{"id":"https://openalex.org/W2117374380","doi":"https://doi.org/10.1002/mrm.10482","title":"Combined diffusion and strain MRI reveals structure and function of human myocardial laminar sheets in vivo","display_name":"Combined diffusion and strain MRI reveals structure and function of human myocardial laminar sheets in vivo","publication_year":2003,"publication_date":"2003-06-13","ids":{"openalex":"https://openalex.org/W2117374380","doi":"https://doi.org/10.1002/mrm.10482","mag":"2117374380","pmid":"https://pubmed.ncbi.nlm.nih.gov/12815685"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.10482","doi":"https://doi.org/10.1002/mrm.10482","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mrm.10482","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mrm.10482","source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mrm.10482","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041615637","display_name":"Jiangang Dou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210092658","display_name":"Harvard\u2013MIT Division of Health Sciences and Technology","ror":"https://ror.org/00jjeh629","country_code":"US","type":"education","lineage":["https://openalex.org/I4210092658"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangang Dou","raw_affiliation_strings":["MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA","Department of Nuclear Engineering, MIT, Cambridge, Massachusetts","Division of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts","MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Nuclear Engineering, MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Division of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4210092658","https://openalex.org/I63966007"]},{"raw_affiliation_string":"MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087358491","display_name":"Wen\u2010Yih Isaac Tseng","orcid":"https://orcid.org/0000-0002-2314-6868","observed_orcids":["https://orcid.org/0000-0002-2314-6868"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen\u2010Yih I. Tseng","raw_affiliation_strings":["Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipei, Taiwan","Department of Radiology, National Taiwan University Medical College, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Optoelectronic Biomedicine, National Taiwan University Medical College, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Department of Radiology, National Taiwan University Medical College, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058866509","display_name":"Timothy G. Reese","orcid":"https://orcid.org/0000-0002-8528-3390","observed_orcids":["https://orcid.org/0000-0002-8528-3390"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy G. Reese","raw_affiliation_strings":["MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111836802","display_name":"Van Jay Wedeen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Van J. Wedeen","raw_affiliation_strings":["MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MGH-NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111836802"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":4.5523,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.95194855,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"50","issue":"1","first_page":"107","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.6025000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.6025000214576721,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.22280000150203705,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventricular-wall-thickening","display_name":"ventricular wall thickening","score":0.8669999837875366},{"id":"https://openalex.org/keywords/myocardial-strain","display_name":"myocardial strain","score":0.8460000157356262},{"id":"https://openalex.org/keywords/myocardial-fiber-architecture","display_name":"myocardial fiber architecture","score":0.671999990940094},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2779559920","wikidata":"https://www.wikidata.org/wiki/Q911138","display_name":"Thickening","level":2,"score":0.6532629728317261},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.49133744835853577},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.49072062969207764},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4303949177265167},{"id":"https://openalex.org/C10134942","wikidata":"https://www.wikidata.org/wiki/Q7280279","display_name":"Radial stress","level":3,"score":0.429298996925354},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38404548168182373},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32912677526474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3253154158592224},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.31213122606277466},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.13276445865631104},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.07628989219665527},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013382","descriptor_name":"Subtraction Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017352","descriptor_name":"Echo-Planar Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrm.10482","doi":"https://doi.org/10.1002/mrm.10482","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mrm.10482","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mrm.10482","source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:12815685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12815685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/mrm.10482","doi":"https://doi.org/10.1002/mrm.10482","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mrm.10482","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mrm.10482","source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2838098303","display_name":null,"funder_award_id":"1R01-HL56737","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117374380.pdf","grobid_xml":"https://content.openalex.org/works/W2117374380.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1550726172","https://openalex.org/W1566007174","https://openalex.org/W1977745841","https://openalex.org/W2009972192","https://openalex.org/W2025180496","https://openalex.org/W2026327114","https://openalex.org/W2032011764","https://openalex.org/W2034121307","https://openalex.org/W2034569048","https://openalex.org/W2039367332","https://openalex.org/W2044017043","https://openalex.org/W2058811138","https://openalex.org/W2062715079","https://openalex.org/W2135926315","https://openalex.org/W2162098060","https://openalex.org/W2244090046","https://openalex.org/W2281294183"],"related_works":["https://openalex.org/W2146496099","https://openalex.org/W2261255914","https://openalex.org/W2026327114","https://openalex.org/W2142243051","https://openalex.org/W14836722","https://openalex.org/W2095854554","https://openalex.org/W175434387","https://openalex.org/W2040360146","https://openalex.org/W2124506606","https://openalex.org/W2162098060"],"abstract_inverted_index":{"The":[0,14,182],"mechanism":[1],"of":[2,50,107,151,176,195,209,212],"ventricular":[3,22,40,89,134,174],"thickening":[4,23,90,103,129,150],"in":[5,11,35,78,122,158],"normal":[6,45,159],"humans":[7,160],"was":[8,42,72,141,161],"investigated":[9],"using":[10],"vivo":[12],"MRI.":[13,69],"hypothesis":[15],"that":[16,185],"myocardial":[17,51,76,85,196],"laminar":[18],"sheets":[19,86],"contribute":[20,87],"to":[21,88,149,163,205],"predominantly":[24],"via":[25],"sheet":[26,29,52,97,99,115,118,197],"shear":[27,116],"and":[28,54,67,101,117,127,166,172,179,199,201],"extension,":[30,100],"as":[31],"previously":[32],"found":[33,162],"invasively":[34],"canine":[36],"studies":[37],"at":[38,56,61],"particular":[39],"sites,":[41],"tested.":[43],"In":[44,83,144],"human":[46],"subjects,":[47],"registered":[48],"images":[49],"architecture":[53,198],"strain":[55,68,77,95],"the":[57,79,123,132,147,170,206],"mid-left":[58],"ventricle":[59],"(mid-LV)":[60],"mid-systole":[62],"were":[63,154],"acquired":[64],"with":[65,114,169],"diffusion":[66],"Sheet":[70,156],"function":[71,157],"analyzed":[73],"by":[74],"computing":[75],"local":[80],"fiber-sheet":[81],"coordinates.":[82],"general,":[84],"through":[91],"all":[92,145],"three":[93],"cross-fiber":[94],"components:":[96],"shear,":[98],"sheet-normal":[102,128],"(previously":[104],"undocumented).":[105],"Each":[106],"these":[108],"components":[109],"demonstrated":[110],"substantial":[111],"spatial":[112],"heterogeneity,":[113],"extension":[119],"usually":[120],"predominant":[121,130],"anterior":[124],"free":[125],"wall,":[126],"near":[131],"right":[133],"(RV)":[135],"insertions.":[136],"However,":[137],"considerable":[138],"intersubject":[139],"variability":[140],"also":[142],"found.":[143],"cases,":[146],"contributions":[148],"fiber":[152,177],"strains":[153],"small.":[155],"be":[164],"heterogeneous":[165],"variable,":[167],"contrasting":[168],"uniform":[171],"symmetric":[173],"patterns":[175],"shortening":[178],"wall":[180],"thickening.":[181],"study":[183],"demonstrates":[184],"noninvasive":[186],"NMR":[187],"imaging":[188],"is":[189,202],"a":[190],"promising":[191],"tool":[192],"for":[193],"investigations":[194],"function,":[200],"particularly":[203],"suited":[204],"evident":[207],"complexity":[208],"this":[210],"field":[211],"study.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
