{"id":"https://openalex.org/W2117209686","doi":"https://doi.org/10.1073/pnas.95.16.9669","title":"Cardiac G s\u03b1 overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway","display_name":"Cardiac G s\u03b1 overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway","publication_year":1998,"publication_date":"1998-08-04","ids":{"openalex":"https://openalex.org/W2117209686","doi":"https://doi.org/10.1073/pnas.95.16.9669","mag":"2117209686","pmid":"https://pubmed.ncbi.nlm.nih.gov/9689139","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/21397"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.16.9669","doi":"https://doi.org/10.1073/pnas.95.16.9669","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.16.9669","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/21397","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044749698","display_name":"Alan S. Lader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan S. Lader","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109917075","display_name":"Yong-Fu Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-Fu Xiao","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701797","display_name":"Yoshihiro Ishikawa","orcid":"https://orcid.org/0000-0003-2013-0518","observed_orcids":["https://orcid.org/0000-0003-2013-0518"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshihiro Ishikawa","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109860158","display_name":"Yanning Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanning Cui","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056890673","display_name":"Dorothy E. Vatner","orcid":"https://orcid.org/0000-0002-2628-6217","observed_orcids":["https://orcid.org/0000-0002-2628-6217"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy E. Vatner","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051551818","display_name":"Stephen F. Vatner","orcid":"https://orcid.org/0000-0003-0521-8634","observed_orcids":["https://orcid.org/0000-0003-0521-8634"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen F. Vatner","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108397384","display_name":"C J Homcy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Charles J. Homcy","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","Takeda Pharmaceutical Company, Limited"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company, Limited","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065381860","display_name":"Horacio F. Cantiello","orcid":"https://orcid.org/0000-0001-7973-0804","observed_orcids":["https://orcid.org/0000-0001-7973-0804"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horacio F. Cantiello","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, Charlestown, MA 02129; Brigham and Women\u2019s Hospital, Boston, MA 02115; New England Regional Primate Research Center, Southborough, MA 01772; COR Therapeutics, South San Francisco, CA 94080; and Department of Medicine, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7819,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93833815,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"95","issue":"16","first_page":"9669","last_page":"9674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.39010000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gs-protein","display_name":"Gs protein","score":0.7020000219345093},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.949999988079071},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.7670000195503235},{"id":"https://openalex.org/keywords/calcium-current","display_name":"calcium current","score":0.6869999766349792},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8830000162124634},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7419999837875366},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.7089999914169312},{"id":"https://openalex.org/keywords/gtpgammas","display_name":"GTP gamma S","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.932602047920227},{"id":"https://openalex.org/C176303035","wikidata":"https://www.wikidata.org/wiki/Q5513929","display_name":"Gs alpha subunit","level":4,"score":0.6850818395614624},{"id":"https://openalex.org/C2778684643","wikidata":"https://www.wikidata.org/wiki/Q5514740","display_name":"GTPgammaS","level":4,"score":0.6709473133087158},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.5319935083389282},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4952374994754791},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.4950837194919586},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.4885433614253998},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4689556956291199},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.45508864521980286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44873955845832825},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4393552541732788},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4309152066707611},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.41369712352752686},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3954841196537018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3845925033092499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3677253723144531},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2412469983100891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1324670910835266}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.95.16.9669","doi":"https://doi.org/10.1073/pnas.95.16.9669","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.16.9669","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:21397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/21397","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9689139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9689139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:21397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/21397","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1167737776","display_name":null,"funder_award_id":"HL38070","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1504366507","display_name":null,"funder_award_id":"HL-45332","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1594977492","display_name":"AUTONOMIC RECEPTOR FUNCTION IN LV HYPERTROPHY &FAILURE","funder_award_id":"7r01hl037404-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1754726001","display_name":"MYOCARDIAL HYPERTROPHY AND HEART FAILURE","funder_award_id":"5p01hl038070-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2161549291","display_name":"AUTONOMIC RECEPTOR FUNCTION IN MYOCARDIAL ISCHEMIA","funder_award_id":"5r01hl045332-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4567760082","display_name":null,"funder_award_id":"HL37404","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1507252795","https://openalex.org/W1586297894","https://openalex.org/W1804785910","https://openalex.org/W1927204294","https://openalex.org/W2001105552","https://openalex.org/W2007813753","https://openalex.org/W2022183184","https://openalex.org/W2043813981","https://openalex.org/W2058031690","https://openalex.org/W2136297988","https://openalex.org/W2138722034","https://openalex.org/W2167744805","https://openalex.org/W2208630254","https://openalex.org/W4231303758"],"related_works":["https://openalex.org/W2036335460","https://openalex.org/W1980534186","https://openalex.org/W4231303758","https://openalex.org/W2117143325","https://openalex.org/W1804785910","https://openalex.org/W2138722034","https://openalex.org/W182386410","https://openalex.org/W2012007314","https://openalex.org/W2175088541","https://openalex.org/W2003740694"],"abstract_inverted_index":{"The":[0,22,80,133],"alpha":[1],"subunit":[2],"of":[3,17,24,51,73,82,90,120,145,150,156],"the":[4,13,18,49,54,117,151],"stimulatory":[5],"heterotrimeric":[6],"G":[7],"protein":[8,103,112],"(Gsalpha)":[9],"is":[10,139,148],"critical":[11],"for":[12],"beta-adrenergic":[14],"receptor":[15],"activation":[16,106,121,155],"cAMP":[19,152],"messenger":[20],"system.":[21],"role":[23,50],"Gsalpha":[25,44,52,83,137],"in":[26,122],"regulating":[27],"cardiac":[28,37,43,92],"Ca2+":[29,56],"channel":[30],"activity,":[31],"however,":[32],"remains":[33],"controversial.":[34],"Cultured":[35],"neonatal":[36],"myocytes":[38,60,93,127],"from":[39,61],"transgenic":[40,62,124],"mice":[41,63],"overexpressing":[42],"were":[45],"used":[46],"to":[47],"assess":[48],"on":[53],"whole-cell":[55],"currents":[57],"(ICa).":[58],"Cardiac":[59],"had":[64],"a":[65,111,142],"490%":[66],"higher":[67],"peak":[68],"ICa":[69,146],"compared":[70],"with":[71,94,110,130,141],"those":[72],"either":[74,123],"wild-type":[75,91,126],"controls":[76],"or":[77,125],"Gsalpha-nonexpressing":[78],"littermates.":[79],"effect":[81,98],"overexpression":[84,138],"was":[85,99],"mimicked":[86],"by":[87,102],"intracellular":[88,108],"dialysis":[89],"GTPgammaS-activated":[95],"Gsalpha.":[96,132],"This":[97],"not":[100],"mediated":[101],"kinase":[104,113],"A":[105,114],"as":[107],"perfusion":[109],"inhibitor":[115],"rendered":[116],"same":[118],"degree":[119],"also":[128],"dialyzed":[129],"activated":[131],"data":[134],"indicate":[135],"that":[136],"associated":[140],"constitutive":[143],"enhancement":[144],"which":[147],"independent":[149],"pathway":[153],"and":[154],"endogenous":[157],"adenylyl":[158],"cyclase.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
