{"id":"https://openalex.org/W2116972312","doi":"https://doi.org/10.1021/pr0700504","title":"Lifetime Proteomic Profiling of an A30P \u03b1-SynucleinDrosophilaModel of Parkinson's Disease","display_name":"Lifetime Proteomic Profiling of an A30P \u03b1-SynucleinDrosophilaModel of Parkinson's Disease","publication_year":2007,"publication_date":"2007-08-07","ids":{"openalex":"https://openalex.org/W2116972312","doi":"https://doi.org/10.1021/pr0700504","mag":"2116972312","pmid":"https://pubmed.ncbi.nlm.nih.gov/17683129"},"language":"en","primary_location":{"id":"doi:10.1021/pr0700504","doi":"https://doi.org/10.1021/pr0700504","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr0700504","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017658559","display_name":"Zhiyin Xun","orcid":"https://orcid.org/0000-0002-9793-4429","observed_orcids":["https://orcid.org/0000-0002-9793-4429"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyin Xun","raw_affiliation_strings":["Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405","Department of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Department of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009725612","display_name":"Ren\u00e3 A. S. Robinson","orcid":"https://orcid.org/0000-0001-6307-8671","observed_orcids":["https://orcid.org/0000-0001-6307-8671"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ren\u00e3 A. Sowell","raw_affiliation_strings":["Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037744823","display_name":"Thomas C. Kaufman","orcid":"https://orcid.org/0000-0003-1406-7671","observed_orcids":["https://orcid.org/0000-0003-1406-7671"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas C. Kaufman","raw_affiliation_strings":["Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007958104","display_name":"David E. Clemmer","orcid":"https://orcid.org/0000-0003-4039-1360","observed_orcids":["https://orcid.org/0000-0003-4039-1360"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Clemmer","raw_affiliation_strings":["Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biology, Indiana University, Bloomington, Indiana, 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.4928,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.92123448,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"9","first_page":"3729","last_page":"3738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/drosophila-model","display_name":"Drosophila model","score":0.9620000123977661},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.800000011920929},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.6000000238418579},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.8080000281333923},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mitochondrial-proteins","display_name":"mitochondrial proteins","score":0.7360000014305115},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.9959999918937683},{"id":"https://openalex.org/keywords/presymptomatic-disease","display_name":"presymptomatic disease","score":0.7200000286102295},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7971236109733582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6591521501541138},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.617030680179596},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5714964270591736},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5262388586997986},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5200045704841614},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4965713620185852},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4919526278972626},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4549131691455841},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.43530574440956116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41042324900627136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33015328645706177},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24772876501083374},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17703813314437866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16949531435966492},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1582854688167572}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/pr0700504","doi":"https://doi.org/10.1021/pr0700504","is_oa":false,"landing_page_url":"https://doi.org/10.1021/pr0700504","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:17683129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17683129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1491813722","display_name":null,"funder_award_id":"R01-AG-024547","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G513743166","display_name":"New proteome technologies: mapping adult D. melanogaster","funder_award_id":"5r01ag024547-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1497427077","https://openalex.org/W1527671059","https://openalex.org/W1638455216","https://openalex.org/W1965778124","https://openalex.org/W1965963335","https://openalex.org/W1976148085","https://openalex.org/W1976316003","https://openalex.org/W1976777120","https://openalex.org/W1977669212","https://openalex.org/W1982282366","https://openalex.org/W1992945893","https://openalex.org/W1997355141","https://openalex.org/W2000156275","https://openalex.org/W2012057434","https://openalex.org/W2024041381","https://openalex.org/W2029220511","https://openalex.org/W2058805971","https://openalex.org/W2059109159","https://openalex.org/W2077769229","https://openalex.org/W2081293666","https://openalex.org/W2089797759","https://openalex.org/W2103017472","https://openalex.org/W2111365278","https://openalex.org/W2127524719","https://openalex.org/W2141652419","https://openalex.org/W2143959688","https://openalex.org/W2148526984","https://openalex.org/W2158930854","https://openalex.org/W2169831780","https://openalex.org/W2178984859"],"related_works":["https://openalex.org/W2123900889","https://openalex.org/W2136721206","https://openalex.org/W4408327911","https://openalex.org/W2102295976","https://openalex.org/W7095878563","https://openalex.org/W2037731046","https://openalex.org/W1970328349","https://openalex.org/W2895917965","https://openalex.org/W7214119356","https://openalex.org/W2132182347"],"abstract_inverted_index":{"A":[0],"survey":[1],"of":[2,12,113,140,172,216],"the":[3,28,63,98,122,157,161,173,182,192,220],"proteome":[4],"changes":[5,58,189,218],"in":[6,16,59,156,169,191],"an":[7,214],"A30P":[8],"alpha-synuclein":[9],"Drosophila":[10,64],"model":[11,66],"Parkinson's":[13],"disease":[14,197,212],"(PD)":[15],"comparison":[17],"to":[18,46,55,207],"age-matched":[19,68],"controls":[20,69],"is":[21],"presented":[22],"for":[23,210,227],"seven":[24],"different":[25],"ages":[26,222],"across":[27,121,202],"adult":[29],"lifespan.":[30,123],"The":[31],"data":[32],"were":[33],"acquired":[34],"by":[35],"a":[36],"shotgun":[37],"proteomic":[38],"approach":[39,100],"that":[40,72,104,116,154,184],"involves":[41],"multidimensional":[42],"liquid":[43],"chromatographies":[44],"coupled":[45],"mass":[47],"spectrometry":[48],"and":[49,67,79,94,136,147,160,178,187,195],"database":[50],"searching":[51],"techniques.":[52],"Semiquantitative":[53],"analysis":[54],"assess":[56],"relative":[57],"protein":[60],"expression":[61],"between":[62],"PD":[65],"provides":[70],"evidence":[71],"28,":[73],"19,":[74],"12,":[75],"5,":[76],"7,":[77],"23,":[78],"17":[80],"proteins":[81,107,143,149],"are":[82,108,163],"significantly":[83],"differentially":[84],"expressed":[85],"at":[86,132,144,150,219],"days":[87,133],"1,":[88,134],"10,":[89,135,152],"20,":[90,175],"30,":[91],"40,":[92,176],"50,":[93,177],"60,":[95],"respectively.":[96],"From":[97],"experimental":[99],"employed,":[101],"it":[102],"appears":[103],"most":[105,225],"dysregulated":[106],"associated":[109,164],"with":[110,165],"narrow":[111],"distributions":[112],"ages,":[114],"such":[115],"disease-associated":[117],"differences":[118],"change":[119],"substantially":[120],"Previous":[124],"measurements":[125],"[J.":[126],"Proteome":[127],"Res.":[128],"2007,":[129],"6,":[130],"348]":[131],"30":[137],"showed":[138],"dysregulation":[139],"actin":[141,158],"cytoskeletal":[142,186],"day":[145,151,174],"1":[146],"mitochondrial":[148,188],"suggesting":[153],"defects":[155],"cytoskeleton":[159],"mitochondria":[162],"dopaminergic":[166],"neuron":[167],"degeneration":[168],"PD.":[170],"Analysis":[171],"60":[179],"animals":[180],"supports":[181],"finding":[183],"these":[185],"predominate":[190],"youngest":[193,221],"(pre-symtomatic":[194],"early":[196],"stages)":[198],"animals.":[199],"Although":[200],"studies":[201],"many":[203],"time":[204],"points":[205],"appear":[206],"be":[208,224],"important":[209,226],"characterizing":[211],"state,":[213],"understanding":[215],"molecular":[217],"should":[223],"addressing":[228],"causation.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}