{"id":"https://openalex.org/W2117023724","doi":"https://doi.org/10.1093/molbev/msi122","title":"Evolution of Proteins and Gene Expression Levels are Coupled in Drosophila and are Independently Associated with mRNA Abundance, Protein Length, and Number of Protein-Protein Interactions","display_name":"Evolution of Proteins and Gene Expression Levels are Coupled in Drosophila and are Independently Associated with mRNA Abundance, Protein Length, and Number of Protein-Protein Interactions","publication_year":2005,"publication_date":"2005-02-09","ids":{"openalex":"https://openalex.org/W2117023724","doi":"https://doi.org/10.1093/molbev/msi122","mag":"2117023724","pmid":"https://pubmed.ncbi.nlm.nih.gov/15746013"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msi122","doi":"https://doi.org/10.1093/molbev/msi122","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msi122","pdf_url":"https://academic.oup.com/mbe/article-pdf/22/5/1345/6314913/msi122.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mbe/article-pdf/22/5/1345/6314913/msi122.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020961284","display_name":"Bernardo Lemos","orcid":"https://orcid.org/0000-0001-6996-9483","observed_orcids":["https://orcid.org/0000-0001-6996-9483"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. Lemos","raw_affiliation_strings":["Department of Organismic and Evolutionary Biology, Harvard University, USA. blemos@oeb.harvard.edu","Department of Organismic and Evolutionary Biology, Harvard University,,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology, Harvard University, USA. blemos@oeb.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology, Harvard University,,USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020961284"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":8.4505,"has_fulltext":true,"cited_by_count":256,"citation_normalized_percentile":{"value":0.98439874,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"22","issue":"5","first_page":"1345","last_page":"1354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gene-expression-evolution","display_name":"gene expression evolution","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.859000027179718},{"id":"https://openalex.org/keywords/protein-length","display_name":"protein length","score":0.6470000147819519},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-expression-polymorphism","display_name":"gene expression polymorphism","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gene-expression-divergence","display_name":"gene expression divergence","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.8270000219345093},{"id":"https://openalex.org/keywords/amino-acid-substitution-rates","display_name":"amino acid substitution rates","score":0.6600000262260437},{"id":"https://openalex.org/keywords/stabilizing-selection","display_name":"stabilizing selection","score":0.902999997138977},{"id":"https://openalex.org/keywords/regulatory-evolution","display_name":"regulatory evolution","score":0.6740000247955322},{"id":"https://openalex.org/keywords/structural-evolution","display_name":"structural evolution","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8954095840454102},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6783831119537354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6656602025032043},{"id":"https://openalex.org/C87253356","wikidata":"https://www.wikidata.org/wiki/Q1106472","display_name":"Codon usage bias","level":4,"score":0.5668171644210815},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5054688453674316},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.45619329810142517},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.450477659702301},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4392591714859009},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.43804699182510376},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.416734516620636},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41002780199050903},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.19646748900413513}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/molbev/msi122","doi":"https://doi.org/10.1093/molbev/msi122","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msi122","pdf_url":"https://academic.oup.com/mbe/article-pdf/22/5/1345/6314913/msi122.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:15746013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15746013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1093/molbev/msi122","doi":"https://doi.org/10.1093/molbev/msi122","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msi122","pdf_url":"https://academic.oup.com/mbe/article-pdf/22/5/1345/6314913/msi122.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117023724.pdf","grobid_xml":"https://content.openalex.org/works/W2117023724.