{"id":"https://openalex.org/W21174161","doi":null,"title":"Pemetrexed in the treatment of thoracic malignancies: a single centre experience in Singapore.","display_name":"Pemetrexed in the treatment of thoracic malignancies: a single centre experience in Singapore.","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W21174161","mag":"21174161","pmid":"https://pubmed.ncbi.nlm.nih.gov/21451928"},"language":"en","primary_location":{"id":"pmid:21451928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21451928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068401391","display_name":"Gilberto De Lima Lopes Jr.","orcid":"https://orcid.org/0000-0002-1151-9903","observed_orcids":["https://orcid.org/0000-0002-1151-9903"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Lopes","raw_affiliation_strings":["Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433. glopes@imc.jhmi.edu","Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433. glopes@imc.jhmi.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006408935","display_name":"Akhil Chopra","orcid":"https://orcid.org/0000-0002-8299-0516","observed_orcids":["https://orcid.org/0000-0002-8299-0516"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Chopra","raw_affiliation_strings":["Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042232313","display_name":"J. Kukutschka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Kukutschka","raw_affiliation_strings":["Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047834574","display_name":"Paloma Portillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Portillo","raw_affiliation_strings":["Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084222109","display_name":"Lavina D. Bharwani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Bharwani","raw_affiliation_strings":["Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034608939","display_name":"ATY Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Chang","raw_affiliation_strings":["Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Singapore International Medical Centre, Johns Hopkins University School of Medicine, 11 Jalan Tan Tock Seng, Level 1, Singapore 308433","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00283386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"3","first_page":"190","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.06930000334978104,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thoracic-tumors","display_name":"thoracic tumors","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cisplatin-combination-chemotherapy","display_name":"cisplatin combination chemotherapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7850000262260437},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7910000085830688},{"id":"https://openalex.org/keywords/asian-patients","display_name":"Asian patients","score":0.7210000157356262},{"id":"https://openalex.org/keywords/singapore","display_name":"Singapore","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9597307443618774},{"id":"https://openalex.org/C2777240266","wikidata":"https://www.wikidata.org/wiki/Q415220","display_name":"Pemetrexed","level":4,"score":0.9415677785873413},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6932430267333984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6690276861190796},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.6226869821548462},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5629990696907043},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.513321578502655},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.49961423873901367},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4662192463874817},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.44602149724960327},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43540796637535095},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4335462749004364},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4288254380226135},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.37142646312713623},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.3561680018901825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09564560651779175}],"mesh":[{"descriptor_ui":"D000068437","descriptor_name":"Pemetrexed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012846","descriptor_name":"Singapore","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21451928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21451928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1996644336","https://openalex.org/W2040376006","https://openalex.org/W2041768451","https://openalex.org/W2069948028","https://openalex.org/W2074026346","https://openalex.org/W2079938100","https://openalex.org/W2083702866","https://openalex.org/W2089869557","https://openalex.org/W2099725888","https://openalex.org/W2102627969","https://openalex.org/W2112621029","https://openalex.org/W2134667653","https://openalex.org/W2139248078","https://openalex.org/W2139939379","https://openalex.org/W2143034231","https://openalex.org/W2156145816","https://openalex.org/W2169984670","https://openalex.org/W2250146656","https://openalex.org/W2284580177","https://openalex.org/W2336518291","https://openalex.org/W2596387873"],"related_works":["https://openalex.org/W619239484","https://openalex.org/W2414338011","https://openalex.org/W2352243816","https://openalex.org/W2390389687","https://openalex.org/W2968292615","https://openalex.org/W2085889668","https://openalex.org/W2625022391","https://openalex.org/W2355793273","https://openalex.org/W2383882140","https://openalex.org/W2334334324"],"abstract_inverted_index":{"INTRODUCTION:":[0],"This":[1],"study":[2,216],"aimed":[3],"to":[4,34,51,130],"examine":[5],"the":[6,36,40,228],"efficacy":[7,37],"and":[8,28,44,63,78,84,91,121,163,192,205,217,225,235],"toxicity":[9,106],"of":[10,20,39,76,82,95,152,169,176,213,230],"pemetrexed":[11,24,177,222],"in":[12,178,207,227],"Singapore.":[13],"METHODS:":[14],"We":[15],"conducted":[16],"a":[17,73,167,185],"retrospective":[18,215],"review":[19,219],"patients":[21,57,112,153,183,232],"treated":[22],"with":[23,70,154,180,233],"between":[25],"July":[26],"2005":[27],"November":[29],"2007.":[30],"RECIST":[31],"was":[32,49,107,133,144,156],"used":[33,50],"assess":[35],"independent":[38],"treating":[41],"physician's":[42],"assessment,":[43],"NCI":[45],"CTC-AE":[46],"version":[47],"3.0":[48],"describe":[52],"adverse":[53],"events.":[54],"RESULTS:":[55],"37":[56],"had":[58,65,72,113,125,184,189,194],"non-small-cell":[59],"lung":[60],"cancer":[61],"(NSCLC)":[62],"six":[64],"malignant":[66],"pleural":[67],"mesothelioma.":[68,236],"Those":[69],"NSCLC":[71,234],"median":[74,94,168],"age":[75,151],"60":[77],"an":[79,114],"ECOG":[80],"PS":[81],"0-1,":[83],"they":[85],"were":[86,98,200],"predominantly":[87],"male,":[88],"ethnic":[89],"Chinese":[90],"smokers.":[92],"A":[93],"two":[96,188],"cycles":[97,175],"delivered":[99],"(total":[100,171],"95;":[101],"range":[102,173],"1-12).":[103],"Grade":[104,197],"3/4":[105,198],"rare.":[108],"Five":[109,161],"(14":[110],"percent)":[111,124],"objective":[115],"response":[116],"(one":[117],"complete,":[118],"four":[119,170],"partial)":[120],"13":[122],"(35":[123],"stable":[126,190],"disease.":[127],"Median":[128,141,150],"time":[129],"treatment":[131,229],"failure":[132],"1.86":[134],"months":[135,146],"(95%":[136,147],"confidence":[137],"interval":[138],"[CI]":[139],"0-6.5).":[140],"overall":[142],"survival":[143],"18.6":[145],"CI":[148],"12.6-27.7).":[149],"mesothelioma":[155],"46.5":[157],"(range":[158],"29-73)":[159],"years.":[160],"men":[162],"one":[164,193,208],"woman":[165],"received":[166],"30,":[172],"1-15)":[174],"combination":[179],"cisplatin.":[181],"Three":[182],"partial":[186],"response,":[187],"disease":[191,195],"progression.":[196],"toxicities":[199],"as":[201],"follows:":[202],"leucopenia,":[203],"neutropenia":[204],"thrombocytopenia":[206],"patient.":[209],"CONCLUSION:":[210],"The":[211],"results":[212],"this":[214],"literature":[218],"show":[220],"that":[221],"is":[223],"safe":[224],"efficacious":[226],"Asian":[231]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}