminated":[107],"applicability":[112],"an":[114],"individualized":[115],"approach":[116],"hypertension":[118],"management":[119],"by":[120],"means":[121],"pharmacokinetic/pharmacodynamic":[123],"modeling":[124],"pharmacogenetic":[126],"testing":[127],"could":[128],"enhance":[129],"pharmacological":[135],"therapy.":[136],"The":[137],"aim":[138],"present":[141],"review":[142],"discuss":[145],"relevance":[147],"treatment":[153],"hypertension.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}