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W791550880","https://openalex.org/W1489817806","https://openalex.org/W1529046634","https://openalex.org/W1539505222","https://openalex.org/W1543415010","https://openalex.org/W1546563018","https://openalex.org/W1774748215","https://openalex.org/W1918164078","https://openalex.org/W1945308210","https://openalex.org/W1971977350","https://openalex.org/W1982309495","https://openalex.org/W1990453950","https://openalex.org/W1995521133","https://openalex.org/W1996529795","https://openalex.org/W2009533642","https://openalex.org/W2026139443","https://openalex.org/W2029158589","https://openalex.org/W2038437697","https://openalex.org/W2053685560","https://openalex.org/W2054755820","https://openalex.org/W2060020017","https://openalex.org/W2065172786","https://openalex.org/W2065669781","https://openalex.org/W2078146553","https://openalex.org/W2080182143","https://openalex.org/W2080717550","https://openalex.org/W2095805667","https://openalex.org/W2097805330","https://openalex.org/W2101868204","https://openalex.org/W2102225814","https://openalex.org/W2104099887","https://openalex.org/W2104315543","https://openalex.org/W2106882534","https://openalex.org/W2110225946","https://openalex.org/W2113275510","https://openalex.org/W2113992630","https://openalex.org/W2115011276","https://openalex.org/W2116088151","https://openalex.org/W2116843300","https://openalex.org/W2117590880","https://openalex.org/W2117936709","https://openalex.org/W2128572161","https://openalex.org/W2129922751","https://openalex.org/W2130871092","https://openalex.org/W2131160279","https://openalex.org/W2134541788","https://openalex.org/W2136749660","https://openalex.org/W2141652419","https://openalex.org/W2142055410","https://openalex.org/W2144885342","https://openalex.org/W2147398075","https://openalex.org/W2150989284","https://openalex.org/W2163480486","https://openalex.org/W2164242630","https://openalex.org/W2170700353","https://openalex.org/W3103071483","https://openalex.org/W3143610562","https://openalex.org/W4234809691","https://openalex.org/W4249966633","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2080717550","https://openalex.org/W2058504948","https://openalex.org/W1529046634","https://openalex.org/W4408182814","https://openalex.org/W2042591828","https://openalex.org/W2887393223","https://openalex.org/W2115847425","https://openalex.org/W7124155757","https://openalex.org/W2068541733","https://openalex.org/W2110705025"],"abstract_inverted_index":{"Organismic":[0],"evolution":[1,105,317],"requires":[2],"that":[3,117,133,172,223,239,251],"variation":[4,74],"at":[5,191,216],"distinct":[6],"hierarchical":[7],"levels":[8,199],"and":[9,21,67,89,100,110,128,154,166,186,204,211,235,238,254,292,303,315],"attributes":[10,44,79,99],"be":[11,189,214],"coherently":[12],"integrated,":[13],"often":[14],"in":[15,75,140,242,267,278],"the":[16,28,37,78,104,135,161,268,297],"face":[17],"of":[18,27,31,72,77,87,106,137,177,200,232,247,265,273,276],"disparate":[19],"environmental":[20],"genetic":[22,68],"pressures.":[23],"A":[24],"central":[25],"part":[26],"evolutionary":[29,73,85,261],"analysis":[30,86],"biological":[32,301],"systems":[33],"remains":[34],"to":[35,93,182,188,207,213,259,310],"decipher":[36],"causal":[38,298],"connections":[39,299],"between":[40,164],"organism-wide":[41],"(or":[42],"genome-wide)":[43],"(e.g.,":[45],"mRNA":[46,193,218,236,285],"abundance,":[47],"protein":[48,88,108,118,146,224,252,281],"length,":[49],"codon":[50],"bias,":[51],"recombination":[52],"rate,":[53,57],"genomic":[54,98],"position,":[55],"mutation":[56],"etc)":[58],"as":[59,61,148,150,290],"well":[60,149],"their":[62,101],"role-together":[63],"with":[64,103,123,145,174,197,229],"mutation,":[65],"selection,":[66],"drift-in":[69],"shaping":[70],"patterns":[71],"any":[76],"themselves.":[80],"Here":[81],"we":[82,170,221],"combine":[83],"genome-wide":[84],"gene":[90,111,125,151,201,255],"expression":[91,112,126,152,202,256],"data":[92,294],"highlight":[94],"fundamental":[95],"relationships":[96],"among":[97,300],"associations":[102],"both":[107,124,230],"sequences":[109,253],"levels.":[113],"Our":[114],"results":[115],"show":[116,131,171,222,244],"divergence":[119,147,203],"is":[120,142,226],"positively":[121],"coupled":[122],"polymorphism":[127,153,205],"divergence.":[129,248],"We":[130,249,287],"moreover":[132],"although":[134],"number":[136,231],"protein-protein":[138,156,233],"interactions":[139,157,234],"Drosophila":[141,243],"negatively":[143,227],"associated":[144,228],"divergence,":[155],"cannot":[158],"account":[159],"for":[160],"observed":[162],"coupling":[163],"regulatory":[165,316],"structural":[167,314],"evolution.":[168],"Furthermore,":[169],"proteins":[173,241],"higher":[175,198,217],"rates":[176],"amino":[178],"acid":[179],"substitutions":[180],"tend":[181,187,206,212],"have":[183,208],"larger":[184],"sizes":[185,210],"expressed":[190,215],"lower":[192],"abundances,":[194],"whereas":[195],"genes":[196],"shorter":[209],"abundances.":[219],"Finally,":[220],"length":[225],"abundance":[237],"interacting":[240],"similar":[245,260],"amounts":[246],"suggest":[250],"are":[257,306],"subjected":[258],"dynamics,":[262],"possibly":[263],"because":[264],"similarity":[266],"fitness":[269],"effect":[270],"(i.e.,":[271],"strength":[272],"stabilizing":[274],"selection)":[275],"disruptions":[277],"a":[279],"gene's":[280],"sequence":[282],"or":[283,312],"its":[284],"expression.":[286],"conclude":[288],"that,":[289],"more":[291],"better":[293],"accumulate,":[295],"understanding":[296],"traits":[302],"how":[304],"they":[305],"integrated":[307],"over":[308],"time":[309],"constrain":[311],"promote":[313],"may":[318],"finally":[319],"become":[320],"possible.":[321]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":21}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
