{"id":"https://openalex.org/W2117086734","doi":"https://doi.org/10.5858/1999-123-1030-mrdihd","title":"Minimal Residual Disease in Hematologic Disorders","display_name":"Minimal Residual Disease in Hematologic Disorders","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2117086734","doi":"https://doi.org/10.5858/1999-123-1030-mrdihd","mag":"2117086734","pmid":"https://pubmed.ncbi.nlm.nih.gov/10539902"},"language":"en","primary_location":{"id":"doi:10.5858/1999-123-1030-mrdihd","doi":"https://doi.org/10.5858/1999-123-1030-mrdihd","is_oa":false,"landing_page_url":"https://doi.org/10.5858/1999-123-1030-mrdihd","pdf_url":null,"source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046097970","display_name":"Stefan H Faderl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Faderl","raw_affiliation_strings":["From the Department of Bioimmunotheraphy, The University of Texas M. D. Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioimmunotheraphy, The University of Texas M. D. Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["From the Department of Bioimmunotheraphy, The University of Texas M. D. Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioimmunotheraphy, The University of Texas M. D. Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084290698","display_name":"Zeev E. Estrov","orcid":"https://orcid.org/0000-0002-1623-3613","observed_orcids":["https://orcid.org/0000-0002-1623-3613"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeev Estrov","raw_affiliation_strings":["From the Department of Bioimmunotheraphy, The University of Texas M. D. Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioimmunotheraphy, The University of Texas M. D. Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.2809,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.32731959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"123","issue":"11","first_page":"1030","last_page":"1034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":1.0},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.765999972820282},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/polymerase-chain-reaction-detection","display_name":"polymerase chain reaction detection","score":0.7300000190734863},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6650000214576721},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.656000018119812},{"id":"https://openalex.org/keywords/mrd-quantification","display_name":"MRD quantification","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mrd-kinetics","display_name":"MRD kinetics","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.8453570008277893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6455435752868652},{"id":"https://openalex.org/C2908741605","wikidata":"https://www.wikidata.org/wiki/Q1963588","display_name":"Hematologic disorders","level":2,"score":0.6285819411277771},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5595948696136475},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.4656204879283905},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.46318507194519043},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4584585726261139},{"id":"https://openalex.org/C2780571819","wikidata":"https://www.wikidata.org/wiki/Q1963588","display_name":"Hematologic disease","level":3,"score":0.4392929971218109},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3966427147388458},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3415876626968384}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5858/1999-123-1030-mrdihd","doi":"https://doi.org/10.5858/1999-123-1030-mrdihd","is_oa":false,"landing_page_url":"https://doi.org/10.5858/1999-123-1030-mrdihd","pdf_url":null,"source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:10539902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10539902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W38386901","https://openalex.org/W44995847","https://openalex.org/W126560450","https://openalex.org/W157448823","https://openalex.org/W955722544","https://openalex.org/W990603645","https://openalex.org/W1489279917","https://openalex.org/W1599349966","https://openalex.org/W1901038908","https://openalex.org/W1917754692","https://openalex.org/W1978319003","https://openalex.org/W1989390667","https://openalex.org/W1994523925","https://openalex.org/W2001823585","https://openalex.org/W2010604055","https://openalex.org/W2011802271","https://openalex.org/W2028978029","https://openalex.org/W2032118018","https://openalex.org/W2037825615","https://openalex.org/W2040899872","https://openalex.org/W2059168305","https://openalex.org/W2063137898","https://openalex.org/W2068661008","https://openalex.org/W2073134303","https://openalex.org/W2144538585","https://openalex.org/W2153400118","https://openalex.org/W2171235287","https://openalex.org/W2258838187","https://openalex.org/W2271826278","https://openalex.org/W2302140131","https://openalex.org/W2339313676","https://openalex.org/W2339475636","https://openalex.org/W2343436836","https://openalex.org/W2396282782","https://openalex.org/W2401025033","https://openalex.org/W2401640396","https://openalex.org/W2404442542","https://openalex.org/W2413182788","https://openalex.org/W2413426251","https://openalex.org/W2416529880","https://openalex.org/W2470477094","https://openalex.org/W6648350475"],"related_works":["https://openalex.org/W2124037560","https://openalex.org/W2404786875","https://openalex.org/W4251671217","https://openalex.org/W4410900208","https://openalex.org/W2121511154","https://openalex.org/W112228619","https://openalex.org/W2129178107","https://openalex.org/W2412058003","https://openalex.org/W1544026905","https://openalex.org/W2095164091"],"abstract_inverted_index":{"In":[0],"almost":[1],"no":[2],"other":[3],"area":[4],"of":[5,11,15,32,48,53,104,114,124],"medical":[6],"oncology":[7],"has":[8,28],"the":[9,30,98,112,122],"introduction":[10],"new":[12,95],"drugs,":[13],"combinations":[14],"chemotherapeutic":[16],"agents,":[17],"and":[18,44,79,92,102,116,127],"novel":[19],"biologic":[20],"treatments":[21],"caused":[22],"such":[23,83],"dramatic":[24],"responses":[25],"as":[26,84,119],"it":[27],"in":[29,75,111,121],"treatment":[31],"malignant":[33],"hematologic":[34],"disorders.":[35],"However,":[36],"despite":[37],"some":[38],"therapeutic":[39],"success,":[40],"many":[41],"patients":[42],"relapse":[43],"die":[45],"from":[46],"recurrence":[47],"their":[49],"disease.":[50],"The":[51],"implications":[52],"minimal":[54],"residual":[55],"disease":[56,62],"(MRD),":[57],"a":[58],"term":[59],"referring":[60],"to":[61],"that":[63],"is":[64],"undetectable":[65],"by":[66],"conventional":[67],"morphologic":[68],"methods,":[69],"have":[70,89],"therefore":[71],"attracted":[72],"increasing":[73],"attention":[74],"recent":[76],"years.":[77],"New":[78],"powerful":[80],"laboratory":[81],"tools":[82],"polymerase":[85],"chain":[86],"reaction":[87],"assays":[88],"extraordinary":[90],"sensitivity":[91],"provide":[93],"exciting":[94],"insights":[96],"into":[97],"detection,":[99],"nature,":[100],"quantification,":[101],"kinetics":[103],"MRD.":[105],"This":[106],"article":[107],"summarizes":[108],"methods":[109],"used":[110],"identification":[113],"MRD":[115],"its":[117],"importance":[118],"exemplified":[120],"case":[123],"acute":[125],"leukemias":[126],"chronic":[128],"myelogenous":[129],"leukemia.":[130]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}