{"id":"https://openalex.org/W2117422305","doi":"https://doi.org/10.1371/journal.pcbi.1002504","title":"The Role of Non-Native Interactions in the Folding of Knotted Proteins","display_name":"The Role of Non-Native Interactions in the Folding of Knotted Proteins","publication_year":2012,"publication_date":"2012-06-14","ids":{"openalex":"https://openalex.org/W2117422305","doi":"https://doi.org/10.1371/journal.pcbi.1002504","mag":"2117422305","pmid":"https://pubmed.ncbi.nlm.nih.gov/22719235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375218"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002504","doi":"https://doi.org/10.1371/journal.pcbi.1002504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002504","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002504&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002504&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087954071","display_name":"Tatjana \u0160krbi\u0107","orcid":"https://orcid.org/0000-0002-8947-8216","observed_orcids":["https://orcid.org/0000-0002-8947-8216"]},"institutions":[{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I4210102606","display_name":"European Centre for Theoretical Studies in Nuclear Physics and Related Areas","ror":"https://ror.org/01gzye136","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210102606"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tatjana \u0160krbi\u0107","raw_affiliation_strings":["ECT*- European Centre for Theoretical Studies in Nuclear Physics and Related Areas, Villazzano (Trento), Italy","LISC - Interdisciplinary Laboratory for Computational Science, Povo (Trento), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ECT*- European Centre for Theoretical Studies in Nuclear Physics and Related Areas, Villazzano (Trento), Italy","institution_ids":["https://openalex.org/I4210102606"]},{"raw_affiliation_string":"LISC - Interdisciplinary Laboratory for Computational Science, Povo (Trento), Italy","institution_ids":["https://openalex.org/I193223587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083284785","display_name":"Cristian Micheletti","orcid":"https://orcid.org/0000-0002-1022-1638","observed_orcids":["https://orcid.org/0000-0002-1022-1638"]},"institutions":[{"id":"https://openalex.org/I138549579","display_name":"Scuola Internazionale Superiore di Studi Avanzati","ror":"https://ror.org/004fze387","country_code":"IT","type":"education","lineage":["https://openalex.org/I138549579"]},{"id":"https://openalex.org/I4210101608","display_name":"Istituto Officina dei Materiali","ror":"https://ror.org/00yfw2296","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210101608","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cristian Micheletti","raw_affiliation_strings":["SISSA - Scuola Internazionale Superiore di Studi Avanzati and CNR-IOM Democritos, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SISSA - Scuola Internazionale Superiore di Studi Avanzati and CNR-IOM Democritos, Trieste, Italy","institution_ids":["https://openalex.org/I138549579","https://openalex.org/I4210101608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103089975","display_name":"Pietro Faccioli","orcid":"https://orcid.org/0000-0002-5546-5054","observed_orcids":["https://orcid.org/0000-0002-5546-5054"]},"institutions":[{"id":"https://openalex.org/I160013858","display_name":"Istituto Nazionale di Fisica Nucleare","ror":"https://ror.org/005ta0471","country_code":"IT","type":"government","lineage":["https://openalex.org/I160013858"]},{"id":"https://openalex.org/I193223587","display_name":"University of Trento","ror":"https://ror.org/05trd4x28","country_code":"IT","type":"education","lineage":["https://openalex.org/I193223587"]},{"id":"https://openalex.org/I4210093299","display_name":"Istituto Nazionale di Fisica Nucleare, Trento Institute for Fundamental Physics And Applications","ror":"https://ror.org/00nhs3j29","country_code":"IT","type":"facility","lineage":["https://openalex.org/I160013858","https://openalex.org/I193223587","https://openalex.org/I4210093299"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pietro Faccioli","raw_affiliation_strings":["Dipartimento di Fisica, Universit\u00e0 degli Studi di Trento, Povo (Trento), Italy","INFN - Istituto Nazionale di Fisica Nucleare, Gruppo Collegato di Trento, Povo (Trento), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Fisica, Universit\u00e0 degli Studi di Trento, Povo (Trento), Italy","institution_ids":["https://openalex.org/I193223587"]},{"raw_affiliation_string":"INFN - Istituto Nazionale di Fisica Nucleare, Gruppo Collegato di Trento, Povo (Trento), Italy","institution_ids":["https://openalex.org/I160013858","https://openalex.org/I4210093299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5083284785","https://openalex.org/A5103089975"],"corresponding_institution_ids":["https://openalex.org/I138549579","https://openalex.org/I160013858","https://openalex.org/I193223587","https://openalex.org/I4210093299","https://openalex.org/I4210101608"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.5691,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91080997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"6","first_page":"e1002504","last_page":"e1002504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10304","display_name":"Geometric