{"id":"https://openalex.org/W2117523148","doi":"https://doi.org/10.1038/417039a","title":"Astroglia induce neurogenesis from adult neural stem cells","display_name":"Astroglia induce neurogenesis from adult neural stem cells","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2117523148","doi":"https://doi.org/10.1038/417039a","mag":"2117523148","pmid":"https://pubmed.ncbi.nlm.nih.gov/11986659"},"language":"en","primary_location":{"id":"doi:10.1038/417039a","doi":"https://doi.org/10.1038/417039a","is_oa":false,"landing_page_url":"https://doi.org/10.1038/417039a","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009183873","display_name":"Hongjun Song","orcid":"https://orcid.org/0000-0002-8720-5310","observed_orcids":["https://orcid.org/0000-0002-8720-5310","https://orcid.org/0000-0003-3307-421X"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongjun Song","raw_affiliation_strings":["Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005296029","display_name":"Charles F. Stevens","orcid":"https://orcid.org/0000-0002-3709-9003","observed_orcids":["https://orcid.org/0000-0002-3709-9003"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles F. Stevens","raw_affiliation_strings":["Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072968010","display_name":"Fred H. Gage","orcid":"https://orcid.org/0000-0002-0938-4106","observed_orcids":["https://orcid.org/0000-0002-0938-4106"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fred H. Gage","raw_affiliation_strings":["Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005296029","https://openalex.org/A5072968010"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1344073410"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":21.6454,"has_fulltext":false,"cited_by_count":1449,"citation_normalized_percentile":{"value":0.99852941,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"417","issue":"6884","first_page":"39","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adult-neural-stem-cells","display_name":"adult neural stem cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neuronal-fate-specification","display_name":"neuronal fate specification","score":0.875},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neuron-astrocyte-interactions","display_name":"astrocyte-neuron interaction","score":0.6959999799728394},{"id":"https://openalex.org/keywords/stem-cell-fate-regulation","display_name":"stem cell fate regulation","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.956871509552002},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8009545207023621},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7532504796981812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6332806944847107},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6019818186759949},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5834457874298096},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4570979177951813},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.441837877035141},{"id":"https://openalex.org/C200707615","wikidata":"https://www.wikidata.org/wiki/Q13652744","display_name":"Neuroepithelial cell","level":4,"score":0.4255688786506653},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4204673767089844},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.282409131526947},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08935382962226868},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06674155592918396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001973","descriptor_name":"Bromodeoxyuridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/417039a","doi":"https://doi.org/10.1038/417039a","is_oa":false,"landing_page_url":"https://doi.org/10.1038/417039a","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:11986659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11986659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Comparative Study"},{"id":"pmh:oai:RePEc:nat:nature:v:417:y:2002:i:6884:d:10.1038_417039a","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/417039a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1484682139","https://openalex.org/W1500488100","https://openalex.org/W1503727145","https://openalex.org/W1504555080","https://openalex.org/W1535641516","https://openalex.org/W1589449569","https://openalex.org/W1643680178","https://openalex.org/W1926043920","https://openalex.org/W1976824219","https://openalex.org/W1979895839","https://openalex.org/W1983955843","https://openalex.org/W1985717414","https://openalex.org/W1987145582","https://openalex.org/W1989346221","https://openalex.org/W1993029198","https://openalex.org/W1993097534","https://openalex.org/W1993629125","https://openalex.org/W2003861928","https://openalex.org/W2004706485","https://openalex.org/W2004774377","https://openalex.org/W2004900120","https://openalex.org/W2008287057","https://openalex.org/W2022600603","https://openalex.org/W2031611126","https://openalex.org/W2034038906","https://openalex.org/W2036838450","https://openalex.org/W2046006021","https://openalex.org/W2051021067","https://openalex.org/W2076324460","https://openalex.org/W2079356804","https://openalex.org/W2084652820","https://openalex.org/W2105904890","https://openalex.org/W2113964043","https://openalex.org/W2119471783","https://openalex.org/W2123048941","https://openalex.org/W2127338217","https://openalex.org/W2131282078","https://openalex.org/W2145235967","https://openalex.org/W2163513779","https://openalex.org/W3125674408","https://openalex.org/W3148499377","https://openalex.org/W4312910407","https://openalex.org/W4313025241","https://openalex.org/W4313152550"],"related_works":["https://openalex.org/W1968242213","https://openalex.org/W2057668321","https://openalex.org/W2909403876","https://openalex.org/W2185709884","https://openalex.org/W4410125609","https://openalex.org/W2130293902","https://openalex.org/W6993085237","https://openalex.org/W147355768","https://openalex.org/W2902147501","https://openalex.org/W1978228545"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":40},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":39},{"year":2018,"cited_by_count":39},{"year":2017,"cited_by_count":56},{"year":2016,"cited_by_count":47},{"year":2015,"cited_by_count":59},{"year":2014,"cited_by_count":57},{"year":2013,"cited_by_count":74},{"year":2012,"cited_by_count":83}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}