{"id":"https://openalex.org/W2117417680","doi":"https://doi.org/10.1152/ajplung.00034.2007","title":"Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature","display_name":"Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2117417680","doi":"https://doi.org/10.1152/ajplung.00034.2007","mag":"2117417680","pmid":"https://pubmed.ncbi.nlm.nih.gov/18024717"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00034.2007","doi":"https://doi.org/10.1152/ajplung.00034.2007","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00034.2007","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048588174","display_name":"David B. Frank","orcid":"https://orcid.org/0000-0002-3064-2069","observed_orcids":["https://orcid.org/0000-0002-3064-2069"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Frank","raw_affiliation_strings":["Department of Cell and Developmental Biology, Vanderbilt Univ. School of Medicine, S3223 Medical Center North, 1161 21 St. South, Nashville, TN 37232-2372, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt Univ. School of Medicine, S3223 Medical Center North, 1161 21 St. South, Nashville, TN 37232-2372, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061868310","display_name":"Jonathan Wayne Lowery","orcid":"https://orcid.org/0000-0002-9942-2945","observed_orcids":["https://orcid.org/0000-0002-9942-2945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Lowery","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047721998","display_name":"Lynda Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynda Anderson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021877905","display_name":"Monique Brink","orcid":"https://orcid.org/0000-0002-4146-1052","observed_orcids":["https://orcid.org/0000-0002-4146-1052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monique Brink","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067574356","display_name":"Jeff Reese","orcid":"https://orcid.org/0000-0001-8751-6146","observed_orcids":["https://orcid.org/0000-0001-8751-6146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Reese","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009531733","display_name":"Mark P. deCaestecker","orcid":"https://orcid.org/0000-0001-7926-1673","observed_orcids":["https://orcid.org/0000-0001-7926-1673","https://orcid.org/0000-0002-5780-4216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark de Caestecker","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7017,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.90054157,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"294","issue":"1","first_page":"L98","last_page":"L109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmpr2","display_name":"BMPR2","score":0.800000011920929},{"id":"https://openalex.org/keywords/familial-pulmonary-arterial-hypertension","display_name":"familial pulmonary arterial hypertension","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hypoxic-pulmonary-hypertension","display_name":"hypoxic pulmonary hypertension","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chronic-hypoxia","display_name":"chronic hypoxia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/smad-signaling","display_name":"Smad signaling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pulmonary-microvascular-endothelial-cells","display_name":"pulmonary microvascular endothelial cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8500000238418579},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.9263267517089844},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.7598928213119507},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7325482964515686},{"id":"https://openalex.org/C29323129","wikidata":"https://www.wikidata.org/wiki/Q3504897","display_name":"Hypoxic pulmonary vasoconstriction","level":3,"score":0.7088418006896973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5132706165313721},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.49372777342796326},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.48573118448257446},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4781166911125183},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4713898301124573},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.46095752716064453},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.43997856974601746},{"id":"https://openalex.org/C2781228645","wikidata":"https://www.wikidata.org/wiki/Q4941575","display_name":"Bone morphogenetic protein receptor","level":4,"score":0.439090758562088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4303470253944397},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.41483959555625916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4021236002445221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.370466947555542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1509213149547577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061453282833099365},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052006","descriptor_name":"Bone Morphogenetic Protein Receptors, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.00034.2007","doi":"https://doi.org/10.1152/ajplung.00034.2007","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00034.2007","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:18024717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18024717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312462","display_name":"University of Vermont","ror":"https://ror.org/0155zta11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1606441445","https://openalex.org/W1963782060","https://openalex.org/W1965554487","https://openalex.org/W1980989951","https://openalex.org/W1993387193","https://openalex.org/W1997617706","https://openalex.org/W1998123371","https://openalex.org/W1999275474","https://openalex.org/W2000228053","https://openalex.org/W2011680378","https://openalex.org/W2017086844","https://openalex.org/W2029399343","https://openalex.org/W2030470655","https://openalex.org/W2042006175","https://openalex.org/W2057097612","https://openalex.org/W2057710785","https://openalex.org/W2083998789","https://openalex.org/W2084954119","https://openalex.org/W2089751994","https://openalex.org/W2096393477","https://openalex.org/W2096807231","https://openalex.org/W2104874723","https://openalex.org/W2107821473","https://openalex.org/W2115508204","https://openalex.org/W2130449101","https://openalex.org/W2130624328","https://openalex.org/W2134132415","https://openalex.org/W2146730628","https://openalex.org/W2152323385","https://openalex.org/W2152501741","https://openalex.org/W2154573929","https://openalex.org/W2157520113","https://openalex.org/W2163394057","https://openalex.org/W2167099419","https://openalex.org/W2168347049","https://openalex.org/W2264997947","https://openalex.org/W2284173849","https://openalex.org/W2313158847","https://openalex.org/W2329530086"],"related_works":["https://openalex.org/W2293954580","https://openalex.org/W2792825729","https://openalex.org/W2518252291","https://openalex.org/W2167099419","https://openalex.org/W7097537057","https://openalex.org/W2146730628","https://openalex.org/W2088465910","https://openalex.org/W2035005764","https://openalex.org/W2070004323","https://openalex.org/W2073741723"],"abstract_inverted_index":{"Patients":[0],"with":[1,69,75],"familial":[2],"pulmonary":[3,30,51,63,112,127,154],"arterial":[4],"hypertension":[5,52],"inherit":[6],"heterozygous":[7,39],"mutations":[8,42],"of":[9,24,132],"the":[10,21,29,106,126],"type":[11],"2":[12],"bone":[13],"morphogenetic":[14],"protein":[15],"(BMP)":[16],"receptor":[17],"BMPR2.":[18],"To":[19],"explore":[20],"cellular":[22],"mechanisms":[23],"this":[25],"disease,":[26],"we":[27],"evaluated":[28],"vascular":[31,64],"responses":[32],"to":[33,56,148,152],"chronic":[34],"hypoxia":[35,57],"in":[36,62,82,94,105,110,136],"mice":[37,47,141],"carrying":[38],"hypomorphic":[40],"Bmpr2":[41,117,137],"(Bmpr2":[43],"delta":[44,118,138],"Ex2/+).":[45],"These":[46,122],"develop":[48],"more":[49],"severe":[50],"after":[53],"prolonged":[54],"exposure":[55],"without":[58],"an":[59],"associated":[60,74],"increase":[61],"remodeling":[65],"or":[66],"proliferation":[67],"compared":[68],"wild-type":[70],"mice.":[71,121],"This":[72],"is":[73,90,129],"defective":[76],"endothelial-dependent":[77],"vasodilatation":[78],"and":[79,102,109,142],"enhanced":[80],"vasoconstriction":[81],"isolated":[83],"intrapulmonary":[84],"artery":[85],"preparations.":[86],"In":[87],"addition,":[88],"there":[89],"a":[91,130],"selective":[92],"decrease":[93],"hypoxia-induced,":[95],"BMP-dependent,":[96],"endothelial":[97,114,145],"nitric":[98],"oxide":[99],"synthase":[100],"expression":[101],"Smad":[103],"signaling":[104,135],"intact":[107],"lungs":[108],"cultured":[111],"microvascular":[113],"cells":[115],"from":[116],"Ex2/+":[119,139],"mutant":[120,140],"findings":[123],"indicate":[124],"that":[125,144],"endothelium":[128],"target":[131],"abnormal":[133],"BMP":[134],"suggest":[143],"dysfunction":[146],"contributes":[147],"their":[149],"increased":[150],"susceptibility":[151],"hypoxic":[153],"hypertension.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
