{"id":"https://openalex.org/W2116883744","doi":"https://doi.org/10.1115/1.2891235","title":"Experimental Studies on Repair of Large Osteochondral Defects at a High Weight Bearing Area of the Knee Joint: A Tissue Engineering Study","display_name":"Experimental Studies on Repair of Large Osteochondral Defects at a High Weight Bearing Area of the Knee Joint: A Tissue Engineering Study","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W2116883744","doi":"https://doi.org/10.1115/1.2891235","mag":"2116883744","pmid":"https://pubmed.ncbi.nlm.nih.gov/1875694"},"language":"en","primary_location":{"id":"doi:10.1115/1.2891235","doi":"https://doi.org/10.1115/1.2891235","is_oa":false,"landing_page_url":"https://doi.org/10.1115/1.2891235","pdf_url":null,"source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109831293","display_name":"Van C. Mow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. C. Mow","raw_affiliation_strings":["Department of Orthopaedic Surgery, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007305042","display_name":"Anthony Ratcliffe","orcid":"https://orcid.org/0000-0002-2025-4265","observed_orcids":["https://orcid.org/0000-0002-2025-4265"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Ratcliffe","raw_affiliation_strings":["Department of Orthopaedic Surgery, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005884274","display_name":"Melvin Paul Rosenwasser","orcid":"https://orcid.org/0000-0002-0516-3824","observed_orcids":["https://orcid.org/0000-0002-0516-3824"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. P. Rosenwasser","raw_affiliation_strings":["Department of Orthopaedic Surgery, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064323409","display_name":"Joseph A. Buckwalter","orcid":"https://orcid.org/0000-0003-4308-7583","observed_orcids":["https://orcid.org/0000-0003-4308-7583"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Buckwalter","raw_affiliation_strings":["University of Iowa, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9868,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.75817869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"113","issue":"2","first_page":"198","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteochondral-lesions","display_name":"osteochondral defects","score":0.9190000295639038},{"id":"https://openalex.org/keywords/articular-cartilage-repair","display_name":"articular cartilage repair","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.8149999976158142},{"id":"https://openalex.org/keywords/autologous-bone-graft","display_name":"autologous bone graft","score":0.8769999742507935},{"id":"https://openalex.org/keywords/distal-femoral-condyle","display_name":"distal femoral condyle","score":0.8519999980926514},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6669999957084656},{"id":"https://openalex.org/keywords/weight-bearing","display_name":"weight bearing","score":0.38600000739097595},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.5109999775886536},{"id":"https://openalex.org/keywords/tissue-adhesives","display_name":"tissue adhesives","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.6960408687591553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6932410001754761},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6073439121246338},{"id":"https://openalex.org/C2777564180","wikidata":"https://www.wikidata.org/wiki/Q3109230","display_name":"Articular cartilage repair","level":5,"score":0.5875877141952515},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5767372846603394},{"id":"https://openalex.org/C2780204347","wikidata":"https://www.wikidata.org/wiki/Q17126173","display_name":"Weight-bearing","level":2,"score":0.4727669060230255},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4601477086544037},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.45177289843559265},{"id":"https://openalex.org/C2781218938","wikidata":"https://www.wikidata.org/wiki/Q2192944","display_name":"Fibrocartilage","level":5,"score":0.45119142532348633},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.45067456364631653},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4397633373737335},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.3819802403450012},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2846301794052124},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23479709029197693},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.23358085751533508},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23163476586341858},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08558622002601624},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007718","descriptor_name":"Knee Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007718","descriptor_name":"Knee