{"id":"https://openalex.org/W2117290190","doi":null,"title":"A Small Molecule Modulator of Hsp90 Improves Experimental Diabetic Neuropathy","display_name":"A Small Molecule Modulator of Hsp90 Improves Experimental Diabetic Neuropathy","publication_year":2010,"publication_date":"2010-07-30","ids":{"openalex":"https://openalex.org/W2117290190","mag":"2117290190"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/6953","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/6953","pdf_url":"http://hdl.handle.net/1808/6953","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1808/6953","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087264992","display_name":"Michael J. Urban","orcid":"https://orcid.org/0000-0001-5077-7043","observed_orcids":["https://orcid.org/0000-0001-5077-7043"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Urban","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5077-7043","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087264992"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.24040000140666962,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.7080000042915344},{"id":"https://openalex.org/keywords/diabetic-peripheral-neuropathy","display_name":"diabetic peripheral neuropathy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.824999988079071},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nerve-conduction-velocity","display_name":"nerve conduction velocity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5569999814033508},{"id":"https://openalex.org/keywords/hsp90-client-proteins","display_name":"Hsp90 client proteins","score":0.6230000257492065},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.518453061580658},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.466169148683548},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4523443281650543},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.43605655431747437},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3548480272293091},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.32831448316574097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.188053697347641},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15523257851600647},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.10536515712738037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08440285921096802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/6953","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/6953","pdf_url":"http://hdl.handle.net/1808/6953","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.838.588","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.838.588","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://kuscholarworks.ku.edu/bitstream/handle/1808/6953/Urban_ku_0099M_11101_DATA_1.pdf%3Bjsessionid%3DAE37836DA43FC0814F0666006CD05DCD?sequence%3D1","raw_type":"text"},{"id":"mag:2117290190","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/bitstream/1808/6953/1/Urban_ku_0099M_11101_DATA_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/6953","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/6953","pdf_url":"http://hdl.handle.net/1808/6953","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117290190.pdf","grobid_xml":"https://content.openalex.org/works/W2117290190.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W176352299","https://openalex.org/W182330661","https://openalex.org/W653519415","https://openalex.org/W1459431390","https://openalex.org/W1599695468","https://openalex.org/W1709109739","https://openalex.org/W1984896763","https://openalex.org/W2026063851","https://openalex.org/W2101298061","https://openalex.org/W2491005338","https://openalex.org/W2530014580"],"related_works":["https://openalex.org/W2530008360","https://openalex.org/W4256093295","https://openalex.org/W2119064835","https://openalex.org/W7097620160","https://openalex.org/W7097017430","https://openalex.org/W2151059178","https://openalex.org/W2003199957","https://openalex.org/W2122055146","https://openalex.org/W2439195794","https://openalex.org/W2107449846"],"abstract_inverted_index":{"Background:":[0],"Current":[1],"Hsp90":[2,58,109,132,363],"inhibitors":[3,31],"are":[4,32],"therapeutically":[5],"problematic.":[6],"Although":[7],"they":[8],"induce":[9,76],"a":[10,22,49,61,67,218,227,239,265,283,291,328],"pro-survival":[11,62],"heat":[12,63,105],"shock":[13,64,106],"response":[14,65,107],"that":[15,26,52,73,343],"promotes":[16],"the":[17,30,40,55,91,101,104,115,147,168,205,348,382,399,412],"refolding":[18,354],"of":[19,42,57,93,103,118,131,142,149,152,158,172,215,231,295,350,358,371,384,391,401,415],"damaged":[20,360],"proteins,":[21],"confounding":[23],"issue":[24],"is":[25,261,408],"at":[27,66],"these":[28],"concentrations":[29],"cytotoxic,":[33],"due":[34],"to":[35,38,54,75,86,178,242,263,352,394],"their":[36],"ability":[37,349],"decrease":[39,112,356],"maturation":[41],"newly":[43],"synthesized":[44],"client":[45],"proteins.":[46,361],"KU-32":[47,153,177,234,253,331,392],"contains":[48],"novobiocin-based":[50],"scaffold":[51],"binds":[53],"C-terminal":[56,362],"and":[59,247,251,306,310,322,377,397],"induces":[60],"concentration":[68],"~10,000":[69],"fold":[70],"lower":[71],"than":[72],"needed":[74],"neurotoxicity.":[77],"This":[78],"creates":[79],"an":[80],"optimal":[81],"therapeutic":[82],"window":[83],"in":[84,122,245,272,304,319,327,381],"which":[85],"operate,":[87],"providing":[88],"promise":[89],"towards":[90],"development":[92],"novel":[94],"neuroprotective":[95],"agents.":[96],"Objective:":[97],"To":[98],"evaluate":[99],"whether":[100],"induction":[102],"through":[108],"modulation":[110],"could":[111],"or":[113,174,189,196,199,355],"reverse":[114],"pathophysiological":[116,413],"progression":[117,414],"diabetic":[119,124,136,159,416],"peripheral":[120],"neuropathy":[121,160],"Type-1":[123],"mice.":[125],"Hypothesis:":[126],"A":[127],"small":[128,376],"molecule":[129],"modulator":[130],"will":[133],"improve":[134,366],"experimental":[135],"neuropathy.":[137,216,417],"Methods:":[138],"After":[139],"8-12":[140],"weeks":[141,237,300],"diabetes":[143],"induced":[144],"by":[145],"streptozotocin,":[146],"effects":[148],"weekly":[150,169,228,292],"doses":[151],"on":[154,211],"several":[155,367],"standard":[156,368],"indices":[157,370],"were":[161],"measured.":[162],"Results:":[163],"Initial":[164],"toxicity":[165],"studies":[166],"employing":[167],"intraperitoneal":[170],"administration":[171],"2":[173],"20":[175,232,296],"mg/kg":[176,233,297],"non-diabetic":[179],"mice":[180,280,289],"over":[181],"6":[182,236,299],"week":[183],"duration":[184],"did":[185,254,332],"not":[186,255,333,409],"alter":[187,256,334],"motor":[188],"sensory":[190,320,335],"nerve":[191,201,323,336],"conduction":[192,324],"velocity":[193,325],"(MNCV/SNCV),":[194],"mechanical":[195,248,307],"thermal":[197,246,305],"sensitivity,":[198,249,308],"intra-epidermal":[200],"fiber":[202,337,379],"density.":[203],"Thus,":[204],"drug":[206],"alone":[207],"had":[208],"no":[209,302],"effect":[210],"altering":[212],"common":[213],"measures":[214],"In":[217,282,312],"12-week":[219,284],"intervention":[220,285,314],"study,":[221,286],"wild-type":[222],"C57":[223],"Bl/6":[224],"animals":[225,316],"receiving":[226,290],"treatment":[229,293],"regimen":[230,294],"for":[235,268,298,404,411],"exhibited":[238],"steady":[240],"recovery":[241],"control":[243],"levels":[244],"MNCV,":[250,309],"SNCV.":[252,311],"metabolic":[257,387],"control.":[258,388],"As":[259],"Hsp70":[260,277,287,403,407],"hypothesized":[262],"be":[264,395],"major":[266],"target":[267],"KU-32,":[269],"its":[270],"necessity":[271],"neuroprotection":[273],"was":[274],"examined":[275],"using":[276],"double":[278],"knockout":[279,288],"(Hsp70.1/Hsp70.3).":[281],"displayed":[301],"improvements":[303],"8-week":[313],"studies,":[315],"demonstrated":[317],"recoveries":[318],"hypoalgesia":[321],"deficits":[326],"dose-dependent":[329,396],"manner.":[330],"innervation.":[338],"Conclusions:":[339],"These":[340],"data":[341],"suggest":[342],"hyperglycemia":[344],"may":[345],"adversely":[346],"impact":[347],"neurons":[351],"promote":[353],"unfolding":[357],"mildly":[359],"modulators":[364],"can":[365],"clinical":[369],"negative":[372],"symptoms":[373],"associated":[374],"with":[375],"large":[378],"dysfunction":[380],"absence":[383],"improving":[385],"overall":[386],"The":[389],"affects":[390],"appear":[393],"require":[398],"presence":[400],"inducible":[402],"efficacy.":[405],"Inducible":[406],"required":[410]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
