{"id":"https://openalex.org/W2116999990","doi":"https://doi.org/10.1093/alcalc/agu083","title":"Potential Contributions of the Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) in the Pathogenesis of Steatohepatitis in a Chronic Plus Binge Rat Model of Alcoholic Liver Disease","display_name":"Potential Contributions of the Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) in the Pathogenesis of Steatohepatitis in a Chronic Plus Binge Rat Model of Alcoholic Liver Disease","publication_year":2015,"publication_date":"2015-01-24","ids":{"openalex":"https://openalex.org/W2116999990","doi":"https://doi.org/10.1093/alcalc/agu083","mag":"2116999990","pmid":"https://pubmed.ncbi.nlm.nih.gov/25618784","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4327341"},"language":"en","primary_location":{"id":"doi:10.1093/alcalc/agu083","doi":"https://doi.org/10.1093/alcalc/agu083","is_oa":false,"landing_page_url":"https://doi.org/10.1093/alcalc/agu083","pdf_url":null,"source":{"id":"https://openalex.org/S102424854","display_name":"Alcohol and Alcoholism","issn_l":"0735-0414","issn":["0735-0414","1464-3502"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and Alcoholism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4327341","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052816211","display_name":"Valerie Zabala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Zabala","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113524880","display_name":"Ming Tong","orcid":"https://orcid.org/0000-0002-4532-5269","observed_orcids":["https://orcid.org/0000-0002-4532-5269"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Tong","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112744594","display_name":"Rosa Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Yu","raw_affiliation_strings":["Department of Neuroscience, Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Ramirez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Ramirez","raw_affiliation_strings":["Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. B. Yalcin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. B. Yalcin","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062371918","display_name":"Silvia Balbo","orcid":"https://orcid.org/0000-0002-7686-0504","observed_orcids":["https://orcid.org/0000-0002-7686-0504"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Balbo","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, Cancer and Cardiovascular Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, Cancer and Cardiovascular Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051039403","display_name":"Elizabeth Silbermann","orcid":"https://orcid.org/0000-0002-8719-8712","observed_orcids":["https://orcid.org/0000-0002-8719-8712"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Silbermann","raw_affiliation_strings":["Warren Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warren Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046129014","display_name":"Chetram Deochand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Deochand","raw_affiliation_strings":["Biotechnology Graduate Program, Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Graduate Program, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049139649","display_name":"Kavin M. Nu\u00f1ez","orcid":"https://orcid.org/0000-0002-5410-9621","observed_orcids":["https://orcid.org/0000-0002-5410-9621"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Nunez","raw_affiliation_strings":["Department of Neuroscience, Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Hecht","raw_affiliation_strings":["Masonic Cancer Center, University of Minnesota, Cancer and Cardiovascular Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masonic Cancer Center, University of Minnesota, Cancer and Cardiovascular Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014095062","display_name":"Suzanne M. de la Monte","orcid":"https://orcid.org/0000-0001-5886-2306","observed_orcids":["https://orcid.org/0000-0001-5886-2306"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. M. de la Monte","raw_affiliation_strings":["Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Pathology and Neurology, and the Division of Neuropathology, Rhode Island Hospital, Providence, RI, USA Suzanne_DeLaMonte_MD@Brown.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Pathology and Neurology, and the Division of Neuropathology, Rhode Island Hospital, Providence, RI, USA Suzanne_DeLaMonte_MD@Brown.edu","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5014095062"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"],"apc_list":{"value":3250,"currency":"GBP","value_usd":4286},"apc_paid":null,"fwci":6.7954,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.9749844,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"50","issue":"2","first_page":"118","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nnk","display_name":"NNK","score":0.906000018119812},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.9480000138282776},{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"steatohepatitis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/binge-drinking","display_name":"binge drinking","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chronic-alcohol-exposure","display_name":"chronic ethanol exposure","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.6669999957084656},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.734000027179718},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.734000027179718},{"id":"https://openalex.org/keywords/igf-signaling","display_name":"IGF signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.890999972820282},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.800000011920929},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8799999952316284},{"id":"https://openalex.org/keywords/long-evans-rats","display_name":"Long-Evans rats","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.6975328922271729},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6823803186416626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.666252076625824},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.6221768856048584},{"id":"https://openalex.org/C2777395278","wikidata":"https://www.wikidata.org/wiki/Q413779","display_name":"Nitrosamine","level":3,"score":0.550841212272644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5161474943161011},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4714088439941406},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4691642224788666},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4136517643928528},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4084606468677521},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34926891326904297},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.25439751148223877},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.20587828755378723},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1765957474708557},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1493322253227234},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002492","descriptor_name":"Central Nervous System Depressants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009602","descriptor_name":"Nitrosamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017526","descriptor_name":"Receptor, IGF Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/alcalc/agu083","doi":"https://doi.org/10.1093/alcalc/agu083","is_oa":false,"landing_page_url":"https://doi.org/10.1093/alcalc/agu083","pdf_url":null,"source":{"id":"https://openalex.org/S102424854","display_name":"Alcohol and Alcoholism","issn_l":"0735-0414","issn":["0735-0414","1464-3502"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and Alcoholism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4327341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4327341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol Alcohol","raw_type":"Text"},{"id":"pmid:25618784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25618784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and alcoholism (Oxford, Oxfordshire)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.673.9506","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.673.9506","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://alcalc.oxfordjournals.org/content/alcalc/50/2/118.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4327341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4327341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol Alcohol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1959846446","display_name":null,"funder_award_id":"CA81301","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3067393624","display_name":"Metabolism of Carcinogenic Tobacco-Specific Nitrosamines","funder_award_id":"R01CA081301","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3279485678","display_name":null,"funder_award_id":"AA-12908","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4540679723","display_name":null,"funder_award_id":"AA11431","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5728038171","display_name":"EFFECTS OF ETHANOL ON INSULIN SIGNALING IN THE BRAIN","funder_award_id":"R01AA012908","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6071260238","display_name":"Advancing the Culture of Ph.D. Learning and Scholarship in Biology and Health Science","funder_award_id":"R25GM083270","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6647153909","display_name":"Research Training Program in Gastroenterology","funder_award_id":"T32DK060415","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7829921397","display_name":"Ethanol, IRS-1  Signaling and Neuronal Migration","funder_award_id":"R37AA011431","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000895342","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA077598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W93825959","https://openalex.org/W1505566704","https://openalex.org/W1505892068","https://openalex.org/W1514450330","https://openalex.org/W1529211016","https://openalex.org/W1543776771","https://openalex.org/W1544011548","https://openalex.org/W1551469511","https://openalex.org/W1553912543","https://openalex.org/W1574483226","https://openalex.org/W1581472418","https://openalex.org/W1585175789","https://openalex.org/W1637996374","https://openalex.org/W1864035700","https://openalex.org/W1945214665","https://openalex.org/W1964209362","https://openalex.org/W1964482562","https://openalex.org/W1964995524","https://openalex.org/W1968132777","https://openalex.org/W1969624260","https://openalex.org/W1975833320","https://openalex.org/W1975996333","https://openalex.org/W1977247288","https://openalex.org/W1981077171","https://openalex.org/W1981362185","https://openalex.org/W1982503433","https://openalex.org/W1983211662","https://openalex.org/W1983979149","https://openalex.org/W1986800512","https://openalex.org/W1987673834","https://openalex.org/W1988879252","https://openalex.org/W1990326789","https://openalex.org/W1991476699","https://openalex.org/W1993781173","https://openalex.org/W1994190235","https://openalex.org/W1995928536","https://openalex.org/W1998275863","https://openalex.org/W1999317672","https://openalex.org/W1999876234","https://openalex.org/W2000999806","https://openalex.org/W2002074