{"id":"https://openalex.org/W2116979157","doi":"https://doi.org/10.1042/bst20110660","title":"UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning","display_name":"UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning","publication_year":2011,"publication_date":"2011-11-21","ids":{"openalex":"https://openalex.org/W2116979157","doi":"https://doi.org/10.1042/bst20110660","mag":"2116979157","pmid":"https://pubmed.ncbi.nlm.nih.gov/22103527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5323249"},"language":"en","primary_location":{"id":"doi:10.1042/bst20110660","doi":"https://doi.org/10.1042/bst20110660","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20110660","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5323249","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035187958","display_name":"David S. Razafsky","orcid":"https://orcid.org/0000-0001-6292-0169","observed_orcids":["https://orcid.org/0000-0001-6292-0169"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Razafsky","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, U.S.A","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061721953","display_name":"Shulun Zang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shulun Zang","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, U.S.A","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056601179","display_name":"Didier M. Hodzic","orcid":"https://orcid.org/0000-0002-2113-8936","observed_orcids":["https://orcid.org/0000-0002-2113-8936"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Didier Hodzic","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO 63110, U.S.A","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.1162,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.08922109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"39","issue":"6","first_page":"1790","last_page":"1794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linc-complex","display_name":"LINC complex","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nuclear-envelope","display_name":"nuclear envelope","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nuclear-positioning","display_name":"nuclear positioning","score":0.984000027179718},{"id":"https://openalex.org/keywords/nuclear-dynamics","display_name":"nuclear dynamics","score":0.7699999809265137},{"id":"https://openalex.org/keywords/nucleoskeleton","display_name":"nucleoskeleton","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.9240000247955322},{"id":"https://openalex.org/keywords/molecular-motors","display_name":"molecular motors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/syncytia","display_name":"syncytia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tissue-morphogenesis","display_name":"tissue morphogenesis","score":0.843999981880188},{"id":"https://openalex.org/keywords/human-disease","display_name":"human disease","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.652428925037384},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.6441085338592529},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5502104163169861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5431436896324158},{"id":"https://openalex.org/C65155139","wikidata":"https://www.wikidata.org/wiki/Q5380912","display_name":"Envelope (radar)","level":3,"score":0.521436870098114},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.4857257008552551},{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.44495147466659546},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.32253390550613403},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.3134501576423645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15013685822486877},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11062014102935791},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0917399525642395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06779652833938599},{"id":"https://openalex.org/C554190296","wikidata":"https://www.wikidata.org/wiki/Q47528","display_name":"Radar","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1042/bst20110660","doi":"https://doi.org/10.1042/bst20110660","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20110660","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},{"id":"pmid:22103527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22103527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5323249","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5323249","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Soc Trans","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5323249","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5323249","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem Soc Trans","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1343798959","display_name":"The nucleus-cytoskeleton connection in health and disease","funder_award_id":"R01GM084204","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1381428186","display_name":null,"funder_award_id":"GM084204","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3153079640","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY002687","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G514528555","display_name":"NUCLEAR DYNAMICS IN RETINAL DEVELOPMENT AND HOMEOSTASIS","funder_award_id":"R01EY022632","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000861881","display_name":"Interdisciplinary Training in Vision Science","funder_award_id":"T32EY013360","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1767420210","https://openalex.org/W1847371669","https://openalex.org/W1913208087","https://openalex.org/W1969191946","https://openalex.org/W1970771850","https://openalex.org/W1971444142","https://openalex.org/W1973269530","https://openalex.org/W1978390749","https://openalex.org/W1987824870","https://openalex.org/W1988954221","https://openalex.org/W1991120047","https://openalex.org/W1992128468","https://openalex.org/W1993552170","https://openalex.org/W2007211356","https://openalex.org/W2009495925","https://openalex.org/W2016402179","https://openalex.org/W2022989270","https://openalex.org/W2025587626","https://openalex.org/W2033731029","https://openalex.org/W2038761244","https://openalex.org/W2046344492","https://openalex.org/W2058549524","https://openalex.org/W2062536168","https://openalex.org/W2065072552","https://openalex.org/W2068432076","https://openalex.org/W2073122398","https://openalex.org/W2074741279","https://openalex.org/W2076228191","https://openalex.org/W2085655013","https://openalex.org/W2086265537","https://openalex.org/W2091376022","https://openalex.org/W2093236103","https://openalex.org/W2094228287","https://openalex.org/W2094856298","https://openalex.org/W2095612044","https://openalex.org/W2109374753","https://openalex.org/W2113101155","https://openalex.org/W2113873325","https://openalex.org/W2114862447","https://openalex.org/W2115309138","https://openalex.org/W2118036121","https://openalex.org/W2118261741","https://openalex.org/W2139486492","https://openalex.org/W2156046782","https://openalex.org/W2163504716","https://openalex.org/W2164503992","https://openalex.org/W2167546995","https://openalex.org/W2168480092","https://openalex.org/W2171402579","https://openalex.org/W2395762000"],"related_works":["https://openalex.org/W2972117381","https://openalex.org/W70298503","https://openalex.org/W2770683005","https://openalex.org/W2912203822","https://openalex.org/W1907693897","https://openalex.org/W7162935581","https://openalex.org/W2890416342","https://openalex.org/W2021688302","https://openalex.org/W7099468925","https://openalex.org/W6982580062"],"abstract_inverted_index":{"Appropriate":[0],"tissue":[1],"morphogenesis":[2],"strictly":[3],"requires":[4],"the":[5,26,32,52,78,89,94,106],"developmental":[6],"regulation":[7],"of":[8,11,16,56,75,81,96,109],"different":[9,36,103],"types":[10],"nuclear":[12,27,33,66,82],"movements.":[13],"LINC":[14,57,97],"(linker":[15],"nucleoskeleton":[17],"and":[18,29,39,86,105],"cytoskeleton)":[19],"complexes":[20,58],"are":[21],"macromolecular":[22],"scaffolds":[23],"that":[24],"span":[25],"envelope":[28],"physically":[30],"connect":[31],"interior":[34],"to":[35,51,71],"cytoskeletal":[37],"elements":[38],"molecular":[40],"motors,":[41],"thereby":[42],"playing":[43],"essential":[44],"roles":[45],"in":[46,53,65,77,100,112],"nucleokinesis.":[47],"Recent":[48],"studies":[49],"dedicated":[50],"vivo":[54,101],"disruption":[55,99],"not":[59],"only":[60],"confirmed":[61],"their":[62],"widespread":[63],"role":[64],"dynamics,":[67],"but":[68],"also":[69],"led":[70],"a":[72],"vigorous":[73],"regain":[74],"interest":[76],"physiological":[79],"relevance":[80],"positioning":[83],"within":[84],"cells":[85],"syncitia.":[87],"In":[88],"present":[90],"paper,":[91],"we":[92],"review":[93],"results":[95],"complex":[98],"across":[102],"organisms":[104],"potential":[107],"implications":[108],"observed":[110],"phenotypes":[111],"human":[113],"diseases.":[114]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}