{"id":"https://openalex.org/W2116971992","doi":"https://doi.org/10.1164/rccm.200110-033oc","title":"Effects of Bronchial Obstruction on Lower Esophageal Sphincter Motility and Gastroesophageal Reflux in Patients with Asthma","display_name":"Effects of Bronchial Obstruction on Lower Esophageal Sphincter Motility and Gastroesophageal Reflux in Patients with Asthma","publication_year":2002,"publication_date":"2002-10-28","ids":{"openalex":"https://openalex.org/W2116971992","doi":"https://doi.org/10.1164/rccm.200110-033oc","mag":"2116971992","pmid":"https://pubmed.ncbi.nlm.nih.gov/12403689"},"language":"en","primary_location":{"id":"doi:10.1164/rccm.200110-033oc","doi":"https://doi.org/10.1164/rccm.200110-033oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200110-033oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022866055","display_name":"Frank Zerbib","orcid":"https://orcid.org/0000-0002-6802-2121","observed_orcids":["https://orcid.org/0000-0002-6802-2121"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frank Zerbib","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111110","https://openalex.org/I4405256745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108553198","display_name":"Olivier Guisset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Guisset","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111110","https://openalex.org/I4405256745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006844238","display_name":"H Lamouliatte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Lamouliatte","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111110","https://openalex.org/I4405256745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113708133","display_name":"Andr\u00e9 Quinton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Quinton","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111110","https://openalex.org/I4405256745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113531741","display_name":"Jean Paul Galmiche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Paul Galmiche","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111110","https://openalex.org/I4405256745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054427451","display_name":"J. Manuel Tunon\u2010de\u2010Lara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210111110","display_name":"H\u00f4pital Saint-Andr\u00e9","ror":"https://ror.org/021959v84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210111110"]},{"id":"https://openalex.org/I4405256745","display_name":"Universit\u00e9 Bordeaux Segalen","ror":"https://ror.org/04gbzm373","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530","https://openalex.org/I4405256745"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Manuel Tunon-de-Lara","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital Saint-Andr\u00e9, Bordeaux; Service des Maladies Respiratoires, H\u00f4pital du Haut-L\u00e9v\u00eaque, Pessac; INSERM U 539, CHU H\u00f4tel Dieu, Nantes; and INSERM E9937, Universit\u00e9 Victor Segalen Bordeaux 2, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210111110","https://openalex.org/I4405256745"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2983,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.91879131,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"166","issue":"9","first_page":"1206","last_page":"1211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gastroesophageal-reflux","display_name":"gastroesophageal reflux","score":0.9300000071525574},{"id":"https://openalex.org/keywords/transient-lower-esophageal-sphincter-relaxations","display_name":"transient lower esophageal sphincter relaxations","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bronchial-obstruction","display_name":"bronchial obstruction","score":0.9670000076293945},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/esophageal-ph","display_name":"esophageal pH","score":0.8579999804496765},{"id":"https://openalex.org/keywords/intermittent-asthma","display_name":"intermittent asthma","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.9339686632156372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9210119843482971},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.8169116973876953},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.7867588400840759},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7757275700569153},{"id":"https://openalex.org/C2778088044","wikidata":"https://www.wikidata.org/wiki/Q279330","display_name":"Bronchospasm","level":3,"score":0.7358288764953613},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5649937987327576},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5263373255729675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.50376957654953},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.501915693283081},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.26211613416671753},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.15856635570526123},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001982","descriptor_name":"Bronchial Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001982","descriptor_name":"Bronchial Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001982","descriptor_name":"Bronchial Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004943","descriptor_name":"Esophagogastric