{"id":"https://openalex.org/W2117006916","doi":null,"title":"Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products","display_name":"Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2117006916","mag":"2117006916"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-108010","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-108010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-108010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110214064","display_name":"Anders E. G. Lindgren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anders E. G. Lindgren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110214064"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.444599986076355,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.444599986076355,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adp-ribosyltransferase","display_name":"ADP-ribosyltransferase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"virtual screening","score":0.8050000071525574},{"id":"https://openalex.org/keywords/thermal-shift-assay","display_name":"thermal shift assay","score":0.7120000123977661},{"id":"https://openalex.org/keywords/alphascreen","display_name":"AlphaScreen","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hopeaphenol","display_name":"hopeaphenol","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.8679999709129333},{"id":"https://openalex.org/keywords/epsilon-viniferin","display_name":"\u03b5-viniferin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/resveratrol-dimers","display_name":"resveratrol dimers","score":0.8289999961853027},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6940722465515137},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5053067803382874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4854724705219269},{"id":"https://openalex.org/C35753019","wikidata":"https://www.wikidata.org/wiki/Q644785","display_name":"Total synthesis","level":2,"score":0.4347127377986908},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.4232184588909149},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4145708382129669},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.37387919425964355},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2519950270652771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2073574960231781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17043137550354004},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-108010","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-108010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2117006916","doi":null,"is_oa":false,"landing_page_url":"https://umu.diva-portal.org/smash/get/diva2:850251/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-108010","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-108010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W63021665","https://openalex.org/W136004727","https://openalex.org/W158273916","https://openalex.org/W622214625","https://openalex.org/W650229644","https://openalex.org/W1502236509","https://openalex.org/W1563667183","https://openalex.org/W1575178924","https://openalex.org/W1596929908","https://openalex.org/W1605578858","https://openalex.org/W1796356094","https://openalex.org/W1797123055","https://openalex.org/W1825629489","https://openalex.org/W1958725539","https://openalex.org/W1963941227","https://openalex.org/W1964719327","https://openalex.org/W1965006127","https://openalex.org/W1966363887","https://openalex.org/W1966505038","https://openalex.org/W1966632784","https://openalex.org/W1967809254","https://openalex.org/W1969335186","https://openalex.org/W1972929187","https://openalex.org/W1973123264","https://openalex.org/W1975272351","https://openalex.org/W1977762520","https://openalex.org/W1984703406","https://openalex.org/W1984795781","https://openalex.org/W1984817726","https://openalex.org/W1985247661","https://openalex.org/W1985768828","https://openalex.org/W1985854865","https://openalex.org/W1993582972","https://openalex.org/W1993619396","https://openalex.org/W1995036780","https://openalex.org/W1998609465","https://openalex.org/W1999150047","https://openalex.org/W1999460643","https://