{"id":"https://openalex.org/W2117146302","doi":null,"title":"Pharmacokinetics and immunological aspects of a phase Ib study with intratumoral administration of recombinant human interleukin-12 in patients with head and neck squamous cell carcinoma: a decrease of T-bet in peripheral blood mononuclear cells.","display_name":"Pharmacokinetics and immunological aspects of a phase Ib study with intratumoral administration of recombinant human interleukin-12 in patients with head and neck squamous cell carcinoma: a decrease of T-bet in peripheral blood mononuclear cells.","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2117146302","mag":"2117146302","pmid":"https://pubmed.ncbi.nlm.nih.gov/12912941"},"language":"en","primary_location":{"id":"pmid:12912941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12912941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110207584","display_name":"Carla ML van Herpen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carla M Van Herpen","raw_affiliation_strings":["Department of Medical Oncology, UMC Nijmegen, 6500 HB Nijmegen, the Netherlands. vanherpen@onco.umcn,nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, UMC Nijmegen, 6500 HB Nijmegen, the Netherlands. vanherpen@onco.umcn,nl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011668598","display_name":"Richard J.F. Huijbens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Huijbens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110063769","display_name":"Maaike W.G. Looman","orcid":"https://orcid.org/0009-0009-8598-8153","observed_orcids":["https://orcid.org/0009-0009-8598-8153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maaike Looman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054219763","display_name":"I. Jolanda M. de Vries","orcid":"https://orcid.org/0000-0002-8653-4040","observed_orcids":["https://orcid.org/0000-0002-8653-4040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanda De Vries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111964828","display_name":"Henri A. M. Marres","orcid":"https://orcid.org/0000-0003-3096-7071","observed_orcids":["https://orcid.org/0000-0003-3096-7071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henri Marres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013771619","display_name":"Johanna Van De Ven","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Van De Ven","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109228856","display_name":"Rob C. Hermsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rob Hermsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015323424","display_name":"Gosse J. Adema","orcid":"https://orcid.org/0000-0002-6750-1665","observed_orcids":["https://orcid.org/0000-0002-6750-1665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gosse J Adema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111940929","display_name":"P H de Mulder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter H De Mulder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1421,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.75389585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"8","first_page":"2950","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.43849998712539673,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.43849998712539673,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.43290001153945923,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8830000162124634},{"id":"https://openalex.org/keywords/t-bet","display_name":"T-bet","score":0.7400000095367432},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8619999885559082},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.43299999833106995},{"id":"https://openalex.org/keywords/immunotherapy-safety","display_name":"immunotherapy safety","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7422212362289429},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6120753288269043},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5796016454696655},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5016689300537109},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.49788856506347656},{"id":"https://openalex.org/C2994460389","wikidata":"https://www.wikidata.org/wiki/Q681817","display_name":"Epidermoid carcinoma","level":3,"score":0.46996021270751953},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46967703104019165},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44841471314430237},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.43736231327056885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4291870594024658},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4249255359172821},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4227454960346222},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.41854792833328247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38012462854385376},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3624168038368225},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.31131747364997864},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.15308701992034912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13893836736679077},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:12912941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12912941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/139526","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/139526","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/139526","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/139526","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research, 