{"id":"https://openalex.org/W2116864064","doi":null,"title":"Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.","display_name":"Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W2116864064","mag":"2116864064","pmid":"https://pubmed.ncbi.nlm.nih.gov/12684431"},"language":"en","primary_location":{"id":"pmid:12684431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12684431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056034569","display_name":"Fortunato Ciardiello","orcid":"https://orcid.org/0000-0002-3369-4841","observed_orcids":["https://orcid.org/0000-0002-3369-4841"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fortunato Ciardiello","raw_affiliation_strings":["Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universit\u00e0 degli Studi di Napoli Federico II, 5-80131 Naples, Italy. fortunatociardiello@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universit\u00e0 degli Studi di Napoli Federico II, 5-80131 Naples, Italy. fortunatociardiello@yahoo.com","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110188292","display_name":"Rosa Caputo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosa Caputo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110448318","display_name":"Vincenzo Damiano","orcid":"https://orcid.org/0009-0004-4249-9804","observed_orcids":["https://orcid.org/0009-0004-4249-9804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo Damiano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110249663","display_name":"Roberta Caputo","orcid":"https://orcid.org/0000-0003-4231-1184","observed_orcids":["https://orcid.org/0000-0003-4231-1184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Caputo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020655022","display_name":"Teresa Troiani","orcid":"https://orcid.org/0000-0002-0646-4901","observed_orcids":["https://orcid.org/0000-0002-0646-4901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Troiani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063910102","display_name":"Donatella Vitagliano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donatella Vitagliano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015782345","display_name":"Francesca Carlomagno","orcid":"https://orcid.org/0000-0002-1483-4677","observed_orcids":["https://orcid.org/0000-0002-1483-4677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Carlomagno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074628156","display_name":"Bianca Maria Veneziani","orcid":"https://orcid.org/0000-0002-1678-4183","observed_orcids":["https://orcid.org/0000-0002-1678-4183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bianca Maria Veneziani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017474339","display_name":"Gabriella Fontanini","orcid":"https://orcid.org/0000-0003-1957-2052","observed_orcids":["https://orcid.org/0000-0003-1957-2052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriella Fontanini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109233132","display_name":"A R Bianco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Raffaele Bianco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050215401","display_name":"Giampaolo Tortora","orcid":"https://orcid.org/0000-0002-1378-4962","observed_orcids":["https://orcid.org/0000-0002-1378-4962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giampaolo Tortora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9568,"has_fulltext":false,"cited_by_count":327,"citation_normalized_percentile":{"value":0.99020157,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"4","first_page":"1546","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vandetanib","display_name":"vandetanib","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vegfr-2-inhibitors","display_name":"VEGFR-2 inhibitors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibition","display_name":"EGFR tyrosine kinase inhibition","score":0.7639999985694885},{"id":"https://openalex.org/keywords/egfr-phosphorylation","display_name":"EGFR phosphorylation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9959999918937683},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/colon-cancer-xenografts","display_name":"colon cancer xenografts","score":0.8830000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.3700000047683716},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5881872773170471},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5875772833824158},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.5113096237182617},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.49712565541267395},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.49342623353004456},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.49273279309272766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4538919925689697},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.427121102809906},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4244837462902069},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4238918423652649},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.412917822599411},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3596285581588745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34627074003219604},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3452950119972229},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.31196579337120056},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3084644079208374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3021891117095947},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23949021100997925},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000362","descriptor_name":"Agar","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:12684431","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