openalex.org/W2000315362","https://openalex.org/W2005145276","https://openalex.org/W2005473844","https://openalex.org/W2005809344","https://openalex.org/W2007355919","https://openalex.org/W2007607335","https://openalex.org/W2012977021","https://openalex.org/W2014292583","https://openalex.org/W2014875983","https://openalex.org/W2015264243","https://openalex.org/W2017171454","https://openalex.org/W2017215338","https://openalex.org/W2017387563","https://openalex.org/W2017398555","https://openalex.org/W2017813215","https://openalex.org/W2019786724","https://openalex.org/W2020264302","https://openalex.org/W2021071631","https://openalex.org/W2021730076","https://openalex.org/W2022350916","https://openalex.org/W2024536147","https://openalex.org/W2027357300","https://openalex.org/W2028456656","https://openalex.org/W2028857014","https://openalex.org/W2033644031","https://openalex.org/W2035090605","https://openalex.org/W2035292911","https://openalex.org/W2036386693","https://openalex.org/W2037074869","https://openalex.org/W2037849836","https://openalex.org/W2038034327","https://openalex.org/W2041909191","https://openalex.org/W2042515294","https://openalex.org/W2043716459","https://openalex.org/W2051766214","https://openalex.org/W2052177327","https://openalex.org/W2052226480","https://openalex.org/W2053572188","https://openalex.org/W2056244796","https://openalex.org/W2057023085","https://openalex.org/W2058058143","https://openalex.org/W2058623521","https://openalex.org/W2059492256","https://openalex.org/W2061252410","https://openalex.org/W2063644741","https://openalex.org/W2067455153","https://openalex.org/W2068991108","https://openalex.org/W2071947177","https://openalex.org/W2072528578","https://openalex.org/W2074730941","https://openalex.org/W2076061292","https://openalex.org/W2076064777","https://openalex.org/W2076592490","https://openalex.org/W2076883432","https://openalex.org/W2078529590","https://openalex.org/W2079199763","https://openalex.org/W2079891276","https://openalex.org/W2080422741","https://openalex.org/W2083059154","https://openalex.org/W2084291773","https://openalex.org/W2084366893","https://openalex.org/W2085215116","https://openalex.org/W2085789404","https://openalex.org/W2094871139","https://openalex.org/W2095556304","https://openalex.org/W2095610366","https://openalex.org/W2096529411","https://openalex.org/W2105545849","https://openalex.org/W2106074593","https://openalex.org/W2106578000","https://openalex.org/W2109361735","https://openalex.org/W2113832407","https://openalex.org/W2116325418","https://openalex.org/W2116633922","https://openalex.org/W2117208569","https://openalex.org/W2118959494","https://openalex.org/W2120620536","https://openalex.org/W2121175754","https://openalex.org/W2130771421","https://openalex.org/W2137297265","https://openalex.org/W2138025831","https://openalex.org/W2138144563","https://openalex.org/W2140249415","https://openalex.org/W2140271440","https://openalex.org/W2141017335","https://openalex.org/W2141474275","https://openalex.org/W2143459714","https://openalex.org/W2144878722","https://openalex.org/W2149464124","https://openalex.org/W2150023287","https://openalex.org/W2150645494","https://openalex.org/W2150967773","https://openalex.org/W2153772742","https://openalex.org/W2154105741","https://openalex.org/W2155184228","https://openalex.org/W2155941123","https://openalex.org/W2158396006","https://openalex.org/W2159198762","https://openalex.org/W2159682317","https://openalex.org/W2166571825","https://openalex.org/W2166594615","https://openalex.org/W2168268248","https://openalex.org/W2169992767","https://openalex.org/W2176519340","https://openalex.org/W2177846120","https://openalex.org/W2193104832","https://openalex.org/W2312636590","https://openalex.org/W2313536468","https://openalex.org/W2318090527","https://openalex.org/W2320556745","https://openalex.org/W2322568743","https://openalex.org/W2325549177","https://openalex.org/W2326400614","https://openalex.org/W2331452414","https://openalex.org/W2416722950","https://openalex.org/W2419733808","https://openalex.org/W2950495029","https://openalex.org/W2950542499","https://openalex.org/W2950661474","https://