9, 2950 - 6","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2117146302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12912941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W249403745","https://openalex.org/W1498677439","https://openalex.org/W1502100938","https://openalex.org/W1517571912","https://openalex.org/W1601403499","https://openalex.org/W1644502582","https://openalex.org/W1821988420","https://openalex.org/W1829938205","https://openalex.org/W1870442784","https://openalex.org/W1912635098","https://openalex.org/W1967261754","https://openalex.org/W1970847065","https://openalex.org/W2011754426","https://openalex.org/W2015201031","https://openalex.org/W2021961431","https://openalex.org/W2029374116","https://openalex.org/W2052001899","https://openalex.org/W2053164450","https://openalex.org/W2053935255","https://openalex.org/W2058279983","https://openalex.org/W2060053956","https://openalex.org/W2072658421","https://openalex.org/W2073765371","https://openalex.org/W2075526337","https://openalex.org/W2087372329","https://openalex.org/W2090269742","https://openalex.org/W2100510996","https://openalex.org/W2102156468","https://openalex.org/W2117597053","https://openalex.org/W2119969523","https://openalex.org/W2121136366","https://openalex.org/W2134917311","https://openalex.org/W2140114661","https://openalex.org/W2145110081","https://openalex.org/W2151707711","https://openalex.org/W2413192894","https://openalex.org/W2415072931"],"related_works":["https://openalex.org/W2119970942","https://openalex.org/W2121136366","https://openalex.org/W2139340015","https://openalex.org/W2051121992","https://openalex.org/W7094274440","https://openalex.org/W2119723878","https://openalex.org/W2783557761","https://openalex.org/W2140114661","https://openalex.org/W2100510996","https://openalex.org/W1821988420"],"abstract_inverted_index":{"The":[0,47],"aim":[1],"of":[2,10,37,58,74,79,120,149,172,176,188,221],"this":[3],"study":[4],"was":[5,51,86,108,198,225,236],"to":[6,44,52,180],"evaluate":[7],"the":[8,54,70,106,181],"tolerability":[9],"intratumoral":[11,59],"administered":[12],"recombinant":[13],"human":[14],"interleukin-12":[15],"(rhIL-12)":[16],"in":[17,62,94,110,117,163,190,241],"patients":[18,27],"with":[19,88,203],"head":[20,63],"and":[21,56,64,72,76,124,132,143,151,234,239],"neck":[22,65],"squamous":[23,66],"cell":[24,67],"carcinoma.":[25],"Six":[26],"were":[28,82,136,139,153,213],"treated":[29],"once":[30],"a":[31,169,193,218,222],"week":[32],"at":[33,230],"two":[34],"dose":[35,232],"levels":[36,233],"100":[38],"or":[39,210],"300":[40],"ng/kg,":[41],"respectively,":[42],"up":[43],"24":[45,144],"weeks.":[46],"primary":[48],"end":[49],"point":[50],"assess":[53],"toxicity":[55],"safety":[57],"injected":[60],"rhIL-12":[61,75,107,229],"carcinoma":[68],"patients;":[69],"pharmacokinetics":[71],"pharmacodynamics":[73],"any":[77],"evidence":[78],"antitumor":[80],"effect":[81],"also":[83],"determined.":[84],"Toxicity":[85],"mild,":[87],"prolonged":[89],"grade":[90],"4":[91],"lymphopenia":[92],"observed":[93,137],"only":[95],"one":[96,216],"patient.":[97],"No":[98,208],"dose-limiting":[99],"toxicities":[100],"occurred.":[101],"In":[102,215,227],"all":[103,125],"six":[104],"patients,":[105],"detectable":[109],"plasma":[111,147],"within":[112],"30":[113],"min.":[114],"Significant":[115],"reductions":[116],"absolute":[118],"number":[119],"peripheral":[121,164],"blood":[122,165],"lymphocytes":[123],"lymphocyte":[126],"subsets,":[127],"especially":[128],"cytotoxic":[129],"T":[130],"cells":[131,167],"natural":[133],"killer":[134],"cells,":[135],"that":[138],"maximal":[140],"between":[141],"12":[142,156,201],"h.":[145,157,207],"Maximal":[146],"concentrations":[148],"IFN-gamma":[150,175],"IL-10":[152],"detected":[154,199],"after":[155,200,205],"A":[158],"real-time":[159],"semiquantitative":[160],"PCR":[161],"analysis":[162],"mononuclear":[166],"showed":[168],"mean":[170],"increase":[171],"mRNA":[173],"encoding":[174],"2.2":[177],"times":[178],"relative":[179],"pretreatment":[182],"sample.":[183],"An":[184],"unexpected,":[185],"significant":[186],"decrease":[187],"80%":[189],"T-bet":[191],"mRNA,":[192],"T-helper":[194],"1":[195],"transcription":[196],"factor,":[197],"h,":[202],"normalization":[204],"48-72":[206],"complete":[209],"partial":[211],"responses":[212],"observed.":[214],"patient,":[217],"40%":[219],"regression":[220],"tumor":[223],"lesion":[224],"noted.":[226],"conclusion,":[228],"these":[231],"schedule":[235],"well":[237],"tolerated":[238],"resulted":[240],"measurable":[242],"immunological":[243],"responses.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}