{"id":"https://openalex.org/W2117572576","doi":"https://doi.org/","title":"[Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs].","display_name":"[Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs].","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2117572576","doi":"https://doi.org/","mag":"2117572576","pmid":"https://pubmed.ncbi.nlm.nih.gov/19194632"},"language":"es","primary_location":{"id":"pmid:19194632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19194632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica de Chile","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.uchile.cl/handle/2250/164736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034509008","display_name":"Luis A. Qui\u00f1ones","orcid":"https://orcid.org/0000-0002-7967-5320","observed_orcids":["https://orcid.org/0000-0002-7967-5320"]},"institutions":[{"id":"https://openalex.org/I4210125667","display_name":"Hospital San Juan de Dios","ror":"https://ror.org/03mt12903","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210125667"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Luis Qui\u00f1ones S","raw_affiliation_strings":["Laboratorio de Carcinog\u00e9nesis Qu\u00edmica y Farmacogen\u00e9tica, IFT, Programa de Farmacolog\u00eda Molecular y Cl\u00ednica, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, and Hospital San Juan de Dios, Santiago, Chile. lquinone@med.uchile.cl","Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Carcinog\u00e9nesis Qu\u00edmica y Farmacogen\u00e9tica, IFT, Programa de Farmacolog\u00eda Molecular y Cl\u00ednica, Instituto de Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad de Chile, and Hospital San Juan de Dios, Santiago, Chile. lquinone@med.uchile.cl","institution_ids":["https://openalex.org/I4210125667","https://openalex.org/I69737025"]},{"raw_affiliation_string":"Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090538996","display_name":"Mario Rosero Pahi","orcid":"https://orcid.org/0000-0002-9546-4064","observed_orcids":["https://orcid.org/0000-0002-9546-4064"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Mario Rosero P","raw_affiliation_strings":["Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Angela Roco A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125667","display_name":"Hospital San Juan de Dios","ror":"https://ror.org/03mt12903","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210125667"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Angela Roco A","raw_affiliation_strings":["Hospital San Juan de Dios., Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital San Juan de Dios., Santiago, Chile","institution_ids":["https://openalex.org/I4210125667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057504451","display_name":"Iv\u00e1n Moreno T","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Moreno T","raw_affiliation_strings":["Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074101505","display_name":"Jaime Sasso A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Jaime Sasso A","raw_affiliation_strings":["Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032093205","display_name":"Nelson Varela","orcid":"https://orcid.org/0000-0002-5229-3007","observed_orcids":["https://orcid.org/0000-0002-5229-3007"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Nelson Varela F","raw_affiliation_strings":["Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074917201","display_name":"Dante C\u00e1ceres","orcid":"https://orcid.org/0000-0001-5404-7961","observed_orcids":["https://orcid.org/0000-0001-5404-7961"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Dante C\u00e1ceres L","raw_affiliation_strings":["Universidad de Chile, Santiago, Chil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Chile, Santiago, Chil","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073206235","display_name":"Iv\u00e1n Saavedra S","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Saavedra S","raw_affiliation_strings":["Universidad de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2082,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.56720465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"136","issue":"10","first_page":"1327","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9909999966621399},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8989999890327454},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9890000224113464},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/drug-detoxification","display_name":"drug detoxification","score":0.8040000200271606},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7009999752044678},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7940000295639038},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.6610000133514404},{"id":"https://openalex.org/keywords/enzyme-repression","display_name":"enzyme repression","score":0.968999981880188},{"id":"https://openalex.org/keywords/personalized-pharmacotherapy","display_name":"individualized drug