Injuries","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D010521","descriptor_name":"Periosteum","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1115/1.2891235","doi":"https://doi.org/10.1115/1.2891235","is_oa":false,"landing_page_url":"https://doi.org/10.1115/1.2891235","pdf_url":null,"source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},{"id":"pmid:1875694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1875694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomechanical engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974828861","https://openalex.org/W2006301167","https://openalex.org/W2318518689","https://openalex.org/W7099859706","https://openalex.org/W2347762194","https://openalex.org/W2382171046","https://openalex.org/W2073554435","https://openalex.org/W7100265031","https://openalex.org/W2042994291","https://openalex.org/W406665738"],"abstract_inverted_index":{"There":[0],"is":[1],"a":[2,83,91,98,254,258],"vast":[3],"clinical":[4,50],"need":[5],"for":[6,38,60,102,131,289],"the":[7,15,61,141,147,176,216,220,231,242,265,282],"development":[8,62,252],"of":[9,17,19,42,63,86,104,108,135,146,151,178,225,241,253,267,276,284],"an":[10,116,121,158,226],"animal":[11,100,180],"model":[12,101,181],"to":[13,69,97,174,182,201,250],"study":[14],"fundamentals":[16],"healing":[18,66],"injured":[20],"or":[21,65,120,281],"diseased":[22],"diarthrodial":[23],"joints":[24,44],"(knee,":[25],"hip,":[26],"shoulder,":[27],"wrist,":[28],"etc).":[29],"Current":[30],"prosthetic":[31],"replacements":[32],"do":[33],"not":[34],"offer":[35],"acceptable":[36],"treatment":[37,51],"injuries":[39],"and":[40,89,165,168,219,223,257],"diseases":[41],"these":[43,129,296],"in":[45,132,140,204],"young":[46],"active":[47],"individuals.":[48],"New":[49,153],"modalities,":[52],"based":[53],"on":[54],"sound":[55],"biologic":[56],"principles,":[57],"are":[58,294],"sought":[59],"repair":[64,107,134,185,217,243],"tissues":[67,196],"engineered":[68],"have":[70,127],"similar":[71,200],"biomechanical":[72],"properties":[73],"as":[74],"normal":[75,205],"articular":[76,206,232],"cartilage.":[77,207],"In":[78],"this":[79,87],"paper":[80],"we":[81,293],"present":[82],"brief":[84],"review":[85],"need,":[88],"propose":[90],"grafting":[92,113,190],"procedure":[93,114,191],"which":[94,197],"may":[95,236,263],"lead":[96],"successful":[99],"studies":[103,211,246],"long":[105,238],"term":[106,239],"major":[109],"osteochondral":[110],"defects.":[111],"This":[112,262],"uses":[115],"autologous":[117],"periosteum-bone":[118],"graft":[119],"autologous-synthetic":[122],"bone":[123],"replacement":[124],"graft.":[125],"We":[126,187],"applied":[128],"grafts":[130],"vivo":[133],"large":[136],"surgically":[137],"created":[138],"defects":[139],"high":[142],"weight":[143],"bearing":[144],"area":[145],"distal":[148],"femoral":[149],"condyle":[150],"mature":[152],"Zealand":[154],"white":[155],"rabbits.":[156],"Further,":[157],"interdisciplinary":[159],"study,":[160],"including":[161],"histochemistry,":[162],"biochemistry":[163],"(composition":[164],"metabolic":[166],"activities),":[167],"biomechanics":[169],"(biphasic":[170],"properties),":[171],"was":[172],"performed":[173],"assess":[175],"feasibility":[177],"our":[179,189,209],"generate":[183],"viable":[184],"tissues.":[186],"found":[188,203],"produced,":[192],"8":[193],"weeks":[194],"postoperatively,":[195],"were":[198],"very":[199],"those":[202],"However,":[208],"histological":[210],"indicate":[212],"incomplete":[213],"bonding":[214],"between":[215],"tissue":[218,287],"adjacent":[221],"cartilage,":[222],"lack":[224],"appropriate":[227],"superficial":[228],"zone":[229],"at":[230],"surface.":[233],"These":[234],"deficiencies":[235],"cause":[237],"failure":[240],"tissue.":[244],"Further":[245],"must":[247],"be":[248],"undertaken":[249],"enhance":[251],"strong":[255],"bond":[256],"collagen-rich":[259],"surface":[260],"zone.":[261],"require":[264],"use":[266,283],"growth":[268,272],"factors":[269,273],"(e.g.,":[270],"transforming":[271],"beta)":[274],"capable":[275],"simulating":[277],"extra":[278],"collagen":[279],"production,":[280],"serum":[285],"derived":[286],"glue":[288],"bonding.":[290],"At":[291],"present,":[292],"pursuing":[295],"studies.":[297]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}