Junction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004943","descriptor_name":"Esophagogastric Junction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015154","descriptor_name":"Esophageal Motility Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015154","descriptor_name":"Esophageal Motility Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016085","descriptor_name":"Bronchoconstrictor Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016085","descriptor_name":"Bronchoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/rccm.200110-033oc","doi":"https://doi.org/10.1164/rccm.200110-033oc","is_oa":false,"landing_page_url":"https://doi.org/10.1164/rccm.200110-033oc","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory and Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:12403689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12403689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W121149184","https://openalex.org/W200640285","https://openalex.org/W207040400","https://openalex.org/W287259570","https://openalex.org/W1491289111","https://openalex.org/W1508863621","https://openalex.org/W1647392156","https://openalex.org/W1945055782","https://openalex.org/W1971442238","https://openalex.org/W1982651321","https://openalex.org/W1999858833","https://openalex.org/W2003539340","https://openalex.org/W2007860313","https://openalex.org/W2020861049","https://openalex.org/W2030147339","https://openalex.org/W2034093856","https://openalex.org/W2040391660","https://openalex.org/W2053298039","https://openalex.org/W2062071217","https://openalex.org/W2074184057","https://openalex.org/W2084991407","https://openalex.org/W2086960999","https://openalex.org/W2088358534","https://openalex.org/W2115224075","https://openalex.org/W2124024297","https://openalex.org/W2140796835","https://openalex.org/W2167823323","https://openalex.org/W2168944093","https://openalex.org/W2188186609","https://openalex.org/W2316070389","https://openalex.org/W2334266544","https://openalex.org/W2336478281","https://openalex.org/W3139831453","https://openalex.org/W4231701691","https://openalex.org/W4236639597","https://openalex.org/W4247866728"],"related_works":["https://openalex.org/W1992674671","https://openalex.org/W2088358534","https://openalex.org/W2396122855","https://openalex.org/W1863444457","https://openalex.org/W1982651321","https://openalex.org/W1647392156","https://openalex.org/W53887727","https://openalex.org/W207040400","https://openalex.org/W2062074907","https://openalex.org/W1999858833"],"abstract_inverted_index":{"The":[0,9],"relationship":[1],"between":[2,105],"gastroesophageal":[3],"reflux":[4,29,138,153,173,189,193],"and":[5,28,36,47,59,99,125,137,169],"asthma":[6,46,76],"remains":[7,198],"unclear.":[8],"aim":[10],"of":[11,19,62,71,80,132,141,146,152,167,172],"this":[12],"study":[13],"was":[14],"to":[15,199],"analyze":[16],"the":[17,63,78,106,130,144,150,165,170,178],"effect":[18],"bronchial":[20,183],"obstruction":[21,184],"on":[22],"lower":[23],"esophageal":[24,37,97],"sphincter":[25],"(LES)":[26],"motility":[27,35],"in":[30,41,86,109,123,129,158,181],"patients":[31,113,159],"with":[32,44,75,114,160],"asthma.":[33],"LES":[34,95,134],"pH":[38],"were":[39,101],"assessed":[40],"eight":[42,48],"subjects":[43,67,74],"intermittent":[45],"healthy":[49,110],"volunteers":[50],"during":[51],"three":[52,107],"consecutive":[53],"30-minute":[54],"periods:":[55],"baseline,":[56],"methacholine-induced":[57,162],"bronchospasm,":[58],"after":[60],"inhalation":[61],"beta2-agonist":[64],"salbutamol.":[65],"Healthy":[66],"inhaled":[68,77],"2":[69],"mg":[70],"methacholine,":[72],"whereas":[73],"dose":[79],"methacholine":[81,93,116],"causing":[82],"a":[83,91,118,126,195],"15%":[84],"fall":[85],"FEV(1),":[87],"as":[88],"determined":[89],"by":[90],"previous":[92],"challenge.":[94],"motility,":[96],"pH,":[98],"FEV(1)":[100,124],"not":[102,149],"significantly":[103],"different":[104],"periods":[108],"subjects.":[111],"In":[112],"asthma,":[115,161,182],"induced":[117],"21.9":[119],"+/-":[120],"2.6%":[121],"decrease":[122],"concomitant":[127],"increase":[128],"rate":[131,145,166],"transient":[133],"relaxation":[135],"(TLESR)":[136],"episodes.":[139,154,174],"Inhalation":[140],"salbutamol":[142],"decreased":[143],"TLESRs":[147],"but":[148],"number":[151,171],"We":[155],"conclude":[156],"that":[157,197],"bronchospasm":[163],"increases":[164],"TLESR":[168],"These":[175],"results":[176],"support":[177],"belief":[179],"that,":[180],"may":[185,191],"be":[186,200],"responsible":[187],"for":[188],"or":[190],"aggravate":[192],"through":[194],"mechanism":[196],"further":[201],"clarified.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}