therapy","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.7810840010643005},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6084070801734924},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5100801587104797},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.46726125478744507},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45732370018959045},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45390522480010986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4253658056259155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3222534656524658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31639134883880615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24698147177696228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1640263795852661},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10852602124214172},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07720640301704407}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:19194632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19194632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista medica de Chile","raw_type":"English Abstract"},{"id":"pmh:oai:repositorio.uchile.cl:2250/164736","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/164736","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Medica de Chile","raw_type":"Art\u00edculo de revista"},{"id":"mag:2117572576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19194632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3110382081","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/164736","pdf_url":null,"source":{"id":"https://openalex.org/S155962516","display_name":"Revista m\u00e9dica de Chile","issn_l":"0034-9887","issn":["0034-9887","0717-6163"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","ki-jl-1","latindex","medline","norway-1","poland-40","russia-white-list-3","scielo"],"host_organization":"https://openalex.org/P4310321632","host_organization_name":"Sociedad M\u00e9dica de Santiago","host_organization_lineage":["https://openalex.org/P4310321632"],"host_organization_lineage_names":["Sociedad M\u00e9dica de Santiago"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista m\u00e9dica de Chile","raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.uchile.cl:2250/164736","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/164736","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Medica de Chile","raw_type":"Art\u00edculo de revista"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W55130144","https://openalex.org/W1912151633","https://openalex.org/W1965821019","https://openalex.org/W1979040428","https://openalex.org/W1981398318","https://openalex.org/W1991791764","https://openalex.org/W1993182297","https://openalex.org/W2015185599","https://openalex.org/W2021856189","https://openalex.org/W2028959752","https://openalex.org/W2049697220","https://openalex.org/W2061411689","https://openalex.org/W2063612390","https://openalex.org/W2091975540","https://openalex.org/W2094969552","https://openalex.org/W2097502628","https://openalex.org/W2102230994","https://openalex.org/W2105902511","https://openalex.org/W2118979497","https://openalex.org/W2123768561","https://openalex.org/W2126139266","https://openalex.org/W2126655188","https://openalex.org/W2132172164","https://openalex.org/W2138334001","https://openalex.org/W2143225906","https://openalex.org/W2144299645","https://openalex.org/W2152992217","https://openalex.org/W2154598042","https://openalex.org/W2159677620","https://openalex.org/W2164922763","https://openalex.org/W2165399419","https://openalex.org/W2189606891","https://openalex.org/W2256501514"],"related_works":["https://openalex.org/W3110382081","https://openalex.org/W7014360656","https://openalex.org/W2003494055","https://openalex.org/W2077522929","https://openalex.org/W1972352373","https://openalex.org/W2390179141","https://openalex.org/W1982547296","https://openalex.org/W1979398278","https://openalex.org/W1965059036","https://openalex.org/W2019980810"],"abstract_inverted_index":{"Cytochrome":[0],"P450":[1,62,80],"enzymes":[2,16,44,81],"are":[3],"very":[4],"important":[5],"to":[6,39,49,114],"metabolize":[7],"anti-carcinogenic":[8],"agents.":[9],"Therefore,":[10],"understanding":[11,108],"the":[12,22,51,68,76,83,97],"role":[13,77],"of":[14,26,35,78,87,99,104,109],"these":[15],"and":[17,48,85,93,96],"their":[18,91],"allele":[19],"variants":[20],"in":[21,54,82],"bioactivation":[23,86],"or":[24],"detoxification":[25],"drugs":[27],"could":[28],"greatly":[29],"benefit":[30],"antineoplastic":[31,46],"pharmacotherapy.":[32,73],"The":[33,107],"aim":[34],"this":[36],"manuscript":[37],"is":[38,65],"give":[40],"information":[41],"about":[42,60],"metabolizing":[43],"for":[45,67],"agents":[47],"relate":[50],"current":[52],"situation":[53],"antitumoral":[55],"pharmacotherapy":[56],"with":[57],"recent":[58],"knowledge":[59],"cytochrome":[61,79],"enzymes.":[63],"This":[64],"crucial":[66],"future":[69],"perspectives":[70],"towards":[71],"personalized":[72],"We":[74],"summarize":[75],"resistance":[84],"several":[88],"antitumor":[89],"agents,":[90],"induction":[92],"repression":[94],"mechanisms":[95],"effect":[98],"genetic":[100,110],"polymorphisms":[101],"on":[102,119],"variability":[103,111],"drug":[105],"metabolization.":[106],"will":[112],"help":[113],"develop":[115],"new":[116],"research":[117],"lines":[118],"innovative":[120],"therapeutic":[121],"possibilities.":[122]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}