{"id":"https://openalex.org/W2116862917","doi":"https://doi.org/10.1007/s00702-012-0854-3","title":"Comparative evaluation of the potency and antigenicity of two distinct BoNT/A-derived formulations","display_name":"Comparative evaluation of the potency and antigenicity of two distinct BoNT/A-derived formulations","publication_year":2012,"publication_date":"2012-07-28","ids":{"openalex":"https://openalex.org/W2116862917","doi":"https://doi.org/10.1007/s00702-012-0854-3","mag":"2116862917","pmid":"https://pubmed.ncbi.nlm.nih.gov/22842675"},"language":"en","primary_location":{"id":"doi:10.1007/s00702-012-0854-3","doi":"https://doi.org/10.1007/s00702-012-0854-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00702-012-0854-3","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062729885","display_name":"Meenakshi S. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Brown","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036181382","display_name":"Greg Nicholson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Nicholson","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057362480","display_name":"Maria C. Ardila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. C. Ardila","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110050123","display_name":"A. Satorius","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Satorius","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076536206","display_name":"Ron S. Broide","orcid":"https://orcid.org/0000-0003-1747-0116","observed_orcids":["https://orcid.org/0000-0003-1747-0116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. S. Broide","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Clarke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Clarke","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112077964","display_name":"Terrence Hunt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"T. Hunt","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"J. Francis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Francis","raw_affiliation_strings":["Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","ALLERGAN INC.'"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Allergan Inc, 2525 Dupont Dr, Mailstop RD3-3B, Irvine, CA, 92612, USA","institution_ids":[]},{"raw_affiliation_string":"ALLERGAN INC.'","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112077964"],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.5907,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.69625699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"120","issue":"2","first_page":"291","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.8579999804496765},{"id":"https://openalex.org/keywords/incobotulinumtoxina","display_name":"incobotulinumtoxinA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/onabotulinumtoxina","display_name":"onabotulinumtoxinA","score":0.9760000109672546},{"id":"https://openalex.org/keywords/xeomin","display_name":"Xeomin","score":0.7179999947547913},{"id":"https://openalex.org/keywords/holotoxin","display_name":"holotoxin","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-potency","display_name":"drug potency","score":0.4519999921321869},{"id":"https://openalex.org/keywords/antigenicity","display_name":"antigenicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9150000214576721},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/lot-to-lot-variability","display_name":"lot-to-lot variation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/drug-interchangeability","display_name":"drug interchangeability","score":0.5709999799728394},{"id":"https://openalex.org/keywords/duration-of-effect","display_name":"duration of effect","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.9433454275131226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5507902503013611},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5455266833305359},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.5128791332244873},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2885730266571045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26587021350860596},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21960103511810303},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19103968143463135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07666048407554626}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00702-012-0854-3","doi":"https://doi.org/10.1007/s00702-012-0854-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00702-012-0854-3","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},{"id":"pmid:22842675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22842675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission (Vienna, Austria : 1996)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W13320146","https://openalex.org/W227318549","https://openalex.org/W1716112521","https://openalex.org/W1747650586","https://openalex.org/W1766552324","https://openalex.org/W1811666348","https://openalex.org/W1829305889","https://openalex.org/W1909586942","https://openalex.org/W1968264840","https://openalex.org/W1971628366","https://openalex.org/W1975946884","https://openalex.org/W1976476391","https://openalex.org/W1976647322","https://openalex.org/W1984109801","https://openalex.org/W1985528581","https://openalex.org/W1995759130","https://openalex.org/W1999983604","https://openalex.org/W2007410119","https://openalex.org/W2008138329","https://openalex.org/W2013906528","https://openalex.org/W2015477988","https://openalex.org/W2027882596","https://openalex.org/W2030125571","https://openalex.org/W2032557647","https://openalex.org/W2038237353","https://openalex.org/W2038833296","https://openalex.org/W2040247683","https://openalex.org/W2041210794","https://openalex.org/W2046085057","https://openalex.org/W2053706041","https://openalex.org/W2066391792","https://openalex.org/W2073003556","https://openalex.org/W2076420398","https://openalex.org/W2080250583","https://openalex.org/W2115806712","https://openalex.org/W2125527494","https://openalex.org/W2156205940","https://openalex.org/W2157512308","https://openalex.org/W2161759684","https://openalex.org/W2166956447","https://openalex.org/W2167719770","https://openalex.org/W2200931552","https://openalex.org/W4230120862"],"related_works":["https://openalex.org/W3034654938","https://openalex.org/W2019371269","https://openalex.org/W2407757779","https://openalex.org/W2408947761","https://openalex.org/W7137040060","https://openalex.org/W4252716580","https://openalex.org/W2076202791","https://openalex.org/W2905303601","https://openalex.org/W3189585686","https://openalex.org/W2810088546"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}