{"id":"https://openalex.org/W2117489679","doi":null,"title":"Multidrug resistant protein-three gene regulation","display_name":"Multidrug resistant protein-three gene regulation","publication_year":2010,"publication_date":"2010-05-18","ids":{"openalex":"https://openalex.org/W2117489679","mag":"2117489679"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt14h425vs","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/14h425vs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111735860","display_name":"Christopher M. Mahaffey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christopher M. Mahaffey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111735860"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.4343000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance-protein-3","display_name":"MDR3","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mrp3","display_name":"MRP3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.972000002861023},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8349999785423279},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/promoter-interactions","display_name":"promoter interactions","score":0.6069999933242798},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.4729999899864197},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7172026038169861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6104040145874023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6061474084854126},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5448454022407532},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5235697627067566},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48041465878486633},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.45560896396636963},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.45448705554008484},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.41867464780807495},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41612452268600464},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4040818512439728},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3744408190250397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3536795377731323},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3271525502204895},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.1633952558040619},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt14h425vs","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/14h425vs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:2117489679","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt14h425vs/qt14h425vs.pdf?t=n4u9ap","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1597466662","https://openalex.org/W1657664159","https://openalex.org/W1896389954","https://openalex.org/W1911655428","https://openalex.org/W1965129145","https://openalex.org/W1984613701","https://openalex.org/W1985385055","https://openalex.org/W1991631628","https://openalex.org/W1995074766","https://openalex.org/W1995445783","https://openalex.org/W1999873667","https://openalex.org/W2014697941","https://openalex.org/W2025923737","https://openalex.org/W2026943045","https://openalex.org/W2029760674","https://openalex.org/W2034117229","https://openalex.org/W2034846190","https://openalex.org/W2041233779","https://openalex.org/W2055498189","https://openalex.org/W2059378857","https://openalex.org/W2062145087","https://openalex.org/W2063318299","https://openalex.org/W2076935230","https://openalex.org/W2080848788","https://openalex.org/W2084644507","https://openalex.org/W2089032508","https://openalex.org/W2096008575","https://openalex.org/W2096171066","https://openalex.org/W2096204304","https://openalex.org/W2098142549","https://openalex.org/W2099523743","https://openalex.org/W2102286060","https://openalex.org/W2103906226","https://openalex.org/W2112359216","https://openalex.org/W2113971187","https://openalex.org/W2115338196","https://openalex.org/W2117514753","https://openalex.org/W2118038334","https://openalex.org/W2118793608","https://openalex.org/W2124335825","https://openalex.org/W2129682060","https://openalex.org/W2129852694","https://openalex.org/W2144477621","https://openalex.org/W2147781659","https://openalex.org/W2148454550","https://openalex.org/W2150782814","https://openalex.org/W2151164193","https://openalex.org/W2151508249","https://openalex.org/W2151625463","https://openalex.org/W2155568044","https://openalex.org/W2159864549","https://openalex.org/W2161446823","https://openalex.org/W2334985540","https://openalex.org/W2399892719"],"related_works":["https://openalex.org/W2049200136","https://openalex.org/W1985599649","https://openalex.org/W1999656616","https://openalex.org/W2037673492","https://openalex.org/W2096171066","https://openalex.org/W2348326505","https://openalex.org/W2608727141","https://openalex.org/W3030501259","https://openalex.org/W2004514687","https://openalex.org/W3028836821"],"abstract_inverted_index":{"This":[0],"dissertation":[1],"is":[2],"presented":[3],"in":[4,26,53,69],"two":[5],"sections.":[6],"Section":[7],"one":[8],"recounts":[9],"my\\ninvestigations":[10],"of":[11,81],"modulating":[12],"the":[13,22,48,55,78,82],"multidrug-resistant":[14],"protein-three":[15],"(MRP3)":[16],"levels,":[17],"by\\neither":[18],"activating":[19],"or":[20],"silencing":[21],"transcription":[23],"factor":[24],"Nrf2,":[25,63],"normal":[27],"lung":[28,36],"cells":[29],"and":[30,32,47,61,64,72],"Keap1\\nwild-type":[31],"mutant":[33],"non-small":[34],"cell":[35,38,70],"carcinoma":[37],"lines":[39,71],"(NSCLC).":[40],"In":[41],"section":[42],"two\\ndirect":[43],"interactions":[44],"between":[45,57],"Nrf2":[46],"MRP3":[49,58,83],"promoter":[50],"were":[51,66],"evaluated":[52],"NSCLC.\\nAdditionally,":[54],"relationships":[56],"mRNA":[59],"levels":[60],"Keap1,":[62],"p53\\nstatus":[65],"also":[67],"investigated":[68],"tumor":[73],"specimens.":[74],"Combined,":[75],"these":[76],"sections\\nexplore":[77],"complex":[79],"regulation":[80],"gene.":[84]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}