and Algebraic Topology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2608","display_name":"Geometry and Topology"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knotted-proteins","display_name":"knotted proteins","score":0.8050000071525574},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.9150000214576721},{"id":"https://openalex.org/keywords/non-native-interactions","display_name":"non-native interactions","score":0.9509999752044678},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.996999979019165},{"id":"https://openalex.org/keywords/ornithine-carbamoyltransferase","display_name":"ornithine carbamoyltransferase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coarse-grained-protein-models","display_name":"coarse-grained protein models","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43869197368621826},{"id":"https://openalex.org/C2909874926","wikidata":"https://www.wikidata.org/wiki/Q420678","display_name":"Ornithine Carbamoyltransferase","level":5,"score":0.4147680401802063},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3764498829841614},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32425546646118164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28907135128974915},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2872132360935211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2406511902809143},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.13909515738487244},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009954","descriptor_name":"Ornithine Carbamoyltransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019878","descriptor_name":"Carboxyl and Carbamoyl Transferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pcbi.1002504","doi":"https://doi.org/10.1371/journal.pcbi.1002504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002504","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002504&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3375218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmid:22719235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22719235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:1203.4365","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1203.4365","pdf_url":"https://arxiv.org/pdf/1203.4365","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:iris.sissa.it:20.500.11767/14143","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/1203.4365","pdf_url":null,"source":{"id":"https://openalex.org/S7407055192","display_name":"SDL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002504","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002504","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:boa.unimib.it:10281/405567","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10281/405567","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:de2c56f85a5a498f80fef32bb046e5da","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/de2c56f85a5a498f80fef32bb046e5da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 6, p e1002504 (2012)","raw_type":"article"},{"id":"pmh:oai:iris.sissa.it:20.500.11767/15065","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11767/15065","pdf_url":null,"source":{"id":"https://openalex.org/S7407055192","display_name":"SDL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unitn.it:11572/91588","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11572/91588","pdf_url":null,"source":{"id":"https://openalex.org/S4377196320","display_name":"Iris (University of Trento)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193223587","host_organization_name":"University of Trento","host_organization_lineage":["https://openalex.org/I193223587"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unive.it:10278/3725613","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10278/3725613","pdf_url":null,"source":{"id":"https://openalex.org/S4306402336","display_name":"ARCA (Universit\u00e0 Ca' Foscari Venezia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149461666","host_organization_name":"Ca' Foscari University of Venice","host_organization_lineage":["https://openalex.org/I149461666"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.48550/arxiv.1203.4365","doi":"https://doi.org/10.48550/arxiv.1203.4365","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1203.4365","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002504","doi":"https://doi.org/10.1371/journal.pcbi.1002504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002504","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002504&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322253","display_name":"Fondazione Bruno Kessler","ror":"https://ror.org/01j33xk10"},{"id":"https://openalex.org/F4320322275","display_name":"Universit\u00e0 degli Studi di Trento","ror":"https://ror.org/05trd4x28"},{"id":"https://openalex.org/F4320326086","display_name":"Provincia Autonoma di Trento","ror":"https://ror.org/017e99q89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117422305.pdf","grobid_xml":"https://content.openalex.org/works/W2117422305.