{"id":"https://openalex.org/W2117297429","doi":"https://doi.org/10.1371/journal.ppat.1002739","title":"HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads","display_name":"HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads","publication_year":2012,"publication_date":"2012-06-14","ids":{"openalex":"https://openalex.org/W2117297429","doi":"https://doi.org/10.1371/journal.ppat.1002739","mag":"2117297429","pmid":"https://pubmed.ncbi.nlm.nih.gov/22719248","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375288"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1002739","doi":"https://doi.org/10.1371/journal.ppat.1002739","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1002739","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002739&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002739&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108420373","display_name":"Jennifer M. Mabuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Mabuka","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Program of Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Program of Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033486140","display_name":"Ruth\u00a0W. Nduati","orcid":"https://orcid.org/0000-0002-7311-9892","observed_orcids":["https://orcid.org/0000-0002-7311-9892"]},"institutions":[{"id":"https://openalex.org/I12859529","display_name":"University of Nairobi","ror":"https://ror.org/02y9nww90","country_code":"KE","type":"education","lineage":["https://openalex.org/I12859529"]}],"countries":["KE"],"is_corresponding":false,"raw_author_name":"Ruth Nduati","raw_affiliation_strings":["Department of Pediatrics, University of Nairobi, Nairobi, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Nairobi, Nairobi, Kenya","institution_ids":["https://openalex.org/I12859529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060299759","display_name":"Katherine Odem\u2010Davis","orcid":"https://orcid.org/0000-0002-9779-2571","observed_orcids":["https://orcid.org/0000-0002-9779-2571"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Odem-Davis","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007502390","display_name":"Dylan Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dylan Peterson","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075328638","display_name":"Julie M. Overbaugh","orcid":"https://orcid.org/0000-0002-0239-9444","observed_orcids":["https://orcid.org/0000-0002-0239-9444"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julie Overbaugh","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075328638"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":8.6745,"has_fulltext":true,"cited_by_count":231,"citation_normalized_percentile":{"value":0.9864745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"8","issue":"6","first_page":"e1002739","last_page":"e1002739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8109999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.17319999635219574,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.7900000214576721},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hiv-1-neutralizing-antibodies","display_name":"HIV-1 neutralizing antibodies","score":0.6859999895095825},{"id":"https://openalex.org/keywords/breastfeeding-transmission","display_name":"breastfeeding transmission","score":0.6539999842643738},{"id":"https://openalex.org/keywords/infant-hiv-infection","display_name":"infant HIV infection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/maternal-viral-load","display_name":"maternal viral load","score":0.6380000114440918},{"id":"https://openalex.org/keywords/hiv-1-envelope","display_name":"HIV-1 envelope","score":0.777999997138977},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.718999981880188},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subtype-a","display_name":"subtype A","score":0.6890000104904175},{"id":"https://openalex.org/keywords/postpartum-women","display_name":"postpartum women","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.9333457350730896},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7278432846069336},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.6381064057350159},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6319814324378967},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6149993538856506},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4919264316558838},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4752473831176758},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.46304088830947876},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.43622493743896484},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.42469996213912964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