152","https://openalex.org/W2003740664","https://openalex.org/W2003951845","https://openalex.org/W2007123357","https://openalex.org/W2012652496","https://openalex.org/W2013891436","https://openalex.org/W2015207436","https://openalex.org/W2017313969","https://openalex.org/W2018016244","https://openalex.org/W2018289835","https://openalex.org/W2019912556","https://openalex.org/W2022186124","https://openalex.org/W2022327379","https://openalex.org/W2024933805","https://openalex.org/W2028265731","https://openalex.org/W2028824782","https://openalex.org/W2034298464","https://openalex.org/W2036404794","https://openalex.org/W2038452544","https://openalex.org/W2041755595","https://openalex.org/W2041816554","https://openalex.org/W2043839229","https://openalex.org/W2045642603","https://openalex.org/W2046111632","https://openalex.org/W2046374458","https://openalex.org/W2047756185","https://openalex.org/W2049525155","https://openalex.org/W2053265248","https://openalex.org/W2058699456","https://openalex.org/W2062678605","https://openalex.org/W2064994122","https://openalex.org/W2066238144","https://openalex.org/W2066453798","https://openalex.org/W2067927016","https://openalex.org/W2068535495","https://openalex.org/W2070329355","https://openalex.org/W2073741175","https://openalex.org/W2074971675","https://openalex.org/W2075235705","https://openalex.org/W2080150721","https://openalex.org/W2080977708","https://openalex.org/W2083913738","https://openalex.org/W2084342216","https://openalex.org/W2084981545","https://openalex.org/W2087061573","https://openalex.org/W2087776886","https://openalex.org/W2089609408","https://openalex.org/W2094550255","https://openalex.org/W2096186956","https://openalex.org/W2100593358","https://openalex.org/W2101604402","https://openalex.org/W2101658474","https://openalex.org/W2103597597","https://openalex.org/W2105541289","https://openalex.org/W2106610537","https://openalex.org/W2106946385","https://openalex.org/W2107832237","https://openalex.org/W2111494523","https://openalex.org/W2124177074","https://openalex.org/W2124925422","https://openalex.org/W2132839457","https://openalex.org/W2137896147","https://openalex.org/W2140695384","https://openalex.org/W2153525019","https://openalex.org/W2155144538","https://openalex.org/W2155256328","https://openalex.org/W2156074740","https://openalex.org/W2157599619","https://openalex.org/W2158405023","https://openalex.org/W2159486148","https://openalex.org/W2165013512","https://openalex.org/W2167019087","https://openalex.org/W2168078392","https://openalex.org/W2169899551","https://openalex.org/W2171441994","https://openalex.org/W2395650324","https://openalex.org/W2413769619","https://openalex.org/W4211110117","https://openalex.org/W4235983477","https://openalex.org/W4238566283","https://openalex.org/W4404638035"],"related_works":["https://openalex.org/W2971858471","https://openalex.org/W2380799757","https://openalex.org/W2121640294","https://openalex.org/W2035729289","https://openalex.org/W7096705448","https://openalex.org/W2810426824","https://openalex.org/W2346193950","https://openalex.org/W2360554504","https://openalex.org/W2318453108","https://openalex.org/W2076170238"],"abstract_inverted_index":{"AIMS:":[0],"Alcoholic":[1],"liver":[2],"disease":[3],"(ALD)":[4],"is":[5],"linked":[6],"to":[7,21,43,49,173,193],"binge":[8,16],"drinking":[9],"and":[10,29,87,91,125,138,145,154,169,179,186],"cigarette":[11],"smoking.":[12],"Heavy":[13],"chronic":[14],"\u00b1":[15,107],"alcohol,":[17],"or":[18,61,81],"low-level":[19],"exposures":[20,42,171],"dietary":[22],"nitrosamines":[23],"cause":[24],"steatohepatitis":[25,110],"with":[26,77,111],"insulin":[27],"resistance":[28,178],"oxidative":[30],"stress":[31],"in":[32,47,88,133,163],"animal":[33],"models.":[34],"This":[35],"study":[36],"examines":[37],"hepatotoxic":[38],"effects":[39,183],"of":[40,114,129,184],"sub-mutagenic":[41],"tobacco-specific":[44],"nitrosamine":[45],"(NNK)":[46],"relation":[48],"ALD.":[50],"METHODS:":[51],"Long":[52],"Evans":[53],"rats":[54,74,94],"were":[55,75,95,102,160],"fed":[56],"liquid":[57],"diets":[58],"containing":[59],"0":[60],"26%":[62],"(caloric)":[63],"ethanol":[64],"(EtOH)":[65],"for":[66],"8":[67],"weeks.":[68],"In":[69],"Weeks":[70,89],"3":[71],"through":[72,143],"8,":[73,92],"treated":[76],"NNK":[78,108,139,155,170,187],"(2":[79],"mg/kg)":[80],"saline":[82],"by":[83],"i.p.":[84],"injection,":[85],"3\u00d7/week,":[86],"7":[90],"EtOH-fed":[93],"binge-administered":[96],"2":[97],"g/kg":[98],"EtOH":[99,106,137,150,185],"3\u00d7/week;":[100],"controls":[101],"given":[103],"saline.":[104],"RESULTS:":[105],"caused":[109],"necrosis,":[112],"disruption":[113],"the":[115,134],"hepatic":[116],"cord":[117],"architecture,":[118],"ballooning":[119],"degeneration,":[120],"early":[121],"fibrosis,":[122],"mitochondrial":[123],"cytopathy":[124],"ER":[126],"disruption.":[127],"Severity":[128],"lesions":[130],"was":[131],"highest":[132],"EtOH+NNK":[135],"group.":[136],"inhibited":[140],"insulin/IGF":[141,177],"signaling":[142],"Akt":[144],"activated":[146],"pro-inflammatory":[147],"cytokines,":[148],"while":[149],"promoted":[151],"lipid":[152],"peroxidation,":[153],"increased":[156],"apoptosis.":[157],"O(6)-methyl-Guanine":[158],"adducts":[159],"only":[161],"detected":[162],"NNK-exposed":[164],"livers.":[165],"CONCLUSION:":[166],"Both":[167],"alcohol":[168],"contribute":[172],"ALD":[174,194],"pathogenesis,":[175],"including":[176],"inflammation.":[180],"The":[181],"differential":[182],"on":[188],"adduct":[189],"formation":[190],"are":[191],"critical":[192],"progression":[195],"among":[196],"alcoholics":[197],"who":[198],"smoke.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}