{"id":"https://openalex.org/W2117464338","doi":"https://doi.org/10.1073/pnas.0603248103","title":"Essential and mutually compensatory roles of \u03b1-mannosidase II and \u03b1-mannosidase IIx in N -glycan processing in vivo in mice","display_name":"Essential and mutually compensatory roles of \u03b1-mannosidase II and \u03b1-mannosidase IIx in N -glycan processing in vivo in mice","publication_year":2006,"publication_date":"2006-06-05","ids":{"openalex":"https://openalex.org/W2117464338","doi":"https://doi.org/10.1073/pnas.0603248103","mag":"2117464338","pmid":"https://pubmed.ncbi.nlm.nih.gov/16754854","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1474017"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0603248103","doi":"https://doi.org/10.1073/pnas.0603248103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0603248103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1474017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042124203","display_name":"Tomoya O. Akama","orcid":"https://orcid.org/0000-0003-4248-6929","observed_orcids":["https://orcid.org/0000-0003-4248-6929"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoya O. Akama","raw_affiliation_strings":["*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071650875","display_name":"Hiroaki Nakagawa","orcid":"https://orcid.org/0000-0001-5103-0814","observed_orcids":["https://orcid.org/0000-0001-5103-0814"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Hiroaki Nakagawa","raw_affiliation_strings":["*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo 001-0021, Japan;","*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;; Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo 001-0021, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo 001-0021, Japan;","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;; Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo 001-0021, Japan;","institution_ids":["https://openalex.org/I188891513","https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108273432","display_name":"Nyet Kui Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nyet Kui Wong","raw_affiliation_strings":["Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004886335","display_name":"Mark Sutton\u2010Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Sutton-Smith","raw_affiliation_strings":["Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080001443","display_name":"Anne Dell","orcid":"https://orcid.org/0000-0003-1380-2347","observed_orcids":["https://orcid.org/0000-0003-1380-2347"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne Dell","raw_affiliation_strings":["Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419311","display_name":"Howard R. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Howard R. Morris","raw_affiliation_strings":["Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;","M-SCAN Mass Spectrometry Research and Training Centre, Silwood Park, Ascot SL5 7PZ, United Kingdom","Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;; M-SCAN Mass Spectrometry Research and Training Centre, Silwood Park, Ascot SL5 7PZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"M-SCAN Mass Spectrometry Research and Training Centre, Silwood Park, Ascot SL5 7PZ, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Biochemistry Division of Molecular Biosciences, Imperial College, London SW7 2AZ, United Kingdom;; M-SCAN Mass Spectrometry Research and Training Centre, Silwood Park, Ascot SL5 7PZ, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105515724","display_name":"Jun Nakayama","orcid":"https://orcid.org/0000-0001-6773-2802","observed_orcids":["https://orcid.org/0000-0001-6773-2802"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nakayama","raw_affiliation_strings":["Department of Pathology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan;","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074428939","display_name":"Shin\u2010Ichiro Nishimura","orcid":"https://orcid.org/0000-0002-6608-8418","observed_orcids":["https://orcid.org/0000-0002-6608-8418"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-Ichiro Nishimura","raw_affiliation_strings":["Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo 001-0021, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo 001-0021, Japan;","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009395001","display_name":"Ashok P Pai","orcid":"https://orcid.org/0000-0003-3095-0288","observed_orcids":["https://orcid.org/0000-0003-3095-0288"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok Pai","raw_affiliation_strings":["*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024936464","display_name":"Kelley W. Moremen","orcid":"https://orcid.org/0000-0003-1768-582X","observed_orcids":["https://orcid.org/0000-0003-1768-582X"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelley W. Moremen","raw_affiliation_strings":["Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602;","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022635870","display_name":"Jamey D. Marth","orcid":"https://orcid.org/0000-0001-9323-1649","observed_orcids":["https://orcid.org/0000-0001-9323-1649"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamey D. Marth","raw_affiliation_strings":["**Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006762365","display_name":"Michiko N. Fukuda","orcid":"https://orcid.org/0000-0003-4120-0490","observed_orcids":["https://orcid.org/0000-0003-4120-0490"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michiko N. Fukuda","raw_affiliation_strings":["*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0226,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.91811747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"103","issue":"24","first_page":"8983","last_page":"8988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-mannosidase-ii","display_name":"alpha-mannosidase II","score":0.9900000095367432},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/n-glycan-processing","display_name":"N-glycan processing","score":0.8859999775886536},{"id":"https://openalex.org/keywords/complex-n-glycans","display_name":"complex N-glycans","score":0.9549999833106995},{"id":"https://openalex.org/keywords/high-mannose-n-glycans","display_name":"high-mannose