{"id":"https://openalex.org/W2117481999","doi":"https://doi.org/10.1186/s12014-015-9080-y","title":"Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer","display_name":"Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer","publication_year":2015,"publication_date":"2015-03-20","ids":{"openalex":"https://openalex.org/W2117481999","doi":"https://doi.org/10.1186/s12014-015-9080-y","mag":"2117481999","pmid":"https://pubmed.ncbi.nlm.nih.gov/25878567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4389343"},"language":"en","primary_location":{"id":"doi:10.1186/s12014-015-9080-y","doi":"https://doi.org/10.1186/s12014-015-9080-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12014-015-9080-y","pdf_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/s12014-015-9080-y","source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/s12014-015-9080-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087743314","display_name":"Henrik J. Johansson","orcid":"https://orcid.org/0000-0003-4729-4205","observed_orcids":["https://orcid.org/0000-0003-4729-4205"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Henrik J Johansson","raw_affiliation_strings":["Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111873024","display_name":"Betzabe Chavez Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Betzabe C Sanchez","raw_affiliation_strings":["Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051167433","display_name":"Jenny Forshed","orcid":"https://orcid.org/0000-0002-1583-1267","observed_orcids":["https://orcid.org/0000-0002-1583-1267"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jenny Forshed","raw_affiliation_strings":["Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044198521","display_name":"Olle St\u00e5l","orcid":"https://orcid.org/0000-0002-8290-0592","observed_orcids":["https://orcid.org/0000-0002-8290-0592"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olle St\u00e5l","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047917882","display_name":"Helena Fohlin","orcid":"https://orcid.org/0000-0003-4336-0949","observed_orcids":["https://orcid.org/0000-0003-4336-0949"]},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]},{"id":"https://openalex.org/I4391767699","display_name":"Region \u00d6sterg\u00f6tland","ror":"https://ror.org/024emf479","country_code":"SE","type":"government","lineage":["https://openalex.org/I4391767699"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Helena Fohlin","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden ; Regional cancer center Southeast Sweden, County Council of \u00d6sterg\u00f6tland, Link\u00f6ping, Sweden","Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden ; Regional cancer center Southeast Sweden, County Council of \u00d6sterg\u00f6tland, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673","https://openalex.org/I4391767699"]},{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087206674","display_name":"Rolf Lewensohn","orcid":"https://orcid.org/0000-0002-9941-9172","observed_orcids":["https://orcid.org/0000-0002-9941-9172"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Rolf Lewensohn","raw_affiliation_strings":["Department of Oncology, Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053177403","display_name":"Per N Hall","orcid":"https://orcid.org/0000-0002-5640-9126","observed_orcids":["https://orcid.org/0000-0002-5640-9126"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Hall","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, 17177, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, 17177, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071571360","display_name":"Jonas C. S. Bergh","orcid":"https://orcid.org/0000-0001-5526-1847","observed_orcids":["https://orcid.org/0000-0001-5526-1847"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jonas Bergh","raw_affiliation_strings":["Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051446198","display_name":"Janne Lehti\u00f6","orcid":"https://orcid.org/0000-0002-8100-9562","observed_orcids":["https://orcid.org/0000-0002-8100-9562"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Janne Lehti\u00f6","raw_affiliation_strings":["Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65, Stockholm, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060320368","display_name":"Barbro Kristina Linderholm","orcid":"https://orcid.org/0000-0003-1531-630X","observed_orcids":["https://orcid.org/0000-0003-1531-630X"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Barbro K Linderholm","raw_affiliation_strings":["Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65 Stockholm, Sweden ; Department of Oncology, Sahlgrenska Academy and University Hospital, SE-413 45 Gothenburg, Sweden","Department of Oncology, Sahlgrenska Academy and University Hospital, SE-413 45, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Oncology-Pathology, Cancer Proteomics Mass spectrometry, Science for Life Laboratory, Karolinska Institutet, SE-171 65 Stockholm, Sweden ; Department of Oncology, Sahlgrenska Academy and University Hospital, SE-413 45 Gothenburg, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I2801112325","https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Oncology, Sahlgrenska Academy and University Hospital, SE-413 45, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5060320368","https://openalex.org/A5087743314"],"corresponding_institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I2801112325","https://openalex.org/I28166907"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":3.1859,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92229776,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"8","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamoxifen-resistance","display_name":"tamoxifen