12684431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/78113","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/78113","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/205610","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/205610","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2116864064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12684431","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W56039399","https://openalex.org/W299656855","https://openalex.org/W1482578950","https://openalex.org/W1505736789","https://openalex.org/W1537447319","https://openalex.org/W1569865130","https://openalex.org/W1756949381","https://openalex.org/W1804903119","https://openalex.org/W1909369107","https://openalex.org/W1913061990","https://openalex.org/W1945415917","https://openalex.org/W1969328947","https://openalex.org/W1970955548","https://openalex.org/W1974165456","https://openalex.org/W1991958278","https://openalex.org/W2001453148","https://openalex.org/W2022039302","https://openalex.org/W2052815740","https://openalex.org/W2054119278","https://openalex.org/W2057458801","https://openalex.org/W2074070420","https://openalex.org/W2088658971","https://openalex.org/W2106764013","https://openalex.org/W2113257521","https://openalex.org/W2116150263","https://openalex.org/W2118146357","https://openalex.org/W2118559000","https://openalex.org/W2122458965","https://openalex.org/W2122880026","https://openalex.org/W2126055089","https://openalex.org/W2127459809","https://openalex.org/W2133138712","https://openalex.org/W2137101013","https://openalex.org/W2140167336","https://openalex.org/W2142760959","https://openalex.org/W2143536404","https://openalex.org/W2149051154","https://openalex.org/W2150048971","https://openalex.org/W2154200023","https://openalex.org/W2155977433","https://openalex.org/W2159506251","https://openalex.org/W2163402367","https://openalex.org/W2166825418","https://openalex.org/W2319962899","https://openalex.org/W3112995499"],"related_works":["https://openalex.org/W2014383618","https://openalex.org/W2145854263","https://openalex.org/W2090699402","https://openalex.org/W2346640639","https://openalex.org/W2118559000","https://openalex.org/W2808177954","https://openalex.org/W2097991473","https://openalex.org/W4317613968","https://openalex.org/W2032003634","https://openalex.org/W2156702383"],"abstract_inverted_index":{"PURPOSE:":[0],"Vascular":[1],"endothelial":[2,11,303],"growth":[3,75,160,182,223,319],"factor":[4,76],"(VEGF)":[5],"is":[6,20,32,52],"a":[7,33,125,154,228,271,329],"major":[8],"mitogen":[9],"for":[10,331],"cells":[12],"and":[13,25,51,79,82,135,169,184,197,266],"enhances":[14],"vascular":[15],"permeability.":[16],"Enhanced":[17],"VEGF":[18,36],"secretion":[19],"found":[21,245],"in":[22,46,54,70,90,93,113,131,153,161,181,185,187,239,257,274,299,340],"human":[23,48,94,136,148,163],"cancers":[24],"correlates":[26],"with":[27,43,98,171,195,251,262,290,338],"increased":[28],"tumor":[29,222,241],"neovascularization.":[30],"ZD6474":[31,66,87,123,150,196,201,238,263,291,310,336],"p.o.":[34],"bioavailable,":[35],"flk-1/KDR":[37],"receptor":[38,77],"(VEGFR-2)":[39],"tyrosine":[40],"kinase":[41],"inhibitor":[42],"antitumor":[44,105,235],"activity":[45,85,106,236],"many":[47],"cancer":[49,95,120,140,210,317,341],"xenografts":[50,211,242],"currently":[53],"Phase":[55],"I":[56],"clinical":[57,333],"development.":[58],"EXPERIMENTAL":[59],"DESIGN:":[60],"We":[61],"tested":[62,112],"the":[63,80,83,147,192,332],"effects":[64],"of":[65,86,107,128,157,203,217,232,237,276,279,286,335],"on":[67],"EGFR":[68,100,129,173,218,322],"phosphorylation":[69,130],"cell":[71,96,143,164,304,318],"expressing":[72],"functional":[73,99,172],"epidermal":[74],"(EGFR)":[78],"antiproliferative":[81],"proapoptotic":[84],"alone":[88],"or":[89,199],"combination":[91],"taxanes":[92,339],"lines":[97,144,165],"but":[101,174],"lacking":[102,175],"VEGFR-2.":[103,176],"The":[104,234],"this":[108],"drug":[109],"was":[110,189,243,255,268],"also":[111,244,312,328],"nude":[114,204],"mice":[115,205,259,281],"bearing":[116,206],"established":[117],"GEO":[118,208,240],"colon":[119,209],"xenografts.":[121],"RESULTS:":[122],"causes":[124],"dose-dependent":[126,155,178,221,230],"inhibition":[127,156,183,216,275],"mouse":[132],"NIH-EGFR":[133],"fibroblasts":[134],"MCF-10A":[137],"ras":[138],"breast":[139],"cells,":[141],"two":[142],"that":[145,298],"overexpress":[146],"EGFR.":[149],"treatment":[151,194,202,261,289],"resulted":[152],"soft":[158],"agar":[159],"seven":[162],"(breast,":[166],"colon,":[167],"gastric,":[168],"ovarian)":[170],"A":[177],"supra-additive":[179],"effect":[180],"apoptosis":[186],"vitro":[188],"observed":[190,256],"by":[191,270,306,320],"combined":[193,250,337],"paclitaxel":[198],"docetaxel.":[200],"palpable":[207],"(which":[212],"are":[213],"sensitive":[214],"to":[215,246,301,315],"signaling)":[219],"induced":[220],"inhibition.":[224],"Immunohistochemical":[225],"analysis":[226],"revealed":[227],"significant":[229,272],"reduction":[231],"neoangiogenesis.":[233],"be":[247,313],"enhanced":[248],"when":[249],"paclitaxel.":[252,293],"Tumor":[253],"regression":[254],"all":[258],"after":[260,288],"plus":[264,292],"paclitaxel,":[265],"it":[267],"accompanied":[269],"potentiation":[273],"angiogenesis.":[277],"Six":[278],"20":[280],"had":[282],"no":[283],"histological":[284],"evidence":[285],"tumors":[287],"CONCLUSIONS:":[294],"This":[295],"study":[296],"suggests":[297],"addition":[300],"inhibiting":[302],"proliferation":[305],"blocking":[307,321],"VEGF-induced":[308],"signaling,":[309],"may":[311],"able":[314],"inhibit":[316],"autocrine":[323],"signaling.":[324],"These":[325],"results":[326],"provide":[327],"rationale":[330],"evaluation":[334],"patients.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