glycans","score":0.9160000085830688},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.7960000038146973},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.925000011920929},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.7760000228881836},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2777174400","wikidata":"https://www.wikidata.org/wiki/Q6750944","display_name":"Mannosidase","level":3,"score":0.9338837265968323},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.6760410070419312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6165376901626587},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5579885244369507},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5426902770996094},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.4769531488418579},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4409756064414978},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4215853214263916},{"id":"https://openalex.org/C2775928797","wikidata":"https://www.wikidata.org/wiki/Q415324","display_name":"Swainsonine","level":2,"score":0.4106808304786682},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.41002941131591797},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3490552306175232},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3268664479255676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31288397312164307},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.17268675565719604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16516515612602234}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008361","descriptor_name":"Mannosidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008361","descriptor_name":"Mannosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043323","descriptor_name":"alpha-Mannosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043323","descriptor_name":"alpha-Mannosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0603248103","doi":"https://doi.org/10.1073/pnas.0603248103","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0603248103","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1474017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1474017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:16754854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16754854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1474017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1474017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3831482693","display_name":"Selective Mannosidase Inhibitors as Cancer Therapeutics","funder_award_id":"U01CA091295","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5662941156","display_name":"Resource for Integrated Glycotechnology","funder_award_id":"2p41rr005351-21","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6478412656","display_name":"Carbohydrate-Dependent Adhesion in Normal and Tumor Cells","funder_award_id":"P01CA071932","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6878423500","display_name":"Mannosidases in Glycoprotein Biosynthesis & Catabolism","funder_award_id":"R01GM047533","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7200424943","display_name":"Biological function of keratan sulfate glycosaminoglycan for corneal extracellula","funder_award_id":"R01EY014620","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G791517991","display_name":null,"funder_award_id":"P41-RR005351","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000906139","display_name":"Glycosyltransferase Function in Development and Disease","funder_award_id":"R01DK048247","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W173263019","https://openalex.org/W1521766197","https://openalex.org/W1549547959","https://openalex.org/W1573624661","https://openalex.org/W1580156821","https://openalex.org/W1586039957","https://openalex.org/W1639179179","https://openalex.org/W1645373081","https://openalex.org/W1966844606","https://openalex.org/W1990402565","https://openalex.org/W1992857857","https://openalex.org/W1999600007","https://openalex.org/W2006388669","https://openalex.org/W2025611972","https://openalex.org/W2037787328","https://openalex.org/W2048207854","https://openalex.org/W2067988431","https://openalex.org/W2071815649","https://openalex.org/W2074237475","https://openalex.org/W2074827684","https://openalex.org/W2082771996","https://openalex.org/W2085581069","https://openalex.org/W2085680371","https://openalex.org/W2092471412","https://openalex.org/W2102214682","https://openalex.org/W2102818185","https://openalex.org/W2105114931","https://openalex.org/W2105381893","https://openalex.org/W2130335997","https://openalex.org/W2131817432","https://openalex.org/W2135275878","https://openalex.org/W2141976152","https://openalex.org/W2152708819","https://openalex.org/W6603578652"],"related_works":["https://openalex.org/W25523547","https://openalex.org/W2036171955","https://openalex.org/W7101042872","https://openalex.org/W123170742","https://openalex.org/W179844543","https://openalex.org/W1575516086","https://openalex.org/W7162080679","https://openalex.org/W1580156821","https://openalex.org/W2102818185","https://openalex.org/W1594473137"],"abstract_inverted_index":{"Many":[0],"proteins":[1],"synthesized":[2],"through":[3],"the":[4,37,157,160],"secretory":[5],"pathway":[6],"receive":[7],"posttranslational":[8],"modifications,":[9],"including":[10],"N-glycosylation.":[11],"alpha-Mannosidase":[12],"II":[13],"(MII)":[14],"is":[15,47,143,168],"a":[16,48,90,114],"key":[17],"enzyme":[18,50],"converting":[19],"precursor":[20],"high-mannose-type":[21],"N-glycans":[22,105],"to":[23],"matured":[24],"complex-type":[25,34,111],"structures.":[26],"Previous":[27],"studies":[28],"showed":[29,133],"that":[30,95,107,141],"MII-null":[31],"mice":[32],"synthesize":[33],"N-glycans,":[35,112],"indicating":[36],"presence":[38],"of":[39,85,104,121,146,159,166],"an":[40,144],"alternative":[41],"pathway.":[42],"Because":[43],"alpha-mannosidase":[44],"IIx":[45],"(MX)":[46],"candidate":[49],"for":[51,99,117,124,156,170],"this":[52],"pathway,":[53],"we":[54],"asked":[55],"whether":[56],"MX":[57,130,142,152],"functions":[58],"in":[59,97,162],"N-glycan":[60,126,138],"processing":[61],"by":[62],"generating":[63],"MII/MX":[64],"double-null":[65],"mice.":[66],"Some":[67],"double-nulls":[68,108],"died":[69,84],"between":[70],"embryonic":[71,172],"days":[72],"15.5":[73],"and":[74,83,131,164,173],"18.5,":[75],"but":[76],"most":[77],"survived":[78],"until":[79],"shortly":[80],"after":[81],"birth":[82],"respiratory":[86],"failure,":[87],"which":[88],"represents":[89],"more":[91],"severe":[92],"phenotype":[93],"than":[94],"seen":[96],"single-nulls":[98],"either":[100,149,165],"gene.":[101],"Structural":[102],"analysis":[103],"revealed":[106],"completely":[109],"lack":[110],"demonstrating":[113],"critical":[115],"role":[116],"at":[118],"least":[119],"one":[120],"these":[122],"enzymes":[123],"effective":[125],"processing.":[127],"Recombinant":[128],"mouse":[129],"MII":[132,150],"identical":[134],"substrate":[135],"specificities":[136],"toward":[137],"substrates,":[139],"suggesting":[140],"isozyme":[145],"MII.":[147],"Thus,":[148],"or":[151],"can":[153],"biochemically":[154],"compensate":[155],"deficiency":[158],"other":[161],"vivo,":[163],"two":[167],"required":[169],"late":[171],"early":[174],"postnatal":[175],"development.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}