resistance","score":0.9020000100135803},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.8190000057220459},{"id":"https://openalex.org/keywords/caps","display_name":"CAPS","score":0.796999990940094},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8510000109672546},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.6809999942779541},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6119999885559082},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8360000252723694},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9290000200271606},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/s100a4","display_name":"S100A4","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hsp90ab1","display_name":"HSP90AB1","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.8179874420166016},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7150609493255615},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6557598114013672},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6439323425292969},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.565265953540802},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.4939625859260559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4729326069355011},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4449029564857483},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.43623054027557373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43036267161369324},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3853608965873718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3852296471595764},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3674784302711487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12014-015-9080-y","doi":"https://doi.org/10.1186/s12014-015-9080-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12014-015-9080-y","pdf_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/s12014-015-9080-y","source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4389343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4389343","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Proteomics","raw_type":"Text"},{"id":"pmid:25878567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25878567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical proteomics","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:liu-125931","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-125931","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12014-015-9080-y","doi":"https://doi.org/10.1186/s12014-015-9080-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12014-015-9080-y","pdf_url":"https://clinicalproteomicsjournal.biomedcentral.com/counter/pdf/10.1186/s12014-015-9080-y","source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323416","display_name":"Sahlgrenska Universitetssjukhuset","ror":"https://ror.org/04vgqjj36"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117481999.pdf","grobid_xml":"https://content.openalex.org/works/W2117481999.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W109896574","https://openalex.org/W597449721","https://openalex.org/W1509160537","https://openalex.org/W1601031438","https://openalex.org/W1605485096","https://openalex.org/W1685108166","https://openalex.org/W1867326360","https://openalex.org/W1961026612","https://openalex.org/W1980538358","https://openalex.org/W1981148075","https://openalex.org/W1987652819","https://openalex.org/W1989970584","https://openalex.org/W1996118868","https://openalex.org/W2001103978","https://openalex.org/W2010645803","https://openalex.org/W2012795967","https://openalex.org/W2013866124","https://openalex.org/W2013956549","https://openalex.org/W2017441789","https://openalex.org/W2017932539","https://openalex.org/W2023517685","https://openalex.org/W2026722048","https://openalex.org/W2027444207","https://openalex.org/W2038294883","https://openalex.org/W2040170958","https://openalex.org/W2057139407","https://openalex.org/W2060153480","https://openalex.org/W2061011762","https://openalex.org/W2071259232","https://openalex.org/W2079563665","https://openalex.org/W2083684518","https://openalex.org/W2088874644","https://openalex.org/W2092107334","https://openalex.org/W2094842579","https://openalex.org/W2113628069","https://openalex.org/W2113745863","https://openalex.org/W2128551987","https://openalex.org/W2131994307","https://openalex.org/W2132839842","https://openalex.org/W2139805080","https://openalex.org/W2142057493","https://openalex.org/W2143173882","https://openalex.org/W2145657329","https://openalex.org/W2148489676","https://openalex.org/W2154589460","https://openalex.org/W2155521816","https://openalex.org/W2156604663","https://openalex.org/W2157795344","https://openalex.org/W2160346983","https://openalex.org/W2160377567","https://openalex.org/W2166135064","https://openalex.org/W2172008556","https://openalex.org/W2184866463","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2567327035","https://openalex.org/W7019688428","https://openalex.org/W2161616458","https://openalex.org/W1606086962","https://openalex.org/W2025290797","https://openalex.org/W175148363","https://openalex.org/W2944039999","https://openalex.org/W1219777200","https://openalex.org/W2145783942","https://openalex.org/W2968591637"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"the":[2,96,110,131,136],"success":[3],"of":[4,11,79,130,143,147],"tamoxifen":[5,42,148,155,166],"since":[6],"its":[7],"introduction,":[8],"about":[9],"one-third":[10],"patients":[12,62],"with":[13,63],"estrogen":[14],"(ER)":[15],"and/or":[16],"progesterone":[17],"receptor":[18],"(PgR)":[19],"-":[20],"positive":[21],"breast":[22],"cancer":[23],"(BC)":[24],"do":[25],"not":[26],"benefit":[27],"from":[28,60,95,103],"therapy.":[29,159],"Here,":[30],"we":[31,57],"aim":[32],"to":[33,71],"identify":[34,139],"molecular":[35],"mechanisms":[36],"and":[37,47,68,127,168],"protein":[38],"biomarkers":[39],"involved":[40,113],"in":[41,109,114,135,150,165],"resistance.":[43],"RESULTS:":[44],"Using":[45],"iTRAQ":[46],"Immobilized":[48],"pH":[49],"gradient-isoelectric":[50],"focusing":[51],"(IPG-IEF)":[52],"mass":[53],"spectrometry":[54],"based":[55],"proteomics":[56],"compared":[58],"tumors":[59],"12":[61,69],"early":[64],"relapses":[65],"(<2":[66],"years)":[67],"responsive":[70],"therapy":[72],"(relapse-free":[73],">":[74],"7":[75],"years).":[76],"A":[77],"panel":[78,111],"13":[80],"proteins":[81,108,134],"(TCEAL4,":[82],"AZGP1,":[83],"S100A10,":[84],"ALDH6A1,":[85],"AHNAK,":[86],"FBP1,":[87],"S100A4,":[88],"HSP90AB1,":[89],"PDXK,":[90],"GFPT1,":[91],"RAB21,":[92],"MX1,":[93],"CAPS)":[94],"3101":[97],"identified":[98],"proteins,":[99],"potentially":[100],"separate":[101],"relapse":[102,137],"non-relapse":[104],"BC":[105],"patients.":[106],"The":[107],"are":[112],"processes":[115],"such":[116],"as":[117,145,156,169],"calcium":[118],"(Ca(2+))":[119],"signaling,":[120],"metabolism,":[121],"epithelial":[122],"mesenchymal":[123],"transition":[124],"(EMT),":[125],"metastasis":[126],"invasion.":[128],"Validation":[129],"highest":[132],"expressed":[133],"group":[138],"high":[140],"tumor":[141],"levels":[142],"CAPS":[144,164],"predictive":[146,172],"response":[149],"a":[151,170],"patient":[152],"cohort":[153],"receiving":[154],"only":[157],"adjuvant":[158],"CONCLUSIONS:":[160],"This":[161],"data":[162],"implicate":[163],"resistance":[167],"potential":[171],"marker.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}