{"id":"https://openalex.org/W2117055698","doi":"https://doi.org/10.1016/j.jalz.2011.05.604","title":"P1\u2010324: Depression predicts progressive brain atrophy in mild cognitive impairment","display_name":"P1\u2010324: Depression predicts progressive brain atrophy in mild cognitive impairment","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2117055698","doi":"https://doi.org/10.1016/j.jalz.2011.05.604","mag":"2117055698"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2011.05.604","doi":"https://doi.org/10.1016/j.jalz.2011.05.604","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.604","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Grace Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Lee","raw_affiliation_strings":["UCLA Los Angeles California United States","UCLA Easton Center for Alzheimer's Disease Research, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Los Angeles California United States","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"UCLA Easton Center for Alzheimer's Disease Research, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089954565","display_name":"Po\u2010Haong Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Po\u2010Haong Lu","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100548510","display_name":"Xue Hua","orcid":"https://orcid.org/0009-0007-7625-4049","observed_orcids":["https://orcid.org/0009-0007-7625-4049"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Hua","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015249191","display_name":"Suh Lee","orcid":"https://orcid.org/0000-0003-1611-8495","observed_orcids":["https://orcid.org/0000-0003-1611-8495"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suh Lee","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035692604","display_name":"Alex Leow","orcid":"https://orcid.org/0000-0002-5660-8651","observed_orcids":["https://orcid.org/0000-0002-5660-8651"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Leow","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111910726","display_name":"Stephanie Wu","orcid":"https://orcid.org/0009-0009-7169-5341","observed_orcids":["https://orcid.org/0009-0009-7169-5341"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Wu","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103506378","display_name":"Ken Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken Nguyen","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032754420","display_name":"Edmond Teng","orcid":"https://orcid.org/0000-0002-1375-857X","observed_orcids":["https://orcid.org/0000-0002-1375-857X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210156876","display_name":"VA Greater Los Angeles Healthcare System","ror":"https://ror.org/05xcarb80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmond Teng","raw_affiliation_strings":["Greater Los Angeles VA/UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greater Los Angeles VA/UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210156876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073660758","display_name":"George Bartzokis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Bartzokis","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014949118","display_name":"Arthur W. Toga","orcid":"https://orcid.org/0000-0001-7902-3755","observed_orcids":["https://orcid.org/0000-0001-7902-3755","https://orcid.org/0000-0003-1454-8643"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur Toga","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford Jack","raw_affiliation_strings":["Mayo Clinic, Rochester, Minnesota;, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, Minnesota;, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102977342","display_name":"Michael Walter Weiner","orcid":"https://orcid.org/0000-0002-0144-1954","observed_orcids":["https://orcid.org/0000-0002-0144-1954","https://orcid.org/0000-0002-7601-0702","https://orcid.org/0000-0002-0877-4583"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Weiner","raw_affiliation_strings":["VA/UCSF San Francisco California United States","Veterans Affairs and UCSF, San Francisco, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA/UCSF San Francisco California United States","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Veterans Affairs and UCSF, San Francisco, California, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867","observed_orcids":["https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0003-2476-2803","https://orcid.org/0000-0002-2305-8438"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Thompson","raw_affiliation_strings":["UCLA, Los Angeles, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA, Los Angeles, California, United States","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.4363,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69172353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"4S_Part_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7572890520095825},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7209900617599487},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6119351387023926},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.5747742652893066},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5536405444145203},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5228319764137268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48288798332214355},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.4802270531654358},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4604395627975464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4062078595161438},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38149136304855347},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.36234164237976074},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.337636798620224},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30179694294929504},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2011.05.604","doi":"https://doi.org/10.1016/j.jalz.2011.05.604","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2011.05.604","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4252548870","https://openalex.org/W2086220368","https://openalex.org/W2617929137","https://openalex.org/W2076917672","https://openalex.org/W2015582590","https://openalex.org/W2110626362","https://openalex.org/W1998666651","https://openalex.org/W2083528533","https://openalex.org/W235510190","https://openalex.org/W1972923385"],"abstract_inverted_index":{"Depression":[0],"has":[1],"been":[2],"shown":[3],"to":[4,15,38,89,145,184,228,230],"predict":[5],"higher":[6],"rates":[7,154],"of":[8,43,150,168,210],"progression":[9,42],"from":[10,55,87,108],"mild":[11],"cognitive":[12],"impairment":[13],"(MCI)":[14],"Alzheimer's":[16,57],"disease":[17],"(AD).":[18],"The":[19,82,166],"current":[20],"study":[21],"examined":[22],"the":[23,40,56,79,109,163],"underlying":[24,201],"neuroanatomical":[25],"changes":[26,203],"associated":[27,175],"with":[28,49,65,115,122,134,176,197],"depression":[29,117,128,194],"in":[30,46,78,85,171,181,195,220],"MCI":[31,47,66,172,198,222],"patients.":[32],"Tensor-based":[33],"morphometry":[34],"(TBM)":[35],"was":[36,143,174],"used":[37,144],"compare":[39],"longitudinal":[41],"brain":[44,152],"atrophy":[45,153,180],"patients":[48,223],"and":[50,67,73,133],"without":[51],"depression.":[52],"245":[53],"subjects":[54,173],"Disease":[58],"Neuroimaging":[59],"Initiative":[60],"(ADNI)":[61],"who":[62,224],"were":[63,76,99,159],"diagnosed":[64],"had":[68],"MRI":[69],"scans":[70],"at":[71],"baseline":[72],"2-year":[74],"follow-up":[75],"included":[77],"present":[80],"study.":[81],"subjects,":[83],"ranging":[84],"age":[86,92],"55":[88],"90":[90],"(mean":[91],"=":[93,97,120,131,140],"74.9":[94],"years,":[95],"sd":[96],"7.0),":[98],"divided":[100],"into":[101],"three":[102,164],"groups":[103],"based":[104],"on":[105],"their":[106],"scores":[107],"Neuropsychiatric":[110],"Inventory":[111],"Questionnaire":[112],"(NPI-Q):":[113],"individuals":[114,196],"reported":[116],"(DEP,":[118],"n":[119,130,139],"47),":[121],"any":[123],"other":[124],"neuropsychiatric":[125,136],"symptom":[126],"except":[127],"(OTHER,":[129],"92),":[132],"no":[135],"symptoms":[137,170,212],"(NOSYMP,":[138],"106).":[141],"TBM":[142],"create":[146],"3D":[147],"Jacobian":[148],"maps":[149],"local":[151],"for":[155],"individual":[156],"participants,":[157],"which":[158],"then":[160],"compared":[161],"across":[162],"groups.":[165],"presence":[167],"depressive":[169,211],"increased":[177],"white":[178],"matter":[179],"regions":[182],"known":[183],"be":[185,214],"affected":[186],"as":[187],"AD":[188],"progresses.":[189],"These":[190],"findings":[191],"suggest":[192],"that":[193,204],"may":[199,213],"reflect":[200],"pathological":[202],"represent":[205],"prodromal":[206],"AD.":[207,231],"Thus,":[208],"assessment":[209],"a":[215],"potentially":[216],"useful":[217],"clinical":[218],"marker":[219],"identifying":[221],"are":[225],"most":[226],"likely":[227],"progress":[229]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