openalex.org/W2951239291","https://openalex.org/W3101180015"],"related_works":["https://openalex.org/W1987001587","https://openalex.org/W2083059154","https://openalex.org/W2809572644","https://openalex.org/W7099255896","https://openalex.org/W2054010174","https://openalex.org/W7100921982","https://openalex.org/W3092389661","https://openalex.org/W3201316694","https://openalex.org/W3112225763","https://openalex.org/W4411284385"],"abstract_inverted_index":{"Diphtheria":[0],"Toxin-like":[1],"ADP-Ribosyltransferases":[2],"The":[3,86,193],"Human":[4],"ADP-ribosyl":[5],"transferases":[6],"(ARTDs)":[7],"are":[8,16,170],"a":[9,59,64,107,214,241,283,303],"group":[10],"of":[11,40,51,61,81,96,109,179,184,188,216,248,255,265,277,285,302,306],"poorly":[12,181],"studied":[13],"enzymes":[14],"which":[15,126,287],"believed":[17],"to":[18,77,134,146,160,200,221,269,292,308],"be":[19],"involved":[20],"in":[21,75,143,164,208,219],"e.g.":[22],"DNA":[23,162],"repair,":[24],"protein":[25],"degradation,":[26],"transcription":[27],"regulation":[28],"and":[29,84,115,158,218,235,243,310],"cell":[30],"death.":[31],"Medicinal":[32],"chemistry":[33,114],"programmes":[34],"aimed":[35],"at":[36],"developing":[37],"selective":[38,94,152],"inhibitors":[39,80,95],"these":[41,52,278],"ARTDs":[42,99],"were":[43,89,119,140,238],"initiated.":[44],"A":[45,68,151],"suitable":[46],"starting":[47],"compound":[48],"for":[49,174,229],"one":[50],"enzymes,":[53],"ARTD3,":[54],"was":[55,72,127,155,198,227],"found":[56,159,199],"by":[57,100],"screening":[58,70],"library":[60],"NAD-mimics":[62],"using":[63,106,122,240],"thermal":[65],"shift":[66],"assay.":[67,150],"virtual":[69],"protocol":[71],"instead":[73],"developed":[74,92],"order":[76,220],"find":[78],"novel":[79],"ARTD7,":[82],"8,":[83],"10.":[85],"hit":[87],"compounds":[88,169],"then":[90],"further":[91],"into":[93],"the":[97,176,180,202,224,249,253,290,300],"corresponding":[98],"systematically":[101],"varying":[102],"different":[103],"structural":[104,116,294],"features":[105],"combination":[108],"synthetic":[110,245,250],"organic":[111],"chemistry,":[112],"computational":[113],"biology.":[117],"Compounds":[118],"initially":[120],"characterized":[121,182],"differential":[123],"scanning":[124],"fluorimetry":[125],"later":[128],"replaced":[129],"with":[130],"an":[131,144,148,260,266],"enzymatic":[132],"assay":[133],"obtain":[135],"IC50":[136],"values.":[137],"Biotinylated":[138],"analogs":[139,307],"also":[141],"synthesized":[142,239],"attempt":[145],"develop":[147],"AlphaScreen":[149],"ARTD3":[153],"inhibitor":[154],"ultimately":[156],"identified":[157],"delay":[161],"repair":[163],"cells":[165],"after":[166],"\u03b3-irradiation.":[167],"These":[168],"potentially":[171],"valuable":[172],"tools":[173],"elucidating":[175],"biological":[177],"role":[178],"ARTD-family":[183],"proteins.":[185],"Total":[186],"Synthesis":[187],"Resveratrol":[189],"Based":[190],"Natural":[191],"Products":[192],"polyphenolic":[194],"natural":[195,280],"product":[196],"(-)-hopeaphenol":[197],"inhibit":[201],"type":[203],"III":[204],"secretion":[205],"system":[206],"present":[207],"certain":[209],"gram-negative":[210],"bacteria.":[211],"(-)-Hopeaphenol":[212],"is":[213],"tetramer":[215],"resveratrol":[217,232,286],"investigate":[222],"whether":[223],"entire":[225],"structure":[226],"essential":[228],"inhibition":[230],"two":[231,279],"dimers,":[233],"\u03b5-viniferin":[234,309],"ampelopsin":[236,271,311],"B,":[237],"flexible":[242],"divergent":[244],"route.":[246],"Highlights":[247],"strategy":[251,298],"include":[252,282],"use":[254],"cyclopropylmethyl":[256],"protecting":[257],"groups,":[258],"allowing":[259],"acid":[261],"mediated":[262],"three-step-one-pot":[263],"deprotection-epimerization-cyclization":[264],"advanced":[267],"intermediate":[268],"form":[270],"B.":[272,312],"All":[273],"previously":[274],"reported":[275],"syntheses":[276],"products":[281],"dimerization":[284],"severly":[288],"limits":[289],"possibilities":[291],"synthesize":[293],"analogs.":[295],"This":[296],"new":[297],"enables":[299],"synthesis":[301],"wide":[304],"variety":[305]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
