{"id":"https://openalex.org/W2117219418","doi":null,"title":"The effect of ascorbate supplementation on the activity of antioxidative enzymes in the rat hypothalamus and adrenals.","display_name":"The effect of ascorbate supplementation on the activity of antioxidative enzymes in the rat hypothalamus and adrenals.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2117219418","mag":"2117219418","pmid":"https://pubmed.ncbi.nlm.nih.gov/19893079"},"language":"en","primary_location":{"id":"pmid:19893079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19893079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General physiology and biophysics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026896626","display_name":"Sinisa F. Djurasevic","orcid":"https://orcid.org/0000-0003-4406-8376","observed_orcids":["https://orcid.org/0000-0003-4406-8376"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Sinisa Djurasevic","raw_affiliation_strings":["Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, P.O.Box S2, Republic of Serbia. sine@bio.bg.ac.rs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, P.O.Box S2, Republic of Serbia. sine@bio.bg.ac.rs","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016706632","display_name":"Gordana Cviji\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordana Cvijic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101410510","display_name":"Jelena D. Djordjevic","orcid":"https://orcid.org/0000-0002-6510-1027","observed_orcids":["https://orcid.org/0000-0002-6510-1027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jelena Djordjevic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003311635","display_name":"Iva Djordjevic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iva Djordjevic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043388647","display_name":"Nebojsa I. Jasnic","orcid":"https://orcid.org/0000-0003-0333-333X","observed_orcids":["https://orcid.org/0000-0003-0333-333X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nebojsa Jasnic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080582143","display_name":"Predrag Z. Vujovic","orcid":"https://orcid.org/0000-0002-9444-4758","observed_orcids":["https://orcid.org/0000-0002-9444-4758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Predrag Vujovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"28 Spec No","issue":null,"first_page":"47","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.3564000129699707,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.75},{"id":"https://openalex.org/keywords/vitamin-c-supplementation","display_name":"vitamin C supplementation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7319999933242798},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.875},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.878000020980835},{"id":"https://openalex.org/keywords/copper-zinc-superoxide-dismutase","display_name":"copper-zinc superoxide dismutase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tissue-specific-effects","display_name":"tissue-specific effects","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.8382916450500488},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.770970344543457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7669305801391602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7645847797393799},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7342110872268677},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6394938230514526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6344574689865112},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.5738712549209595},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5546327829360962},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4778275489807129},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4776414930820465},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.4764167070388794},{"id":"https://openalex.org/C2993790521","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxide","level":4,"score":0.4227929711341858},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.41047725081443787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29291144013404846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22493776679039001},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10611355304718018}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19893079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19893079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General physiology and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W36108890","https://openalex.org/W1496352321","https://openalex.org/W1507958108","https://openalex.org/W1517698775","https://openalex.org/W1523119366","https://openalex.org/W1534324993","https://openalex.org/W1576198188","https://openalex.org/W1596210726","https://openalex.org/W1750690213","https://openalex.org/W1887679324","https://openalex.org/W1967518425","https://openalex.org/W1975938614","https://openalex.org/W1978407431","https://openalex.org/W1987370192","https://openalex.org/W1987729839","https://openalex.org/W2015380696","https://openalex.org/W2032115652","https://openalex.org/W2038561595","https://openalex.org/W2047687145","https://openalex.org/W2061242359","https://openalex.org/W2068038845","https://openalex.org/W2078843599","https://openalex.org/W2079405203","https://openalex.org/W2086673983","https://openalex.org/W2094709506","https://openalex.org/W2095584115","https://openalex.org/W2098898065","https://openalex.org/W2099271969","https://openalex.org/W2107488940","https://openalex.org/W2113112540","https://openalex.org/W2132420952","https://openalex.org/W2133617024","https://openalex.org/W2254746452","https://openalex.org/W2282466928","https://openalex.org/W3154795780"],"related_works":["https://openalex.org/W2106859974","https://openalex.org/W2032115652","https://openalex.org/W1963570716","https://openalex.org/W2469169723","https://openalex.org/W1985987401","https://openalex.org/W2056019897","https://openalex.org/W2063795296","https://openalex.org/W7131783035","https://openalex.org/W1983184573","https://openalex.org/W2101347477"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,8,12,46,54,63,68,81,84,106,117,134,146],"effect":[3],"of":[4,17,48,56,65,70,108,120,130,136],"vitamin":[5,34,91],"C":[6,35,92],"on":[7],"oxidative":[9],"status":[10],"in":[11,87,105,139],"hypothalamus":[13],"and":[14,67,111],"adrenal":[15],"glands":[16],"rats":[18],"supplemented":[19],"by":[20,102],"its":[21],"two":[22],"doses":[23],"over":[24],"a":[25],"four-week":[26],"period.":[27],"The":[28],"results":[29],"obtained":[30],"have":[31],"shown":[32],"that":[33,90],"exerts":[36],"effects":[37,75],"which":[38,76],"are":[39,77,100],"tissue":[40],"specific.":[41],"In":[42],"hypothalamus,":[43],"it":[44],"decreased":[45],"activity":[47,64,107],"copper":[49],"zinc":[50],"superoxide":[51],"dismutase":[52],"(CuZnSOD),":[53],"concentration":[55],"hydrogen":[57],"peroxide":[58],"(H2O2),":[59],"as":[60,62,113,115,143],"well":[61,114],"catalase":[66],"level":[69,135],"lipid":[71,137],"peroxidation,":[72],"thus":[73],"causing":[74],"obviously":[78],"antioxidative.":[79],"On":[80],"other":[82],"hand,":[83],"changes":[85,125],"detected":[86],"adrenals":[88,140],"indicate":[89],"there":[93],"performs":[94],"some":[95],"other,":[96],"specific":[97],"functions.":[98],"They":[99],"followed":[101],"an":[103],"increase":[104],"both":[109],"CuZnSOD":[110],"MnSOD,":[112],"with":[116],"consequent":[118],"rise":[119],"H2O2":[121],"content.":[122],"However,":[123],"these":[124],"seem":[126],"not":[127],"to":[128,145],"be":[129],"pro-oxidative":[131],"nature":[132],"since":[133],"peroxidation":[138],"remains":[141],"unchanged":[142],"compared":[144],"controls.":[147]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