4217204451560974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2951001822948456},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.1123248040676117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008895","descriptor_name":"Milk, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1002739","doi":"https://doi.org/10.1371/journal.ppat.1002739","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1002739","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002739&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3375288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3375288","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:22719248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22719248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.2728","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.2728","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2e/2b/ppat.1002739.PMC3375288.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:83e5c3061c3741d7bfcc6fe3c6682880","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/83e5c3061c3741d7bfcc6fe3c6682880","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 8, Iss 6, p e1002739 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/124098","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/HIV_Specific_Antibodies_Capable_of_ADCC_Are_Common_in_Breastmilk_and_Are_Associated_with_Reduced_Risk_of_Transmission_in_Women_with_High_Viral_Loads/124098","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.60692/6egye-yhm42","doi":"https://doi.org/10.60692/6egye-yhm42","is_oa":true,"landing_page_url":"https://doi.org/10.60692/6egye-yhm42","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/xejvx-25s75","doi":"https://doi.org/10.60692/xejvx-25s75","is_oa":true,"landing_page_url":"https://doi.org/10.60692/xejvx-25s75","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1002739","doi":"https://doi.org/10.1371/journal.ppat.1002739","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1002739","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002739&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3865545756","display_name":"AIDS International Training and Research Program","funder_award_id":"D43TW000007","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"},{"id":"https://openalex.org/G4654858350","display_name":"The role of antibodies in mother to child HIV transmission","funder_award_id":"R01AI076105","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6224628218","display_name":null,"funder_award_id":"AI076105","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000880613","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA015704","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117297429.pdf","grobid_xml":"https://content.openalex.org/works/W2117297429.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W13771988","https://openalex.org/W109927889","https://openalex.org/W320510261","https://openalex.org/W1519574375","https://openalex.org/W1526155675","https://openalex.org/W1528863278","https://openalex.org/W1529373421","https://openalex.org/W1558874088","https://openalex.org/W1559624477","https://openalex.org/W1812611692","https://openalex.org/W1860192217","https://openalex.org/W1887985700","https://openalex.org/W1909386356","https://openalex.org/W1911905725","https://openalex.org/W1965175217","https://openalex.org/W1967011492","https://openalex.org/W1970797784","https://openalex.org/W1972708677","https://openalex.org/W1977405563","https://openalex.org/W1979529463","https://openalex.org/W1990745725","https://openalex.org/W1992347020","https://openalex.org/W1995214526","https://openalex.org/W1995622193","https://openalex.org/W1998383398","https://openalex.org/W2000361373","https://openalex.org/W2002357866","https://openalex.org/W2007089984","https://openalex.org/W2014013017","https://openalex.org/W2019437320","https://openalex.org/W2021644405","https://openalex.org/W2028027326","https://openalex.org/W2031123012","https://openalex.org/W2031491768","https://openalex.org/W2036018115","https://openalex.org/W2037352835","https://openalex.org/W2040953482","https://openalex.org/W2047563805","https://openalex.org/W2053486722","https://openalex.org/W2054292852","https://openalex.org/W2054645651","https://openalex.org/W2055402290","https://openalex.org/W2069370553","https://openalex.org/W2071134665","https://openalex.org/W2080739918","https://openalex.org/W2084197987","https://openalex.org/W2084310667","https://openalex.org/W2085988761","https://openalex.org/W2089163673","https://openalex.org/W2090756925","https://openalex.org/W2095331952","https://openalex.org/W2095497026","https://openalex.org/W2097384910","https://openalex.org/W2100225119","https://openalex.org/W2100258665","https://openalex.org/W2100890648","https://openalex.org/W2102674010","https://openalex.org/W2102678302","https://openalex.org/W2103515118","https://openalex.org/W2106231392","https://openalex.org/W2107916369","https://openalex.org/W2109912655","https://openalex.org/W2110011873","https://openalex.org/W2116351132","https://openalex.org/W2118489929","https://openalex.org/W2121856068","https://openalex.org/W2124039449","https://openalex.org/W2130271632","https://openalex.org/W2134490058","https://openalex.org/W2136056069","https://openalex.org/W2137708508","https://openalex.org/W2138922145","https://openalex.org/W2139897201","https://openalex.org/W2145067766","https://openalex.org/W2146579560","https://openalex.org/W2147947123","https://openalex.org/W2151235890","https://openalex.org/W2154053721","https://openalex.org/W2155551707","https://openalex.org/W2157994668","https://openalex.org/W2158498221","https://openalex.org/W2162278954","https://openalex.org/W2164723930","https://openalex.org/W2167983396","https://openalex.org/W2168947828","https://openalex.org/W2176219107","https://openalex.org/W2178394769","https://openalex.org/W2179834311","https://openalex.org/W2317393981","https://openalex.org/W2408044878","https://openalex.org/W2908365452","https://openalex.org/W4245781185","https://openalex.org/W6674834655"],"related_works":["https://openalex.org/W7099871757","https://openalex.org/W2100890648","https://openalex.org/W2265581643","https://openalex.org/W7025180005","https://openalex.org/W4221050938","https://openalex.org/W7126309805","https://openalex.org/W2155225197","https://openalex.org/W7143528638","https://openalex.org/W2157960645","https://openalex.org/W1999972716"],"abstract_inverted_index":{"There":[0],"are":[1],"limited":[2,268],"data":[3],"describing":[4],"the":[5,73,94,103,109,151,211],"functional":[6],"characteristics":[7],"of":[8,24,126,140,146,202,226,261,275,290],"HIV-1":[9,29,178],"specific":[10,180,263],"antibodies":[11,26,67,200],"in":[12,19,44,76,115,168,174,194,210],"breast":[13,121],"milk":[14,122],"(BM)":[15],"and":[16,33,36,46,55,64,117,154,206,232,265],"their":[17],"role":[18],"breastfeeding":[20],"transmission.":[21],"The":[22,164],"ability":[23],"BM":[25,45],"to":[27,87,92,188],"bind":[28],"envelope,":[30],"neutralize":[31],"heterologous":[32,106],"autologous":[34,111],"viruses":[35,112],"direct":[37],"antibody-dependent":[38],"cell":[39],"cytotoxicity":[40],"(ADCC)":[41],"were":[42,113,139,155,183,204,221],"analyzed":[43],"plasma":[47,65,88,171,279],"obtained":[48],"soon":[49],"after":[50],"delivery":[51],"from":[52,120,213],"10":[53,147],"non-transmitting":[54],"9":[56],"transmitting":[57],"women":[58,128,276],"with":[59,158,223,246,267,277],"high":[60,278],"systemic":[61],"viral":[62,280],"loads":[63,281],"neutralizing":[66,269],"(NAbs).":[68],"Because":[69],"subtype":[70,75,80,104],"A":[71,81,105],"is":[72,287],"dominant":[74],"this":[77,272],"cohort,":[78],"a":[79,288],"envelope":[82,179,262],"variant":[83],"that":[84,100,256,283,292],"was":[85,90,172,243],"sensitive":[86],"NAbs":[89,101,138,228],"used":[91],"assess":[93],"different":[95],"antibody":[96,176],"activities.":[97],"We":[98],"found":[99],"against":[102,134],"virus":[107],"and/or":[108],"woman's":[110],"rare":[114],"IgG":[116,181,219,227,264],"IgA":[118,266],"purified":[119],"supernatant":[123],"(BMS)--only":[124],"4":[125],"19":[127,215],"had":[129],"any":[130],"detectable":[131],"NAb":[132,166],"activity":[133,167,235,286],"either":[135],"virus.":[136],"Detected":[137],"low":[141,165,259],"potency":[142],"(median":[143],"IC50":[144],"value":[145],"versus":[148,170,196],"647":[149],"for":[150,192],"corresponding":[152],"plasma)":[153],"not":[156],"associated":[157,222,245],"infant":[159,247,295],"infection":[160,248,296],"(p":[161,229,236,250],"=":[162,230,237,251],"0.58).":[163],"BMS":[169,195,212,217,233,240,257],"reflected":[173],"binding":[175],"levels:":[177],"titers":[182,220],"2.2":[184],"log(10)":[185,190],"lower":[186,191],"(compared":[187],"0.59":[189],"IgA)":[193],"plasma.":[197],"In":[198],"contrast,":[199],"capable":[201],"ADCC":[203,234,241,285],"common":[205],"could":[207],"be":[208],"detected":[209],"all":[214],"women.":[216],"envelope-specific":[218],"both":[224],"detection":[225],"0.0001)":[231],"0.014).":[238],"Importantly,":[239],"capacity":[242],"inversely":[244],"risk":[249],"0.039).":[252],"Our":[253],"findings":[254],"indicate":[255],"has":[258],"levels":[260],"activity.":[270],"However,":[271],"small":[273],"study":[274],"suggests":[282],"breastmilk":[284],"correlate":[289],"transmission":[291],"may":[293],"impact":[294],"risk.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
