{"id":"https://openalex.org/W2117267351","doi":"https://doi.org/10.1158/0008-5472.can-07-6822","title":"Signatures Associated with Rejection or Recurrence in HER-2/ neu \u2013Positive Mammary Tumors","display_name":"Signatures Associated with Rejection or Recurrence in HER-2/ neu \u2013Positive Mammary Tumors","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W2117267351","doi":"https://doi.org/10.1158/0008-5472.can-07-6822","mag":"2117267351","pmid":"https://pubmed.ncbi.nlm.nih.gov/18381452","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2478745"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-07-6822","doi":"https://doi.org/10.1158/0008-5472.can-07-6822","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-07-6822","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2478745","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080415699","display_name":"Andrea Worschech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210147757","display_name":"Genelux (United States)","ror":"https://ror.org/055afwm56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Worschech","raw_affiliation_strings":["3Immunogenetics Laboratory, Department of Transfusion Medicine, NIH, Bethesda, Maryland;","4Genelux Corp., San Diego Science Center, San Diego, California;","5Institute for Biochemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Immunogenetics Laboratory, Department of Transfusion Medicine, NIH, Bethesda, Maryland;","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"4Genelux Corp., San Diego Science Center, San Diego, California;","institution_ids":["https://openalex.org/I4210147757"]},{"raw_affiliation_string":"5Institute for Biochemistry and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074048193","display_name":"Maciej Kmieciak","orcid":"https://orcid.org/0000-0002-0889-5529","observed_orcids":["https://orcid.org/0000-0002-0889-5529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maciej Kmieciak","raw_affiliation_strings":["1Microbiology and Immunology and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Microbiology and Immunology and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031005364","display_name":"Keith L. Knutson","orcid":"https://orcid.org/0000-0001-9932-4467","observed_orcids":["https://orcid.org/0000-0001-9932-4467"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith L. Knutson","raw_affiliation_strings":["7Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064069772","display_name":"Harry D. Bear","orcid":"https://orcid.org/0000-0002-7632-9019","observed_orcids":["https://orcid.org/0000-0002-7632-9019"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry D. Bear","raw_affiliation_strings":["2Surgery, Virginia Commonwealth University School of Medicine, Massey Cancer Center, Richmond, Virginia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Surgery, Virginia Commonwealth University School of Medicine, Massey Cancer Center, Richmond, Virginia;","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110073","display_name":"Aladar A. Szalay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210147757","display_name":"Genelux (United States)","ror":"https://ror.org/055afwm56","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147757"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Aladar A. Szalay","raw_affiliation_strings":["4Genelux Corp., San Diego Science Center, San Diego, California;","6Virchow Center for Experimental Biomedicine, Institute for Biochemistry and Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Genelux Corp., San Diego Science Center, San Diego, California;","institution_ids":["https://openalex.org/I4210147757"]},{"raw_affiliation_string":"6Virchow Center for Experimental Biomedicine, Institute for Biochemistry and Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany; and","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049816096","display_name":"Ena Wang","orcid":"https://orcid.org/0000-0001-6606-6510","observed_orcids":["https://orcid.org/0000-0001-6606-6510"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ena Wang","raw_affiliation_strings":["3Immunogenetics Laboratory, Department of Transfusion Medicine, NIH, Bethesda, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Immunogenetics Laboratory, Department of Transfusion Medicine, NIH, Bethesda, Maryland;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059941996","display_name":"Francesco Maria Marincola","orcid":"https://orcid.org/0000-0001-6423-391X","observed_orcids":["https://orcid.org/0000-0001-6423-391X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesco M. Marincola","raw_affiliation_strings":["3Immunogenetics Laboratory, Department of Transfusion Medicine, NIH, Bethesda, Maryland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Immunogenetics Laboratory, Department of Transfusion Medicine, NIH, Bethesda, Maryland;","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024340698","display_name":"Masoud H. Manjili","orcid":"https://orcid.org/0000-0001-7511-2953","observed_orcids":["https://orcid.org/0000-0001-7511-2953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masoud H. Manjili","raw_affiliation_strings":["1Microbiology and Immunology and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Microbiology and Immunology and Departments of","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4966,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93233264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"7","first_page":"2436","last_page":"2446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5723000168800354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.21220000088214874,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1800999939441681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.652999997138977},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-antigen-loss","display_name":"tumor antigen loss","score":0.6209999918937683},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.5649999976158142},{"id":"https://openalex.org/keywords/tumor-immune-tolerance","display_name":"tumor immune tolerance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7979999780654907},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.6129999756813049},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8949999809265137},{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signaling","display_name":"suppressor of cytokine signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6812738180160522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6163104176521301},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6156882643699646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5680187344551086},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4846666157245636},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48163217306137085},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.42770108580589294},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.42584237456321716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4135749936103821},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3802657425403595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071222","descriptor_name":"Suppressor of Cytokine Signaling 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053701","descriptor_name":"Receptors, Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053701","descriptor_name":"Receptors, Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-07-6822","doi":"https://doi.org/10.1158/0008-5472.can-07-6822","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-07-6822","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:18381452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18381452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1412478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2478745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2478745","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2478745","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1412478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2478745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6412201502","display_name":"Enhancement of HER-2/neu-based therapy using HSP110","funder_award_id":"R01CA104757","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000888536","display_name":"Massey Cancer Center -\u00a0Cancer Center Support Grant","funder_award_id":"P30CA016059","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W28051091","https://openalex.org/W150683283","https://openalex.org/W1483828791","https://openalex.org/W1492737592","https://openalex.org/W1521600055","https://openalex.org/W1527011538","https://openalex.org/W1572267688","https://openalex.org/W1593325979","https://openalex.org/W1869421738","https://openalex.org/W1982093899","https://openalex.org/W1989076816","https://openalex.org/W1996014355","https://openalex.org/W2003683670","https://openalex.org/W2004316987","https://openalex.org/W2025657275","https://openalex.org/W2034030391","https://openalex.org/W2034763496","https://openalex.org/W2035027025","https://openalex.org/W2051221638","https://openalex.org/W2053308866","https://openalex.org/W2055853764","https://openalex.org/W2064656497","https://openalex.org/W2093630279","https://openalex.org/W2096151993","https://openalex.org/W2097531825","https://openalex.org/W2098020683","https://openalex.org/W2099312792","https://openalex.org/W2099613594","https://openalex.org/W2103018035","https://openalex.org/W2105551399","https://openalex.org/W2117139840","https://openalex.org/W2119171379","https://openalex.org/W2123817930","https://openalex.org/W2126061030","https://openalex.org/W2130147570","https://openalex.org/W2137074525","https://openalex.org/W2138722443","https://openalex.org/W2140330371","https://openalex.org/W2142300779","https://openalex.org/W2147784618","https://openalex.org/W2148523692","https://openalex.org/W2148668177","https://openalex.org/W2149752630","https://openalex.org/W2150926065","https://openalex.org/W2153629059","https://openalex.org/W2154697747","https://openalex.org/W2158697714","https://openalex.org/W2160344066","https://openalex.org/W2161691060","https://openalex.org/W2165064029","https://openalex.org/W2168669893"],"related_works":["https://openalex.org/W1621615533","https://openalex.org/W1996014355","https://openalex.org/W182866891","https://openalex.org/W2125552337","https://openalex.org/W2750783852","https://openalex.org/W1595610190","https://openalex.org/W2142483688","https://openalex.org/W2153629059","https://openalex.org/W6990584340","https://openalex.org/W2058864999"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"shown":[3],"T-cell-mediated":[4],"rejection":[5,19,95,112,143,180],"of":[6,20,25,30,36,71,98,109,120,129,149,163,183,185,200,209,216,231,234],"the":[7,47,91,106,135,189,207,229],"neu-overexpressing":[8],"mammary":[9],"carcinoma":[10],"cells":[11,54],"(MMC)":[12],"in":[13,73,205,237],"wild-type":[14,57],"FVB":[15,58],"mice.":[16,137],"However,":[17],"following":[18],"primary":[21],"tumors,":[22,100],"a":[23,28,31,42,168,225],"fraction":[24],"animals":[26],"experienced":[27],"recurrence":[29,124],"neu":[32],"antigen-negative":[33],"variant":[34],"(ANV)":[35],"MMC":[37,63,72,99,110],"(tumor":[38,86],"evasion":[39,158],"model)":[40],"after":[41],"long":[43],"latency":[44],"period.":[45],"In":[46],"present":[48],"study,":[49],"we":[50,101],"determined":[51],"that":[52,115,141,176,203],"T":[53],"derived":[55],"from":[56],"mice":[59,78],"can":[60,68],"specifically":[61],"recognize":[62],"by":[64,134],"secreting":[65],"IFN-gamma":[66],"and":[67,82,152,165,172,214,220],"induce":[69],"apoptosis":[70],"vitro.":[74],"Neu":[75],"transgenic":[76,136],"(FVBN202)":[77],"develop":[79],"spontaneous":[80],"tumors":[81],"cannot":[83],"reject":[84],"it":[85,117],"tolerance":[87,97,131,191],"model).":[88],"To":[89],"dissect":[90],"mechanisms":[92,132,202],"associated":[93],"with":[94,113,167],"or":[96,127],"compared":[102],"transcriptional":[103],"patterns":[104],"within":[105],"tumor":[107,121,157,190],"microenvironment":[108],"undergoing":[111],"those":[114],"resisted":[116],"either":[118],"because":[119,128,182],"evasion/antigen":[122],"loss":[123],"(ANV":[125],"tumors)":[126],"intrinsic":[130],"displayed":[133,194],"Gene":[138],"profiling":[139],"confirmed":[140],"immune":[142,174,195,235],"is":[144],"primarily":[145],"mediated":[146],"through":[147,198],"activation":[148,162,199],"IFN-stimulated":[150],"genes":[151],"T-cell":[153],"effector":[154],"mechanisms.":[155],"The":[156],"model":[159,192],"showed":[160],"combined":[161],"Th1":[164],"Th2":[166,171],"deviation":[169],"toward":[170],"humoral":[173],"responses":[175],"failed":[177],"to":[178],"achieve":[179],"likely":[181],"lack":[184],"target":[186],"antigen.":[187],"Interestingly,":[188],"instead":[193],"suppression":[196],"pathways":[197],"regulatory":[201],"included":[204],"particular":[206],"overexpression":[208],"interleukin-10":[210],"(IL-10),":[211],"IL-10":[212],"receptor,":[213],"suppressor":[215],"cytokine":[217],"signaling":[218],"(SOCS)-1":[219],"SOCS-3.":[221],"These":[222],"data":[223],"provide":[224],"road":[226],"map":[227],"for":[228],"identification":[230],"novel":[232],"biomarkers":[233],"responsiveness":[236],"clinical":[238],"trials.":[239]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}