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W620325508","https://openalex.org/W1487703784","https://openalex.org/W1504639393","https://openalex.org/W1530495800","https://openalex.org/W1541939753","https://openalex.org/W1607929127","https://openalex.org/W1963560096","https://openalex.org/W1966853719","https://openalex.org/W1967865324","https://openalex.org/W1974873337","https://openalex.org/W1979018519","https://openalex.org/W1997196750","https://openalex.org/W2000645278","https://openalex.org/W2008798066","https://openalex.org/W2012267681","https://openalex.org/W2015588812","https://openalex.org/W2016374046","https://openalex.org/W2018783142","https://openalex.org/W2022652120","https://openalex.org/W2023765957","https://openalex.org/W2027059526","https://openalex.org/W2028238143","https://openalex.org/W2031542494","https://openalex.org/W2031814977","https://openalex.org/W2045994733","https://openalex.org/W2050679015","https://openalex.org/W2051093082","https://openalex.org/W2053569158","https://openalex.org/W2060804379","https://openalex.org/W2068853089","https://openalex.org/W2070816181","https://openalex.org/W2082388363","https://openalex.org/W2086339678","https://openalex.org/W2090627622","https://openalex.org/W2098586421","https://openalex.org/W2102212328","https://openalex.org/W2108067237","https://openalex.org/W2115005877","https://openalex.org/W2115713787","https://openalex.org/W2126996906","https://openalex.org/W2127408623","https://openalex.org/W2131404542","https://openalex.org/W2135190106","https://openalex.org/W2135452602","https://openalex.org/W2136624897","https://openalex.org/W2139433006","https://openalex.org/W2149355630","https://openalex.org/W2154083418","https://openalex.org/W2156407143","https://openalex.org/W2158397714","https://openalex.org/W2159701144","https://openalex.org/W2162355408","https://openalex.org/W2162739292","https://openalex.org/W2171153313","https://openalex.org/W2171546617","https://openalex.org/W2598799394","https://openalex.org/W2997436936","https://openalex.org/W3092029811","https://openalex.org/W3103568817","https://openalex.org/W4205666823","https://openalex.org/W4254180029","https://openalex.org/W6986715048"],"related_works":["https://openalex.org/W7096191685","https://openalex.org/W1981158539","https://openalex.org/W3173890370","https://openalex.org/W4385659485","https://openalex.org/W7096438971","https://openalex.org/W7023965431","https://openalex.org/W2090627622","https://openalex.org/W2949777054","https://openalex.org/W1839487174","https://openalex.org/W2038494121"],"abstract_inverted_index":{"Stochastic":[0],"simulations":[1],"of":[2,18,47,102,110,118,136,141],"coarse-grained":[3],"protein":[4,19,74],"models":[5],"are":[6,52,161],"used":[7],"to":[8,12,78,121],"investigate":[9],"the":[10,60,70,82,91,103,107,111,116,119,142],"propensity":[11,77,87],"form":[13,79],"knots":[14],"in":[15],"early":[16,153,167],"stages":[17,155],"folding.":[20],"The":[21,139],"study":[22],"is":[23,98],"carried":[24],"out":[25],"comparatively":[26],"for":[27,90,95,163],"two":[28,44,112],"homologous":[29],"carbamoyltransferases,":[30],"a":[31,76],"natively-knotted":[32,147],"N-acetylornithine":[33],"carbamoyltransferase":[34,40],"(AOTCase)":[35],"and":[36,59,66,129,156,165],"an":[37],"unknotted":[38],"ornithine":[39],"(OTCase).":[41],"In":[42],"addition,":[43],"different":[45,108],"sets":[46],"pairwise":[48],"amino":[49],"acid":[50],"interactions":[51,160],"considered:":[53],"one":[54],"promoting":[55,164],"exclusively":[56],"native":[57],"interactions,":[58,85],"other":[61,134],"additionally":[62],"including":[63],"non-native":[64,84,158],"quasi-chemical":[65],"electrostatic":[67],"interactions.":[68],"With":[69,81],"former":[71],"model":[72],"neither":[73],"shows":[75],"knots.":[80],"additional":[83],"knotting":[86,168],"remains":[88],"negligible":[89],"natively-unknotted":[92],"OTCase":[93],"while":[94],"AOTCase":[96],"it":[97],"much":[99],"enhanced.":[100],"Analysis":[101],"trajectories":[104],"suggests":[105],"that":[106,146,157],"entanglement":[109],"transcarbamylases":[113],"follows":[114],"from":[115,124],"tendency":[117],"C-terminal":[120],"point":[122],"away":[123],"(for":[125,132],"OTCase)":[126],"or":[127],"approach":[128],"eventually":[130],"thread":[131],"AOTCase)":[133],"regions":[135],"partly-folded":[137],"protein.":[138],"analysis":[140],"OTCase/AOTCase":[143],"pair":[144],"clarifies":[145],"proteins":[148],"can":[149],"spontaneously":[150],"knot":[151],"during":[152],"folding":[154],"sequence-dependent":[159],"important":[162],"disfavouring":[166],"events.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
